A phase I study of bevacizumab (B) in combination with everolimus (E) and erlotinib (E) in advanced cancer (BEE) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-02

AUTHORS

Karen E. Bullock, William P. Petros, Islam Younis, Hope E. Uronis, Michael A. Morse, Gerard C. Blobe, S. Yousuf Zafar, Jon P. Gockerman, Joanne J. Lager, Roxanne Truax, Kellen L. Meadows, Leigh A. Howard, Margot M. O’Neill, Gloria Broadwater, Herbert I. Hurwitz, Johanna C. Bendell

ABSTRACT

PURPOSE: VEGF, mTOR, and EGFR inhibitors have demonstrated anti-tumor and anti-angiogenic effects alone and in combination with each other. This study evaluated the safety, tolerability, and pharmacokinetics of bevacizumab, everolimus, and erlotinib combination. METHODS: Doublet therapy consisted of bevacizumab at 10 mg/kg every 14 days and everolimus 5 mg daily which escalated to 10 mg daily. Erlotinib 75 mg daily was added to the phase II dose recommended phase II dose (RPTD) of bevacizumab and everolimus. Dose-limiting toxicity (DLT) was assessed in cycle 1. RESULTS: Forty-eight patients with advanced solid malignancies were evaluable for DLT and efficacy. No DLTs were observed in the doublet dose escalation. Two DLTs (grade 3 mucositis and grade 3 rash) were observed with the addition of erlotinib 75 mg daily. Consequently, triplet doses were adjusted and were better tolerated. Four patients had a partial response. Median progression-free survival (PFS) for the doublet therapy was 6.0 months (0.5 to 32+ months) and 5.5 months (0.8 to 27+ months) for the triplet therapy. Systemic exposure of everolimus was significantly higher in combination with erlotinib (476 ± 161 ng h/mL) compared to when given alone (393 ± 156 ng h/mL; P = 0.020). CONCLUSIONS: The RPTD for the doublet therapy is bevacizumab 10 mg/kg every 14 days and everolimus 10 mg daily, and the RPTD for the triplet therapy is bevacizumab 5 mg/kg every 14 days, everolimus 5 mg and erlotinib 75 mg daily. Prolonged disease stability was demonstrated in tumors known to respond to mTOR inhibition and potentially resistant to VEGF blockade. More... »

PAGES

465-474

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00280-010-1507-6

DOI

http://dx.doi.org/10.1007/s00280-010-1507-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024060636

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21079958


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiogenesis Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal, Humanized", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bevacizumab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Erlotinib Hydrochloride", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Everolimus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Maximum Tolerated Dose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quinazolines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sirolimus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "United States Department of the Navy", 
          "id": "https://www.grid.ac/institutes/grid.420434.5", 
          "name": [
            "Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA", 
            "United States Navy, 23708, Portsmouth, VA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bullock", 
        "givenName": "Karen E.", 
        "id": "sg:person.010662333705.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010662333705.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "West Virginia University", 
          "id": "https://www.grid.ac/institutes/grid.268154.c", 
          "name": [
            "Mary Babb Randolph Cancer Center, West Virginia University, 26506, Morgantown, WV, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petros", 
        "givenName": "William P.", 
        "id": "sg:person.0610003000.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610003000.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "United States Food and Drug Administration", 
          "id": "https://www.grid.ac/institutes/grid.417587.8", 
          "name": [
            "Mary Babb Randolph Cancer Center, West Virginia University, 26506, Morgantown, WV, USA", 
            "United States Food and Drug Administration, 20993, Silver Spring, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Younis", 
        "givenName": "Islam", 
        "id": "sg:person.0740224571.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740224571.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uronis", 
        "givenName": "Hope E.", 
        "id": "sg:person.01257037273.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257037273.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morse", 
        "givenName": "Michael A.", 
        "id": "sg:person.013700705377.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013700705377.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blobe", 
        "givenName": "Gerard C.", 
        "id": "sg:person.0754271650.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754271650.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yousuf Zafar", 
        "givenName": "S.", 
        "id": "sg:person.01110705575.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110705575.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gockerman", 
        "givenName": "Jon P.", 
        "id": "sg:person.0663550257.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663550257.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sanofi (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417555.7", 
          "name": [
            "Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA", 
            "Sanofi-aventis, 19355, Malvern, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lager", 
        "givenName": "Joanne J.", 
        "id": "sg:person.01345523445.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345523445.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Truax", 
        "givenName": "Roxanne", 
        "id": "sg:person.01133626763.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133626763.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meadows", 
        "givenName": "Kellen L.", 
        "id": "sg:person.014460031617.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014460031617.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Howard", 
        "givenName": "Leigh A.", 
        "id": "sg:person.01226602651.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226602651.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Neill", 
        "givenName": "Margot M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Broadwater", 
        "givenName": "Gloria", 
        "id": "sg:person.0610532363.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610532363.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hurwitz", 
        "givenName": "Herbert I.", 
        "id": "sg:person.01242177577.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242177577.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sarah Cannon", 
          "id": "https://www.grid.ac/institutes/grid.419513.b", 
          "name": [
            "Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA", 
            "Sarah Cannon Research Institute, 37203, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bendell", 
        "givenName": "Johanna C.", 
        "id": "sg:person.01174064377.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174064377.38"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/rcm.323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000976184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.16.7858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003360569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.20.7004-7014.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003444276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-06-0166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004420604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.01.8234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005188382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.01.8234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005188382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci36898e1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005914517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.09.6305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006135184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.20.0766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006224899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci36898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006518790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.12.0949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007216105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa065044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007947936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa061884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008302687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-0088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010049573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)61904-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010511397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.21187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010675017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra0707704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013325677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa032691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014051315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.02.840", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014320224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017181181", 
          "https://doi.org/10.1038/sj.bjc.6603055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017181181", 
          "https://doi.org/10.1038/sj.bjc.6603055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra0706596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021959499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/dmd.105.007765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022880120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa060655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025111240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025497309", 
          "https://doi.org/10.1038/sj.bjc.6604269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.transproceed.2008.10.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026270291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-010-1307-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029072898", 
          "https://doi.org/10.1007/s00280-010-1307-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-010-1307-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029072898", 
          "https://doi.org/10.1007/s00280-010-1307-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-06-0007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031639815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/92.3.205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032301848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(03)00235-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035641353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(03)00235-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035641353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-199936060-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036352762", 
          "https://doi.org/10.2165/00003088-199936060-00004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa066838", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037798278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.12.8637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039829431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-2235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044561256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(08)61039-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045744105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-06-0416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046442333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/00912700222011148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049534810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/89.15.1138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052997391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.22816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053514231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.06.081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064204278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076995655", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.23.16_suppl.9028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079369079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.23.16_suppl.3096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079369153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.26.15_suppl.8051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079372639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.28.15_suppl.4031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083943171"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-02", 
    "datePublishedReg": "2011-02-01", 
    "description": "PURPOSE: VEGF, mTOR, and EGFR inhibitors have demonstrated anti-tumor and anti-angiogenic effects alone and in combination with each other. This study evaluated the safety, tolerability, and pharmacokinetics of bevacizumab, everolimus, and erlotinib combination.\nMETHODS: Doublet therapy consisted of bevacizumab at 10 mg/kg every 14 days and everolimus 5 mg daily which escalated to 10 mg daily. Erlotinib 75 mg daily was added to the phase II dose recommended phase II dose (RPTD) of bevacizumab and everolimus. Dose-limiting toxicity (DLT) was assessed in cycle 1.\nRESULTS: Forty-eight patients with advanced solid malignancies were evaluable for DLT and efficacy. No DLTs were observed in the doublet dose escalation. Two DLTs (grade 3 mucositis and grade 3 rash) were observed with the addition of erlotinib 75 mg daily. Consequently, triplet doses were adjusted and were better tolerated. Four patients had a partial response. Median progression-free survival (PFS) for the doublet therapy was 6.0 months (0.5 to 32+ months) and 5.5 months (0.8 to 27+ months) for the triplet therapy. Systemic exposure of everolimus was significantly higher in combination with erlotinib (476 \u00b1 161 ng h/mL) compared to when given alone (393 \u00b1 156 ng h/mL; P = 0.020).\nCONCLUSIONS: The RPTD for the doublet therapy is bevacizumab 10 mg/kg every 14 days and everolimus 10 mg daily, and the RPTD for the triplet therapy is bevacizumab 5 mg/kg every 14 days, everolimus 5 mg and erlotinib 75 mg daily. Prolonged disease stability was demonstrated in tumors known to respond to mTOR inhibition and potentially resistant to VEGF blockade.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00280-010-1507-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2420933", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1088364", 
        "issn": [
          "0344-5704", 
          "1432-0843"
        ], 
        "name": "Cancer Chemotherapy and Pharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "67"
      }
    ], 
    "name": "A phase I study of bevacizumab (B) in combination with everolimus (E) and erlotinib (E) in advanced cancer (BEE)", 
    "pagination": "465-474", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "72a157a527570fbd3f2b74eb70dc453adb7ec72d163f7f6b9ad8e66e8ee37f14"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21079958"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7806519"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00280-010-1507-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024060636"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00280-010-1507-6", 
      "https://app.dimensions.ai/details/publication/pub.1024060636"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000512.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00280-010-1507-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00280-010-1507-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00280-010-1507-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00280-010-1507-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00280-010-1507-6'


 

This table displays all metadata directly associated to this object as RDF triples.

406 TRIPLES      21 PREDICATES      92 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00280-010-1507-6 schema:about N026c9edb138047dfb324eceedab07e46
2 N03ff9fff90d34074832c8fd096409eb5
3 N19c5292622ab4def84e34c88840353dd
4 N31559c9efeef45ffbaed1ec7cff21886
5 N323da1d9fd9a499282a249b8e554198e
6 N3663e17cb3ad4e89a05ad9352ba4f520
7 N37e74f505cdc450bb1089fed22f9976b
8 N3a7296d297d440a89096ae5ad8e1e794
9 N6111409280934dcf9ddecbec3aede679
10 N646e049d8557452cbc86395fbc38a9fc
11 N71f0ec29d5c64f2fa48fa819fa2d5404
12 N87998a80befe4e35adf110dc258d06b3
13 N9854f4d69fe04e7ab751c1d6f812bfb1
14 Na1bc5897eb8446dcb47c65c1968c571f
15 Na959423427364a3b9bff1ae674ecdb8d
16 Nad818b676db3442bb199dec524c22562
17 Nbb2bcca79da946f9acf45df46c817a40
18 Ncb0d3c73def745aabaaa292a7ae3c778
19 Ncbf71d589c404a0985ff8d19fc52b601
20 Ne62c7743e1464cfea7000441c3b801d0
21 anzsrc-for:11
22 anzsrc-for:1103
23 schema:author Nc992ba7228e94927b4ce37ee74a70eac
24 schema:citation sg:pub.10.1007/s00280-010-1307-z
25 sg:pub.10.1038/sj.bjc.6603055
26 sg:pub.10.1038/sj.bjc.6604269
27 sg:pub.10.2165/00003088-199936060-00004
28 https://app.dimensions.ai/details/publication/pub.1076995655
29 https://doi.org/10.1002/cncr.22816
30 https://doi.org/10.1002/jcb.21187
31 https://doi.org/10.1002/rcm.323
32 https://doi.org/10.1016/j.transproceed.2008.10.013
33 https://doi.org/10.1016/s0140-6736(07)61904-7
34 https://doi.org/10.1016/s0140-6736(08)61039-9
35 https://doi.org/10.1016/s0959-8049(03)00235-1
36 https://doi.org/10.1056/nejmoa032691
37 https://doi.org/10.1056/nejmoa060655
38 https://doi.org/10.1056/nejmoa061884
39 https://doi.org/10.1056/nejmoa065044
40 https://doi.org/10.1056/nejmoa066838
41 https://doi.org/10.1056/nejmra0706596
42 https://doi.org/10.1056/nejmra0707704
43 https://doi.org/10.1093/jnci/89.15.1138
44 https://doi.org/10.1093/jnci/92.3.205
45 https://doi.org/10.1124/dmd.105.007765
46 https://doi.org/10.1128/mcb.22.20.7004-7014.2002
47 https://doi.org/10.1158/1078-0432.ccr-05-2235
48 https://doi.org/10.1158/1078-0432.ccr-07-0088
49 https://doi.org/10.1158/1535-7163.mct-06-0007
50 https://doi.org/10.1158/1535-7163.mct-06-0166
51 https://doi.org/10.1158/1535-7163.mct-06-0416
52 https://doi.org/10.1172/jci36898
53 https://doi.org/10.1172/jci36898e1
54 https://doi.org/10.1177/00912700222011148
55 https://doi.org/10.1200/jco.2005.01.8234
56 https://doi.org/10.1200/jco.2005.02.840
57 https://doi.org/10.1200/jco.2005.06.081
58 https://doi.org/10.1200/jco.2005.23.16_suppl.3096
59 https://doi.org/10.1200/jco.2005.23.16_suppl.9028
60 https://doi.org/10.1200/jco.2006.09.6305
61 https://doi.org/10.1200/jco.2007.12.0949
62 https://doi.org/10.1200/jco.2007.12.8637
63 https://doi.org/10.1200/jco.2008.16.7858
64 https://doi.org/10.1200/jco.2008.20.0766
65 https://doi.org/10.1200/jco.2008.26.15_suppl.8051
66 https://doi.org/10.1200/jco.2010.28.15_suppl.4031
67 schema:datePublished 2011-02
68 schema:datePublishedReg 2011-02-01
69 schema:description PURPOSE: VEGF, mTOR, and EGFR inhibitors have demonstrated anti-tumor and anti-angiogenic effects alone and in combination with each other. This study evaluated the safety, tolerability, and pharmacokinetics of bevacizumab, everolimus, and erlotinib combination. METHODS: Doublet therapy consisted of bevacizumab at 10 mg/kg every 14 days and everolimus 5 mg daily which escalated to 10 mg daily. Erlotinib 75 mg daily was added to the phase II dose recommended phase II dose (RPTD) of bevacizumab and everolimus. Dose-limiting toxicity (DLT) was assessed in cycle 1. RESULTS: Forty-eight patients with advanced solid malignancies were evaluable for DLT and efficacy. No DLTs were observed in the doublet dose escalation. Two DLTs (grade 3 mucositis and grade 3 rash) were observed with the addition of erlotinib 75 mg daily. Consequently, triplet doses were adjusted and were better tolerated. Four patients had a partial response. Median progression-free survival (PFS) for the doublet therapy was 6.0 months (0.5 to 32+ months) and 5.5 months (0.8 to 27+ months) for the triplet therapy. Systemic exposure of everolimus was significantly higher in combination with erlotinib (476 ± 161 ng h/mL) compared to when given alone (393 ± 156 ng h/mL; P = 0.020). CONCLUSIONS: The RPTD for the doublet therapy is bevacizumab 10 mg/kg every 14 days and everolimus 10 mg daily, and the RPTD for the triplet therapy is bevacizumab 5 mg/kg every 14 days, everolimus 5 mg and erlotinib 75 mg daily. Prolonged disease stability was demonstrated in tumors known to respond to mTOR inhibition and potentially resistant to VEGF blockade.
70 schema:genre research_article
71 schema:inLanguage en
72 schema:isAccessibleForFree true
73 schema:isPartOf N5621076f185f486c95475d50e9158ab5
74 Nb270d26a6b764468a0c23debef319ae5
75 sg:journal.1088364
76 schema:name A phase I study of bevacizumab (B) in combination with everolimus (E) and erlotinib (E) in advanced cancer (BEE)
77 schema:pagination 465-474
78 schema:productId N3afeb20156b54ece98b8cbcc6788c9c8
79 N77a3c55ef3544957b8a825d27bfef137
80 N99f6302d65294afd9acf17c0275fdc59
81 Na80eb35658de49a0aac8805ac74c51a7
82 Ncca147e317744831b87c8571d6039bf9
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024060636
84 https://doi.org/10.1007/s00280-010-1507-6
85 schema:sdDatePublished 2019-04-10T22:32
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher N176ae61e729243b9a6ff7d0b5797cbf0
88 schema:url http://link.springer.com/10.1007%2Fs00280-010-1507-6
89 sgo:license sg:explorer/license/
90 sgo:sdDataset articles
91 rdf:type schema:ScholarlyArticle
92 N026c9edb138047dfb324eceedab07e46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Sirolimus
94 rdf:type schema:DefinedTerm
95 N03ff9fff90d34074832c8fd096409eb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Maximum Tolerated Dose
97 rdf:type schema:DefinedTerm
98 N0add0e9685a84472b56c2b7e26504b5f rdf:first sg:person.014460031617.65
99 rdf:rest Nba74eaae01be4c498a255701166f7455
100 N176ae61e729243b9a6ff7d0b5797cbf0 schema:name Springer Nature - SN SciGraph project
101 rdf:type schema:Organization
102 N17f225793b5e42dbafc24e7214ba623c rdf:first sg:person.0740224571.03
103 rdf:rest N45ea8dc5f8d041ed912c6d31e94f941d
104 N19c5292622ab4def84e34c88840353dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Humans
106 rdf:type schema:DefinedTerm
107 N2fc41348a0cf4f9aa9d623689af2a12c schema:affiliation https://www.grid.ac/institutes/grid.189509.c
108 schema:familyName O’Neill
109 schema:givenName Margot M.
110 rdf:type schema:Person
111 N31559c9efeef45ffbaed1ec7cff21886 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Male
113 rdf:type schema:DefinedTerm
114 N323da1d9fd9a499282a249b8e554198e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Aged
116 rdf:type schema:DefinedTerm
117 N3663e17cb3ad4e89a05ad9352ba4f520 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Disease-Free Survival
119 rdf:type schema:DefinedTerm
120 N37e74f505cdc450bb1089fed22f9976b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Everolimus
122 rdf:type schema:DefinedTerm
123 N39ee4b86fa1e48b38c1190aed2a1a36f rdf:first sg:person.01174064377.38
124 rdf:rest rdf:nil
125 N3a7296d297d440a89096ae5ad8e1e794 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Middle Aged
127 rdf:type schema:DefinedTerm
128 N3afeb20156b54ece98b8cbcc6788c9c8 schema:name doi
129 schema:value 10.1007/s00280-010-1507-6
130 rdf:type schema:PropertyValue
131 N3dda7a3fb9f8490a8ca631eab5a91cb4 rdf:first N2fc41348a0cf4f9aa9d623689af2a12c
132 rdf:rest N7f08c0fc95fa4701ae98db6204c3dd8d
133 N45ea8dc5f8d041ed912c6d31e94f941d rdf:first sg:person.01257037273.91
134 rdf:rest N9bb2f97e35474817b19a40e1425ea298
135 N5401a091528a4651890f2952b4bf1c5a rdf:first sg:person.0663550257.48
136 rdf:rest Nf25e3b0d182a4f7292aafa00c8cdb860
137 N5621076f185f486c95475d50e9158ab5 schema:volumeNumber 67
138 rdf:type schema:PublicationVolume
139 N6111409280934dcf9ddecbec3aede679 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Quinazolines
141 rdf:type schema:DefinedTerm
142 N646e049d8557452cbc86395fbc38a9fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Erlotinib Hydrochloride
144 rdf:type schema:DefinedTerm
145 N71f0ec29d5c64f2fa48fa819fa2d5404 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Antibodies, Monoclonal
147 rdf:type schema:DefinedTerm
148 N77a3c55ef3544957b8a825d27bfef137 schema:name readcube_id
149 schema:value 72a157a527570fbd3f2b74eb70dc453adb7ec72d163f7f6b9ad8e66e8ee37f14
150 rdf:type schema:PropertyValue
151 N7f08c0fc95fa4701ae98db6204c3dd8d rdf:first sg:person.0610532363.22
152 rdf:rest Na07f7fa65dd54e65842db79fe0cff5af
153 N87998a80befe4e35adf110dc258d06b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Treatment Outcome
155 rdf:type schema:DefinedTerm
156 N9101bbe72f0e4bcabd39a44bb07a4f2c rdf:first sg:person.01110705575.00
157 rdf:rest N5401a091528a4651890f2952b4bf1c5a
158 N953033050c7c47a1be2885b8a874c2e3 rdf:first sg:person.0754271650.99
159 rdf:rest N9101bbe72f0e4bcabd39a44bb07a4f2c
160 N9854f4d69fe04e7ab751c1d6f812bfb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Angiogenesis Inhibitors
162 rdf:type schema:DefinedTerm
163 N99f6302d65294afd9acf17c0275fdc59 schema:name dimensions_id
164 schema:value pub.1024060636
165 rdf:type schema:PropertyValue
166 N9bb2f97e35474817b19a40e1425ea298 rdf:first sg:person.013700705377.06
167 rdf:rest N953033050c7c47a1be2885b8a874c2e3
168 Na07f7fa65dd54e65842db79fe0cff5af rdf:first sg:person.01242177577.68
169 rdf:rest N39ee4b86fa1e48b38c1190aed2a1a36f
170 Na1bc5897eb8446dcb47c65c1968c571f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Antineoplastic Combined Chemotherapy Protocols
172 rdf:type schema:DefinedTerm
173 Na80eb35658de49a0aac8805ac74c51a7 schema:name nlm_unique_id
174 schema:value 7806519
175 rdf:type schema:PropertyValue
176 Na959423427364a3b9bff1ae674ecdb8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Neoplasms
178 rdf:type schema:DefinedTerm
179 Nad818b676db3442bb199dec524c22562 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Bevacizumab
181 rdf:type schema:DefinedTerm
182 Nb270d26a6b764468a0c23debef319ae5 schema:issueNumber 2
183 rdf:type schema:PublicationIssue
184 Nba74eaae01be4c498a255701166f7455 rdf:first sg:person.01226602651.18
185 rdf:rest N3dda7a3fb9f8490a8ca631eab5a91cb4
186 Nbb2bcca79da946f9acf45df46c817a40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Antibodies, Monoclonal, Humanized
188 rdf:type schema:DefinedTerm
189 Nc992ba7228e94927b4ce37ee74a70eac rdf:first sg:person.010662333705.10
190 rdf:rest Nef32abae1db44bae94e243b9362e356a
191 Ncb0d3c73def745aabaaa292a7ae3c778 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Adult
193 rdf:type schema:DefinedTerm
194 Ncbf71d589c404a0985ff8d19fc52b601 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Female
196 rdf:type schema:DefinedTerm
197 Ncca147e317744831b87c8571d6039bf9 schema:name pubmed_id
198 schema:value 21079958
199 rdf:type schema:PropertyValue
200 Nda07538b2af4481daab49e438888d64c rdf:first sg:person.01133626763.37
201 rdf:rest N0add0e9685a84472b56c2b7e26504b5f
202 Ne62c7743e1464cfea7000441c3b801d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Protein Kinase Inhibitors
204 rdf:type schema:DefinedTerm
205 Nef32abae1db44bae94e243b9362e356a rdf:first sg:person.0610003000.44
206 rdf:rest N17f225793b5e42dbafc24e7214ba623c
207 Nf25e3b0d182a4f7292aafa00c8cdb860 rdf:first sg:person.01345523445.18
208 rdf:rest Nda07538b2af4481daab49e438888d64c
209 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
210 schema:name Medical and Health Sciences
211 rdf:type schema:DefinedTerm
212 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
213 schema:name Clinical Sciences
214 rdf:type schema:DefinedTerm
215 sg:grant.2420933 http://pending.schema.org/fundedItem sg:pub.10.1007/s00280-010-1507-6
216 rdf:type schema:MonetaryGrant
217 sg:journal.1088364 schema:issn 0344-5704
218 1432-0843
219 schema:name Cancer Chemotherapy and Pharmacology
220 rdf:type schema:Periodical
221 sg:person.010662333705.10 schema:affiliation https://www.grid.ac/institutes/grid.420434.5
222 schema:familyName Bullock
223 schema:givenName Karen E.
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010662333705.10
225 rdf:type schema:Person
226 sg:person.01110705575.00 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
227 schema:familyName Yousuf Zafar
228 schema:givenName S.
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110705575.00
230 rdf:type schema:Person
231 sg:person.01133626763.37 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
232 schema:familyName Truax
233 schema:givenName Roxanne
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133626763.37
235 rdf:type schema:Person
236 sg:person.01174064377.38 schema:affiliation https://www.grid.ac/institutes/grid.419513.b
237 schema:familyName Bendell
238 schema:givenName Johanna C.
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174064377.38
240 rdf:type schema:Person
241 sg:person.01226602651.18 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
242 schema:familyName Howard
243 schema:givenName Leigh A.
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226602651.18
245 rdf:type schema:Person
246 sg:person.01242177577.68 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
247 schema:familyName Hurwitz
248 schema:givenName Herbert I.
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242177577.68
250 rdf:type schema:Person
251 sg:person.01257037273.91 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
252 schema:familyName Uronis
253 schema:givenName Hope E.
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257037273.91
255 rdf:type schema:Person
256 sg:person.01345523445.18 schema:affiliation https://www.grid.ac/institutes/grid.417555.7
257 schema:familyName Lager
258 schema:givenName Joanne J.
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345523445.18
260 rdf:type schema:Person
261 sg:person.013700705377.06 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
262 schema:familyName Morse
263 schema:givenName Michael A.
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013700705377.06
265 rdf:type schema:Person
266 sg:person.014460031617.65 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
267 schema:familyName Meadows
268 schema:givenName Kellen L.
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014460031617.65
270 rdf:type schema:Person
271 sg:person.0610003000.44 schema:affiliation https://www.grid.ac/institutes/grid.268154.c
272 schema:familyName Petros
273 schema:givenName William P.
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610003000.44
275 rdf:type schema:Person
276 sg:person.0610532363.22 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
277 schema:familyName Broadwater
278 schema:givenName Gloria
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610532363.22
280 rdf:type schema:Person
281 sg:person.0663550257.48 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
282 schema:familyName Gockerman
283 schema:givenName Jon P.
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663550257.48
285 rdf:type schema:Person
286 sg:person.0740224571.03 schema:affiliation https://www.grid.ac/institutes/grid.417587.8
287 schema:familyName Younis
288 schema:givenName Islam
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740224571.03
290 rdf:type schema:Person
291 sg:person.0754271650.99 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
292 schema:familyName Blobe
293 schema:givenName Gerard C.
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754271650.99
295 rdf:type schema:Person
296 sg:pub.10.1007/s00280-010-1307-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1029072898
297 https://doi.org/10.1007/s00280-010-1307-z
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/sj.bjc.6603055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017181181
300 https://doi.org/10.1038/sj.bjc.6603055
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/sj.bjc.6604269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025497309
303 https://doi.org/10.1038/sj.bjc.6604269
304 rdf:type schema:CreativeWork
305 sg:pub.10.2165/00003088-199936060-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036352762
306 https://doi.org/10.2165/00003088-199936060-00004
307 rdf:type schema:CreativeWork
308 https://app.dimensions.ai/details/publication/pub.1076995655 schema:CreativeWork
309 https://doi.org/10.1002/cncr.22816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053514231
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1002/jcb.21187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010675017
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1002/rcm.323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000976184
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.transproceed.2008.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026270291
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/s0140-6736(07)61904-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010511397
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/s0140-6736(08)61039-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045744105
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/s0959-8049(03)00235-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035641353
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1056/nejmoa032691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014051315
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1056/nejmoa060655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025111240
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1056/nejmoa061884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008302687
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1056/nejmoa065044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007947936
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1056/nejmoa066838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037798278
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1056/nejmra0706596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021959499
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1056/nejmra0707704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013325677
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1093/jnci/89.15.1138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052997391
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1093/jnci/92.3.205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032301848
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1124/dmd.105.007765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022880120
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1128/mcb.22.20.7004-7014.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003444276
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1158/1078-0432.ccr-05-2235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044561256
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1158/1078-0432.ccr-07-0088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010049573
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1158/1535-7163.mct-06-0007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031639815
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1158/1535-7163.mct-06-0166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004420604
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1158/1535-7163.mct-06-0416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046442333
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1172/jci36898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006518790
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1172/jci36898e1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005914517
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1177/00912700222011148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049534810
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1200/jco.2005.01.8234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005188382
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1200/jco.2005.02.840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014320224
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1200/jco.2005.06.081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204278
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1200/jco.2005.23.16_suppl.3096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079369153
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1200/jco.2005.23.16_suppl.9028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079369079
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1200/jco.2006.09.6305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006135184
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1200/jco.2007.12.0949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007216105
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1200/jco.2007.12.8637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039829431
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1200/jco.2008.16.7858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003360569
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1200/jco.2008.20.0766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006224899
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1200/jco.2008.26.15_suppl.8051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079372639
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1200/jco.2010.28.15_suppl.4031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083943171
384 rdf:type schema:CreativeWork
385 https://www.grid.ac/institutes/grid.189509.c schema:alternateName Duke University Hospital
386 schema:name Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA
387 rdf:type schema:Organization
388 https://www.grid.ac/institutes/grid.268154.c schema:alternateName West Virginia University
389 schema:name Mary Babb Randolph Cancer Center, West Virginia University, 26506, Morgantown, WV, USA
390 rdf:type schema:Organization
391 https://www.grid.ac/institutes/grid.417555.7 schema:alternateName Sanofi (United States)
392 schema:name Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA
393 Sanofi-aventis, 19355, Malvern, PA, USA
394 rdf:type schema:Organization
395 https://www.grid.ac/institutes/grid.417587.8 schema:alternateName United States Food and Drug Administration
396 schema:name Mary Babb Randolph Cancer Center, West Virginia University, 26506, Morgantown, WV, USA
397 United States Food and Drug Administration, 20993, Silver Spring, MD, USA
398 rdf:type schema:Organization
399 https://www.grid.ac/institutes/grid.419513.b schema:alternateName Sarah Cannon
400 schema:name Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA
401 Sarah Cannon Research Institute, 37203, Nashville, TN, USA
402 rdf:type schema:Organization
403 https://www.grid.ac/institutes/grid.420434.5 schema:alternateName United States Department of the Navy
404 schema:name Duke University Medical Center, Seeley G. Mudd Bldg, 10 Bryan Searle Drive, Box 3052, 27710, Durham, NC, USA
405 United States Navy, 23708, Portsmouth, VA, USA
406 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...