Risk and outcomes of chemotherapy-induced diarrhea (CID) among patients with colorectal cancer receiving multi-cycle chemotherapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-10

AUTHORS

Dorothy M. Keefe, Linda S. Elting, Hoang T. Nguyen, Steven M. Grunberg, Giuseppe Aprile, Antony Bonaventura, Sudarsha Selva-Nayagam, Andrea Barsevick, Bogda Koczwara, Stephen T. Sonis

ABSTRACT

BACKGROUND: Diarrhea is a common toxicity of chemotherapy, but the practice of reporting only severe grades (≥ 3) in clinical trials results in misleading conclusions of significance. Epidemiology remains poorly described, and effects of multi-cycle regimens have not been investigated. To better understand the risks, symptom burden and consequences of CID, we studied patients receiving chemotherapy for colorectal cancer (CRC). METHODS: One hundred and fourteen patients receiving FOLFOX (95 patients, 530 cycles), FOLFOX + monoclonal antibodies (10 patients, 49 cycles) or FOLFIRI (9 patients, 50 cycles) were enrolled. CID was identified from diaries at baseline and daily during up to 8 chemotherapy cycles using supplemental questions on the Oral Mucositis Daily Questionnaire, a valid tool for collecting patient-reported outcomes of regimen-related mucosal injury. Patients scored CID severity from 0 "none" to 10 "worst possible," and quantity from "little" to "severe" on a 5-point scale. Quality of life was measured using the FACT-G, and fatigue using the FACIT fatigue scale. RESULTS: CID occurred in 89% of patients on FOLFIRI, 50% on FOLFOX + monoclonal antibodies and 56% on FOLFOX alone. The risk of a first episode was highest during Cycle 1 (35 %) and dropped to <10% during Cycles 3-5. Patients with CID reported poorer quality of life scores than those without CID (77.1 vs 80.7). CONCLUSIONS: Diarrhea occurs more commonly than typically appreciated during chemotherapy for CRC. Risk is highest during first exposure, suggesting variable susceptibility. Identification of this high-risk subgroup for prophylaxis could improve the quality of life. More... »

PAGES

675-680

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00280-014-2526-5

DOI

http://dx.doi.org/10.1007/s00280-014-2526-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037975934

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25055935


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Australia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Camptothecin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Canada", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diarrhea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Screening Assays, Antitumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Europe", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunologic Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leucovorin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organoplatinum Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prevalence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quality of Life", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Assessment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Surveys and Questionnaires", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "United States", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Adelaide", 
          "id": "https://www.grid.ac/institutes/grid.1010.0", 
          "name": [
            "University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Keefe", 
        "givenName": "Dorothy M.", 
        "id": "sg:person.014607232302.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014607232302.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Elting", 
        "givenName": "Linda S.", 
        "id": "sg:person.01041100073.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041100073.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nguyen", 
        "givenName": "Hoang T.", 
        "id": "sg:person.0673066560.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673066560.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Vermont", 
          "id": "https://www.grid.ac/institutes/grid.59062.38", 
          "name": [
            "University of Vermont, Burlington, VT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grunberg", 
        "givenName": "Steven M.", 
        "id": "sg:person.01251452227.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251452227.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "University and General Hospital, Udine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aprile", 
        "givenName": "Giuseppe", 
        "id": "sg:person.01150115462.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150115462.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mater Private Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416562.2", 
          "name": [
            "Calvary Mater Hospital, Newcastle, NSW, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonaventura", 
        "givenName": "Antony", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Adelaide Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416075.1", 
          "name": [
            "Royal Adelaide Hospital, Adelaide, SA, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Selva-Nayagam", 
        "givenName": "Sudarsha", 
        "id": "sg:person.01115076320.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115076320.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thomas Jefferson University", 
          "id": "https://www.grid.ac/institutes/grid.265008.9", 
          "name": [
            "Thomas Jefferson University, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barsevick", 
        "givenName": "Andrea", 
        "id": "sg:person.0753577767.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753577767.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Flinders Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.414925.f", 
          "name": [
            "Flinders Medical Centre, Adelaide, SA, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koczwara", 
        "givenName": "Bogda", 
        "id": "sg:person.01335135331.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335135331.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Brigham and Women's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.62560.37", 
          "name": [
            "Brigham and Women\u2019s Hospital, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sonis", 
        "givenName": "Stephen T.", 
        "id": "sg:person.01230421137.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230421137.93"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1080/07357900802132550", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001531765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpsychores.2012.10.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009066345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1015276414526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019271543", 
          "https://doi.org/10.1023/a:1015276414526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.20162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021904357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0163278705275341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028882032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0163278705275341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028882032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1705250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030150333", 
          "https://doi.org/10.1038/sj.bmt.1705250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-012-1644-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035950226", 
          "https://doi.org/10.1007/s00520-012-1644-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.23898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040579348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1758834009355164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064077267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1758834009355164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064077267"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-10", 
    "datePublishedReg": "2014-10-01", 
    "description": "BACKGROUND: Diarrhea is a common toxicity of chemotherapy, but the practice of reporting only severe grades (\u2265 3) in clinical trials results in misleading conclusions of significance. Epidemiology remains poorly described, and effects of multi-cycle regimens have not been investigated. To better understand the risks, symptom burden and consequences of CID, we studied patients receiving chemotherapy for colorectal cancer (CRC).\nMETHODS: One hundred and fourteen patients receiving FOLFOX (95 patients, 530 cycles), FOLFOX + monoclonal antibodies (10 patients, 49 cycles) or FOLFIRI (9 patients, 50 cycles) were enrolled. CID was identified from diaries at baseline and daily during up to 8 chemotherapy cycles using supplemental questions on the Oral Mucositis Daily Questionnaire, a valid tool for collecting patient-reported outcomes of regimen-related mucosal injury. Patients scored CID severity from 0 \"none\" to 10 \"worst possible,\" and quantity from \"little\" to \"severe\" on a 5-point scale. Quality of life was measured using the FACT-G, and fatigue using the FACIT fatigue scale.\nRESULTS: CID occurred in 89% of patients on FOLFIRI, 50% on FOLFOX + monoclonal antibodies and 56% on FOLFOX alone. The risk of a first episode was highest during Cycle 1 (35 %) and dropped to <10% during Cycles 3-5. Patients with CID reported poorer quality of life scores than those without CID (77.1 vs 80.7).\nCONCLUSIONS: Diarrhea occurs more commonly than typically appreciated during chemotherapy for CRC. Risk is highest during first exposure, suggesting variable susceptibility. Identification of this high-risk subgroup for prophylaxis could improve the quality of life.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00280-014-2526-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1088364", 
        "issn": [
          "0344-5704", 
          "1432-0843"
        ], 
        "name": "Cancer Chemotherapy and Pharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "74"
      }
    ], 
    "name": "Risk and outcomes of chemotherapy-induced diarrhea (CID) among patients with colorectal cancer receiving multi-cycle chemotherapy", 
    "pagination": "675-680", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b4e7912e17c835f6f79e5b2f8e0b62f5262db42d883ee5cba6701eea06d347b5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25055935"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7806519"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00280-014-2526-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037975934"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00280-014-2526-5", 
      "https://app.dimensions.ai/details/publication/pub.1037975934"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000514.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00280-014-2526-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00280-014-2526-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00280-014-2526-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00280-014-2526-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00280-014-2526-5'


 

This table displays all metadata directly associated to this object as RDF triples.

288 TRIPLES      21 PREDICATES      64 URIs      47 LITERALS      35 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00280-014-2526-5 schema:about N07cc69592bc44587a4f60712cfb20039
2 N0bfa464d6ee1427b84eb335b18648df3
3 N17569083888945598f8fb3c966535169
4 N192eae997c3e42908de5c2252708e7cf
5 N262a52c4f3f64d979c630baf9f1bcddb
6 N2f24042636224b45bec425d0d5da285f
7 N42d51b93a85d45949cb0ce414644318c
8 N5886577c0eb64542896d763bc18a9011
9 N6a8d2f263bfe4899a831983bd91bca10
10 N7cd7c9fd897241c2b6eaea42ae30f677
11 N7f8f69bc71b3417393489979b70f2885
12 N80fe84a3942c49f5a2413f0433d13407
13 N96e9a235e4b24e32b476f987c1f48818
14 N99c12ac60f7545f388c6a1573d765750
15 Na0ce7b7ccbdd47b58105a6729cf387df
16 Nab2da7f0475e49f5b697545639552329
17 Nab63211b421240f4b50bcd554750bfd9
18 Nb0ea561a26fb4cb58dbdb1eb51f05ef8
19 Nc1cfdac88e5248c888f40c60898ee55e
20 Nc2ee4d1e93bc44c2885e4759dfc14c4b
21 Nd17430526aa047f3a5cad6231d49e32b
22 Nd9d0d883959544119c08dcb1e919f280
23 Ne028bb5ad95441809e8db38dacda1cc6
24 Nee8acf1430a049819096f2744f101f2b
25 Nf5975de23df4432ab7bae94fd11d0ded
26 Nfbf2e32b06bd474db4db56684bf01ea6
27 anzsrc-for:11
28 anzsrc-for:1112
29 schema:author Nf5f4fdfcaf834cb4bf9a003be9c7d24b
30 schema:citation sg:pub.10.1007/s00520-012-1644-z
31 sg:pub.10.1023/a:1015276414526
32 sg:pub.10.1038/sj.bmt.1705250
33 https://doi.org/10.1002/cncr.20162
34 https://doi.org/10.1002/cncr.23898
35 https://doi.org/10.1016/j.jpsychores.2012.10.011
36 https://doi.org/10.1080/07357900802132550
37 https://doi.org/10.1177/0163278705275341
38 https://doi.org/10.1177/1758834009355164
39 schema:datePublished 2014-10
40 schema:datePublishedReg 2014-10-01
41 schema:description BACKGROUND: Diarrhea is a common toxicity of chemotherapy, but the practice of reporting only severe grades (≥ 3) in clinical trials results in misleading conclusions of significance. Epidemiology remains poorly described, and effects of multi-cycle regimens have not been investigated. To better understand the risks, symptom burden and consequences of CID, we studied patients receiving chemotherapy for colorectal cancer (CRC). METHODS: One hundred and fourteen patients receiving FOLFOX (95 patients, 530 cycles), FOLFOX + monoclonal antibodies (10 patients, 49 cycles) or FOLFIRI (9 patients, 50 cycles) were enrolled. CID was identified from diaries at baseline and daily during up to 8 chemotherapy cycles using supplemental questions on the Oral Mucositis Daily Questionnaire, a valid tool for collecting patient-reported outcomes of regimen-related mucosal injury. Patients scored CID severity from 0 "none" to 10 "worst possible," and quantity from "little" to "severe" on a 5-point scale. Quality of life was measured using the FACT-G, and fatigue using the FACIT fatigue scale. RESULTS: CID occurred in 89% of patients on FOLFIRI, 50% on FOLFOX + monoclonal antibodies and 56% on FOLFOX alone. The risk of a first episode was highest during Cycle 1 (35 %) and dropped to <10% during Cycles 3-5. Patients with CID reported poorer quality of life scores than those without CID (77.1 vs 80.7). CONCLUSIONS: Diarrhea occurs more commonly than typically appreciated during chemotherapy for CRC. Risk is highest during first exposure, suggesting variable susceptibility. Identification of this high-risk subgroup for prophylaxis could improve the quality of life.
42 schema:genre research_article
43 schema:inLanguage en
44 schema:isAccessibleForFree false
45 schema:isPartOf N1b15e8be103d4bafbf3bf74122744f23
46 N79fbbdeb216346ee9fc27173b00cf36e
47 sg:journal.1088364
48 schema:name Risk and outcomes of chemotherapy-induced diarrhea (CID) among patients with colorectal cancer receiving multi-cycle chemotherapy
49 schema:pagination 675-680
50 schema:productId N067c035bc6e04af89d0f2ca3c5bbace6
51 N1c558bddfcf14bacbe7a8a9a2c5a2cc1
52 N3cef62f960e94394b6a28121ab305054
53 Nb2381829afa947fcb22d02ced771b115
54 Needf8ead4bc4457097ec4345645d00c4
55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037975934
56 https://doi.org/10.1007/s00280-014-2526-5
57 schema:sdDatePublished 2019-04-10T20:47
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher N0b0b60ef581a43929157580f2a8ca282
60 schema:url http://link.springer.com/10.1007%2Fs00280-014-2526-5
61 sgo:license sg:explorer/license/
62 sgo:sdDataset articles
63 rdf:type schema:ScholarlyArticle
64 N067c035bc6e04af89d0f2ca3c5bbace6 schema:name nlm_unique_id
65 schema:value 7806519
66 rdf:type schema:PropertyValue
67 N07cc69592bc44587a4f60712cfb20039 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Surveys and Questionnaires
69 rdf:type schema:DefinedTerm
70 N0b0b60ef581a43929157580f2a8ca282 schema:name Springer Nature - SN SciGraph project
71 rdf:type schema:Organization
72 N0bfa464d6ee1427b84eb335b18648df3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Camptothecin
74 rdf:type schema:DefinedTerm
75 N17569083888945598f8fb3c966535169 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Drug Screening Assays, Antitumor
77 rdf:type schema:DefinedTerm
78 N192eae997c3e42908de5c2252708e7cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Risk Assessment
80 rdf:type schema:DefinedTerm
81 N1b15e8be103d4bafbf3bf74122744f23 schema:volumeNumber 74
82 rdf:type schema:PublicationVolume
83 N1c558bddfcf14bacbe7a8a9a2c5a2cc1 schema:name readcube_id
84 schema:value b4e7912e17c835f6f79e5b2f8e0b62f5262db42d883ee5cba6701eea06d347b5
85 rdf:type schema:PropertyValue
86 N262a52c4f3f64d979c630baf9f1bcddb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Humans
88 rdf:type schema:DefinedTerm
89 N28c5095898ec4fb4811ae88f1867f673 rdf:first sg:person.01335135331.50
90 rdf:rest Na8330d77cdc24199b8c0ff89145d8cee
91 N2f24042636224b45bec425d0d5da285f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Colorectal Neoplasms
93 rdf:type schema:DefinedTerm
94 N3b14df9ea0994d97b8eb383fb7dab96c rdf:first N662e22307c264e39bdaeb3396a79f176
95 rdf:rest N561fc35c7dcf4e9baea99f3a1a18bc4f
96 N3cef62f960e94394b6a28121ab305054 schema:name pubmed_id
97 schema:value 25055935
98 rdf:type schema:PropertyValue
99 N42d51b93a85d45949cb0ce414644318c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Female
101 rdf:type schema:DefinedTerm
102 N48ef4f69843b4e6785931626d0896917 rdf:first sg:person.01150115462.24
103 rdf:rest N3b14df9ea0994d97b8eb383fb7dab96c
104 N561fc35c7dcf4e9baea99f3a1a18bc4f rdf:first sg:person.01115076320.15
105 rdf:rest N563a20f1c4b94e97b086797a4629c1eb
106 N563a20f1c4b94e97b086797a4629c1eb rdf:first sg:person.0753577767.19
107 rdf:rest N28c5095898ec4fb4811ae88f1867f673
108 N5886577c0eb64542896d763bc18a9011 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Canada
110 rdf:type schema:DefinedTerm
111 N62d04a3f94a64b7fbc7f101833aeaa53 rdf:first sg:person.01251452227.53
112 rdf:rest N48ef4f69843b4e6785931626d0896917
113 N662e22307c264e39bdaeb3396a79f176 schema:affiliation https://www.grid.ac/institutes/grid.416562.2
114 schema:familyName Bonaventura
115 schema:givenName Antony
116 rdf:type schema:Person
117 N6a8d2f263bfe4899a831983bd91bca10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Neoplasm Staging
119 rdf:type schema:DefinedTerm
120 N79fbbdeb216346ee9fc27173b00cf36e schema:issueNumber 4
121 rdf:type schema:PublicationIssue
122 N7cd7c9fd897241c2b6eaea42ae30f677 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Organoplatinum Compounds
124 rdf:type schema:DefinedTerm
125 N7f8f69bc71b3417393489979b70f2885 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Immunologic Factors
127 rdf:type schema:DefinedTerm
128 N80fe84a3942c49f5a2413f0433d13407 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name United States
130 rdf:type schema:DefinedTerm
131 N96e9a235e4b24e32b476f987c1f48818 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Antineoplastic Agents
133 rdf:type schema:DefinedTerm
134 N99c12ac60f7545f388c6a1573d765750 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Fluorouracil
136 rdf:type schema:DefinedTerm
137 Na0ce7b7ccbdd47b58105a6729cf387df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Quality of Life
139 rdf:type schema:DefinedTerm
140 Na1e3c65a560845498eabb0240620c3c8 rdf:first sg:person.01041100073.43
141 rdf:rest Nef0a64db354d471fa5266d5ea15ebf8e
142 Na8330d77cdc24199b8c0ff89145d8cee rdf:first sg:person.01230421137.93
143 rdf:rest rdf:nil
144 Nab2da7f0475e49f5b697545639552329 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Male
146 rdf:type schema:DefinedTerm
147 Nab63211b421240f4b50bcd554750bfd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Middle Aged
149 rdf:type schema:DefinedTerm
150 Nb0ea561a26fb4cb58dbdb1eb51f05ef8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Diarrhea
152 rdf:type schema:DefinedTerm
153 Nb2381829afa947fcb22d02ced771b115 schema:name dimensions_id
154 schema:value pub.1037975934
155 rdf:type schema:PropertyValue
156 Nc1cfdac88e5248c888f40c60898ee55e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Antibodies, Monoclonal
158 rdf:type schema:DefinedTerm
159 Nc2ee4d1e93bc44c2885e4759dfc14c4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Europe
161 rdf:type schema:DefinedTerm
162 Nd17430526aa047f3a5cad6231d49e32b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Treatment Outcome
164 rdf:type schema:DefinedTerm
165 Nd9d0d883959544119c08dcb1e919f280 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Antineoplastic Combined Chemotherapy Protocols
167 rdf:type schema:DefinedTerm
168 Ne028bb5ad95441809e8db38dacda1cc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Leucovorin
170 rdf:type schema:DefinedTerm
171 Nee8acf1430a049819096f2744f101f2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Severity of Illness Index
173 rdf:type schema:DefinedTerm
174 Needf8ead4bc4457097ec4345645d00c4 schema:name doi
175 schema:value 10.1007/s00280-014-2526-5
176 rdf:type schema:PropertyValue
177 Nef0a64db354d471fa5266d5ea15ebf8e rdf:first sg:person.0673066560.86
178 rdf:rest N62d04a3f94a64b7fbc7f101833aeaa53
179 Nf19e4466568140418eec19f056be5990 schema:name University and General Hospital, Udine, Italy
180 rdf:type schema:Organization
181 Nf5975de23df4432ab7bae94fd11d0ded schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Prevalence
183 rdf:type schema:DefinedTerm
184 Nf5f4fdfcaf834cb4bf9a003be9c7d24b rdf:first sg:person.014607232302.53
185 rdf:rest Na1e3c65a560845498eabb0240620c3c8
186 Nfbf2e32b06bd474db4db56684bf01ea6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Australia
188 rdf:type schema:DefinedTerm
189 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
190 schema:name Medical and Health Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
193 schema:name Oncology and Carcinogenesis
194 rdf:type schema:DefinedTerm
195 sg:journal.1088364 schema:issn 0344-5704
196 1432-0843
197 schema:name Cancer Chemotherapy and Pharmacology
198 rdf:type schema:Periodical
199 sg:person.01041100073.43 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
200 schema:familyName Elting
201 schema:givenName Linda S.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041100073.43
203 rdf:type schema:Person
204 sg:person.01115076320.15 schema:affiliation https://www.grid.ac/institutes/grid.416075.1
205 schema:familyName Selva-Nayagam
206 schema:givenName Sudarsha
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115076320.15
208 rdf:type schema:Person
209 sg:person.01150115462.24 schema:affiliation Nf19e4466568140418eec19f056be5990
210 schema:familyName Aprile
211 schema:givenName Giuseppe
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150115462.24
213 rdf:type schema:Person
214 sg:person.01230421137.93 schema:affiliation https://www.grid.ac/institutes/grid.62560.37
215 schema:familyName Sonis
216 schema:givenName Stephen T.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230421137.93
218 rdf:type schema:Person
219 sg:person.01251452227.53 schema:affiliation https://www.grid.ac/institutes/grid.59062.38
220 schema:familyName Grunberg
221 schema:givenName Steven M.
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251452227.53
223 rdf:type schema:Person
224 sg:person.01335135331.50 schema:affiliation https://www.grid.ac/institutes/grid.414925.f
225 schema:familyName Koczwara
226 schema:givenName Bogda
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335135331.50
228 rdf:type schema:Person
229 sg:person.014607232302.53 schema:affiliation https://www.grid.ac/institutes/grid.1010.0
230 schema:familyName Keefe
231 schema:givenName Dorothy M.
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014607232302.53
233 rdf:type schema:Person
234 sg:person.0673066560.86 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
235 schema:familyName Nguyen
236 schema:givenName Hoang T.
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673066560.86
238 rdf:type schema:Person
239 sg:person.0753577767.19 schema:affiliation https://www.grid.ac/institutes/grid.265008.9
240 schema:familyName Barsevick
241 schema:givenName Andrea
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753577767.19
243 rdf:type schema:Person
244 sg:pub.10.1007/s00520-012-1644-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1035950226
245 https://doi.org/10.1007/s00520-012-1644-z
246 rdf:type schema:CreativeWork
247 sg:pub.10.1023/a:1015276414526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019271543
248 https://doi.org/10.1023/a:1015276414526
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/sj.bmt.1705250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030150333
251 https://doi.org/10.1038/sj.bmt.1705250
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1002/cncr.20162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021904357
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1002/cncr.23898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040579348
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.jpsychores.2012.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009066345
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1080/07357900802132550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001531765
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1177/0163278705275341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028882032
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1177/1758834009355164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064077267
264 rdf:type schema:CreativeWork
265 https://www.grid.ac/institutes/grid.1010.0 schema:alternateName University of Adelaide
266 schema:name University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia
267 rdf:type schema:Organization
268 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
269 schema:name MD Anderson Cancer Center, Houston, TX, USA
270 rdf:type schema:Organization
271 https://www.grid.ac/institutes/grid.265008.9 schema:alternateName Thomas Jefferson University
272 schema:name Thomas Jefferson University, Philadelphia, PA, USA
273 rdf:type schema:Organization
274 https://www.grid.ac/institutes/grid.414925.f schema:alternateName Flinders Medical Centre
275 schema:name Flinders Medical Centre, Adelaide, SA, Australia
276 rdf:type schema:Organization
277 https://www.grid.ac/institutes/grid.416075.1 schema:alternateName Royal Adelaide Hospital
278 schema:name Royal Adelaide Hospital, Adelaide, SA, Australia
279 rdf:type schema:Organization
280 https://www.grid.ac/institutes/grid.416562.2 schema:alternateName Mater Private Hospital
281 schema:name Calvary Mater Hospital, Newcastle, NSW, Australia
282 rdf:type schema:Organization
283 https://www.grid.ac/institutes/grid.59062.38 schema:alternateName University of Vermont
284 schema:name University of Vermont, Burlington, VT, USA
285 rdf:type schema:Organization
286 https://www.grid.ac/institutes/grid.62560.37 schema:alternateName Brigham and Women's Hospital
287 schema:name Brigham and Women’s Hospital, Boston, MA, USA
288 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...