A phase I trial of flavopiridol in relapsed multiple myeloma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-11-16

AUTHORS

Craig C. Hofmeister, Ming Poi, Mindy A. Bowers, Weiqiang Zhao, Mitch A. Phelps, Don M. Benson, Eric H. Kraut, Sherif Farag, Yvonne A. Efebera, Jennifer Sexton, Thomas S. Lin, Michael Grever, John C. Byrd

ABSTRACT

PurposeFlavopiridol is primarily a cyclin-dependent kinase-9 inhibitor, and we performed a dose escalation trial to determine the maximum tolerated dose and safety and generate a pharmacokinetic (PK) profile.MethodsPatients with a diagnosis of relapsed myeloma after at least two prior treatments were included. Flavopiridol was administered as a bolus and then continuous infusion weekly for 4 weeks in a 6-week cycle.ResultsFifteen patients were treated at three dose levels (30 mg/m2 bolus, 30 mg/m2 CIV to 50 mg/m2 bolus, and 50 mg/m2 CIV). Cytopenias were significant, and elevated transaminases (grade 4 in 3 patients, grade 3 in 4 patients, and grade 2 in 3 patients) were noted but were transient. Diarrhea (grade 3 in 6 patients and grade 2 in 5 patients) did not lead to hospital admission. There were no confirmed partial responses although one patient with t(4;14) had a decrease in his monoclonal protein >50 % that did not persist. PK properties were similar to prior publications, and immunohistochemical staining for cyclin D1 and phospho-retinoblastoma did not predict response.ConclusionsFlavopiridol as a single agent given by bolus and then infusion caused significant diarrhea, cytopenias, and transaminase elevation but only achieved marginal responses in relapsed myeloma (ClinicalTrials.gov identifier NCT00112723). More... »

PAGES

249-257

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00280-013-2347-y

DOI

http://dx.doi.org/10.1007/s00280-013-2347-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052880160

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24241210


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flavonoids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multiple Myeloma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Piperidines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recurrence", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Hematology, The Ohio State University, B321 Starling Loving Hall, 320 West 10th Avenue, 43210, Columbus, OH, USA", 
          "id": "http://www.grid.ac/institutes/grid.261331.4", 
          "name": [
            "Division of Hematology, The Ohio State University, B321 Starling Loving Hall, 320 West 10th Avenue, 43210, Columbus, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hofmeister", 
        "givenName": "Craig C.", 
        "id": "sg:person.0646046513.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646046513.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacy, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA", 
          "id": "http://www.grid.ac/institutes/grid.261331.4", 
          "name": [
            "Department of Pharmacy, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Poi", 
        "givenName": "Ming", 
        "id": "sg:person.01264011344.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264011344.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA", 
          "id": "http://www.grid.ac/institutes/grid.261331.4", 
          "name": [
            "The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bowers", 
        "givenName": "Mindy A.", 
        "id": "sg:person.01165073662.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165073662.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, College of Medicine, The Ohio State University, Columbus, OH, USA", 
          "id": "http://www.grid.ac/institutes/grid.261331.4", 
          "name": [
            "Department of Pathology, College of Medicine, The Ohio State University, Columbus, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Weiqiang", 
        "id": "sg:person.0606000650.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606000650.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "College of Pharmacy, The Ohio State University, Columbus, OH, USA", 
          "id": "http://www.grid.ac/institutes/grid.261331.4", 
          "name": [
            "College of Pharmacy, The Ohio State University, Columbus, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Phelps", 
        "givenName": "Mitch A.", 
        "id": "sg:person.015542026572.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015542026572.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, The Ohio State University, B321 Starling Loving Hall, 320 West 10th Avenue, 43210, Columbus, OH, USA", 
          "id": "http://www.grid.ac/institutes/grid.261331.4", 
          "name": [
            "Division of Hematology, The Ohio State University, B321 Starling Loving Hall, 320 West 10th Avenue, 43210, Columbus, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benson", 
        "givenName": "Don M.", 
        "id": "sg:person.011746564122.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011746564122.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, The Ohio State University, B321 Starling Loving Hall, 320 West 10th Avenue, 43210, Columbus, OH, USA", 
          "id": "http://www.grid.ac/institutes/grid.261331.4", 
          "name": [
            "Division of Hematology, The Ohio State University, B321 Starling Loving Hall, 320 West 10th Avenue, 43210, Columbus, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kraut", 
        "givenName": "Eric H.", 
        "id": "sg:person.01012674343.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012674343.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "College of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA", 
          "id": "http://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "College of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Farag", 
        "givenName": "Sherif", 
        "id": "sg:person.016603046517.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016603046517.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, The Ohio State University, B321 Starling Loving Hall, 320 West 10th Avenue, 43210, Columbus, OH, USA", 
          "id": "http://www.grid.ac/institutes/grid.261331.4", 
          "name": [
            "Division of Hematology, The Ohio State University, B321 Starling Loving Hall, 320 West 10th Avenue, 43210, Columbus, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Efebera", 
        "givenName": "Yvonne A.", 
        "id": "sg:person.01136654742.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136654742.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA", 
          "id": "http://www.grid.ac/institutes/grid.261331.4", 
          "name": [
            "The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sexton", 
        "givenName": "Jennifer", 
        "id": "sg:person.01006373162.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006373162.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oncology Research and Development, GlaxoSmithKline, Philadelphia, PA, USA", 
          "id": "http://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "Oncology Research and Development, GlaxoSmithKline, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Thomas S.", 
        "id": "sg:person.012331532622.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012331532622.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, The Ohio State University, B321 Starling Loving Hall, 320 West 10th Avenue, 43210, Columbus, OH, USA", 
          "id": "http://www.grid.ac/institutes/grid.261331.4", 
          "name": [
            "Division of Hematology, The Ohio State University, B321 Starling Loving Hall, 320 West 10th Avenue, 43210, Columbus, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grever", 
        "givenName": "Michael", 
        "id": "sg:person.01235220307.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235220307.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, The Ohio State University, B321 Starling Loving Hall, 320 West 10th Avenue, 43210, Columbus, OH, USA", 
          "id": "http://www.grid.ac/institutes/grid.261331.4", 
          "name": [
            "Division of Hematology, The Ohio State University, B321 Starling Loving Hall, 320 West 10th Avenue, 43210, Columbus, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Byrd", 
        "givenName": "John C.", 
        "id": "sg:person.01115130607.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115130607.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1208619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033897711", 
          "https://doi.org/10.1038/sj.onc.1208619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002540802", 
          "https://doi.org/10.1038/sj.leu.2402609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019043910", 
          "https://doi.org/10.1038/nature03094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2404284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033553106", 
          "https://doi.org/10.1038/sj.leu.2404284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038937039", 
          "https://doi.org/10.1038/nature07064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011776336", 
          "https://doi.org/10.1038/onc.2009.510"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-11-16", 
    "datePublishedReg": "2013-11-16", 
    "description": "PurposeFlavopiridol is primarily a cyclin-dependent kinase-9 inhibitor, and we performed a dose escalation trial to determine the maximum tolerated dose and safety and generate a pharmacokinetic (PK) profile.MethodsPatients with a diagnosis of relapsed myeloma after at least two prior treatments were included. Flavopiridol was administered as a bolus and then continuous infusion weekly for 4\u00a0weeks in a 6-week cycle.ResultsFifteen patients were treated at three dose levels (30\u00a0mg/m2 bolus, 30\u00a0mg/m2 CIV to 50\u00a0mg/m2 bolus, and 50\u00a0mg/m2 CIV). Cytopenias were significant, and elevated transaminases (grade 4 in 3 patients, grade 3 in 4 patients, and grade 2 in 3 patients) were noted but were transient. Diarrhea (grade 3 in 6 patients and grade 2 in 5 patients) did not lead to hospital admission. There were no confirmed partial responses although one patient with t(4;14) had a decrease in his monoclonal protein >50\u00a0% that did not persist. PK properties were similar to prior publications, and immunohistochemical staining for cyclin D1 and phospho-retinoblastoma did not predict response.ConclusionsFlavopiridol as a single agent given by bolus and then infusion caused significant diarrhea, cytopenias, and transaminase elevation but only achieved marginal responses in relapsed myeloma (ClinicalTrials.gov identifier NCT00112723).", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00280-013-2347-y", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2688806", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2416454", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2423251", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438819", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1088364", 
        "issn": [
          "0344-5704", 
          "1432-0843"
        ], 
        "name": "Cancer Chemotherapy and Pharmacology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "73"
      }
    ], 
    "keywords": [
      "dose-escalation trial", 
      "phase I trial", 
      "cyclin-dependent kinase 9 (CDK9) inhibitors", 
      "infusion weekly", 
      "ResultsFifteen patients", 
      "escalation trial", 
      "elevated transaminases", 
      "significant diarrhea", 
      "partial response", 
      "hospital admission", 
      "I trial", 
      "multiple myeloma", 
      "immunohistochemical staining", 
      "phospho-retinoblastoma", 
      "pharmacokinetic profile", 
      "dose levels", 
      "single agent", 
      "monoclonal protein", 
      "prior treatment", 
      "PK properties", 
      "cyclin D1", 
      "myeloma", 
      "cytopenias", 
      "patients", 
      "diarrhea", 
      "bolus", 
      "trials", 
      "flavopiridol", 
      "MethodsPatients", 
      "response", 
      "admission", 
      "infusion", 
      "prior publications", 
      "transaminase", 
      "diagnosis", 
      "dose", 
      "marginal response", 
      "weeks", 
      "weekly", 
      "staining", 
      "treatment", 
      "inhibitors", 
      "D1", 
      "elevation", 
      "safety", 
      "agents", 
      "levels", 
      "decrease", 
      "protein", 
      "profile", 
      "publications", 
      "cycle", 
      "maximum", 
      "properties"
    ], 
    "name": "A phase I trial of flavopiridol in relapsed multiple myeloma", 
    "pagination": "249-257", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1052880160"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00280-013-2347-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24241210"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00280-013-2347-y", 
      "https://app.dimensions.ai/details/publication/pub.1052880160"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T20:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_584.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00280-013-2347-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00280-013-2347-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00280-013-2347-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00280-013-2347-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00280-013-2347-y'


 

This table displays all metadata directly associated to this object as RDF triples.

285 TRIPLES      21 PREDICATES      95 URIs      81 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00280-013-2347-y schema:about N0a89925e17ff409e87609942763a1eec
2 N5b65a5295c714ffea343affdaeb15424
3 N627b075cdf754fe9bb2083e67676d0b8
4 N62deee48c1da47398b43c39f7c3c3ab8
5 N8fb106fccbf544129f6aeaff6ef29dcb
6 N91341055d77d4c55a082c74f95f46ecc
7 N958f21d0e20d42c0898f5b2b8dfbf5f2
8 Nbb7b86bd3f0a46c9b89c6686c3898de0
9 Ncfe3b17117204e788645211fcd22e4e3
10 Nfa2afeeff7a349a98193c450a150dfea
11 anzsrc-for:11
12 anzsrc-for:1112
13 schema:author N5f9470948a0e4d059bb15170a7aa108c
14 schema:citation sg:pub.10.1038/nature03094
15 sg:pub.10.1038/nature07064
16 sg:pub.10.1038/onc.2009.510
17 sg:pub.10.1038/sj.leu.2402609
18 sg:pub.10.1038/sj.leu.2404284
19 sg:pub.10.1038/sj.onc.1208619
20 schema:datePublished 2013-11-16
21 schema:datePublishedReg 2013-11-16
22 schema:description PurposeFlavopiridol is primarily a cyclin-dependent kinase-9 inhibitor, and we performed a dose escalation trial to determine the maximum tolerated dose and safety and generate a pharmacokinetic (PK) profile.MethodsPatients with a diagnosis of relapsed myeloma after at least two prior treatments were included. Flavopiridol was administered as a bolus and then continuous infusion weekly for 4 weeks in a 6-week cycle.ResultsFifteen patients were treated at three dose levels (30 mg/m2 bolus, 30 mg/m2 CIV to 50 mg/m2 bolus, and 50 mg/m2 CIV). Cytopenias were significant, and elevated transaminases (grade 4 in 3 patients, grade 3 in 4 patients, and grade 2 in 3 patients) were noted but were transient. Diarrhea (grade 3 in 6 patients and grade 2 in 5 patients) did not lead to hospital admission. There were no confirmed partial responses although one patient with t(4;14) had a decrease in his monoclonal protein >50 % that did not persist. PK properties were similar to prior publications, and immunohistochemical staining for cyclin D1 and phospho-retinoblastoma did not predict response.ConclusionsFlavopiridol as a single agent given by bolus and then infusion caused significant diarrhea, cytopenias, and transaminase elevation but only achieved marginal responses in relapsed myeloma (ClinicalTrials.gov identifier NCT00112723).
23 schema:genre article
24 schema:isAccessibleForFree true
25 schema:isPartOf N7663aa040060467682e997a9ce1d24ee
26 Nbdfdae2613b64663bceebdc2c2704c0f
27 sg:journal.1088364
28 schema:keywords D1
29 I trial
30 MethodsPatients
31 PK properties
32 ResultsFifteen patients
33 admission
34 agents
35 bolus
36 cycle
37 cyclin D1
38 cyclin-dependent kinase 9 (CDK9) inhibitors
39 cytopenias
40 decrease
41 diagnosis
42 diarrhea
43 dose
44 dose levels
45 dose-escalation trial
46 elevated transaminases
47 elevation
48 escalation trial
49 flavopiridol
50 hospital admission
51 immunohistochemical staining
52 infusion
53 infusion weekly
54 inhibitors
55 levels
56 marginal response
57 maximum
58 monoclonal protein
59 multiple myeloma
60 myeloma
61 partial response
62 patients
63 pharmacokinetic profile
64 phase I trial
65 phospho-retinoblastoma
66 prior publications
67 prior treatment
68 profile
69 properties
70 protein
71 publications
72 response
73 safety
74 significant diarrhea
75 single agent
76 staining
77 transaminase
78 treatment
79 trials
80 weekly
81 weeks
82 schema:name A phase I trial of flavopiridol in relapsed multiple myeloma
83 schema:pagination 249-257
84 schema:productId N0e043ee2550c431b9a0a8f3b70943711
85 Nbd6a0697f6d94746a400cc3bb5c3c8e0
86 Nbfc5110e7ad7421a8819d12db724a0b3
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052880160
88 https://doi.org/10.1007/s00280-013-2347-y
89 schema:sdDatePublished 2022-11-24T20:55
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N5ff54a92fd6e477b98302bbd7f30c198
92 schema:url https://doi.org/10.1007/s00280-013-2347-y
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N0a89925e17ff409e87609942763a1eec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Piperidines
98 rdf:type schema:DefinedTerm
99 N0e043ee2550c431b9a0a8f3b70943711 schema:name pubmed_id
100 schema:value 24241210
101 rdf:type schema:PropertyValue
102 N15d752942e89409eaf00f8d607369d42 rdf:first sg:person.016603046517.16
103 rdf:rest N66677b4a0c6c49288ac758db5761b827
104 N1c6f00e63a184182bdc2abbc2c73610f rdf:first sg:person.01264011344.00
105 rdf:rest Nd762955dc7434fc8a9a86a9420bf9947
106 N3305001f76f24c3b8543d2c0438de85e rdf:first sg:person.01012674343.62
107 rdf:rest N15d752942e89409eaf00f8d607369d42
108 N548172cb5aa84c439b0435340bab4529 rdf:first sg:person.01115130607.09
109 rdf:rest rdf:nil
110 N5b65a5295c714ffea343affdaeb15424 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Humans
112 rdf:type schema:DefinedTerm
113 N5f9470948a0e4d059bb15170a7aa108c rdf:first sg:person.0646046513.55
114 rdf:rest N1c6f00e63a184182bdc2abbc2c73610f
115 N5ff54a92fd6e477b98302bbd7f30c198 schema:name Springer Nature - SN SciGraph project
116 rdf:type schema:Organization
117 N627b075cdf754fe9bb2083e67676d0b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Antineoplastic Agents
119 rdf:type schema:DefinedTerm
120 N62deee48c1da47398b43c39f7c3c3ab8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Aged, 80 and over
122 rdf:type schema:DefinedTerm
123 N66677b4a0c6c49288ac758db5761b827 rdf:first sg:person.01136654742.16
124 rdf:rest N75aaa56de9364f0c87452ed109952867
125 N75aaa56de9364f0c87452ed109952867 rdf:first sg:person.01006373162.09
126 rdf:rest N7a1a5686363f412c93a3928df6d87ab5
127 N7663aa040060467682e997a9ce1d24ee schema:issueNumber 2
128 rdf:type schema:PublicationIssue
129 N7a1a5686363f412c93a3928df6d87ab5 rdf:first sg:person.012331532622.31
130 rdf:rest Na535d1514c974e01b21b09ddf47377b5
131 N8fb106fccbf544129f6aeaff6ef29dcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Recurrence
133 rdf:type schema:DefinedTerm
134 N91341055d77d4c55a082c74f95f46ecc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Flavonoids
136 rdf:type schema:DefinedTerm
137 N958f21d0e20d42c0898f5b2b8dfbf5f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Middle Aged
139 rdf:type schema:DefinedTerm
140 Na535d1514c974e01b21b09ddf47377b5 rdf:first sg:person.01235220307.54
141 rdf:rest N548172cb5aa84c439b0435340bab4529
142 Nbb7b86bd3f0a46c9b89c6686c3898de0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Dose-Response Relationship, Drug
144 rdf:type schema:DefinedTerm
145 Nbd6a0697f6d94746a400cc3bb5c3c8e0 schema:name doi
146 schema:value 10.1007/s00280-013-2347-y
147 rdf:type schema:PropertyValue
148 Nbdfdae2613b64663bceebdc2c2704c0f schema:volumeNumber 73
149 rdf:type schema:PublicationVolume
150 Nbfc5110e7ad7421a8819d12db724a0b3 schema:name dimensions_id
151 schema:value pub.1052880160
152 rdf:type schema:PropertyValue
153 Ncdb2052f2e284ed09563543d602e0e0c rdf:first sg:person.0606000650.00
154 rdf:rest Nfe6fe33859d940fa9d625fe718c5bb72
155 Ncfe3b17117204e788645211fcd22e4e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Multiple Myeloma
157 rdf:type schema:DefinedTerm
158 Nd762955dc7434fc8a9a86a9420bf9947 rdf:first sg:person.01165073662.11
159 rdf:rest Ncdb2052f2e284ed09563543d602e0e0c
160 Ndf0e884826184a7fa9510a99296ae222 rdf:first sg:person.011746564122.47
161 rdf:rest N3305001f76f24c3b8543d2c0438de85e
162 Nfa2afeeff7a349a98193c450a150dfea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Aged
164 rdf:type schema:DefinedTerm
165 Nfe6fe33859d940fa9d625fe718c5bb72 rdf:first sg:person.015542026572.38
166 rdf:rest Ndf0e884826184a7fa9510a99296ae222
167 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
168 schema:name Medical and Health Sciences
169 rdf:type schema:DefinedTerm
170 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
171 schema:name Oncology and Carcinogenesis
172 rdf:type schema:DefinedTerm
173 sg:grant.2416454 http://pending.schema.org/fundedItem sg:pub.10.1007/s00280-013-2347-y
174 rdf:type schema:MonetaryGrant
175 sg:grant.2423251 http://pending.schema.org/fundedItem sg:pub.10.1007/s00280-013-2347-y
176 rdf:type schema:MonetaryGrant
177 sg:grant.2438819 http://pending.schema.org/fundedItem sg:pub.10.1007/s00280-013-2347-y
178 rdf:type schema:MonetaryGrant
179 sg:grant.2688806 http://pending.schema.org/fundedItem sg:pub.10.1007/s00280-013-2347-y
180 rdf:type schema:MonetaryGrant
181 sg:journal.1088364 schema:issn 0344-5704
182 1432-0843
183 schema:name Cancer Chemotherapy and Pharmacology
184 schema:publisher Springer Nature
185 rdf:type schema:Periodical
186 sg:person.01006373162.09 schema:affiliation grid-institutes:grid.261331.4
187 schema:familyName Sexton
188 schema:givenName Jennifer
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006373162.09
190 rdf:type schema:Person
191 sg:person.01012674343.62 schema:affiliation grid-institutes:grid.261331.4
192 schema:familyName Kraut
193 schema:givenName Eric H.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012674343.62
195 rdf:type schema:Person
196 sg:person.01115130607.09 schema:affiliation grid-institutes:grid.261331.4
197 schema:familyName Byrd
198 schema:givenName John C.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115130607.09
200 rdf:type schema:Person
201 sg:person.01136654742.16 schema:affiliation grid-institutes:grid.261331.4
202 schema:familyName Efebera
203 schema:givenName Yvonne A.
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136654742.16
205 rdf:type schema:Person
206 sg:person.01165073662.11 schema:affiliation grid-institutes:grid.261331.4
207 schema:familyName Bowers
208 schema:givenName Mindy A.
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165073662.11
210 rdf:type schema:Person
211 sg:person.011746564122.47 schema:affiliation grid-institutes:grid.261331.4
212 schema:familyName Benson
213 schema:givenName Don M.
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011746564122.47
215 rdf:type schema:Person
216 sg:person.012331532622.31 schema:affiliation grid-institutes:grid.418019.5
217 schema:familyName Lin
218 schema:givenName Thomas S.
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012331532622.31
220 rdf:type schema:Person
221 sg:person.01235220307.54 schema:affiliation grid-institutes:grid.261331.4
222 schema:familyName Grever
223 schema:givenName Michael
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235220307.54
225 rdf:type schema:Person
226 sg:person.01264011344.00 schema:affiliation grid-institutes:grid.261331.4
227 schema:familyName Poi
228 schema:givenName Ming
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264011344.00
230 rdf:type schema:Person
231 sg:person.015542026572.38 schema:affiliation grid-institutes:grid.261331.4
232 schema:familyName Phelps
233 schema:givenName Mitch A.
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015542026572.38
235 rdf:type schema:Person
236 sg:person.016603046517.16 schema:affiliation grid-institutes:grid.257413.6
237 schema:familyName Farag
238 schema:givenName Sherif
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016603046517.16
240 rdf:type schema:Person
241 sg:person.0606000650.00 schema:affiliation grid-institutes:grid.261331.4
242 schema:familyName Zhao
243 schema:givenName Weiqiang
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606000650.00
245 rdf:type schema:Person
246 sg:person.0646046513.55 schema:affiliation grid-institutes:grid.261331.4
247 schema:familyName Hofmeister
248 schema:givenName Craig C.
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646046513.55
250 rdf:type schema:Person
251 sg:pub.10.1038/nature03094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019043910
252 https://doi.org/10.1038/nature03094
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/nature07064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038937039
255 https://doi.org/10.1038/nature07064
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/onc.2009.510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011776336
258 https://doi.org/10.1038/onc.2009.510
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/sj.leu.2402609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002540802
261 https://doi.org/10.1038/sj.leu.2402609
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/sj.leu.2404284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033553106
264 https://doi.org/10.1038/sj.leu.2404284
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/sj.onc.1208619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033897711
267 https://doi.org/10.1038/sj.onc.1208619
268 rdf:type schema:CreativeWork
269 grid-institutes:grid.257413.6 schema:alternateName College of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
270 schema:name College of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
271 rdf:type schema:Organization
272 grid-institutes:grid.261331.4 schema:alternateName College of Pharmacy, The Ohio State University, Columbus, OH, USA
273 Department of Pathology, College of Medicine, The Ohio State University, Columbus, OH, USA
274 Department of Pharmacy, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
275 Division of Hematology, The Ohio State University, B321 Starling Loving Hall, 320 West 10th Avenue, 43210, Columbus, OH, USA
276 The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
277 schema:name College of Pharmacy, The Ohio State University, Columbus, OH, USA
278 Department of Pathology, College of Medicine, The Ohio State University, Columbus, OH, USA
279 Department of Pharmacy, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
280 Division of Hematology, The Ohio State University, B321 Starling Loving Hall, 320 West 10th Avenue, 43210, Columbus, OH, USA
281 The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
282 rdf:type schema:Organization
283 grid-institutes:grid.418019.5 schema:alternateName Oncology Research and Development, GlaxoSmithKline, Philadelphia, PA, USA
284 schema:name Oncology Research and Development, GlaxoSmithKline, Philadelphia, PA, USA
285 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...