Differing effects of adjuvant chemotherapy according to BRCA1 nuclear expression in gastric cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06

AUTHORS

Jin Won Kim, Hyun Jin Cho, Miso Kim, Kyung-Hun Lee, Min A. Kim, Sae-Won Han, Do-Youn Oh, Hyuk-Joon Lee, Seock-Ah Im, Tae-You Kim, Han-Kwang Yang, Woo Ho Kim, Yung-Jue Bang

ABSTRACT

BACKGROUND: We aimed to investigate the role of BRCA1 nuclear expression in sporadic gastric cancer; currently, the role remains unknown. METHODS: Patients with gastric cancer who received curative operation with D2 dissection were enrolled in this study. Adjuvant chemotherapy was administered at the discretion of the physician. According to BRCA1 nuclear expression analysis by immunohistochemistry (IHC) on tissue microarrays using anti-BRCA1 antibody MS110, BRCA1 expression was classified as negative, low expression, and high expression. RESULTS: Among 318 cases, 155 cases (48.7 %) were identified as BRCA1-negative by IHC and 96 cases (30.2 %) revealed BRCA1 low expression, 67 cases (21.0 %) showed BRCA1 high expression. The negative or reduced expression of BRCA1 was more frequent in more advanced-stage disease (p < 0.001) and was associated with perineural invasion (p = 0.032). Disease-free survival (DFS) was significantly decreased with reduced BRCA1 expression (p = 0.027). This tendency was also observed in overall survival (OS), although the difference was not significant. The poorer prognosis of BRCA1-negative tumors was overcome through adjuvant chemotherapy. The benefit of adjuvant chemotherapy for DFS and OS in stage III was enhanced only in BRCA1-negative tumors (p < 0.001, p < 0.001, respectively), but not in BRCA1-positive tumors (p = 0.236, p = 0.148, respectively). CONCLUSION: The reduction of BRCA1 nuclear expression is associated with advanced stage and perineural invasion. Moreover, negative BRCA1 nuclear expression is a predictive marker regarding the benefit of adjuvant chemotherapy in sporadic gastric cancer; these novel findings are of great importance, and further, larger studies are warranted. More... »

PAGES

1435-1443

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00280-013-2141-x

DOI

http://dx.doi.org/10.1007/s00280-013-2141-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001859832

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23633032


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "BRCA1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Seoul National University Bundang Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehang-ro, 110-744, Jongno-gu, Seoul, Republic of Korea", 
            "Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Bundang-gu, 463-707, Seongnam, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jin Won", 
        "id": "sg:person.01016137225.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016137225.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehang-ro, 110-744, Jongno-gu, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "Hyun Jin", 
        "id": "sg:person.01344625244.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344625244.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehang-ro, 110-744, Jongno-gu, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Miso", 
        "id": "sg:person.0710513761.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710513761.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehang-ro, 110-744, Jongno-gu, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Kyung-Hun", 
        "id": "sg:person.01007250706.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007250706.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Pathology, Seoul National University College of Medicine, 101 Daehang-ro, 110-744, Jongno-gu, Seoul, Republic of Korea", 
            "Cancer Research Institute, Seoul National University, 101 Daehang-ro, 110-799, Jongno-gu, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Min A.", 
        "id": "sg:person.0665463216.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665463216.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehang-ro, 110-744, Jongno-gu, Seoul, Republic of Korea", 
            "Cancer Research Institute, Seoul National University, 101 Daehang-ro, 110-799, Jongno-gu, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Sae-Won", 
        "id": "sg:person.0626600563.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626600563.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehang-ro, 110-744, Jongno-gu, Seoul, Republic of Korea", 
            "Cancer Research Institute, Seoul National University, 101 Daehang-ro, 110-799, Jongno-gu, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oh", 
        "givenName": "Do-Youn", 
        "id": "sg:person.0726553273.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726553273.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Surgery, Seoul National University College of Medicine, 101 Daehang-ro, 110-744, Jongno-gu, Seoul, Republic of Korea", 
            "Cancer Research Institute, Seoul National University, 101 Daehang-ro, 110-799, Jongno-gu, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hyuk-Joon", 
        "id": "sg:person.011242043254.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011242043254.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehang-ro, 110-744, Jongno-gu, Seoul, Republic of Korea", 
            "Cancer Research Institute, Seoul National University, 101 Daehang-ro, 110-799, Jongno-gu, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Im", 
        "givenName": "Seock-Ah", 
        "id": "sg:person.01212754274.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212754274.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehang-ro, 110-744, Jongno-gu, Seoul, Republic of Korea", 
            "Cancer Research Institute, Seoul National University, 101 Daehang-ro, 110-799, Jongno-gu, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Tae-You", 
        "id": "sg:person.012010335604.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012010335604.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Surgery, Seoul National University College of Medicine, 101 Daehang-ro, 110-744, Jongno-gu, Seoul, Republic of Korea", 
            "Cancer Research Institute, Seoul National University, 101 Daehang-ro, 110-799, Jongno-gu, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Han-Kwang", 
        "id": "sg:person.015267175234.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015267175234.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Pathology, Seoul National University College of Medicine, 101 Daehang-ro, 110-744, Jongno-gu, Seoul, Republic of Korea", 
            "Cancer Research Institute, Seoul National University, 101 Daehang-ro, 110-799, Jongno-gu, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Woo Ho", 
        "id": "sg:person.016630576674.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016630576674.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehang-ro, 110-744, Jongno-gu, Seoul, Republic of Korea", 
            "Cancer Research Institute, Seoul National University, 101 Daehang-ro, 110-799, Jongno-gu, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bang", 
        "givenName": "Yung-Jue", 
        "id": "sg:person.01363602512.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363602512.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/6029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000114075", 
          "https://doi.org/10.1038/6029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/6029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000114075", 
          "https://doi.org/10.1038/6029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(10)60892-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000475882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19990621)84:3<258::aid-ijc10>3.0.co;2-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000937758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3816/clc.2008.n.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001487053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(02)11087-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006163001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/028418602753669526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013730348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2007.10.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017349216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600969", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027201309", 
          "https://doi.org/10.1038/sj.bjc.6600969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600969", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027201309", 
          "https://doi.org/10.1038/sj.bjc.6600969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027496341", 
          "https://doi.org/10.1038/sj.onc.1202086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027496341", 
          "https://doi.org/10.1038/sj.onc.1202086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djh312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031159340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.18.1365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032615477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.11.3902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038110208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20010701)92:1<54::aid-cncr1291>3.0.co;2-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041341830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02841860802004974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041688246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1525-1438.2006.00504.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046837371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.11080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049973628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4067/s0716-97602008000300007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050451536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/jhc.4a6544.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050543830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/jhc.4a6544.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050543830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2010.01514.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050747602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2010.01514.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050747602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.270.5237.789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062551544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.12.6.1245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071510698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.7.5.949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071536270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4143/crt.2004.36.4.214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072255565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4143/crt.2004.36.4.214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072255565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080018509", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082886861", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-06", 
    "datePublishedReg": "2013-06-01", 
    "description": "BACKGROUND: We aimed to investigate the role of BRCA1 nuclear expression in sporadic gastric cancer; currently, the role remains unknown.\nMETHODS: Patients with gastric cancer who received curative operation with D2 dissection were enrolled in this study. Adjuvant chemotherapy was administered at the discretion of the physician. According to BRCA1 nuclear expression analysis by immunohistochemistry (IHC) on tissue microarrays using anti-BRCA1 antibody MS110, BRCA1 expression was classified as negative, low expression, and high expression.\nRESULTS: Among 318 cases, 155 cases (48.7 %) were identified as BRCA1-negative by IHC and 96 cases (30.2 %) revealed BRCA1 low expression, 67 cases (21.0 %) showed BRCA1 high expression. The negative or reduced expression of BRCA1 was more frequent in more advanced-stage disease (p < 0.001) and was associated with perineural invasion (p = 0.032). Disease-free survival (DFS) was significantly decreased with reduced BRCA1 expression (p = 0.027). This tendency was also observed in overall survival (OS), although the difference was not significant. The poorer prognosis of BRCA1-negative tumors was overcome through adjuvant chemotherapy. The benefit of adjuvant chemotherapy for DFS and OS in stage III was enhanced only in BRCA1-negative tumors (p < 0.001, p < 0.001, respectively), but not in BRCA1-positive tumors (p = 0.236, p = 0.148, respectively).\nCONCLUSION: The reduction of BRCA1 nuclear expression is associated with advanced stage and perineural invasion. Moreover, negative BRCA1 nuclear expression is a predictive marker regarding the benefit of adjuvant chemotherapy in sporadic gastric cancer; these novel findings are of great importance, and further, larger studies are warranted.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00280-013-2141-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1088364", 
        "issn": [
          "0344-5704", 
          "1432-0843"
        ], 
        "name": "Cancer Chemotherapy and Pharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "71"
      }
    ], 
    "name": "Differing effects of adjuvant chemotherapy according to BRCA1 nuclear expression in gastric cancer", 
    "pagination": "1435-1443", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "08dc00db9f8779af38d71a1b53af5b80b6c7bfbc4969a76d4d12fc93b86aec78"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23633032"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7806519"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00280-013-2141-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1001859832"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00280-013-2141-x", 
      "https://app.dimensions.ai/details/publication/pub.1001859832"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000509.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00280-013-2141-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00280-013-2141-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00280-013-2141-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00280-013-2141-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00280-013-2141-x'


 

This table displays all metadata directly associated to this object as RDF triples.

316 TRIPLES      21 PREDICATES      74 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00280-013-2141-x schema:about N1f7a0700b5f8492a88b8b01c8f387b95
2 N416425e91ca5422fa3359e8fab5d0279
3 N4e6e96d77ceb40138aa95c15702fb502
4 N51a90c7c7e874a58b6a515b6414a7190
5 N6280eb0758c14a989b19ebee279ab36b
6 N66a97a41f9e14751af26cf603092ff88
7 N7d79b8198e9d42bcaf7e15dba4664b8e
8 N8c6865c7a9614ecabca6918ba3a1de07
9 N98857aadd85c4a63a4497e5e61ad729b
10 N98d590219b604e76a39cb141d41fe5f3
11 N9e138ad97d0a44ab8bc98597c648e2c2
12 Na1041283785243c2a808e7ca5d224d28
13 Nba7cccf5c48e4ba18c751d530370fe8a
14 Nd5c5a17b1a0f45f78b678ddc35d20dbe
15 Ndc7aa4a2feba4fe98e321d898e1bc7b4
16 Ne4b035d6026a468f88d4bb99bcd10355
17 Ne817e3417aab4e0bb8380d90179a63b9
18 Nedadb8ca2f9e4e9c9e8ffc136dc0cf04
19 Nf7edf094671c4ae19a4a9aa84a4918f5
20 Nfcecbfd9fd7e43cd9b5ff55e9412f240
21 anzsrc-for:11
22 anzsrc-for:1112
23 schema:author N16970b234e204937add5f921f69f7e30
24 schema:citation sg:pub.10.1038/6029
25 sg:pub.10.1038/sj.bjc.6600969
26 sg:pub.10.1038/sj.onc.1202086
27 https://app.dimensions.ai/details/publication/pub.1080018509
28 https://app.dimensions.ai/details/publication/pub.1082886861
29 https://doi.org/10.1002/(sici)1097-0215(19990621)84:3<258::aid-ijc10>3.0.co;2-h
30 https://doi.org/10.1002/1097-0142(20010701)92:1<54::aid-cncr1291>3.0.co;2-8
31 https://doi.org/10.1002/cncr.11080
32 https://doi.org/10.1016/j.humpath.2007.10.011
33 https://doi.org/10.1016/s0140-6736(02)11087-7
34 https://doi.org/10.1016/s0140-6736(10)60892-6
35 https://doi.org/10.1080/028418602753669526
36 https://doi.org/10.1080/02841860802004974
37 https://doi.org/10.1093/jnci/94.18.1365
38 https://doi.org/10.1093/jnci/djh312
39 https://doi.org/10.1111/j.1349-7006.2010.01514.x
40 https://doi.org/10.1111/j.1525-1438.2006.00504.x
41 https://doi.org/10.1126/science.270.5237.789
42 https://doi.org/10.1200/jco.2007.11.3902
43 https://doi.org/10.1369/jhc.4a6544.2005
44 https://doi.org/10.3816/clc.2008.n.048
45 https://doi.org/10.3892/ijo.12.6.1245
46 https://doi.org/10.3892/or.7.5.949
47 https://doi.org/10.4067/s0716-97602008000300007
48 https://doi.org/10.4143/crt.2004.36.4.214
49 schema:datePublished 2013-06
50 schema:datePublishedReg 2013-06-01
51 schema:description BACKGROUND: We aimed to investigate the role of BRCA1 nuclear expression in sporadic gastric cancer; currently, the role remains unknown. METHODS: Patients with gastric cancer who received curative operation with D2 dissection were enrolled in this study. Adjuvant chemotherapy was administered at the discretion of the physician. According to BRCA1 nuclear expression analysis by immunohistochemistry (IHC) on tissue microarrays using anti-BRCA1 antibody MS110, BRCA1 expression was classified as negative, low expression, and high expression. RESULTS: Among 318 cases, 155 cases (48.7 %) were identified as BRCA1-negative by IHC and 96 cases (30.2 %) revealed BRCA1 low expression, 67 cases (21.0 %) showed BRCA1 high expression. The negative or reduced expression of BRCA1 was more frequent in more advanced-stage disease (p < 0.001) and was associated with perineural invasion (p = 0.032). Disease-free survival (DFS) was significantly decreased with reduced BRCA1 expression (p = 0.027). This tendency was also observed in overall survival (OS), although the difference was not significant. The poorer prognosis of BRCA1-negative tumors was overcome through adjuvant chemotherapy. The benefit of adjuvant chemotherapy for DFS and OS in stage III was enhanced only in BRCA1-negative tumors (p < 0.001, p < 0.001, respectively), but not in BRCA1-positive tumors (p = 0.236, p = 0.148, respectively). CONCLUSION: The reduction of BRCA1 nuclear expression is associated with advanced stage and perineural invasion. Moreover, negative BRCA1 nuclear expression is a predictive marker regarding the benefit of adjuvant chemotherapy in sporadic gastric cancer; these novel findings are of great importance, and further, larger studies are warranted.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree false
55 schema:isPartOf N3efc89cd7f554d1386311d08b752fcdd
56 N6db59133d0c34cef87af1ca9eb61ca60
57 sg:journal.1088364
58 schema:name Differing effects of adjuvant chemotherapy according to BRCA1 nuclear expression in gastric cancer
59 schema:pagination 1435-1443
60 schema:productId N01a3c24dfa6c4331a88877d52e89064e
61 N1210d437e5994484967fbcc0dbe8a249
62 N28d448f16d3249aabdb0d8f821601d57
63 Nb94bb346845a42b386e66a566221a1d5
64 Nfa87877c6f894e6ba1787cc59d737edb
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001859832
66 https://doi.org/10.1007/s00280-013-2141-x
67 schema:sdDatePublished 2019-04-10T21:36
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher N0557af7d6b5547bbae3c580ed6f159bf
70 schema:url http://link.springer.com/10.1007%2Fs00280-013-2141-x
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N01a3c24dfa6c4331a88877d52e89064e schema:name dimensions_id
75 schema:value pub.1001859832
76 rdf:type schema:PropertyValue
77 N0557af7d6b5547bbae3c580ed6f159bf schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 N1210d437e5994484967fbcc0dbe8a249 schema:name nlm_unique_id
80 schema:value 7806519
81 rdf:type schema:PropertyValue
82 N16970b234e204937add5f921f69f7e30 rdf:first sg:person.01016137225.18
83 rdf:rest N730dfeed5a9c45efac6ac7c99d2cc96a
84 N1c6fb96f06fb482fa340be1bb8473234 rdf:first sg:person.015267175234.94
85 rdf:rest N9488bb4d41e346b6a3a32fa34c0ca85e
86 N1f7a0700b5f8492a88b8b01c8f387b95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Predictive Value of Tests
88 rdf:type schema:DefinedTerm
89 N1fe0f9b69f914d42a4fafcb8c95c0c9f rdf:first sg:person.012010335604.34
90 rdf:rest N1c6fb96f06fb482fa340be1bb8473234
91 N28d448f16d3249aabdb0d8f821601d57 schema:name pubmed_id
92 schema:value 23633032
93 rdf:type schema:PropertyValue
94 N3efc89cd7f554d1386311d08b752fcdd schema:volumeNumber 71
95 rdf:type schema:PublicationVolume
96 N416425e91ca5422fa3359e8fab5d0279 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Neoplasm Staging
98 rdf:type schema:DefinedTerm
99 N4e6e96d77ceb40138aa95c15702fb502 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Cell Nucleus
101 rdf:type schema:DefinedTerm
102 N51a90c7c7e874a58b6a515b6414a7190 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Humans
104 rdf:type schema:DefinedTerm
105 N5ca11838e1274ed08751eb49c966936b rdf:first sg:person.01212754274.50
106 rdf:rest N1fe0f9b69f914d42a4fafcb8c95c0c9f
107 N6280eb0758c14a989b19ebee279ab36b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Aged, 80 and over
109 rdf:type schema:DefinedTerm
110 N66a97a41f9e14751af26cf603092ff88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name BRCA1 Protein
112 rdf:type schema:DefinedTerm
113 N6db59133d0c34cef87af1ca9eb61ca60 schema:issueNumber 6
114 rdf:type schema:PublicationIssue
115 N730dfeed5a9c45efac6ac7c99d2cc96a rdf:first sg:person.01344625244.03
116 rdf:rest N74d72bfd08bc46bfbac340f472cf435e
117 N74d72bfd08bc46bfbac340f472cf435e rdf:first sg:person.0710513761.38
118 rdf:rest Nc36f595ee5f94af5a45a2019736a233f
119 N7d79b8198e9d42bcaf7e15dba4664b8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Middle Aged
121 rdf:type schema:DefinedTerm
122 N8c6865c7a9614ecabca6918ba3a1de07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Neoplasm Invasiveness
124 rdf:type schema:DefinedTerm
125 N9488bb4d41e346b6a3a32fa34c0ca85e rdf:first sg:person.016630576674.47
126 rdf:rest Nf0096adf9c984982ac11d567a053fab2
127 N94a779e6da8f4ffb8d675d50c00c7a26 rdf:first sg:person.0665463216.06
128 rdf:rest Nf5f1e24d004841769aa84854ca954728
129 N98857aadd85c4a63a4497e5e61ad729b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Disease-Free Survival
131 rdf:type schema:DefinedTerm
132 N98d590219b604e76a39cb141d41fe5f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Chemotherapy, Adjuvant
134 rdf:type schema:DefinedTerm
135 N9e138ad97d0a44ab8bc98597c648e2c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Biomarkers, Tumor
137 rdf:type schema:DefinedTerm
138 Na1041283785243c2a808e7ca5d224d28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Stomach Neoplasms
140 rdf:type schema:DefinedTerm
141 Nb94bb346845a42b386e66a566221a1d5 schema:name doi
142 schema:value 10.1007/s00280-013-2141-x
143 rdf:type schema:PropertyValue
144 Nba7cccf5c48e4ba18c751d530370fe8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Kaplan-Meier Estimate
146 rdf:type schema:DefinedTerm
147 Nbfc33d512a5344eabae354779578679b rdf:first sg:person.0726553273.50
148 rdf:rest Nddc8de1feda843cfb48314afd19c8a7c
149 Nc36f595ee5f94af5a45a2019736a233f rdf:first sg:person.01007250706.46
150 rdf:rest N94a779e6da8f4ffb8d675d50c00c7a26
151 Nd5c5a17b1a0f45f78b678ddc35d20dbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Severity of Illness Index
153 rdf:type schema:DefinedTerm
154 Ndc7aa4a2feba4fe98e321d898e1bc7b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Antineoplastic Combined Chemotherapy Protocols
156 rdf:type schema:DefinedTerm
157 Nddc8de1feda843cfb48314afd19c8a7c rdf:first sg:person.011242043254.34
158 rdf:rest N5ca11838e1274ed08751eb49c966936b
159 Ne4b035d6026a468f88d4bb99bcd10355 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Aged
161 rdf:type schema:DefinedTerm
162 Ne817e3417aab4e0bb8380d90179a63b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Immunohistochemistry
164 rdf:type schema:DefinedTerm
165 Nedadb8ca2f9e4e9c9e8ffc136dc0cf04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Female
167 rdf:type schema:DefinedTerm
168 Nf0096adf9c984982ac11d567a053fab2 rdf:first sg:person.01363602512.42
169 rdf:rest rdf:nil
170 Nf5f1e24d004841769aa84854ca954728 rdf:first sg:person.0626600563.08
171 rdf:rest Nbfc33d512a5344eabae354779578679b
172 Nf7edf094671c4ae19a4a9aa84a4918f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Adult
174 rdf:type schema:DefinedTerm
175 Nfa87877c6f894e6ba1787cc59d737edb schema:name readcube_id
176 schema:value 08dc00db9f8779af38d71a1b53af5b80b6c7bfbc4969a76d4d12fc93b86aec78
177 rdf:type schema:PropertyValue
178 Nfcecbfd9fd7e43cd9b5ff55e9412f240 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Male
180 rdf:type schema:DefinedTerm
181 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
182 schema:name Medical and Health Sciences
183 rdf:type schema:DefinedTerm
184 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
185 schema:name Oncology and Carcinogenesis
186 rdf:type schema:DefinedTerm
187 sg:journal.1088364 schema:issn 0344-5704
188 1432-0843
189 schema:name Cancer Chemotherapy and Pharmacology
190 rdf:type schema:Periodical
191 sg:person.01007250706.46 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
192 schema:familyName Lee
193 schema:givenName Kyung-Hun
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007250706.46
195 rdf:type schema:Person
196 sg:person.01016137225.18 schema:affiliation https://www.grid.ac/institutes/grid.412480.b
197 schema:familyName Kim
198 schema:givenName Jin Won
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016137225.18
200 rdf:type schema:Person
201 sg:person.011242043254.34 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
202 schema:familyName Lee
203 schema:givenName Hyuk-Joon
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011242043254.34
205 rdf:type schema:Person
206 sg:person.012010335604.34 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
207 schema:familyName Kim
208 schema:givenName Tae-You
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012010335604.34
210 rdf:type schema:Person
211 sg:person.01212754274.50 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
212 schema:familyName Im
213 schema:givenName Seock-Ah
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212754274.50
215 rdf:type schema:Person
216 sg:person.01344625244.03 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
217 schema:familyName Cho
218 schema:givenName Hyun Jin
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344625244.03
220 rdf:type schema:Person
221 sg:person.01363602512.42 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
222 schema:familyName Bang
223 schema:givenName Yung-Jue
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363602512.42
225 rdf:type schema:Person
226 sg:person.015267175234.94 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
227 schema:familyName Yang
228 schema:givenName Han-Kwang
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015267175234.94
230 rdf:type schema:Person
231 sg:person.016630576674.47 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
232 schema:familyName Kim
233 schema:givenName Woo Ho
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016630576674.47
235 rdf:type schema:Person
236 sg:person.0626600563.08 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
237 schema:familyName Han
238 schema:givenName Sae-Won
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626600563.08
240 rdf:type schema:Person
241 sg:person.0665463216.06 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
242 schema:familyName Kim
243 schema:givenName Min A.
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665463216.06
245 rdf:type schema:Person
246 sg:person.0710513761.38 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
247 schema:familyName Kim
248 schema:givenName Miso
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710513761.38
250 rdf:type schema:Person
251 sg:person.0726553273.50 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
252 schema:familyName Oh
253 schema:givenName Do-Youn
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726553273.50
255 rdf:type schema:Person
256 sg:pub.10.1038/6029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000114075
257 https://doi.org/10.1038/6029
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/sj.bjc.6600969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027201309
260 https://doi.org/10.1038/sj.bjc.6600969
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/sj.onc.1202086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027496341
263 https://doi.org/10.1038/sj.onc.1202086
264 rdf:type schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1080018509 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1082886861 schema:CreativeWork
267 https://doi.org/10.1002/(sici)1097-0215(19990621)84:3<258::aid-ijc10>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1000937758
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/1097-0142(20010701)92:1<54::aid-cncr1291>3.0.co;2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041341830
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1002/cncr.11080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049973628
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.humpath.2007.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017349216
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0140-6736(02)11087-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006163001
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0140-6736(10)60892-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000475882
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1080/028418602753669526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013730348
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1080/02841860802004974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041688246
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1093/jnci/94.18.1365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032615477
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1093/jnci/djh312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031159340
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1111/j.1349-7006.2010.01514.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050747602
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1111/j.1525-1438.2006.00504.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046837371
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1126/science.270.5237.789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062551544
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1200/jco.2007.11.3902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038110208
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1369/jhc.4a6544.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050543830
296 rdf:type schema:CreativeWork
297 https://doi.org/10.3816/clc.2008.n.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001487053
298 rdf:type schema:CreativeWork
299 https://doi.org/10.3892/ijo.12.6.1245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071510698
300 rdf:type schema:CreativeWork
301 https://doi.org/10.3892/or.7.5.949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071536270
302 rdf:type schema:CreativeWork
303 https://doi.org/10.4067/s0716-97602008000300007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050451536
304 rdf:type schema:CreativeWork
305 https://doi.org/10.4143/crt.2004.36.4.214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072255565
306 rdf:type schema:CreativeWork
307 https://www.grid.ac/institutes/grid.31501.36 schema:alternateName Seoul National University
308 schema:name Cancer Research Institute, Seoul National University, 101 Daehang-ro, 110-799, Jongno-gu, Seoul, Republic of Korea
309 Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehang-ro, 110-744, Jongno-gu, Seoul, Republic of Korea
310 Department of Pathology, Seoul National University College of Medicine, 101 Daehang-ro, 110-744, Jongno-gu, Seoul, Republic of Korea
311 Department of Surgery, Seoul National University College of Medicine, 101 Daehang-ro, 110-744, Jongno-gu, Seoul, Republic of Korea
312 rdf:type schema:Organization
313 https://www.grid.ac/institutes/grid.412480.b schema:alternateName Seoul National University Bundang Hospital
314 schema:name Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Bundang-gu, 463-707, Seongnam, Republic of Korea
315 Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehang-ro, 110-744, Jongno-gu, Seoul, Republic of Korea
316 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...