Phase II study of sequential cisplatin plus 5-fluorouracil/leucovorin (5-FU/LV) followed by irinotecan plus 5-FU/LV followed by docetaxel plus 5-FU/LV in ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-08

AUTHORS

Fotios Loupakis, Gianluca Masi, Lorenzo Fornaro, Enrico Vasile, Giacomo Allegrini, Eloise Fontana, Cristina Granetto, Lisa Salvatore, Lucia Mentuccia, Michele Andreuccetti, Enrico Cortesi, Marco Merlano, Stefano Cascinu, Alfredo Falcone

ABSTRACT

PURPOSE: 5-Fluorouracil (5-FU) plus cisplatin (C) can be considered a standard option for advanced gastric cancer (AGC). Irinotecan (Ir) and docetaxel (D) are active agents with no complete cross-resistance with C and 5-FU. Concomitant combination of Ir or D with C and 5-FU is feasible, but with substantial toxicities. A different way to include all active agents in first-line treatment of AGC may be to use them sequentially. We aimed to evaluate the activity and the safety profile of sequential chemotherapy with 5-FU-based doublets with C, Ir and D in the first-line treatment of AGC. METHODS: We conducted a phase II study of first-line sequential chemotherapy in metastatic GC. Treatment consisted of 3 cycles of C + infused 5-FU and leucovorin (CFL) followed by 3 cycles of Ir + 5-FU/LV (IrFL) followed by 3 cycles of D + 5-FU/LV (DFL). Primary end-point was response rate. RESULTS: Forty-six patients were enrolled, median age 60 years, sites of disease (single/multiple) = 9/37, PS 0/1 = 27/19, gastric/gastro-oesophageal junction = 39/7. Median number of cycles was 9. Main grade 3-4 toxicities were neutropenia (37%), febrile neutropenia (2%), diarrhoea (4%), stomatitis (9%). Response rate after the planned 9 cycles was 45% (15 partial and 5 complete responses among 43 evaluable patients). Median PFS and OS: 6.8 and 11.1 months, respectively. CONCLUSION: This sequential treatment is feasible with a favourable safety profile and produced encouraging results in terms of activity and efficacy. More... »

PAGES

559-566

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00280-009-1196-1

DOI

http://dx.doi.org/10.1007/s00280-009-1196-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030197918

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20237927


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00280-009-1196-1'


 

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