Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-05

AUTHORS

Jan Hendrik Hooijberg, Gerrit Jansen, Ietje Kathmann, Rob Pieters, Adrie C. Laan, Ina van Zantwijk, Gertjan J. L. Kaspers, Godefridus J. Peters

ABSTRACT

Cellular folate concentration was earlier reported to be a critical factor in the activity and expression of the multidrug resistance protein MRP1 (ABCC1). Since MRP1 mediates resistance to a variety of therapeutic drugs, we investigated whether the cellular folate concentration influences the MRP1-mediated cellular resistance against drugs. As a model system, we used the human ovarian carcinoma cell line 2008wt, and its stably MRP1/ABCC1-transfected subline 2008/MRP1. These cell types have a moderate and high expression of MRP1, respectively. In folate-deprived 2008/MRP1 cells, the MRP1-mediated efflux of its model substrate calcein decreased to ~55 % of the initial efflux rate under folate-rich conditions. In 2008wt cells, only a small decrease in efflux was observed. Folate depletion for 5-10 days markedly increased (~500 %) cellular steady-state accumulation of calcein in 2008/MRP1 cells and moderately in 2008wt cells. A subsequent short (24 h) exposure to 2.3 μM L-leucovorin decreased calcein levels again in MRP1-overexpressing cells. Folate deprivation markedly increased growth inhibitory effects of the established MRP1 substrates daunorubicin (~twofold), doxorubicin (~fivefold), and methotrexate (~83-fold) in MRP1-overexpressing cells, proportional to MRP1 expression. In conclusion, this study demonstrates that increased cellular folate concentrations induce MRP1/ABCC1-related drug efflux and drug resistance. These results have important implications in the understanding of the role of MRP1 and its homologs in clinical drug resistance. More... »

PAGES

911-917

References to SciGraph publications

  • 2003-04. Novel antifolate drugs in CURRENT ONCOLOGY REPORTS
  • 2009-08. Toward an optimal use of folic acid: an advisory report of the Health Council of the Netherlands in EUROPEAN JOURNAL OF CLINICAL NUTRITION
  • 2003-10. Transcriptional regulation of ABC drug transporters in ONCOGENE
  • 2003-10. Resistance to antifolates in ONCOGENE
  • 2003-10. The MRP family of drug efflux pumps in ONCOGENE
  • 2001-12. Complete Characterization of the Human ABC Gene Family in JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00280-014-2421-0

    DOI

    http://dx.doi.org/10.1007/s00280-014-2421-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021404621

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24595806


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Pharmacology and Pharmaceutical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biological Transport", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Resistance", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Folic Acid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Methotrexate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multidrug Resistance-Associated Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Clinical Chemistry, Slotervaartziekenhuis Amsterdam, Amsterdam, The Netherlands", 
                "Department of Pediatric Hematology/Oncology, VU University Medical Center (VUMC), Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hooijberg", 
            "givenName": "Jan Hendrik", 
            "id": "sg:person.01030106014.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030106014.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Rheumatology, VU University Medical Center (VUMC), Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jansen", 
            "givenName": "Gerrit", 
            "id": "sg:person.01273433134.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273433134.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Medical Oncology, VU University Medical Center (VUMC), De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kathmann", 
            "givenName": "Ietje", 
            "id": "sg:person.0600545135.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600545135.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Pediatric Oncology, Sophia Children Hospital, Rotterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pieters", 
            "givenName": "Rob", 
            "id": "sg:person.0625515736.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625515736.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Medical Oncology, VU University Medical Center (VUMC), De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Laan", 
            "givenName": "Adrie C.", 
            "id": "sg:person.0762046663.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762046663.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Pediatric Hematology/Oncology, VU University Medical Center (VUMC), Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van Zantwijk", 
            "givenName": "Ina", 
            "id": "sg:person.01037356625.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037356625.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Pediatric Hematology/Oncology, VU University Medical Center (VUMC), Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kaspers", 
            "givenName": "Gertjan J. L.", 
            "id": "sg:person.014154361037.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014154361037.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Medical Oncology, VU University Medical Center (VUMC), De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peters", 
            "givenName": "Godefridus J.", 
            "id": "sg:person.01255301342.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255301342.17"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.96.12.6914", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000343646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/pterid-2013-0019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001071921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(94)90554-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002551248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-2952(94)90554-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002551248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.1780391203", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006475885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/92.16.1295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008088052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/abio.1998.2779", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011754255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206946", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015819318", 
              "https://doi.org/10.1038/sj.onc.1206946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206946", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015819318", 
              "https://doi.org/10.1038/sj.onc.1206946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1079/phn2001144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017961207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejcn.2009.2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019773671", 
              "https://doi.org/10.1038/ejcn.2009.2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/biof.174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020135352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biochem.71.102301.093055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022925891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1995.1344", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029298841"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206953", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029844928", 
              "https://doi.org/10.1038/sj.onc.1206953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206953", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029844928", 
              "https://doi.org/10.1038/sj.onc.1206953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-pharmtox-011613-135959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030459365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1742-4658.2011.08235.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032618503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0005-2736(99)00167-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032951503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206950", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033359097", 
              "https://doi.org/10.1038/sj.onc.1206950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206950", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033359097", 
              "https://doi.org/10.1038/sj.onc.1206950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-5793(95)00677-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035310560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(12)62001-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036328128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m008251200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036981946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.28038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038935405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-2952(02)01615-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041039929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-2952(02)01615-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041039929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bcp.2003.12.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041165036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/18.5.869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044005394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(97)84450-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045357440"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11912-003-0098-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045418198", 
              "https://doi.org/10.1007/s11912-003-0098-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1012823120935", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048518435", 
              "https://doi.org/10.1023/a:1012823120935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m209186200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051768227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/92.23.1934", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053537254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/83.24.1806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059816954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1360704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062477732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2003.11.136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064203976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/138920011798062274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069176021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074474441", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jn/130.2.129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074605260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074889455", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mol.60.6.1288", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074958462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075060928", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jn/132.9.2792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075120297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jn/133.11.3731s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076594494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079508646", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1993.11.1.5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082798665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082889936", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083350359", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-05", 
        "datePublishedReg": "2014-05-01", 
        "description": "Cellular folate concentration was earlier reported to be a critical factor in the activity and expression of the multidrug resistance protein MRP1 (ABCC1). Since MRP1 mediates resistance to a variety of therapeutic drugs, we investigated whether the cellular folate concentration influences the MRP1-mediated cellular resistance against drugs. As a model system, we used the human ovarian carcinoma cell line 2008wt, and its stably MRP1/ABCC1-transfected subline 2008/MRP1. These cell types have a moderate and high expression of MRP1, respectively. In folate-deprived 2008/MRP1 cells, the MRP1-mediated efflux of its model substrate calcein decreased to ~55 % of the initial efflux rate under folate-rich conditions. In 2008wt cells, only a small decrease in efflux was observed. Folate depletion for 5-10 days markedly increased (~500 %) cellular steady-state accumulation of calcein in 2008/MRP1 cells and moderately in 2008wt cells. A subsequent short (24 h) exposure to 2.3 \u03bcM L-leucovorin decreased calcein levels again in MRP1-overexpressing cells. Folate deprivation markedly increased growth inhibitory effects of the established MRP1 substrates daunorubicin (~twofold), doxorubicin (~fivefold), and methotrexate (~83-fold) in MRP1-overexpressing cells, proportional to MRP1 expression. In conclusion, this study demonstrates that increased cellular folate concentrations induce MRP1/ABCC1-related drug efflux and drug resistance. These results have important implications in the understanding of the role of MRP1 and its homologs in clinical drug resistance.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00280-014-2421-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1088364", 
            "issn": [
              "0344-5704", 
              "1432-0843"
            ], 
            "name": "Cancer Chemotherapy and Pharmacology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "73"
          }
        ], 
        "name": "Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1)", 
        "pagination": "911-917", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "65fb406e9e550d32bc8b2fef29d9dc55d74a5cea67e664ed51f48ad6384c3228"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24595806"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "7806519"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00280-014-2421-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1021404621"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00280-014-2421-0", 
          "https://app.dimensions.ai/details/publication/pub.1021404621"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T02:00", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000512.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs00280-014-2421-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00280-014-2421-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00280-014-2421-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00280-014-2421-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00280-014-2421-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    283 TRIPLES      21 PREDICATES      80 URIs      28 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00280-014-2421-0 schema:about N31cbfb180e2a4164b3e50aabf623342a
    2 N42a3c249df104e90a02f466e8f621596
    3 N4ddd47e05d424a1fa790f1e2bb5be381
    4 N62c969e07ed643f09a1d314b6caf8fe2
    5 N7d197ab691224c81a1cdc77f6f778a9f
    6 Ne6ce5e445c644bcd8852113435e5a6ed
    7 Nf39eecc5c75a4c1d9531c19bd47243a3
    8 anzsrc-for:11
    9 anzsrc-for:1115
    10 schema:author Nb1e15e9599b648d89d1abc67ef45a304
    11 schema:citation sg:pub.10.1007/s11912-003-0098-3
    12 sg:pub.10.1023/a:1012823120935
    13 sg:pub.10.1038/ejcn.2009.2
    14 sg:pub.10.1038/sj.onc.1206946
    15 sg:pub.10.1038/sj.onc.1206950
    16 sg:pub.10.1038/sj.onc.1206953
    17 https://app.dimensions.ai/details/publication/pub.1074474441
    18 https://app.dimensions.ai/details/publication/pub.1074889455
    19 https://app.dimensions.ai/details/publication/pub.1075060928
    20 https://app.dimensions.ai/details/publication/pub.1079508646
    21 https://app.dimensions.ai/details/publication/pub.1082889936
    22 https://app.dimensions.ai/details/publication/pub.1083350359
    23 https://doi.org/10.1002/art.1780391203
    24 https://doi.org/10.1002/biof.174
    25 https://doi.org/10.1002/ijc.28038
    26 https://doi.org/10.1006/abio.1998.2779
    27 https://doi.org/10.1006/bbrc.1995.1344
    28 https://doi.org/10.1016/0006-2952(94)90554-1
    29 https://doi.org/10.1016/0014-5793(95)00677-2
    30 https://doi.org/10.1016/j.bcp.2003.12.022
    31 https://doi.org/10.1016/s0005-2736(99)00167-4
    32 https://doi.org/10.1016/s0006-2952(02)01615-5
    33 https://doi.org/10.1016/s0140-6736(12)62001-7
    34 https://doi.org/10.1016/s0959-8049(97)84450-4
    35 https://doi.org/10.1073/pnas.96.12.6914
    36 https://doi.org/10.1074/jbc.m008251200
    37 https://doi.org/10.1074/jbc.m209186200
    38 https://doi.org/10.1079/phn2001144
    39 https://doi.org/10.1093/carcin/18.5.869
    40 https://doi.org/10.1093/jn/130.2.129
    41 https://doi.org/10.1093/jn/132.9.2792
    42 https://doi.org/10.1093/jn/133.11.3731s
    43 https://doi.org/10.1093/jnci/83.24.1806
    44 https://doi.org/10.1093/jnci/92.16.1295
    45 https://doi.org/10.1093/jnci/92.23.1934
    46 https://doi.org/10.1111/j.1742-4658.2011.08235.x
    47 https://doi.org/10.1124/mol.60.6.1288
    48 https://doi.org/10.1126/science.1360704
    49 https://doi.org/10.1146/annurev-pharmtox-011613-135959
    50 https://doi.org/10.1146/annurev.biochem.71.102301.093055
    51 https://doi.org/10.1200/jco.1993.11.1.5
    52 https://doi.org/10.1200/jco.2003.11.136
    53 https://doi.org/10.1515/pterid-2013-0019
    54 https://doi.org/10.2174/138920011798062274
    55 schema:datePublished 2014-05
    56 schema:datePublishedReg 2014-05-01
    57 schema:description Cellular folate concentration was earlier reported to be a critical factor in the activity and expression of the multidrug resistance protein MRP1 (ABCC1). Since MRP1 mediates resistance to a variety of therapeutic drugs, we investigated whether the cellular folate concentration influences the MRP1-mediated cellular resistance against drugs. As a model system, we used the human ovarian carcinoma cell line 2008wt, and its stably MRP1/ABCC1-transfected subline 2008/MRP1. These cell types have a moderate and high expression of MRP1, respectively. In folate-deprived 2008/MRP1 cells, the MRP1-mediated efflux of its model substrate calcein decreased to ~55 % of the initial efflux rate under folate-rich conditions. In 2008wt cells, only a small decrease in efflux was observed. Folate depletion for 5-10 days markedly increased (~500 %) cellular steady-state accumulation of calcein in 2008/MRP1 cells and moderately in 2008wt cells. A subsequent short (24 h) exposure to 2.3 μM L-leucovorin decreased calcein levels again in MRP1-overexpressing cells. Folate deprivation markedly increased growth inhibitory effects of the established MRP1 substrates daunorubicin (~twofold), doxorubicin (~fivefold), and methotrexate (~83-fold) in MRP1-overexpressing cells, proportional to MRP1 expression. In conclusion, this study demonstrates that increased cellular folate concentrations induce MRP1/ABCC1-related drug efflux and drug resistance. These results have important implications in the understanding of the role of MRP1 and its homologs in clinical drug resistance.
    58 schema:genre research_article
    59 schema:inLanguage en
    60 schema:isAccessibleForFree true
    61 schema:isPartOf N0860d54a135f4b74ab2e7f7e806f01af
    62 N2489012f9e68422e8efbf17dffcd0ce6
    63 sg:journal.1088364
    64 schema:name Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1)
    65 schema:pagination 911-917
    66 schema:productId N3b71921e56984c92a2e88640b1ec99e8
    67 N3e332a76bb8943bd8a80eeedc45cfca4
    68 N9d7c302b495948f099b56bd2d4a9a1c8
    69 Nc1b778aba949441ebae90d01f9bc4947
    70 Nd328fd627fc846c1868905d7c9f4008d
    71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021404621
    72 https://doi.org/10.1007/s00280-014-2421-0
    73 schema:sdDatePublished 2019-04-11T02:00
    74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    75 schema:sdPublisher N5dcc591e70be4c97bc48b3bcc0c8b1a1
    76 schema:url http://link.springer.com/10.1007%2Fs00280-014-2421-0
    77 sgo:license sg:explorer/license/
    78 sgo:sdDataset articles
    79 rdf:type schema:ScholarlyArticle
    80 N0860d54a135f4b74ab2e7f7e806f01af schema:issueNumber 5
    81 rdf:type schema:PublicationIssue
    82 N2489012f9e68422e8efbf17dffcd0ce6 schema:volumeNumber 73
    83 rdf:type schema:PublicationVolume
    84 N31cbfb180e2a4164b3e50aabf623342a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    85 schema:name Cell Line, Tumor
    86 rdf:type schema:DefinedTerm
    87 N3b71921e56984c92a2e88640b1ec99e8 schema:name pubmed_id
    88 schema:value 24595806
    89 rdf:type schema:PropertyValue
    90 N3e332a76bb8943bd8a80eeedc45cfca4 schema:name readcube_id
    91 schema:value 65fb406e9e550d32bc8b2fef29d9dc55d74a5cea67e664ed51f48ad6384c3228
    92 rdf:type schema:PropertyValue
    93 N42a3c249df104e90a02f466e8f621596 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Folic Acid
    95 rdf:type schema:DefinedTerm
    96 N4ddd47e05d424a1fa790f1e2bb5be381 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Biological Transport
    98 rdf:type schema:DefinedTerm
    99 N4fb2030eb14c4560bebc1fbca79a6ff9 rdf:first sg:person.01273433134.01
    100 rdf:rest Nc9ef8c57bbd047eaa6b901de965e6405
    101 N5dcc591e70be4c97bc48b3bcc0c8b1a1 schema:name Springer Nature - SN SciGraph project
    102 rdf:type schema:Organization
    103 N62c969e07ed643f09a1d314b6caf8fe2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Drug Resistance
    105 rdf:type schema:DefinedTerm
    106 N7d197ab691224c81a1cdc77f6f778a9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Humans
    108 rdf:type schema:DefinedTerm
    109 N9d7c302b495948f099b56bd2d4a9a1c8 schema:name dimensions_id
    110 schema:value pub.1021404621
    111 rdf:type schema:PropertyValue
    112 N9ddc0d8887024d64b83b220b488834e1 rdf:first sg:person.014154361037.28
    113 rdf:rest Nd8431f1198a1478ca1ae3621b58c5180
    114 Nad4bf8cd67ad486488d145ee7a964b67 rdf:first sg:person.01037356625.38
    115 rdf:rest N9ddc0d8887024d64b83b220b488834e1
    116 Nb1e15e9599b648d89d1abc67ef45a304 rdf:first sg:person.01030106014.11
    117 rdf:rest N4fb2030eb14c4560bebc1fbca79a6ff9
    118 Nc1b778aba949441ebae90d01f9bc4947 schema:name doi
    119 schema:value 10.1007/s00280-014-2421-0
    120 rdf:type schema:PropertyValue
    121 Nc9ef8c57bbd047eaa6b901de965e6405 rdf:first sg:person.0600545135.26
    122 rdf:rest Nd211ac8756a840c785b18dd9d4d701bb
    123 Ncc69339808c048e7b626f9119b091bad rdf:first sg:person.0762046663.00
    124 rdf:rest Nad4bf8cd67ad486488d145ee7a964b67
    125 Nd211ac8756a840c785b18dd9d4d701bb rdf:first sg:person.0625515736.01
    126 rdf:rest Ncc69339808c048e7b626f9119b091bad
    127 Nd328fd627fc846c1868905d7c9f4008d schema:name nlm_unique_id
    128 schema:value 7806519
    129 rdf:type schema:PropertyValue
    130 Nd8431f1198a1478ca1ae3621b58c5180 rdf:first sg:person.01255301342.17
    131 rdf:rest rdf:nil
    132 Ne6ce5e445c644bcd8852113435e5a6ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Methotrexate
    134 rdf:type schema:DefinedTerm
    135 Nf39eecc5c75a4c1d9531c19bd47243a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Multidrug Resistance-Associated Proteins
    137 rdf:type schema:DefinedTerm
    138 Nf3b39d16e34f4c90a0ef35e79f359b0c schema:name Department of Pediatric Oncology, Sophia Children Hospital, Rotterdam, The Netherlands
    139 rdf:type schema:Organization
    140 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    141 schema:name Medical and Health Sciences
    142 rdf:type schema:DefinedTerm
    143 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
    144 schema:name Pharmacology and Pharmaceutical Sciences
    145 rdf:type schema:DefinedTerm
    146 sg:journal.1088364 schema:issn 0344-5704
    147 1432-0843
    148 schema:name Cancer Chemotherapy and Pharmacology
    149 rdf:type schema:Periodical
    150 sg:person.01030106014.11 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    151 schema:familyName Hooijberg
    152 schema:givenName Jan Hendrik
    153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030106014.11
    154 rdf:type schema:Person
    155 sg:person.01037356625.38 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    156 schema:familyName van Zantwijk
    157 schema:givenName Ina
    158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037356625.38
    159 rdf:type schema:Person
    160 sg:person.01255301342.17 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    161 schema:familyName Peters
    162 schema:givenName Godefridus J.
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255301342.17
    164 rdf:type schema:Person
    165 sg:person.01273433134.01 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    166 schema:familyName Jansen
    167 schema:givenName Gerrit
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273433134.01
    169 rdf:type schema:Person
    170 sg:person.014154361037.28 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    171 schema:familyName Kaspers
    172 schema:givenName Gertjan J. L.
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014154361037.28
    174 rdf:type schema:Person
    175 sg:person.0600545135.26 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    176 schema:familyName Kathmann
    177 schema:givenName Ietje
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600545135.26
    179 rdf:type schema:Person
    180 sg:person.0625515736.01 schema:affiliation Nf3b39d16e34f4c90a0ef35e79f359b0c
    181 schema:familyName Pieters
    182 schema:givenName Rob
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625515736.01
    184 rdf:type schema:Person
    185 sg:person.0762046663.00 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    186 schema:familyName Laan
    187 schema:givenName Adrie C.
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762046663.00
    189 rdf:type schema:Person
    190 sg:pub.10.1007/s11912-003-0098-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045418198
    191 https://doi.org/10.1007/s11912-003-0098-3
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1023/a:1012823120935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048518435
    194 https://doi.org/10.1023/a:1012823120935
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/ejcn.2009.2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019773671
    197 https://doi.org/10.1038/ejcn.2009.2
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/sj.onc.1206946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015819318
    200 https://doi.org/10.1038/sj.onc.1206946
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/sj.onc.1206950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033359097
    203 https://doi.org/10.1038/sj.onc.1206950
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/sj.onc.1206953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029844928
    206 https://doi.org/10.1038/sj.onc.1206953
    207 rdf:type schema:CreativeWork
    208 https://app.dimensions.ai/details/publication/pub.1074474441 schema:CreativeWork
    209 https://app.dimensions.ai/details/publication/pub.1074889455 schema:CreativeWork
    210 https://app.dimensions.ai/details/publication/pub.1075060928 schema:CreativeWork
    211 https://app.dimensions.ai/details/publication/pub.1079508646 schema:CreativeWork
    212 https://app.dimensions.ai/details/publication/pub.1082889936 schema:CreativeWork
    213 https://app.dimensions.ai/details/publication/pub.1083350359 schema:CreativeWork
    214 https://doi.org/10.1002/art.1780391203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006475885
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1002/biof.174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020135352
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1002/ijc.28038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038935405
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1006/abio.1998.2779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011754255
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1006/bbrc.1995.1344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029298841
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1016/0006-2952(94)90554-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002551248
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1016/0014-5793(95)00677-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035310560
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1016/j.bcp.2003.12.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041165036
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1016/s0005-2736(99)00167-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032951503
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1016/s0006-2952(02)01615-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041039929
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1016/s0140-6736(12)62001-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036328128
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1016/s0959-8049(97)84450-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045357440
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1073/pnas.96.12.6914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000343646
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1074/jbc.m008251200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036981946
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1074/jbc.m209186200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051768227
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1079/phn2001144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017961207
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1093/carcin/18.5.869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044005394
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1093/jn/130.2.129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074605260
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1093/jn/132.9.2792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075120297
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1093/jn/133.11.3731s schema:sameAs https://app.dimensions.ai/details/publication/pub.1076594494
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1093/jnci/83.24.1806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059816954
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1093/jnci/92.16.1295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008088052
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1093/jnci/92.23.1934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053537254
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1111/j.1742-4658.2011.08235.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032618503
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1124/mol.60.6.1288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074958462
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1126/science.1360704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062477732
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1146/annurev-pharmtox-011613-135959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030459365
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1146/annurev.biochem.71.102301.093055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022925891
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1200/jco.1993.11.1.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082798665
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1200/jco.2003.11.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203976
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1515/pterid-2013-0019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001071921
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.2174/138920011798062274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069176021
    277 rdf:type schema:CreativeWork
    278 https://www.grid.ac/institutes/grid.16872.3a schema:alternateName VU University Medical Center
    279 schema:name Department of Clinical Chemistry, Slotervaartziekenhuis Amsterdam, Amsterdam, The Netherlands
    280 Department of Medical Oncology, VU University Medical Center (VUMC), De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    281 Department of Pediatric Hematology/Oncology, VU University Medical Center (VUMC), Amsterdam, The Netherlands
    282 Department of Rheumatology, VU University Medical Center (VUMC), Amsterdam, The Netherlands
    283 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...