Phase II study of docetaxel, cisplatin, and 5-FU induction chemotherapy followed by chemoradiotherapy in locoregionally advanced nasopharyngeal cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-02

AUTHORS

Woo Kyun Bae, Jun Eul Hwang, Hyun Jeong Shim, Sang Hee Cho, Joon Kyoo Lee, Sang-Chul Lim, Woong-Ki Chung, Ik-Joo Chung

ABSTRACT

PURPOSE: This study sought to determine the feasibility and safety of induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (5-FU) triple combination chemotherapy (TPF) followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal cancer (NPC). METHODS: Patients with advanced NPC were treated with three cycles of induction chemotherapy. Docetaxel (70 mg/m2) and cisplatin (75 mg/m2) were given on day 1, followed by 5-FU (1,000 mg/m2) as a continuous infusion for 4 days. After induction chemotherapy, cisplatin was given at a dose of 100 mg/m2 every 3 weeks with radiotherapy. RESULTS: Thirty-three patients were enrolled; all patients were stage III (n=4, 12.1%) or IV (n=29, 87.9%). Among the patients, 32 patients completed both induction TPF therapy and CCRT, with responses as follows: Wve patients (15.2%) achieved a complete response (CR), and 27 patients (81.8%) a partial response (PR). At 6 weeks after CCRT, 23 patients (69.7%) had a CR and 9 patients (27.3%) a PR. The 3-year progression-free survival was 75.6% and the 3-year overall survival was 86.1%. Neutropenia (72.7%), febrile neutropenia (9.1%), and nausea (9.1%) were the most severe toxicities (grade 3-4) during induction chemotherapy, and mucositis (39.4%), fatigue (15.2%), and nausea (9.1%) were the most common toxicities (grade 3-4) during CCRT. CONCLUSIONS: Although most patients had stage IV NPC, the TPF induction chemotherapy followed by CCRT showed promising activity with manageable toxicity. These results demonstrated the possibility of effective treatment with the aim of not only a palliative, but also a curative, approach to the treatment of advanced NPC. More... »

PAGES

589

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00280-009-1152-0

DOI

http://dx.doi.org/10.1007/s00280-009-1152-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037175669

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19830427


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cisplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Docetaxel", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Administration Schedule", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feasibility Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mucositis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nasopharyngeal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nausea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neutropenia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Taxoids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Chonnam National University", 
          "id": "https://www.grid.ac/institutes/grid.14005.30", 
          "name": [
            "Department of Hematology-Oncology, Chonnam National University Medical School, 501-757, Gwangju, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bae", 
        "givenName": "Woo Kyun", 
        "id": "sg:person.01027453017.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027453017.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University", 
          "id": "https://www.grid.ac/institutes/grid.14005.30", 
          "name": [
            "Department of Hematology-Oncology, Chonnam National University Medical School, 501-757, Gwangju, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hwang", 
        "givenName": "Jun Eul", 
        "id": "sg:person.01211121126.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211121126.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University", 
          "id": "https://www.grid.ac/institutes/grid.14005.30", 
          "name": [
            "Department of Hematology-Oncology, Chonnam National University Medical School, 501-757, Gwangju, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shim", 
        "givenName": "Hyun Jeong", 
        "id": "sg:person.01074672526.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074672526.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University Hwasun Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411602.0", 
          "name": [
            "Department of Hematology-Oncology, Chonnam National University Medical School, 501-757, Gwangju, Korea", 
            "Department of Internal Medicine, Chonnam National University Hwasun Hospital, 160 Ilsim-ri, Hwasun-eup, 519-809, Hwasun-gun, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "Sang Hee", 
        "id": "sg:person.0650056626.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650056626.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University", 
          "id": "https://www.grid.ac/institutes/grid.14005.30", 
          "name": [
            "Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School, 501-757, Gwangju, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Joon Kyoo", 
        "id": "sg:person.01362376202.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362376202.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University", 
          "id": "https://www.grid.ac/institutes/grid.14005.30", 
          "name": [
            "Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School, 501-757, Gwangju, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lim", 
        "givenName": "Sang-Chul", 
        "id": "sg:person.0601066365.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601066365.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University", 
          "id": "https://www.grid.ac/institutes/grid.14005.30", 
          "name": [
            "Radiation Oncology, Chonnam National University Medical School, 501-757, Gwangju, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "Woong-Ki", 
        "id": "sg:person.014317617372.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014317617372.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University", 
          "id": "https://www.grid.ac/institutes/grid.14005.30", 
          "name": [
            "Department of Hematology-Oncology, Chonnam National University Medical School, 501-757, Gwangju, Korea", 
            "The Brain Korea 21 Project, Center for Biomedical Human Resources, Chonnam National University Medical School, 501-757, Gwangju, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "Ik-Joo", 
        "id": "sg:person.01023725662.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023725662.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2004.09.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003110615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)66698-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003322195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)66698-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003322195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2005.06.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003805508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2006.06.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007265543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.18.1545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012102481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(96)80007-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017863034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(96)80007-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017863034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.05.178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019265434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1008255220284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019493254", 
          "https://doi.org/10.1023/a:1008255220284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.12.081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020023847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa071028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021180850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000151363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024819222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(95)00516-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026503852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/14737140.6.3.383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031719529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.16.790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034557475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa070956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036306943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdf268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042580771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2008.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044261404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdg163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045729326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.00.1990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046275705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.00.1990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046275705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(98)00280-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051831500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1023/a:1008390929826", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056303681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.08.149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.06.158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.5.1350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074777241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.annonc.a058908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082564512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.4.1310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083246618"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-02", 
    "datePublishedReg": "2010-02-01", 
    "description": "PURPOSE: This study sought to determine the feasibility and safety of induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (5-FU) triple combination chemotherapy (TPF) followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal cancer (NPC).\nMETHODS: Patients with advanced NPC were treated with three cycles of induction chemotherapy. Docetaxel (70 mg/m2) and cisplatin (75 mg/m2) were given on day 1, followed by 5-FU (1,000 mg/m2) as a continuous infusion for 4 days. After induction chemotherapy, cisplatin was given at a dose of 100 mg/m2 every 3 weeks with radiotherapy.\nRESULTS: Thirty-three patients were enrolled; all patients were stage III (n=4, 12.1%) or IV (n=29, 87.9%). Among the patients, 32 patients completed both induction TPF therapy and CCRT, with responses as follows: Wve patients (15.2%) achieved a complete response (CR), and 27 patients (81.8%) a partial response (PR). At 6 weeks after CCRT, 23 patients (69.7%) had a CR and 9 patients (27.3%) a PR. The 3-year progression-free survival was 75.6% and the 3-year overall survival was 86.1%. Neutropenia (72.7%), febrile neutropenia (9.1%), and nausea (9.1%) were the most severe toxicities (grade 3-4) during induction chemotherapy, and mucositis (39.4%), fatigue (15.2%), and nausea (9.1%) were the most common toxicities (grade 3-4) during CCRT.\nCONCLUSIONS: Although most patients had stage IV NPC, the TPF induction chemotherapy followed by CCRT showed promising activity with manageable toxicity. These results demonstrated the possibility of effective treatment with the aim of not only a palliative, but also a curative, approach to the treatment of advanced NPC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00280-009-1152-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1088364", 
        "issn": [
          "0344-5704", 
          "1432-0843"
        ], 
        "name": "Cancer Chemotherapy and Pharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "65"
      }
    ], 
    "name": "Phase II study of docetaxel, cisplatin, and 5-FU induction chemotherapy followed by chemoradiotherapy in locoregionally advanced nasopharyngeal cancer", 
    "pagination": "589", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b1176cdb4d5288e2e3103771bedc1d02d8c17851b999677eb08e76ff2d4b0e86"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19830427"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7806519"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00280-009-1152-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037175669"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00280-009-1152-0", 
      "https://app.dimensions.ai/details/publication/pub.1037175669"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13073_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00280-009-1152-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00280-009-1152-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00280-009-1152-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00280-009-1152-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00280-009-1152-0'


 

This table displays all metadata directly associated to this object as RDF triples.

287 TRIPLES      21 PREDICATES      76 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00280-009-1152-0 schema:about N0d93fb4cc6d6448d85193bf836a76fce
2 N26a342b88f8241dbb647b538b5d635aa
3 N511926a5962d46a2b01e3d6600fcbfae
4 N515558b6900d408fb6abc70ebb901922
5 N52c5ac12c1284b96ab01e3c30ae8b023
6 N6260838369454634a93fdfe10ba0a36c
7 N688cc1e690f946788cb377ac83b11f7b
8 N6ed425ab1fe2469f86dfbf2be4909fc9
9 N733936bd592c49ee98b43a556bd80d97
10 N8e59cc6b9c664263a5df473188bd85af
11 N956cb0158e984474ae518ed3d78886bc
12 Nb33e8eb4a53f4e59a0ee404db4efc1a6
13 Nb434febb30d9474dac1d4ffeb6b8869d
14 Nbbcfb0c1dc9b493db9ae1320e7df5356
15 Ncb063970a4434f0a9540c9c32f479325
16 Nd274ea3922a84c5f8289022cc039c4f4
17 Nd3bb9454ca1e4c49bae1ee88b37ef9e0
18 Nda5cbf88bb2c4062ba9cccf610bf8181
19 Ne5972e9ca4464bef9794432241652e71
20 Nff92f28be94e4e529773cc4cee899eb4
21 anzsrc-for:11
22 anzsrc-for:1112
23 schema:author Nafe0a6a00b304d9f9890098564b19963
24 schema:citation sg:pub.10.1023/a:1008255220284
25 https://doi.org/10.1016/0360-3016(95)00516-2
26 https://doi.org/10.1016/j.ijrobp.2004.09.050
27 https://doi.org/10.1016/j.ijrobp.2005.06.037
28 https://doi.org/10.1016/j.ijrobp.2006.06.016
29 https://doi.org/10.1016/j.radonc.2008.02.003
30 https://doi.org/10.1016/s0140-6736(05)66698-6
31 https://doi.org/10.1016/s0360-3016(96)80007-1
32 https://doi.org/10.1016/s0959-8049(98)00280-9
33 https://doi.org/10.1023/a:1008390929826
34 https://doi.org/10.1056/nejmoa070956
35 https://doi.org/10.1056/nejmoa071028
36 https://doi.org/10.1093/annonc/mdf268
37 https://doi.org/10.1093/annonc/mdg163
38 https://doi.org/10.1093/oxfordjournals.annonc.a058908
39 https://doi.org/10.1159/000151363
40 https://doi.org/10.1200/jco.1998.16.4.1310
41 https://doi.org/10.1200/jco.2001.19.5.1350
42 https://doi.org/10.1200/jco.2002.07.011
43 https://doi.org/10.1200/jco.2002.08.149
44 https://doi.org/10.1200/jco.2003.06.158
45 https://doi.org/10.1200/jco.2004.00.1990
46 https://doi.org/10.1200/jco.2004.05.178
47 https://doi.org/10.1200/jco.2005.12.081
48 https://doi.org/10.1200/jco.2005.16.790
49 https://doi.org/10.1200/jco.2008.18.1545
50 https://doi.org/10.1586/14737140.6.3.383
51 schema:datePublished 2010-02
52 schema:datePublishedReg 2010-02-01
53 schema:description PURPOSE: This study sought to determine the feasibility and safety of induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (5-FU) triple combination chemotherapy (TPF) followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal cancer (NPC). METHODS: Patients with advanced NPC were treated with three cycles of induction chemotherapy. Docetaxel (70 mg/m2) and cisplatin (75 mg/m2) were given on day 1, followed by 5-FU (1,000 mg/m2) as a continuous infusion for 4 days. After induction chemotherapy, cisplatin was given at a dose of 100 mg/m2 every 3 weeks with radiotherapy. RESULTS: Thirty-three patients were enrolled; all patients were stage III (n=4, 12.1%) or IV (n=29, 87.9%). Among the patients, 32 patients completed both induction TPF therapy and CCRT, with responses as follows: Wve patients (15.2%) achieved a complete response (CR), and 27 patients (81.8%) a partial response (PR). At 6 weeks after CCRT, 23 patients (69.7%) had a CR and 9 patients (27.3%) a PR. The 3-year progression-free survival was 75.6% and the 3-year overall survival was 86.1%. Neutropenia (72.7%), febrile neutropenia (9.1%), and nausea (9.1%) were the most severe toxicities (grade 3-4) during induction chemotherapy, and mucositis (39.4%), fatigue (15.2%), and nausea (9.1%) were the most common toxicities (grade 3-4) during CCRT. CONCLUSIONS: Although most patients had stage IV NPC, the TPF induction chemotherapy followed by CCRT showed promising activity with manageable toxicity. These results demonstrated the possibility of effective treatment with the aim of not only a palliative, but also a curative, approach to the treatment of advanced NPC.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree false
57 schema:isPartOf N70a143dae4d140209a4d2c8015a9c921
58 Nbddcba1ac4ab456bba2e25ac3e034cbc
59 sg:journal.1088364
60 schema:name Phase II study of docetaxel, cisplatin, and 5-FU induction chemotherapy followed by chemoradiotherapy in locoregionally advanced nasopharyngeal cancer
61 schema:pagination 589
62 schema:productId N442d9c68e5c94402bc434de735a15269
63 N7a6355bf24b340bcb18154101953f9ce
64 Nccb12ba3e5284c10a46c4e54a4f73f41
65 Nd609c98742c043a9ac1b0bc50cc0181b
66 Ndbc5faba30b447c988acab6355c2f6a4
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037175669
68 https://doi.org/10.1007/s00280-009-1152-0
69 schema:sdDatePublished 2019-04-11T14:27
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N53bb236812044cc38a61b7924e6e0b87
72 schema:url http://link.springer.com/10.1007/s00280-009-1152-0
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N0d93fb4cc6d6448d85193bf836a76fce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Fluorouracil
78 rdf:type schema:DefinedTerm
79 N1c1322751df74355a39111e602fd4a7a rdf:first sg:person.01074672526.49
80 rdf:rest Ne9178b3f3af349cb9f446956bdf70032
81 N219aeeb93b174ecaa3ee2f1d8e3880f3 rdf:first sg:person.01023725662.02
82 rdf:rest rdf:nil
83 N26a342b88f8241dbb647b538b5d635aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Humans
85 rdf:type schema:DefinedTerm
86 N3c1b0dd2dbe34b5990e76688e82c3e65 rdf:first sg:person.0601066365.37
87 rdf:rest Nab4f681b7c514151a87b258a1cdc5967
88 N442d9c68e5c94402bc434de735a15269 schema:name dimensions_id
89 schema:value pub.1037175669
90 rdf:type schema:PropertyValue
91 N498004c00e434b4bbf9d153637c2e43c rdf:first sg:person.01362376202.49
92 rdf:rest N3c1b0dd2dbe34b5990e76688e82c3e65
93 N511926a5962d46a2b01e3d6600fcbfae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Combined Modality Therapy
95 rdf:type schema:DefinedTerm
96 N515558b6900d408fb6abc70ebb901922 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Drug Administration Schedule
98 rdf:type schema:DefinedTerm
99 N52c5ac12c1284b96ab01e3c30ae8b023 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Kaplan-Meier Estimate
101 rdf:type schema:DefinedTerm
102 N53bb236812044cc38a61b7924e6e0b87 schema:name Springer Nature - SN SciGraph project
103 rdf:type schema:Organization
104 N6260838369454634a93fdfe10ba0a36c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Neoplasm Staging
106 rdf:type schema:DefinedTerm
107 N688cc1e690f946788cb377ac83b11f7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Cisplatin
109 rdf:type schema:DefinedTerm
110 N6ed425ab1fe2469f86dfbf2be4909fc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Mucositis
112 rdf:type schema:DefinedTerm
113 N70a143dae4d140209a4d2c8015a9c921 schema:issueNumber 3
114 rdf:type schema:PublicationIssue
115 N733936bd592c49ee98b43a556bd80d97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Nasopharyngeal Neoplasms
117 rdf:type schema:DefinedTerm
118 N7a6355bf24b340bcb18154101953f9ce schema:name readcube_id
119 schema:value b1176cdb4d5288e2e3103771bedc1d02d8c17851b999677eb08e76ff2d4b0e86
120 rdf:type schema:PropertyValue
121 N8e59cc6b9c664263a5df473188bd85af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Docetaxel
123 rdf:type schema:DefinedTerm
124 N956cb0158e984474ae518ed3d78886bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Feasibility Studies
126 rdf:type schema:DefinedTerm
127 Nab4f681b7c514151a87b258a1cdc5967 rdf:first sg:person.014317617372.35
128 rdf:rest N219aeeb93b174ecaa3ee2f1d8e3880f3
129 Nafe0a6a00b304d9f9890098564b19963 rdf:first sg:person.01027453017.38
130 rdf:rest Nb0a50543d7f145eb8f54a9ddef989831
131 Nb0a50543d7f145eb8f54a9ddef989831 rdf:first sg:person.01211121126.13
132 rdf:rest N1c1322751df74355a39111e602fd4a7a
133 Nb33e8eb4a53f4e59a0ee404db4efc1a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Nausea
135 rdf:type schema:DefinedTerm
136 Nb434febb30d9474dac1d4ffeb6b8869d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Middle Aged
138 rdf:type schema:DefinedTerm
139 Nbbcfb0c1dc9b493db9ae1320e7df5356 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Antineoplastic Combined Chemotherapy Protocols
141 rdf:type schema:DefinedTerm
142 Nbddcba1ac4ab456bba2e25ac3e034cbc schema:volumeNumber 65
143 rdf:type schema:PublicationVolume
144 Ncb063970a4434f0a9540c9c32f479325 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Neutropenia
146 rdf:type schema:DefinedTerm
147 Nccb12ba3e5284c10a46c4e54a4f73f41 schema:name doi
148 schema:value 10.1007/s00280-009-1152-0
149 rdf:type schema:PropertyValue
150 Nd274ea3922a84c5f8289022cc039c4f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Female
152 rdf:type schema:DefinedTerm
153 Nd3bb9454ca1e4c49bae1ee88b37ef9e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Male
155 rdf:type schema:DefinedTerm
156 Nd609c98742c043a9ac1b0bc50cc0181b schema:name nlm_unique_id
157 schema:value 7806519
158 rdf:type schema:PropertyValue
159 Nda5cbf88bb2c4062ba9cccf610bf8181 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Adult
161 rdf:type schema:DefinedTerm
162 Ndbc5faba30b447c988acab6355c2f6a4 schema:name pubmed_id
163 schema:value 19830427
164 rdf:type schema:PropertyValue
165 Ne5972e9ca4464bef9794432241652e71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Taxoids
167 rdf:type schema:DefinedTerm
168 Ne9178b3f3af349cb9f446956bdf70032 rdf:first sg:person.0650056626.63
169 rdf:rest N498004c00e434b4bbf9d153637c2e43c
170 Nff92f28be94e4e529773cc4cee899eb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Treatment Outcome
172 rdf:type schema:DefinedTerm
173 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
174 schema:name Medical and Health Sciences
175 rdf:type schema:DefinedTerm
176 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
177 schema:name Oncology and Carcinogenesis
178 rdf:type schema:DefinedTerm
179 sg:journal.1088364 schema:issn 0344-5704
180 1432-0843
181 schema:name Cancer Chemotherapy and Pharmacology
182 rdf:type schema:Periodical
183 sg:person.01023725662.02 schema:affiliation https://www.grid.ac/institutes/grid.14005.30
184 schema:familyName Chung
185 schema:givenName Ik-Joo
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023725662.02
187 rdf:type schema:Person
188 sg:person.01027453017.38 schema:affiliation https://www.grid.ac/institutes/grid.14005.30
189 schema:familyName Bae
190 schema:givenName Woo Kyun
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027453017.38
192 rdf:type schema:Person
193 sg:person.01074672526.49 schema:affiliation https://www.grid.ac/institutes/grid.14005.30
194 schema:familyName Shim
195 schema:givenName Hyun Jeong
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074672526.49
197 rdf:type schema:Person
198 sg:person.01211121126.13 schema:affiliation https://www.grid.ac/institutes/grid.14005.30
199 schema:familyName Hwang
200 schema:givenName Jun Eul
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211121126.13
202 rdf:type schema:Person
203 sg:person.01362376202.49 schema:affiliation https://www.grid.ac/institutes/grid.14005.30
204 schema:familyName Lee
205 schema:givenName Joon Kyoo
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362376202.49
207 rdf:type schema:Person
208 sg:person.014317617372.35 schema:affiliation https://www.grid.ac/institutes/grid.14005.30
209 schema:familyName Chung
210 schema:givenName Woong-Ki
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014317617372.35
212 rdf:type schema:Person
213 sg:person.0601066365.37 schema:affiliation https://www.grid.ac/institutes/grid.14005.30
214 schema:familyName Lim
215 schema:givenName Sang-Chul
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601066365.37
217 rdf:type schema:Person
218 sg:person.0650056626.63 schema:affiliation https://www.grid.ac/institutes/grid.411602.0
219 schema:familyName Cho
220 schema:givenName Sang Hee
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650056626.63
222 rdf:type schema:Person
223 sg:pub.10.1023/a:1008255220284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019493254
224 https://doi.org/10.1023/a:1008255220284
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/0360-3016(95)00516-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026503852
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.ijrobp.2004.09.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003110615
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.ijrobp.2005.06.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003805508
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.ijrobp.2006.06.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007265543
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.radonc.2008.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044261404
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s0140-6736(05)66698-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003322195
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/s0360-3016(96)80007-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017863034
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0959-8049(98)00280-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051831500
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1023/a:1008390929826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056303681
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1056/nejmoa070956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036306943
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1056/nejmoa071028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021180850
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1093/annonc/mdf268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042580771
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1093/annonc/mdg163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045729326
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1093/oxfordjournals.annonc.a058908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082564512
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1159/000151363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024819222
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1200/jco.1998.16.4.1310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083246618
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1200/jco.2001.19.5.1350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074777241
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1200/jco.2002.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203015
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1200/jco.2002.08.149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203100
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1200/jco.2003.06.158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203699
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1200/jco.2004.00.1990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046275705
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1200/jco.2004.05.178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019265434
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1200/jco.2005.12.081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020023847
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1200/jco.2005.16.790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034557475
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1200/jco.2008.18.1545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012102481
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1586/14737140.6.3.383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031719529
277 rdf:type schema:CreativeWork
278 https://www.grid.ac/institutes/grid.14005.30 schema:alternateName Chonnam National University
279 schema:name Department of Hematology-Oncology, Chonnam National University Medical School, 501-757, Gwangju, Korea
280 Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School, 501-757, Gwangju, Korea
281 Radiation Oncology, Chonnam National University Medical School, 501-757, Gwangju, Korea
282 The Brain Korea 21 Project, Center for Biomedical Human Resources, Chonnam National University Medical School, 501-757, Gwangju, Korea
283 rdf:type schema:Organization
284 https://www.grid.ac/institutes/grid.411602.0 schema:alternateName Chonnam National University Hwasun Hospital
285 schema:name Department of Hematology-Oncology, Chonnam National University Medical School, 501-757, Gwangju, Korea
286 Department of Internal Medicine, Chonnam National University Hwasun Hospital, 160 Ilsim-ri, Hwasun-eup, 519-809, Hwasun-gun, Korea
287 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...