Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06-12

AUTHORS

R. P. Jones, P. Sutton, R. M. D. Greensmith, A. Santoyo-Castelazo, D. F. Carr, R. Jenkins, C. Rowe, J. Hamlett, B. K. Park, M. Terlizzo, E. O’Grady, P. Ghaneh, S. W. Fenwick, H. Z. Malik, G. J. Poston, N. R. Kitteringham

ABSTRACT

PurposeThe response of colorectal liver metastases to the cytotoxic agent irinotecan varies widely. Attempts to correlate tumour metabolism with response have been mixed. This study investigated the hepatic metabolism of irinotecan as a potential predictor of tumour response to irinotecan-eluting beads (DEBIRI).MethodsTen patients with colorectal liver metastases were treated with 200 mg irinotecan (as DEBIRI) as part of the PARAGON II study. Hepatic expression of key metabolising enzymes was measured using mass spectrometry-based proteomics. Serum drug concentrations and hepatic irinotecan metabolism were characterised and correlated with tumour response.ResultsSerum concentrations of irinotecan metabolites did not correlate with hepatic metabolism or pathological response. There was a strong correlation between hepatic CES-2 expression and activation of irinotecan (r2 = 0.96, p < 0.001). Patients with a UGT1A1*28 6/7 SNP showed no difference in drug metabolism or pathological response. Hepatic CES-2 mediated activation of irinotecan clearly correlated with tumour replacement by fibrosis (r2 = 0.54, p = 0.01).ConclusionThis study provides the first evidence that hepatic activation of irinotecan predicts tumour response. Delivery of liver-targeted irinotecan to normal liver tissue rather than tumour may be a more rational approach to maximise response. More... »

PAGES

359-368

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00280-013-2199-5

DOI

http://dx.doi.org/10.1007/s00280-013-2199-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005485939

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23756919


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Phytogenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biotransformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Western", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Camptothecin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Delivery Systems", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucuronosyltransferase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Irinotecan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mass Spectrometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microsomes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Northwest Hepatobiliary Unit, Aintree University Hospital, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.411255.6", 
          "name": [
            "School of Cancer Studies, Institute of Translational Medicine, University of Liverpool, L69 3GA, Liverpool, UK", 
            "MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK", 
            "Northwest Hepatobiliary Unit, Aintree University Hospital, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "R. P.", 
        "id": "sg:person.01047077510.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047077510.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "School of Cancer Studies, Institute of Translational Medicine, University of Liverpool, L69 3GA, Liverpool, UK", 
            "MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sutton", 
        "givenName": "P.", 
        "id": "sg:person.01243470217.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243470217.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Greensmith", 
        "givenName": "R. M. D.", 
        "id": "sg:person.0762730630.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762730630.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santoyo-Castelazo", 
        "givenName": "A.", 
        "id": "sg:person.01214452725.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214452725.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carr", 
        "givenName": "D. F.", 
        "id": "sg:person.0726051134.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726051134.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jenkins", 
        "givenName": "R.", 
        "id": "sg:person.0756336504.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756336504.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rowe", 
        "givenName": "C.", 
        "id": "sg:person.0766275427.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766275427.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamlett", 
        "givenName": "J.", 
        "id": "sg:person.01146566750.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146566750.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "B. K.", 
        "id": "sg:person.010730736267.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010730736267.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Histopathology, Aintree University Hospital, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.411255.6", 
          "name": [
            "Department of Histopathology, Aintree University Hospital, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Terlizzo", 
        "givenName": "M.", 
        "id": "sg:person.01100100172.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100100172.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Aintree University Hospital, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.411255.6", 
          "name": [
            "Department of Radiology, Aintree University Hospital, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Grady", 
        "givenName": "E.", 
        "id": "sg:person.01302757346.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302757346.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Cancer Studies, Institute of Translational Medicine, University of Liverpool, L69 3GA, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "School of Cancer Studies, Institute of Translational Medicine, University of Liverpool, L69 3GA, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ghaneh", 
        "givenName": "P.", 
        "id": "sg:person.07372440237.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07372440237.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northwest Hepatobiliary Unit, Aintree University Hospital, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.411255.6", 
          "name": [
            "Northwest Hepatobiliary Unit, Aintree University Hospital, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fenwick", 
        "givenName": "S. W.", 
        "id": "sg:person.01332774747.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332774747.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northwest Hepatobiliary Unit, Aintree University Hospital, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.411255.6", 
          "name": [
            "Northwest Hepatobiliary Unit, Aintree University Hospital, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malik", 
        "givenName": "H. Z.", 
        "id": "sg:person.016255541362.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016255541362.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northwest Hepatobiliary Unit, Aintree University Hospital, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.411255.6", 
          "name": [
            "Northwest Hepatobiliary Unit, Aintree University Hospital, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Poston", 
        "givenName": "G. J.", 
        "id": "sg:person.0607370647.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607370647.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK", 
          "id": "http://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kitteringham", 
        "givenName": "N. R.", 
        "id": "sg:person.01264420373.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264420373.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.bjc.6690364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006486347", 
          "https://doi.org/10.1038/sj.bjc.6690364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002929789", 
          "https://doi.org/10.1038/sj.bjc.6604673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-010-1288-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012691102", 
          "https://doi.org/10.1245/s10434-010-1288-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.tpj.6500072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023319869", 
          "https://doi.org/10.1038/sj.tpj.6500072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00335-010-9284-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029785100", 
          "https://doi.org/10.1007/s00335-010-9284-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-012-2335-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052082386", 
          "https://doi.org/10.1245/s10434-012-2335-1"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-06-12", 
    "datePublishedReg": "2013-06-12", 
    "description": "PurposeThe response of colorectal liver metastases to the cytotoxic agent irinotecan varies widely. Attempts to correlate tumour metabolism with response have been mixed. This study investigated the hepatic metabolism of irinotecan as a potential predictor of tumour response to irinotecan-eluting beads (DEBIRI).MethodsTen patients with colorectal liver metastases were treated with 200\u00a0mg irinotecan (as DEBIRI) as part of the PARAGON II study. Hepatic expression of key metabolising enzymes was measured using mass spectrometry-based proteomics. Serum drug concentrations and hepatic irinotecan metabolism were characterised and correlated with tumour response.ResultsSerum concentrations of irinotecan metabolites did not correlate with hepatic metabolism or pathological response. There was a strong correlation between hepatic CES-2 expression and activation of irinotecan (r2\u00a0=\u00a00.96, p\u00a0<\u00a00.001). Patients with a UGT1A1*28 6/7 SNP showed no difference in drug metabolism or pathological response. Hepatic CES-2 mediated activation of irinotecan clearly correlated with tumour replacement by fibrosis (r2\u00a0=\u00a00.54, p\u00a0=\u00a00.01).ConclusionThis study provides the first evidence that hepatic activation of irinotecan predicts tumour response. Delivery of liver-targeted irinotecan to normal liver tissue rather than tumour may be a more rational approach to maximise response.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00280-013-2199-5", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2787213", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1088364", 
        "issn": [
          "0344-5704", 
          "1432-0843"
        ], 
        "name": "Cancer Chemotherapy and Pharmacology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "72"
      }
    ], 
    "keywords": [
      "colorectal liver metastases", 
      "tumor response", 
      "liver metastases", 
      "activation of irinotecan", 
      "II study", 
      "pathological response", 
      "hepatic metabolism", 
      "hepatic activation", 
      "phase II study", 
      "serum drug concentrations", 
      "normal liver tissue", 
      "ResultsSerum concentrations", 
      "tumor replacement", 
      "MethodsTen patients", 
      "hepatic expression", 
      "irinotecan metabolite", 
      "ConclusionThis study", 
      "irinotecan metabolism", 
      "irinotecan", 
      "metabolising enzymes", 
      "PurposeThe response", 
      "liver tissue", 
      "tumor metabolism", 
      "drug concentrations", 
      "drug metabolism", 
      "potential predictors", 
      "patients", 
      "metastasis", 
      "metabolism", 
      "activation", 
      "CES-2", 
      "exploratory findings", 
      "first evidence", 
      "rational approach", 
      "response", 
      "DEBIRI", 
      "fibrosis", 
      "expression", 
      "tumors", 
      "UGT1A1", 
      "study", 
      "mass spectrometry-based proteomics", 
      "strong correlation", 
      "spectrometry-based proteomics", 
      "predictors", 
      "tissue", 
      "metabolites", 
      "delivery", 
      "concentration", 
      "findings", 
      "evidence", 
      "replacement", 
      "differences", 
      "correlation", 
      "SNPs", 
      "enzyme", 
      "proteomics", 
      "attempt", 
      "part", 
      "beads", 
      "approach"
    ], 
    "name": "Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study", 
    "pagination": "359-368", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005485939"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00280-013-2199-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23756919"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00280-013-2199-5", 
      "https://app.dimensions.ai/details/publication/pub.1005485939"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_590.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00280-013-2199-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00280-013-2199-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00280-013-2199-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00280-013-2199-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00280-013-2199-5'


 

This table displays all metadata directly associated to this object as RDF triples.

338 TRIPLES      21 PREDICATES      110 URIs      96 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00280-013-2199-5 schema:about N22700c4c404a4200af173a638350917e
2 N291982d51db445edb5b4acc8b85b227c
3 N556e2eda749f4cb48fa19c0aba9e59e4
4 N56fb1a42efdd4fa4af593a9cb1db38fd
5 N73c07aa87f5d430aa31ced542f88c151
6 N8552ea93b6e24267826011b59f0c7405
7 N8b7446ae35dc48da860c8a8f1ca90cc0
8 N9678aeea2b2545de85956749711bf6cf
9 N97d498ec081b49c89e3c9d0da9f00cc0
10 Na7ef3f2110164ddfa66d523da705a147
11 Naca4f8c2c6804aea8851232e04b7d93e
12 Nc1b42d48e065499c81b2a169dd404fb3
13 Nc333ac0957504ce990835f4ccac52f57
14 Nd5f2e8bfbfa4458bbfd4e0abae446bba
15 Nd9b4092d8c6146b09b11770e9ca4c716
16 Ndb5a072fbe3948f092011e27e303fa98
17 Ne2014813f1bc4c2bb4936f16f8f9a547
18 Nf760d283f617490db8e4d7b9a4873590
19 anzsrc-for:11
20 anzsrc-for:1115
21 schema:author Nb1648133e46543b09999bbed7e9536c4
22 schema:citation sg:pub.10.1007/s00335-010-9284-4
23 sg:pub.10.1038/sj.bjc.6604673
24 sg:pub.10.1038/sj.bjc.6690364
25 sg:pub.10.1038/sj.tpj.6500072
26 sg:pub.10.1245/s10434-010-1288-5
27 sg:pub.10.1245/s10434-012-2335-1
28 schema:datePublished 2013-06-12
29 schema:datePublishedReg 2013-06-12
30 schema:description PurposeThe response of colorectal liver metastases to the cytotoxic agent irinotecan varies widely. Attempts to correlate tumour metabolism with response have been mixed. This study investigated the hepatic metabolism of irinotecan as a potential predictor of tumour response to irinotecan-eluting beads (DEBIRI).MethodsTen patients with colorectal liver metastases were treated with 200 mg irinotecan (as DEBIRI) as part of the PARAGON II study. Hepatic expression of key metabolising enzymes was measured using mass spectrometry-based proteomics. Serum drug concentrations and hepatic irinotecan metabolism were characterised and correlated with tumour response.ResultsSerum concentrations of irinotecan metabolites did not correlate with hepatic metabolism or pathological response. There was a strong correlation between hepatic CES-2 expression and activation of irinotecan (r2 = 0.96, p < 0.001). Patients with a UGT1A1*28 6/7 SNP showed no difference in drug metabolism or pathological response. Hepatic CES-2 mediated activation of irinotecan clearly correlated with tumour replacement by fibrosis (r2 = 0.54, p = 0.01).ConclusionThis study provides the first evidence that hepatic activation of irinotecan predicts tumour response. Delivery of liver-targeted irinotecan to normal liver tissue rather than tumour may be a more rational approach to maximise response.
31 schema:genre article
32 schema:isAccessibleForFree false
33 schema:isPartOf N4beec167a43f489fb224289da61462ce
34 Nfe6e7f3a38c84d92a37cf965cb9d79de
35 sg:journal.1088364
36 schema:keywords CES-2
37 ConclusionThis study
38 DEBIRI
39 II study
40 MethodsTen patients
41 PurposeThe response
42 ResultsSerum concentrations
43 SNPs
44 UGT1A1
45 activation
46 activation of irinotecan
47 approach
48 attempt
49 beads
50 colorectal liver metastases
51 concentration
52 correlation
53 delivery
54 differences
55 drug concentrations
56 drug metabolism
57 enzyme
58 evidence
59 exploratory findings
60 expression
61 fibrosis
62 findings
63 first evidence
64 hepatic activation
65 hepatic expression
66 hepatic metabolism
67 irinotecan
68 irinotecan metabolism
69 irinotecan metabolite
70 liver metastases
71 liver tissue
72 mass spectrometry-based proteomics
73 metabolising enzymes
74 metabolism
75 metabolites
76 metastasis
77 normal liver tissue
78 part
79 pathological response
80 patients
81 phase II study
82 potential predictors
83 predictors
84 proteomics
85 rational approach
86 replacement
87 response
88 serum drug concentrations
89 spectrometry-based proteomics
90 strong correlation
91 study
92 tissue
93 tumor metabolism
94 tumor replacement
95 tumor response
96 tumors
97 schema:name Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study
98 schema:pagination 359-368
99 schema:productId N0ce953522b744f1facad94fe1711cdbe
100 N26c103e9299a4e6bac70b4e3930aab47
101 N86c7e3612b87401cbf979088efcff6ae
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005485939
103 https://doi.org/10.1007/s00280-013-2199-5
104 schema:sdDatePublished 2022-12-01T06:31
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher N5d1b863549a24058b0801f1466c7303d
107 schema:url https://doi.org/10.1007/s00280-013-2199-5
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N049d3eadfebe4eb193c1793b27e80132 rdf:first sg:person.0756336504.39
112 rdf:rest Nf23d571a65114a1797a235e2635766d6
113 N0ce953522b744f1facad94fe1711cdbe schema:name pubmed_id
114 schema:value 23756919
115 rdf:type schema:PropertyValue
116 N1174715c1cca424d87cc373e7da6c98a rdf:first sg:person.0607370647.42
117 rdf:rest N6074b768fed649f9905ce87ff3689482
118 N17cbc8635bdb412f882fe3c2bea5ab4c rdf:first sg:person.010730736267.50
119 rdf:rest N98b3770dd12245dcaa69658e065610fc
120 N1dfeff071308471b93bafcace6ad9254 rdf:first sg:person.07372440237.86
121 rdf:rest Nf2f72975a000475994f515b1ba1fd628
122 N22700c4c404a4200af173a638350917e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Prospective Studies
124 rdf:type schema:DefinedTerm
125 N26c103e9299a4e6bac70b4e3930aab47 schema:name doi
126 schema:value 10.1007/s00280-013-2199-5
127 rdf:type schema:PropertyValue
128 N291982d51db445edb5b4acc8b85b227c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Drug Delivery Systems
130 rdf:type schema:DefinedTerm
131 N2a327b8d58374a9e93349d3dc4e2010b rdf:first sg:person.01243470217.24
132 rdf:rest N7a2b176a48b044e4b56d30a0fd6b6c15
133 N4beec167a43f489fb224289da61462ce schema:issueNumber 2
134 rdf:type schema:PublicationIssue
135 N556e2eda749f4cb48fa19c0aba9e59e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Irinotecan
137 rdf:type schema:DefinedTerm
138 N56fb1a42efdd4fa4af593a9cb1db38fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Colorectal Neoplasms
140 rdf:type schema:DefinedTerm
141 N5d1b863549a24058b0801f1466c7303d schema:name Springer Nature - SN SciGraph project
142 rdf:type schema:Organization
143 N5ebfbb12b414448f88a308d31ae14570 rdf:first sg:person.0726051134.05
144 rdf:rest N049d3eadfebe4eb193c1793b27e80132
145 N6074b768fed649f9905ce87ff3689482 rdf:first sg:person.01264420373.12
146 rdf:rest rdf:nil
147 N6fe215a5e560478da059246acdaacd71 rdf:first sg:person.01214452725.14
148 rdf:rest N5ebfbb12b414448f88a308d31ae14570
149 N73c07aa87f5d430aa31ced542f88c151 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Microsomes
151 rdf:type schema:DefinedTerm
152 N77e35b25d04e4fad9dee1130956a45c9 rdf:first sg:person.016255541362.46
153 rdf:rest N1174715c1cca424d87cc373e7da6c98a
154 N7a2b176a48b044e4b56d30a0fd6b6c15 rdf:first sg:person.0762730630.16
155 rdf:rest N6fe215a5e560478da059246acdaacd71
156 N7f85ec143db1491db1fb4032b37f6385 rdf:first sg:person.01302757346.72
157 rdf:rest N1dfeff071308471b93bafcace6ad9254
158 N8552ea93b6e24267826011b59f0c7405 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Camptothecin
160 rdf:type schema:DefinedTerm
161 N86c7e3612b87401cbf979088efcff6ae schema:name dimensions_id
162 schema:value pub.1005485939
163 rdf:type schema:PropertyValue
164 N8b7446ae35dc48da860c8a8f1ca90cc0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Glucuronosyltransferase
166 rdf:type schema:DefinedTerm
167 N9678aeea2b2545de85956749711bf6cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Antineoplastic Agents, Phytogenic
169 rdf:type schema:DefinedTerm
170 N97d498ec081b49c89e3c9d0da9f00cc0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Reproducibility of Results
172 rdf:type schema:DefinedTerm
173 N98b3770dd12245dcaa69658e065610fc rdf:first sg:person.01100100172.94
174 rdf:rest N7f85ec143db1491db1fb4032b37f6385
175 Na7ef3f2110164ddfa66d523da705a147 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Liver Neoplasms
177 rdf:type schema:DefinedTerm
178 Naca4f8c2c6804aea8851232e04b7d93e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Liver
180 rdf:type schema:DefinedTerm
181 Nb1648133e46543b09999bbed7e9536c4 rdf:first sg:person.01047077510.45
182 rdf:rest N2a327b8d58374a9e93349d3dc4e2010b
183 Nc1b42d48e065499c81b2a169dd404fb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Blotting, Western
185 rdf:type schema:DefinedTerm
186 Nc333ac0957504ce990835f4ccac52f57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Genotype
188 rdf:type schema:DefinedTerm
189 Nd5f2e8bfbfa4458bbfd4e0abae446bba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Biotransformation
191 rdf:type schema:DefinedTerm
192 Nd9b4092d8c6146b09b11770e9ca4c716 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Humans
194 rdf:type schema:DefinedTerm
195 Ndb5a072fbe3948f092011e27e303fa98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Mass Spectrometry
197 rdf:type schema:DefinedTerm
198 Ne160cf052a7e4063b68d8334c0a44211 rdf:first sg:person.01146566750.15
199 rdf:rest N17cbc8635bdb412f882fe3c2bea5ab4c
200 Ne2014813f1bc4c2bb4936f16f8f9a547 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Neoplasm Proteins
202 rdf:type schema:DefinedTerm
203 Nf23d571a65114a1797a235e2635766d6 rdf:first sg:person.0766275427.21
204 rdf:rest Ne160cf052a7e4063b68d8334c0a44211
205 Nf2f72975a000475994f515b1ba1fd628 rdf:first sg:person.01332774747.90
206 rdf:rest N77e35b25d04e4fad9dee1130956a45c9
207 Nf760d283f617490db8e4d7b9a4873590 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name DNA, Neoplasm
209 rdf:type schema:DefinedTerm
210 Nfe6e7f3a38c84d92a37cf965cb9d79de schema:volumeNumber 72
211 rdf:type schema:PublicationVolume
212 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
213 schema:name Medical and Health Sciences
214 rdf:type schema:DefinedTerm
215 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
216 schema:name Pharmacology and Pharmaceutical Sciences
217 rdf:type schema:DefinedTerm
218 sg:grant.2787213 http://pending.schema.org/fundedItem sg:pub.10.1007/s00280-013-2199-5
219 rdf:type schema:MonetaryGrant
220 sg:journal.1088364 schema:issn 0344-5704
221 1432-0843
222 schema:name Cancer Chemotherapy and Pharmacology
223 schema:publisher Springer Nature
224 rdf:type schema:Periodical
225 sg:person.01047077510.45 schema:affiliation grid-institutes:grid.411255.6
226 schema:familyName Jones
227 schema:givenName R. P.
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047077510.45
229 rdf:type schema:Person
230 sg:person.010730736267.50 schema:affiliation grid-institutes:grid.10025.36
231 schema:familyName Park
232 schema:givenName B. K.
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010730736267.50
234 rdf:type schema:Person
235 sg:person.01100100172.94 schema:affiliation grid-institutes:grid.411255.6
236 schema:familyName Terlizzo
237 schema:givenName M.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100100172.94
239 rdf:type schema:Person
240 sg:person.01146566750.15 schema:affiliation grid-institutes:grid.10025.36
241 schema:familyName Hamlett
242 schema:givenName J.
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146566750.15
244 rdf:type schema:Person
245 sg:person.01214452725.14 schema:affiliation grid-institutes:grid.10025.36
246 schema:familyName Santoyo-Castelazo
247 schema:givenName A.
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214452725.14
249 rdf:type schema:Person
250 sg:person.01243470217.24 schema:affiliation grid-institutes:grid.10025.36
251 schema:familyName Sutton
252 schema:givenName P.
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243470217.24
254 rdf:type schema:Person
255 sg:person.01264420373.12 schema:affiliation grid-institutes:grid.10025.36
256 schema:familyName Kitteringham
257 schema:givenName N. R.
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264420373.12
259 rdf:type schema:Person
260 sg:person.01302757346.72 schema:affiliation grid-institutes:grid.411255.6
261 schema:familyName O’Grady
262 schema:givenName E.
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302757346.72
264 rdf:type schema:Person
265 sg:person.01332774747.90 schema:affiliation grid-institutes:grid.411255.6
266 schema:familyName Fenwick
267 schema:givenName S. W.
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332774747.90
269 rdf:type schema:Person
270 sg:person.016255541362.46 schema:affiliation grid-institutes:grid.411255.6
271 schema:familyName Malik
272 schema:givenName H. Z.
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016255541362.46
274 rdf:type schema:Person
275 sg:person.0607370647.42 schema:affiliation grid-institutes:grid.411255.6
276 schema:familyName Poston
277 schema:givenName G. J.
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607370647.42
279 rdf:type schema:Person
280 sg:person.0726051134.05 schema:affiliation grid-institutes:grid.10025.36
281 schema:familyName Carr
282 schema:givenName D. F.
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726051134.05
284 rdf:type schema:Person
285 sg:person.07372440237.86 schema:affiliation grid-institutes:grid.10025.36
286 schema:familyName Ghaneh
287 schema:givenName P.
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07372440237.86
289 rdf:type schema:Person
290 sg:person.0756336504.39 schema:affiliation grid-institutes:grid.10025.36
291 schema:familyName Jenkins
292 schema:givenName R.
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756336504.39
294 rdf:type schema:Person
295 sg:person.0762730630.16 schema:affiliation grid-institutes:grid.10025.36
296 schema:familyName Greensmith
297 schema:givenName R. M. D.
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762730630.16
299 rdf:type schema:Person
300 sg:person.0766275427.21 schema:affiliation grid-institutes:grid.10025.36
301 schema:familyName Rowe
302 schema:givenName C.
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766275427.21
304 rdf:type schema:Person
305 sg:pub.10.1007/s00335-010-9284-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029785100
306 https://doi.org/10.1007/s00335-010-9284-4
307 rdf:type schema:CreativeWork
308 sg:pub.10.1038/sj.bjc.6604673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002929789
309 https://doi.org/10.1038/sj.bjc.6604673
310 rdf:type schema:CreativeWork
311 sg:pub.10.1038/sj.bjc.6690364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006486347
312 https://doi.org/10.1038/sj.bjc.6690364
313 rdf:type schema:CreativeWork
314 sg:pub.10.1038/sj.tpj.6500072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023319869
315 https://doi.org/10.1038/sj.tpj.6500072
316 rdf:type schema:CreativeWork
317 sg:pub.10.1245/s10434-010-1288-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012691102
318 https://doi.org/10.1245/s10434-010-1288-5
319 rdf:type schema:CreativeWork
320 sg:pub.10.1245/s10434-012-2335-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052082386
321 https://doi.org/10.1245/s10434-012-2335-1
322 rdf:type schema:CreativeWork
323 grid-institutes:grid.10025.36 schema:alternateName Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
324 MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
325 School of Cancer Studies, Institute of Translational Medicine, University of Liverpool, L69 3GA, Liverpool, UK
326 schema:name Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
327 MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
328 School of Cancer Studies, Institute of Translational Medicine, University of Liverpool, L69 3GA, Liverpool, UK
329 rdf:type schema:Organization
330 grid-institutes:grid.411255.6 schema:alternateName Department of Histopathology, Aintree University Hospital, Liverpool, UK
331 Department of Radiology, Aintree University Hospital, Liverpool, UK
332 Northwest Hepatobiliary Unit, Aintree University Hospital, Liverpool, UK
333 schema:name Department of Histopathology, Aintree University Hospital, Liverpool, UK
334 Department of Radiology, Aintree University Hospital, Liverpool, UK
335 MRC Centre for Drug Safety Science, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
336 Northwest Hepatobiliary Unit, Aintree University Hospital, Liverpool, UK
337 School of Cancer Studies, Institute of Translational Medicine, University of Liverpool, L69 3GA, Liverpool, UK
338 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...