Differing effects of adjuvant chemotherapy according to BRCA1 nuclear expression in gastric cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-04-30

AUTHORS

Jin Won Kim, Hyun Jin Cho, Miso Kim, Kyung-Hun Lee, Min A. Kim, Sae-Won Han, Do-Youn Oh, Hyuk-Joon Lee, Seock-Ah Im, Tae-You Kim, Han-Kwang Yang, Woo Ho Kim, Yung-Jue Bang

ABSTRACT

BackgroundWe aimed to investigate the role of BRCA1 nuclear expression in sporadic gastric cancer; currently, the role remains unknown.MethodsPatients with gastric cancer who received curative operation with D2 dissection were enrolled in this study. Adjuvant chemotherapy was administered at the discretion of the physician. According to BRCA1 nuclear expression analysis by immunohistochemistry (IHC) on tissue microarrays using anti-BRCA1 antibody MS110, BRCA1 expression was classified as negative, low expression, and high expression.ResultsAmong 318 cases, 155 cases (48.7 %) were identified as BRCA1-negative by IHC and 96 cases (30.2 %) revealed BRCA1 low expression, 67 cases (21.0 %) showed BRCA1 high expression. The negative or reduced expression of BRCA1 was more frequent in more advanced-stage disease (p < 0.001) and was associated with perineural invasion (p = 0.032). Disease-free survival (DFS) was significantly decreased with reduced BRCA1 expression (p = 0.027). This tendency was also observed in overall survival (OS), although the difference was not significant. The poorer prognosis of BRCA1-negative tumors was overcome through adjuvant chemotherapy. The benefit of adjuvant chemotherapy for DFS and OS in stage III was enhanced only in BRCA1-negative tumors (p < 0.001, p < 0.001, respectively), but not in BRCA1-positive tumors (p = 0.236, p = 0.148, respectively).ConclusionThe reduction of BRCA1 nuclear expression is associated with advanced stage and perineural invasion. Moreover, negative BRCA1 nuclear expression is a predictive marker regarding the benefit of adjuvant chemotherapy in sporadic gastric cancer; these novel findings are of great importance, and further, larger studies are warranted. More... »

PAGES

1435-1443

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00280-013-2141-x

DOI

http://dx.doi.org/10.1007/s00280-013-2141-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001859832

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23633032


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29 schema:description BackgroundWe aimed to investigate the role of BRCA1 nuclear expression in sporadic gastric cancer; currently, the role remains unknown.MethodsPatients with gastric cancer who received curative operation with D2 dissection were enrolled in this study. Adjuvant chemotherapy was administered at the discretion of the physician. According to BRCA1 nuclear expression analysis by immunohistochemistry (IHC) on tissue microarrays using anti-BRCA1 antibody MS110, BRCA1 expression was classified as negative, low expression, and high expression.ResultsAmong 318 cases, 155 cases (48.7 %) were identified as BRCA1-negative by IHC and 96 cases (30.2 %) revealed BRCA1 low expression, 67 cases (21.0 %) showed BRCA1 high expression. The negative or reduced expression of BRCA1 was more frequent in more advanced-stage disease (p < 0.001) and was associated with perineural invasion (p = 0.032). Disease-free survival (DFS) was significantly decreased with reduced BRCA1 expression (p = 0.027). This tendency was also observed in overall survival (OS), although the difference was not significant. The poorer prognosis of BRCA1-negative tumors was overcome through adjuvant chemotherapy. The benefit of adjuvant chemotherapy for DFS and OS in stage III was enhanced only in BRCA1-negative tumors (p < 0.001, p < 0.001, respectively), but not in BRCA1-positive tumors (p = 0.236, p = 0.148, respectively).ConclusionThe reduction of BRCA1 nuclear expression is associated with advanced stage and perineural invasion. Moreover, negative BRCA1 nuclear expression is a predictive marker regarding the benefit of adjuvant chemotherapy in sporadic gastric cancer; these novel findings are of great importance, and further, larger studies are warranted.
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36 schema:keywords BRCA1
37 BRCA1 expression
38 BRCA1 high expression
39 BRCA1 low expression
40 BRCA1 nuclear expression
41 BRCA1 nuclear expression analysis
42 BRCA1-negative
43 BRCA1-negative tumors
44 BRCA1-positive tumors
45 BackgroundWe
46 ConclusionThe reduction
47 D2 dissection
48 MS110
49 MethodsPatients
50 ResultsAmong 318 cases
51 adjuvant chemotherapy
52 advanced stage
53 advanced-stage disease
54 analysis
55 anti-BRCA1 antibody MS110
56 antibody MS110
57 benefits
58 cancer
59 cases
60 chemotherapy
61 curative operation
62 differences
63 discretion
64 disease
65 disease-free survival
66 dissection
67 effect
68 expression
69 expression analysis
70 findings
71 gastric cancer
72 great importance
73 high expression
74 immunohistochemistry
75 importance
76 invasion
77 larger study
78 low expression
79 markers
80 microarrays
81 negative BRCA1 nuclear expression
82 novel findings
83 nuclear expression
84 nuclear expression analysis
85 operation
86 overall survival
87 perineural invasion
88 physicians
89 poor prognosis
90 predictive marker
91 prognosis
92 reduced expression
93 reduction
94 role
95 sporadic gastric cancer
96 stage
97 stage III
98 study
99 survival
100 tendency
101 tissue microarray
102 tumors
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