Expression of an activated mammalian target of rapamycin (mTOR) in gastroenteropancreatic neuroendocrine tumors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-04

AUTHORS

Takashi Shida, Takashi Kishimoto, Mitsuko Furuya, Takashi Nikaido, Keiji Koda, Shigetsugu Takano, Fumio Kimura, Hiroaki Shimizu, Hiroyuki Yoshidome, Masayuki Ohtsuka, Tohru Tanizawa, Yukio Nakatani, Masaru Miyazaki

ABSTRACT

AIMS: Gastroenteropancreatic neuroendocrine tumors are rare, and the current WHO classification divides this tumor entity into well-differentiated (neuro)endocrine tumors, well-differentiated (neuro)endocrine carcinomas, and poorly differentiated (neuro)endocrine carcinomas. Poorly differentiated (neuro)endocrine carcinoma is extremely aggressive, and no appropriate therapeutic approach has been established. The mammalian target of rapamycin (mTOR), an important regulator of cell proliferation and protein translation, is activated in various malignancies. Recent phase II trial has revealed the efficacy of mTOR inhibitor (RAD001; everolimus) against low-to-intermediate grade neuroendocrine tumors. However, the beneficial role of mTOR inhibitor against poorly neuroendocrine carcinoma remains uncertain. The purpose of the present study was to determine the activation of mTOR in gastropancreatic neuroendocrine tumors, especially in poorly differentiated neuroendocrine carcinomas. METHODS: Expression of p-mTOR(Ser2448) was assessed by immunohistochemistry in 20 gastropancreatic neuroendocrine tumors (seven well-differentiated neuroendocrine tumors, four well-differentiated neuroendocrine carcinomas, and nine poorly differentiated neuroendocrine carcinomas). Double immunohistochemistry was performed with p-Akt for patients with high p-mTOR expression. RESULTS: Expression of mTOR was seen in 9 (45%) of 20 gastroenteropancreatic neuroendocrine tumors. High expression of p-mTOR was seen in 6 (67%) of 9 poorly differentiated neuroendocrine carcinomas which was higher than the expression rate of well-differentiated neuroendocrine tumors and carcinomas, 3 (27%) of 11. All large cell neuroendocrine carcinomas showed high p-mTOR expression. Some tumor cells showed positive staining for p-mTOR co-expressed p-Akt. CONCLUSIONS: High expression rate of p-mTOR in poorly differentiated neuroendocrine carcinomas (large-cell type) may suggest the potential role of mTOR inhibitors as effective therapeutic agents for this highly malignant disease. More... »

PAGES

889-893

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00280-009-1094-6

DOI

http://dx.doi.org/10.1007/s00280-009-1094-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048417181

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19657638


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Large Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Neuroendocrine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Small Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastrointestinal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intracellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "TOR Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shida", 
        "givenName": "Takashi", 
        "id": "sg:person.01054077577.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054077577.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kishimoto", 
        "givenName": "Takashi", 
        "id": "sg:person.0647356473.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647356473.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yokohama City University", 
          "id": "https://www.grid.ac/institutes/grid.268441.d", 
          "name": [
            "Department of Pathology, Yokohama City University, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Furuya", 
        "givenName": "Mitsuko", 
        "id": "sg:person.01100154471.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100154471.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jikei University", 
          "id": "https://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Department of Pathology, Jikei University School of Medicine, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nikaido", 
        "givenName": "Takashi", 
        "id": "sg:person.0715471673.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715471673.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Teikyo University", 
          "id": "https://www.grid.ac/institutes/grid.264706.1", 
          "name": [
            "Department of Surgery, Teikyo University, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koda", 
        "givenName": "Keiji", 
        "id": "sg:person.0647155176.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647155176.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takano", 
        "givenName": "Shigetsugu", 
        "id": "sg:person.01266546053.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266546053.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kimura", 
        "givenName": "Fumio", 
        "id": "sg:person.01127754745.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127754745.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimizu", 
        "givenName": "Hiroaki", 
        "id": "sg:person.01103413111.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103413111.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshidome", 
        "givenName": "Hiroyuki", 
        "id": "sg:person.016423226454.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016423226454.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohtsuka", 
        "givenName": "Masayuki", 
        "id": "sg:person.0653527253.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653527253.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of Diagnostic Pathology, Chiba University Graduate School of Medicine, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanizawa", 
        "givenName": "Tohru", 
        "id": "sg:person.0763605073.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763605073.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of Diagnostic Pathology, Chiba University Graduate School of Medicine, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakatani", 
        "givenName": "Yukio", 
        "id": "sg:person.01361705101.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361705101.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyazaki", 
        "givenName": "Masaru", 
        "id": "sg:person.0773025611.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773025611.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1196/annals.1294.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001423908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2008.121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002354258", 
          "https://doi.org/10.1038/modpathol.2008.121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.16.7858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003360569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.01.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009536631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.275.10.7416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010907659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-2166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025316300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e318159371c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027719162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e318159371c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027719162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3440427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034944112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3440427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034944112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(08)61039-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045744105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/0264-6021:3440427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056714364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.273.5272.239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062553595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.5.11.3458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072293974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075210998", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077005544", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-04", 
    "datePublishedReg": "2010-04-01", 
    "description": "AIMS: Gastroenteropancreatic neuroendocrine tumors are rare, and the current WHO classification divides this tumor entity into well-differentiated (neuro)endocrine tumors, well-differentiated (neuro)endocrine carcinomas, and poorly differentiated (neuro)endocrine carcinomas. Poorly differentiated (neuro)endocrine carcinoma is extremely aggressive, and no appropriate therapeutic approach has been established. The mammalian target of rapamycin (mTOR), an important regulator of cell proliferation and protein translation, is activated in various malignancies. Recent phase II trial has revealed the efficacy of mTOR inhibitor (RAD001; everolimus) against low-to-intermediate grade neuroendocrine tumors. However, the beneficial role of mTOR inhibitor against poorly neuroendocrine carcinoma remains uncertain. The purpose of the present study was to determine the activation of mTOR in gastropancreatic neuroendocrine tumors, especially in poorly differentiated neuroendocrine carcinomas.\nMETHODS: Expression of p-mTOR(Ser2448) was assessed by immunohistochemistry in 20 gastropancreatic neuroendocrine tumors (seven well-differentiated neuroendocrine tumors, four well-differentiated neuroendocrine carcinomas, and nine poorly differentiated neuroendocrine carcinomas). Double immunohistochemistry was performed with p-Akt for patients with high p-mTOR expression.\nRESULTS: Expression of mTOR was seen in 9 (45%) of 20 gastroenteropancreatic neuroendocrine tumors. High expression of p-mTOR was seen in 6 (67%) of 9 poorly differentiated neuroendocrine carcinomas which was higher than the expression rate of well-differentiated neuroendocrine tumors and carcinomas, 3 (27%) of 11. All large cell neuroendocrine carcinomas showed high p-mTOR expression. Some tumor cells showed positive staining for p-mTOR co-expressed p-Akt.\nCONCLUSIONS: High expression rate of p-mTOR in poorly differentiated neuroendocrine carcinomas (large-cell type) may suggest the potential role of mTOR inhibitors as effective therapeutic agents for this highly malignant disease.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00280-009-1094-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1088364", 
        "issn": [
          "0344-5704", 
          "1432-0843"
        ], 
        "name": "Cancer Chemotherapy and Pharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "65"
      }
    ], 
    "name": "Expression of an activated mammalian target of rapamycin (mTOR) in gastroenteropancreatic neuroendocrine tumors", 
    "pagination": "889-893", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e6a6b4535dfd5e1a23bbda4f9beb267daf0cd00860cf29bceeebae9973eb9b30"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19657638"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7806519"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00280-009-1094-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048417181"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00280-009-1094-6", 
      "https://app.dimensions.ai/details/publication/pub.1048417181"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13106_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00280-009-1094-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00280-009-1094-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00280-009-1094-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00280-009-1094-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00280-009-1094-6'


 

This table displays all metadata directly associated to this object as RDF triples.

269 TRIPLES      21 PREDICATES      59 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00280-009-1094-6 schema:about N188886de43ad4547a3d064d364e8c968
2 N1f896ff7990d4da2b933206c95799481
3 N3692567236ac42c89de5fba8bc5f521a
4 N4f64dc9853b8496f8178b5c6a3ae3b43
5 N5e141a7b71c445d0a247da89a4c1e658
6 N67ebaa957e3248b1b8edd78c78787e14
7 N744e9070f9a243af8beadff5f844774e
8 N77bff49dbd3448bd8e9d4d1e2bf5b453
9 N7a022b3a2e4049f5b247b16c2546d3ba
10 Nad793c8d1e1f435fb5197f2db33d46d9
11 Nbb58ab57831d4148b3cba8e25a061eba
12 Nbf7778567fec476cb294b9993eb9cc85
13 Nc4599af83b514cc3a6debf02060691c0
14 Ndb1835408131420b90956c5220bdb244
15 Nef3faa7b1e624494a8b5b652a9b01c9c
16 Nf8dab6ea3a2545aebc02f24fb3d36974
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N715c2d3edec04525a7e18201d348c8c2
20 schema:citation sg:pub.10.1038/modpathol.2008.121
21 https://app.dimensions.ai/details/publication/pub.1075210998
22 https://app.dimensions.ai/details/publication/pub.1077005544
23 https://doi.org/10.1016/j.cell.2006.01.016
24 https://doi.org/10.1016/s0140-6736(08)61039-9
25 https://doi.org/10.1042/0264-6021:3440427
26 https://doi.org/10.1042/bj3440427
27 https://doi.org/10.1074/jbc.275.10.7416
28 https://doi.org/10.1097/pas.0b013e318159371c
29 https://doi.org/10.1126/science.273.5272.239
30 https://doi.org/10.1158/1078-0432.ccr-08-2166
31 https://doi.org/10.1196/annals.1294.002
32 https://doi.org/10.1200/jco.2008.16.7858
33 https://doi.org/10.4161/cbt.5.11.3458
34 schema:datePublished 2010-04
35 schema:datePublishedReg 2010-04-01
36 schema:description AIMS: Gastroenteropancreatic neuroendocrine tumors are rare, and the current WHO classification divides this tumor entity into well-differentiated (neuro)endocrine tumors, well-differentiated (neuro)endocrine carcinomas, and poorly differentiated (neuro)endocrine carcinomas. Poorly differentiated (neuro)endocrine carcinoma is extremely aggressive, and no appropriate therapeutic approach has been established. The mammalian target of rapamycin (mTOR), an important regulator of cell proliferation and protein translation, is activated in various malignancies. Recent phase II trial has revealed the efficacy of mTOR inhibitor (RAD001; everolimus) against low-to-intermediate grade neuroendocrine tumors. However, the beneficial role of mTOR inhibitor against poorly neuroendocrine carcinoma remains uncertain. The purpose of the present study was to determine the activation of mTOR in gastropancreatic neuroendocrine tumors, especially in poorly differentiated neuroendocrine carcinomas. METHODS: Expression of p-mTOR(Ser2448) was assessed by immunohistochemistry in 20 gastropancreatic neuroendocrine tumors (seven well-differentiated neuroendocrine tumors, four well-differentiated neuroendocrine carcinomas, and nine poorly differentiated neuroendocrine carcinomas). Double immunohistochemistry was performed with p-Akt for patients with high p-mTOR expression. RESULTS: Expression of mTOR was seen in 9 (45%) of 20 gastroenteropancreatic neuroendocrine tumors. High expression of p-mTOR was seen in 6 (67%) of 9 poorly differentiated neuroendocrine carcinomas which was higher than the expression rate of well-differentiated neuroendocrine tumors and carcinomas, 3 (27%) of 11. All large cell neuroendocrine carcinomas showed high p-mTOR expression. Some tumor cells showed positive staining for p-mTOR co-expressed p-Akt. CONCLUSIONS: High expression rate of p-mTOR in poorly differentiated neuroendocrine carcinomas (large-cell type) may suggest the potential role of mTOR inhibitors as effective therapeutic agents for this highly malignant disease.
37 schema:genre research_article
38 schema:inLanguage en
39 schema:isAccessibleForFree false
40 schema:isPartOf N94b69ed8b37543e090daf091c0f03bae
41 Ne6a0e5e3209944739581ee6b44b77b9c
42 sg:journal.1088364
43 schema:name Expression of an activated mammalian target of rapamycin (mTOR) in gastroenteropancreatic neuroendocrine tumors
44 schema:pagination 889-893
45 schema:productId N17e0833953294c859da304aa714dcc97
46 N6ae9b3d7f139427fb3823a3b1444204a
47 N6caaf84c98ba47b1a985ef254ef19bbd
48 N8c8f4bde4e624e0093b38a7736e163a4
49 Ne3a37f0e7d4f4170a876f320955242c6
50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048417181
51 https://doi.org/10.1007/s00280-009-1094-6
52 schema:sdDatePublished 2019-04-11T14:34
53 schema:sdLicense https://scigraph.springernature.com/explorer/license/
54 schema:sdPublisher N566fb7716c494b72bf281cee7f4157c8
55 schema:url http://link.springer.com/10.1007/s00280-009-1094-6
56 sgo:license sg:explorer/license/
57 sgo:sdDataset articles
58 rdf:type schema:ScholarlyArticle
59 N06acd1751a514d62bb1432a99c48d634 rdf:first sg:person.0647155176.80
60 rdf:rest N82848f5d014f4578a0de40d507ac7fd8
61 N17e0833953294c859da304aa714dcc97 schema:name nlm_unique_id
62 schema:value 7806519
63 rdf:type schema:PropertyValue
64 N188886de43ad4547a3d064d364e8c968 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Female
66 rdf:type schema:DefinedTerm
67 N1cab096e2761448093eb74741c247a18 rdf:first sg:person.01100154471.33
68 rdf:rest Nd5d7315a2e6843fcbdc7de2c5fd36506
69 N1f896ff7990d4da2b933206c95799481 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Adult
71 rdf:type schema:DefinedTerm
72 N3692567236ac42c89de5fba8bc5f521a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name TOR Serine-Threonine Kinases
74 rdf:type schema:DefinedTerm
75 N36abcc513c6b43f2b4fd0ab965bbdc3e rdf:first sg:person.01127754745.32
76 rdf:rest N9e2c4e997c634d819f6af6449ddfa55f
77 N4f64dc9853b8496f8178b5c6a3ae3b43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Aged
79 rdf:type schema:DefinedTerm
80 N566fb7716c494b72bf281cee7f4157c8 schema:name Springer Nature - SN SciGraph project
81 rdf:type schema:Organization
82 N5e141a7b71c445d0a247da89a4c1e658 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Male
84 rdf:type schema:DefinedTerm
85 N67ebaa957e3248b1b8edd78c78787e14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Intracellular Signaling Peptides and Proteins
87 rdf:type schema:DefinedTerm
88 N6ae9b3d7f139427fb3823a3b1444204a schema:name pubmed_id
89 schema:value 19657638
90 rdf:type schema:PropertyValue
91 N6caaf84c98ba47b1a985ef254ef19bbd schema:name doi
92 schema:value 10.1007/s00280-009-1094-6
93 rdf:type schema:PropertyValue
94 N715c2d3edec04525a7e18201d348c8c2 rdf:first sg:person.01054077577.24
95 rdf:rest N73bbb519092b464faf07625c56662608
96 N73bbb519092b464faf07625c56662608 rdf:first sg:person.0647356473.51
97 rdf:rest N1cab096e2761448093eb74741c247a18
98 N744e9070f9a243af8beadff5f844774e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Pancreatic Neoplasms
100 rdf:type schema:DefinedTerm
101 N7647a7b656214ccc8413ce19509c4da3 rdf:first sg:person.01361705101.91
102 rdf:rest Nee264f89b8e64e2eadc44f1cb19465d3
103 N77bff49dbd3448bd8e9d4d1e2bf5b453 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Carcinoma, Neuroendocrine
105 rdf:type schema:DefinedTerm
106 N7a022b3a2e4049f5b247b16c2546d3ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Aged, 80 and over
108 rdf:type schema:DefinedTerm
109 N82848f5d014f4578a0de40d507ac7fd8 rdf:first sg:person.01266546053.57
110 rdf:rest N36abcc513c6b43f2b4fd0ab965bbdc3e
111 N8c8f4bde4e624e0093b38a7736e163a4 schema:name dimensions_id
112 schema:value pub.1048417181
113 rdf:type schema:PropertyValue
114 N94b69ed8b37543e090daf091c0f03bae schema:issueNumber 5
115 rdf:type schema:PublicationIssue
116 N9e2c4e997c634d819f6af6449ddfa55f rdf:first sg:person.01103413111.45
117 rdf:rest Nb79dbcf0cbc94283a57fcb538f40d19f
118 Nad793c8d1e1f435fb5197f2db33d46d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Humans
120 rdf:type schema:DefinedTerm
121 Nb79dbcf0cbc94283a57fcb538f40d19f rdf:first sg:person.016423226454.74
122 rdf:rest Ne27f0224fe0448138260329d5c1f1867
123 Nbb58ab57831d4148b3cba8e25a061eba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Middle Aged
125 rdf:type schema:DefinedTerm
126 Nbb83ea4794b242c088df7b7ea59f72ac rdf:first sg:person.0763605073.24
127 rdf:rest N7647a7b656214ccc8413ce19509c4da3
128 Nbf7778567fec476cb294b9993eb9cc85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Carcinoma, Large Cell
130 rdf:type schema:DefinedTerm
131 Nc4599af83b514cc3a6debf02060691c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Carcinoma, Small Cell
133 rdf:type schema:DefinedTerm
134 Nd5d7315a2e6843fcbdc7de2c5fd36506 rdf:first sg:person.0715471673.50
135 rdf:rest N06acd1751a514d62bb1432a99c48d634
136 Ndb1835408131420b90956c5220bdb244 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Protein-Serine-Threonine Kinases
138 rdf:type schema:DefinedTerm
139 Ne27f0224fe0448138260329d5c1f1867 rdf:first sg:person.0653527253.30
140 rdf:rest Nbb83ea4794b242c088df7b7ea59f72ac
141 Ne3a37f0e7d4f4170a876f320955242c6 schema:name readcube_id
142 schema:value e6a6b4535dfd5e1a23bbda4f9beb267daf0cd00860cf29bceeebae9973eb9b30
143 rdf:type schema:PropertyValue
144 Ne6a0e5e3209944739581ee6b44b77b9c schema:volumeNumber 65
145 rdf:type schema:PublicationVolume
146 Nee264f89b8e64e2eadc44f1cb19465d3 rdf:first sg:person.0773025611.35
147 rdf:rest rdf:nil
148 Nef3faa7b1e624494a8b5b652a9b01c9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Gastrointestinal Neoplasms
150 rdf:type schema:DefinedTerm
151 Nf8dab6ea3a2545aebc02f24fb3d36974 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Young Adult
153 rdf:type schema:DefinedTerm
154 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
155 schema:name Medical and Health Sciences
156 rdf:type schema:DefinedTerm
157 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
158 schema:name Oncology and Carcinogenesis
159 rdf:type schema:DefinedTerm
160 sg:journal.1088364 schema:issn 0344-5704
161 1432-0843
162 schema:name Cancer Chemotherapy and Pharmacology
163 rdf:type schema:Periodical
164 sg:person.01054077577.24 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
165 schema:familyName Shida
166 schema:givenName Takashi
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054077577.24
168 rdf:type schema:Person
169 sg:person.01100154471.33 schema:affiliation https://www.grid.ac/institutes/grid.268441.d
170 schema:familyName Furuya
171 schema:givenName Mitsuko
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100154471.33
173 rdf:type schema:Person
174 sg:person.01103413111.45 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
175 schema:familyName Shimizu
176 schema:givenName Hiroaki
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103413111.45
178 rdf:type schema:Person
179 sg:person.01127754745.32 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
180 schema:familyName Kimura
181 schema:givenName Fumio
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127754745.32
183 rdf:type schema:Person
184 sg:person.01266546053.57 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
185 schema:familyName Takano
186 schema:givenName Shigetsugu
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266546053.57
188 rdf:type schema:Person
189 sg:person.01361705101.91 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
190 schema:familyName Nakatani
191 schema:givenName Yukio
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361705101.91
193 rdf:type schema:Person
194 sg:person.016423226454.74 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
195 schema:familyName Yoshidome
196 schema:givenName Hiroyuki
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016423226454.74
198 rdf:type schema:Person
199 sg:person.0647155176.80 schema:affiliation https://www.grid.ac/institutes/grid.264706.1
200 schema:familyName Koda
201 schema:givenName Keiji
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647155176.80
203 rdf:type schema:Person
204 sg:person.0647356473.51 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
205 schema:familyName Kishimoto
206 schema:givenName Takashi
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647356473.51
208 rdf:type schema:Person
209 sg:person.0653527253.30 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
210 schema:familyName Ohtsuka
211 schema:givenName Masayuki
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653527253.30
213 rdf:type schema:Person
214 sg:person.0715471673.50 schema:affiliation https://www.grid.ac/institutes/grid.411898.d
215 schema:familyName Nikaido
216 schema:givenName Takashi
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715471673.50
218 rdf:type schema:Person
219 sg:person.0763605073.24 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
220 schema:familyName Tanizawa
221 schema:givenName Tohru
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763605073.24
223 rdf:type schema:Person
224 sg:person.0773025611.35 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
225 schema:familyName Miyazaki
226 schema:givenName Masaru
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773025611.35
228 rdf:type schema:Person
229 sg:pub.10.1038/modpathol.2008.121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002354258
230 https://doi.org/10.1038/modpathol.2008.121
231 rdf:type schema:CreativeWork
232 https://app.dimensions.ai/details/publication/pub.1075210998 schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1077005544 schema:CreativeWork
234 https://doi.org/10.1016/j.cell.2006.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009536631
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s0140-6736(08)61039-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045744105
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1042/0264-6021:3440427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056714364
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1042/bj3440427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034944112
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1074/jbc.275.10.7416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010907659
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1097/pas.0b013e318159371c schema:sameAs https://app.dimensions.ai/details/publication/pub.1027719162
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1126/science.273.5272.239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062553595
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1158/1078-0432.ccr-08-2166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025316300
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1196/annals.1294.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001423908
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1200/jco.2008.16.7858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003360569
253 rdf:type schema:CreativeWork
254 https://doi.org/10.4161/cbt.5.11.3458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072293974
255 rdf:type schema:CreativeWork
256 https://www.grid.ac/institutes/grid.136304.3 schema:alternateName Chiba University
257 schema:name Department of Diagnostic Pathology, Chiba University Graduate School of Medicine, Chiba, Japan
258 Department of General Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan
259 Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba, Japan
260 rdf:type schema:Organization
261 https://www.grid.ac/institutes/grid.264706.1 schema:alternateName Teikyo University
262 schema:name Department of Surgery, Teikyo University, Chiba, Japan
263 rdf:type schema:Organization
264 https://www.grid.ac/institutes/grid.268441.d schema:alternateName Yokohama City University
265 schema:name Department of Pathology, Yokohama City University, Kanagawa, Japan
266 rdf:type schema:Organization
267 https://www.grid.ac/institutes/grid.411898.d schema:alternateName Jikei University
268 schema:name Department of Pathology, Jikei University School of Medicine, Tokyo, Japan
269 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...