Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-11

AUTHORS

Robert Mauritz, Godefridus J. Peters, Ietje Kathmann, Habte Teshale, Paul Noordhuis, Elizabeth M. Comijn, Herbert M. Pinedo, Gerrit Jansen

ABSTRACT

Murine L1210 leukaemia cells expressing either the reduced folate carrier (RFC) or the membrane folate receptor (MFR) were studied in vitro and in vivo to assess the dynamics of membrane transport of two categories antifolates; folate-based inhibitors of dihydrofolate reductase (methotrexate, edatrexate, aminopterin, PT523, and PT644) and thymidylate synthase (TS) [CB3717, raltitrexed, plevitrexed (BGC9331), pemetrexed and GW1843]. The potency of in situ inhibition of TS was used as an endpoint to analyze the in vitro dynamics of RFC/MFR-membrane transport of these antifolates. Both for L1210-RFC and L1210-MFR cells, the potency of in situ TS inhibition was closely correlated with increasing affinities of these transporters for the antifolates (r = 0.64, P < 0.05 and r = -0.65, P < 0.05, respectively). Within the group of antifolates for which MFR had a low binding affinity, those that had the ability to become polyglutamylated, were more potent inhibitors of TS in situ activity than non-polyglutamatable antifolates. In vivo activity of methotrexate, edatrexate, raltitrexed and pemetrexed was assessed in L1210-RFC and L1210-MFR bearing mice that were fed either a standard or a folate-deficient chow. Dietary folate depletion significantly reduced the MTD for methotrexate (sevenfold), edatrexate (sevenfold), raltitrexed (50-fold) and pemetrexed (150-fold). Based on increased life spans, antitumor effects of methotrexate and edatrexate were markedly better in L1210-RFC bearing mice on the folate-deficient chow (ILS: 455 and 544%, respectively) than on standard chow (ILS: 213 and 263%, respectively). No therapeutic effects of methotrexate and edatrexate were observed for L1210-MFR bearing mice on either chow condition, which may be consistent with the low binding affinity for MFR. Irrespective of the folate diet status, pemetrexed and raltitrexed were inactive against both L1210-RFC and L1210-MFR bearing mice, which may be due to high circulating plasma thymidine levels. Collectively, this study underscores that modulation of dietary folate status can provide a basis within which the therapeutic effect of antifolates may be further improved. More... »

PAGES

937-948

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00280-008-0683-0

DOI

http://dx.doi.org/10.1007/s00280-008-0683-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053743201

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18283461


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ascitic Fluid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Transport", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Folate Receptors, GPI-Anchored", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Folic Acid Antagonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Folic Acid Deficiency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Vitro Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia L1210", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Maximum Tolerated Dose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Transport Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred DBA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyglutamic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Cell Surface", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reduced Folate Carrier Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tetrahydrofolate Dehydrogenase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thymidylate Synthase", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Medical Oncology, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mauritz", 
        "givenName": "Robert", 
        "id": "sg:person.0645332635.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645332635.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Medical Oncology, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peters", 
        "givenName": "Godefridus J.", 
        "id": "sg:person.01255301342.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255301342.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Medical Oncology, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kathmann", 
        "givenName": "Ietje", 
        "id": "sg:person.0600545135.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600545135.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Medical Oncology, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Teshale", 
        "givenName": "Habte", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Medical Oncology, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noordhuis", 
        "givenName": "Paul", 
        "id": "sg:person.01171546142.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171546142.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Medical Oncology, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Comijn", 
        "givenName": "Elizabeth M.", 
        "id": "sg:person.013473012337.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013473012337.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Medical Oncology, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pinedo", 
        "givenName": "Herbert M.", 
        "id": "sg:person.01016732673.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016732673.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jansen", 
        "givenName": "Gerrit", 
        "id": "sg:person.01273433134.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273433134.01"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-9009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002631220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-007-9049-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003553463", 
          "https://doi.org/10.1007/s10555-007-9049-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-007-9049-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003553463", 
          "https://doi.org/10.1007/s10555-007-9049-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.drup.2006.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004515166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.132.1.35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004848209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.39.22974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006007206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-005-0115-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008530951", 
          "https://doi.org/10.1007/s00280-005-0115-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-005-0115-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008530951", 
          "https://doi.org/10.1007/s00280-005-0115-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-1066-03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009592571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-2034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010187263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19980105)75:1<125::aid-ijc19>3.0.co;2-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010329026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(94)90103-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011276203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(94)90103-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011276203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-59259-725-3_14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011665662", 
          "https://doi.org/10.1007/978-1-59259-725-3_14"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4615-2960-6_93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012282808", 
          "https://doi.org/10.1007/978-1-4615-2960-6_93"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/13543784.5.6.719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012565716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0899-9007(01)00618-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014958722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(96)00347-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015171581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.2000.02071.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015436846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-005-4541-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016798569", 
          "https://doi.org/10.1007/s10637-005-4541-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-005-4541-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016798569", 
          "https://doi.org/10.1007/s10637-005-4541-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.83.16.5983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016863685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0959-8049(95)00172-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017099685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-59259-725-3_20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017540635", 
          "https://doi.org/10.1007/978-1-59259-725-3_20"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.14.7842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018428858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0083-6729(03)01012-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020010647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.46.30189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024128522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.addr.2004.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024317773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-4048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028114996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001813-200501000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028681767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001813-200501000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028681767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-007-9048-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031189710", 
          "https://doi.org/10.1007/s10555-007-9048-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-007-9048-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031189710", 
          "https://doi.org/10.1007/s10555-007-9048-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.09.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034570301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0230884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038930893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0230884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038930893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00202.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040033882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-0355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040881104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.addr.2004.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041904527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-003-0625-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045241343", 
          "https://doi.org/10.1007/s00280-003-0625-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(97)84450-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045357440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(93)90604-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047478112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(93)90604-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047478112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(92)90089-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047682989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(92)90089-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047682989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(85)90788-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049215064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(85)90788-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049215064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(84)90089-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053719614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-2952(84)90089-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053719614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00446a042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055176575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/sonc.2002.37465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057078615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/sonc.2002.37465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057078615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1310359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062474502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074254081", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074273176", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074474441", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074563014", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074805958", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075309841", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077007485", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077069081", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077206566", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077833310", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078035410", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078733707", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079250634", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079469206", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079995109", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081908522", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082015539", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082132799", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082393884", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082415552", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1995.13.7.1649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082430897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082446082", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082802906", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.annonc.a059353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082883751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083060235", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.9.2943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083316814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083339597", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083347234", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083347573", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-11", 
    "datePublishedReg": "2008-11-01", 
    "description": "Murine L1210 leukaemia cells expressing either the reduced folate carrier (RFC) or the membrane folate receptor (MFR) were studied in vitro and in vivo to assess the dynamics of membrane transport of two categories antifolates; folate-based inhibitors of dihydrofolate reductase (methotrexate, edatrexate, aminopterin, PT523, and PT644) and thymidylate synthase (TS) [CB3717, raltitrexed, plevitrexed (BGC9331), pemetrexed and GW1843]. The potency of in situ inhibition of TS was used as an endpoint to analyze the in vitro dynamics of RFC/MFR-membrane transport of these antifolates. Both for L1210-RFC and L1210-MFR cells, the potency of in situ TS inhibition was closely correlated with increasing affinities of these transporters for the antifolates (r = 0.64, P < 0.05 and r = -0.65, P < 0.05, respectively). Within the group of antifolates for which MFR had a low binding affinity, those that had the ability to become polyglutamylated, were more potent inhibitors of TS in situ activity than non-polyglutamatable antifolates. In vivo activity of methotrexate, edatrexate, raltitrexed and pemetrexed was assessed in L1210-RFC and L1210-MFR bearing mice that were fed either a standard or a folate-deficient chow. Dietary folate depletion significantly reduced the MTD for methotrexate (sevenfold), edatrexate (sevenfold), raltitrexed (50-fold) and pemetrexed (150-fold). Based on increased life spans, antitumor effects of methotrexate and edatrexate were markedly better in L1210-RFC bearing mice on the folate-deficient chow (ILS: 455 and 544%, respectively) than on standard chow (ILS: 213 and 263%, respectively). No therapeutic effects of methotrexate and edatrexate were observed for L1210-MFR bearing mice on either chow condition, which may be consistent with the low binding affinity for MFR. Irrespective of the folate diet status, pemetrexed and raltitrexed were inactive against both L1210-RFC and L1210-MFR bearing mice, which may be due to high circulating plasma thymidine levels. Collectively, this study underscores that modulation of dietary folate status can provide a basis within which the therapeutic effect of antifolates may be further improved.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00280-008-0683-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1088364", 
        "issn": [
          "0344-5704", 
          "1432-0843"
        ], 
        "name": "Cancer Chemotherapy and Pharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "62"
      }
    ], 
    "name": "Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo", 
    "pagination": "937-948", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fffc6814bc47790827eed544073b04cec837f7934a488be9327cc346baa436fd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18283461"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7806519"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00280-008-0683-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1053743201"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00280-008-0683-0", 
      "https://app.dimensions.ai/details/publication/pub.1053743201"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13087_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00280-008-0683-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00280-008-0683-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00280-008-0683-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00280-008-0683-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00280-008-0683-0'


 

This table displays all metadata directly associated to this object as RDF triples.

394 TRIPLES      21 PREDICATES      120 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00280-008-0683-0 schema:about N02b3650508354823ae223eaa9f42e17e
2 N146e709b052c49588c167c5e93f844a3
3 N16467fa778784e5eaa24d35d27dfceac
4 N1889c6ac9a844f71a49c39c4af854968
5 N3dc6646d5e394705905c66f552860d64
6 N59deb7a3b74441c8a2c10ccec360dc8b
7 N615d835d69454f9aae032fbd0e96364c
8 N7107c5fef2cb434d9eb81d55cdda44bb
9 N7b2befc7088d4b4fb0eb9951fcdf42ff
10 N81186839e40046709b40c39ca2558fc1
11 Nb14867b0c2ab431bb02727147fab78e9
12 Nbe09a3b62a1c413fba0f54d7855dbda7
13 Nc4e905a79b8a42fcb2296f1472fe3246
14 Nc97bf9be0e7f4e44982bb06126034a24
15 Nce97225f79544dc08bc934986ac3204c
16 Nd9189719600b48978bbb6fb6e29548e9
17 Ne47a1632ba52442a97e37042b74d8219
18 Neb3a5ed86c7449d1974dd31e4af7c9ef
19 Neff6e59fbbda4547b167d38f22f0f40b
20 Nf3bf6f74b4884e88a113133a4fff9202
21 Nf676c1e99e4b42f9b95cb0e7291a1751
22 anzsrc-for:06
23 anzsrc-for:0601
24 schema:author Ncd9e636c0d4a4d1fb762bc3d2b0d363e
25 schema:citation sg:pub.10.1007/978-1-4615-2960-6_93
26 sg:pub.10.1007/978-1-59259-725-3_14
27 sg:pub.10.1007/978-1-59259-725-3_20
28 sg:pub.10.1007/s00280-003-0625-9
29 sg:pub.10.1007/s00280-005-0115-3
30 sg:pub.10.1007/s10555-007-9048-0
31 sg:pub.10.1007/s10555-007-9049-z
32 sg:pub.10.1007/s10637-005-4541-1
33 https://app.dimensions.ai/details/publication/pub.1074254081
34 https://app.dimensions.ai/details/publication/pub.1074273176
35 https://app.dimensions.ai/details/publication/pub.1074474441
36 https://app.dimensions.ai/details/publication/pub.1074563014
37 https://app.dimensions.ai/details/publication/pub.1074805958
38 https://app.dimensions.ai/details/publication/pub.1075309841
39 https://app.dimensions.ai/details/publication/pub.1077007485
40 https://app.dimensions.ai/details/publication/pub.1077069081
41 https://app.dimensions.ai/details/publication/pub.1077206566
42 https://app.dimensions.ai/details/publication/pub.1077833310
43 https://app.dimensions.ai/details/publication/pub.1078035410
44 https://app.dimensions.ai/details/publication/pub.1078733707
45 https://app.dimensions.ai/details/publication/pub.1079250634
46 https://app.dimensions.ai/details/publication/pub.1079469206
47 https://app.dimensions.ai/details/publication/pub.1079995109
48 https://app.dimensions.ai/details/publication/pub.1081908522
49 https://app.dimensions.ai/details/publication/pub.1082015539
50 https://app.dimensions.ai/details/publication/pub.1082132799
51 https://app.dimensions.ai/details/publication/pub.1082393884
52 https://app.dimensions.ai/details/publication/pub.1082415552
53 https://app.dimensions.ai/details/publication/pub.1082446082
54 https://app.dimensions.ai/details/publication/pub.1082802906
55 https://app.dimensions.ai/details/publication/pub.1083060235
56 https://app.dimensions.ai/details/publication/pub.1083339597
57 https://app.dimensions.ai/details/publication/pub.1083347234
58 https://app.dimensions.ai/details/publication/pub.1083347573
59 https://doi.org/10.1002/(sici)1097-0215(19980105)75:1<125::aid-ijc19>3.0.co;2-f
60 https://doi.org/10.1016/0006-2952(84)90089-3
61 https://doi.org/10.1016/0006-2952(85)90788-9
62 https://doi.org/10.1016/0006-2952(92)90089-2
63 https://doi.org/10.1016/0006-2952(93)90604-u
64 https://doi.org/10.1016/0006-2952(94)90103-1
65 https://doi.org/10.1016/0006-2952(96)00347-4
66 https://doi.org/10.1016/0959-8049(95)00172-f
67 https://doi.org/10.1016/j.addr.2004.01.001
68 https://doi.org/10.1016/j.addr.2004.01.003
69 https://doi.org/10.1016/j.cell.2006.09.041
70 https://doi.org/10.1016/j.drup.2006.09.001
71 https://doi.org/10.1016/s0083-6729(03)01012-4
72 https://doi.org/10.1016/s0899-9007(01)00618-9
73 https://doi.org/10.1016/s0959-8049(97)84450-4
74 https://doi.org/10.1021/bi00446a042
75 https://doi.org/10.1042/bst0230884
76 https://doi.org/10.1046/j.1365-2141.2000.02071.x
77 https://doi.org/10.1053/sonc.2002.37465
78 https://doi.org/10.1073/pnas.83.16.5983
79 https://doi.org/10.1074/jbc.270.14.7842
80 https://doi.org/10.1074/jbc.270.39.22974
81 https://doi.org/10.1074/jbc.273.46.30189
82 https://doi.org/10.1083/jcb.132.1.35
83 https://doi.org/10.1093/oxfordjournals.annonc.a059353
84 https://doi.org/10.1097/00001813-200501000-00001
85 https://doi.org/10.1126/science.1310359
86 https://doi.org/10.1152/ajpcell.00202.2007
87 https://doi.org/10.1158/0008-5472.can-05-2034
88 https://doi.org/10.1158/0008-5472.can-05-4048
89 https://doi.org/10.1158/1078-0432.ccr-05-0355
90 https://doi.org/10.1158/1078-0432.ccr-05-9009
91 https://doi.org/10.1158/1078-0432.ccr-1066-03
92 https://doi.org/10.1200/jco.1995.13.7.1649
93 https://doi.org/10.1200/jco.1998.16.9.2943
94 https://doi.org/10.1517/13543784.5.6.719
95 schema:datePublished 2008-11
96 schema:datePublishedReg 2008-11-01
97 schema:description Murine L1210 leukaemia cells expressing either the reduced folate carrier (RFC) or the membrane folate receptor (MFR) were studied in vitro and in vivo to assess the dynamics of membrane transport of two categories antifolates; folate-based inhibitors of dihydrofolate reductase (methotrexate, edatrexate, aminopterin, PT523, and PT644) and thymidylate synthase (TS) [CB3717, raltitrexed, plevitrexed (BGC9331), pemetrexed and GW1843]. The potency of in situ inhibition of TS was used as an endpoint to analyze the in vitro dynamics of RFC/MFR-membrane transport of these antifolates. Both for L1210-RFC and L1210-MFR cells, the potency of in situ TS inhibition was closely correlated with increasing affinities of these transporters for the antifolates (r = 0.64, P < 0.05 and r = -0.65, P < 0.05, respectively). Within the group of antifolates for which MFR had a low binding affinity, those that had the ability to become polyglutamylated, were more potent inhibitors of TS in situ activity than non-polyglutamatable antifolates. In vivo activity of methotrexate, edatrexate, raltitrexed and pemetrexed was assessed in L1210-RFC and L1210-MFR bearing mice that were fed either a standard or a folate-deficient chow. Dietary folate depletion significantly reduced the MTD for methotrexate (sevenfold), edatrexate (sevenfold), raltitrexed (50-fold) and pemetrexed (150-fold). Based on increased life spans, antitumor effects of methotrexate and edatrexate were markedly better in L1210-RFC bearing mice on the folate-deficient chow (ILS: 455 and 544%, respectively) than on standard chow (ILS: 213 and 263%, respectively). No therapeutic effects of methotrexate and edatrexate were observed for L1210-MFR bearing mice on either chow condition, which may be consistent with the low binding affinity for MFR. Irrespective of the folate diet status, pemetrexed and raltitrexed were inactive against both L1210-RFC and L1210-MFR bearing mice, which may be due to high circulating plasma thymidine levels. Collectively, this study underscores that modulation of dietary folate status can provide a basis within which the therapeutic effect of antifolates may be further improved.
98 schema:genre research_article
99 schema:inLanguage en
100 schema:isAccessibleForFree true
101 schema:isPartOf N8fbed97d820d433088188efb05817de3
102 N939a98377c4849c4aa45bc5d17457a3f
103 sg:journal.1088364
104 schema:name Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo
105 schema:pagination 937-948
106 schema:productId N297719f450c445f0ab1c0f2c510946c4
107 N587c6642b6e34bbc916e6fb055adb041
108 Na7ee574071fc4368ab6429a859678d93
109 Ncf2741d2afca40ac974529f6d432118a
110 Ne8f8b699d3f74a5eb0d999e32f188458
111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053743201
112 https://doi.org/10.1007/s00280-008-0683-0
113 schema:sdDatePublished 2019-04-11T14:30
114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
115 schema:sdPublisher Nd99acea2682b4f688f1396f4247c5a1b
116 schema:url http://link.springer.com/10.1007/s00280-008-0683-0
117 sgo:license sg:explorer/license/
118 sgo:sdDataset articles
119 rdf:type schema:ScholarlyArticle
120 N02b3650508354823ae223eaa9f42e17e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Cell Line, Tumor
122 rdf:type schema:DefinedTerm
123 N0f8bef1bb0114883857e3c1cbb070f1d rdf:first sg:person.01171546142.92
124 rdf:rest N66b69155534b4b05885b0ae08468cb76
125 N146e709b052c49588c167c5e93f844a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Membrane Transport Proteins
127 rdf:type schema:DefinedTerm
128 N16467fa778784e5eaa24d35d27dfceac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Mice
130 rdf:type schema:DefinedTerm
131 N1889c6ac9a844f71a49c39c4af854968 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Biological Transport
133 rdf:type schema:DefinedTerm
134 N297719f450c445f0ab1c0f2c510946c4 schema:name nlm_unique_id
135 schema:value 7806519
136 rdf:type schema:PropertyValue
137 N32e4e41fd8ee420fbfc069d7a045b266 rdf:first sg:person.01016732673.95
138 rdf:rest Nb0784cac033740ae94d511934914997a
139 N3dc6646d5e394705905c66f552860d64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Tetrahydrofolate Dehydrogenase
141 rdf:type schema:DefinedTerm
142 N587c6642b6e34bbc916e6fb055adb041 schema:name readcube_id
143 schema:value fffc6814bc47790827eed544073b04cec837f7934a488be9327cc346baa436fd
144 rdf:type schema:PropertyValue
145 N59deb7a3b74441c8a2c10ccec360dc8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Reduced Folate Carrier Protein
147 rdf:type schema:DefinedTerm
148 N615d835d69454f9aae032fbd0e96364c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Ascitic Fluid
150 rdf:type schema:DefinedTerm
151 N66b69155534b4b05885b0ae08468cb76 rdf:first sg:person.013473012337.33
152 rdf:rest N32e4e41fd8ee420fbfc069d7a045b266
153 N7107c5fef2cb434d9eb81d55cdda44bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name In Vitro Techniques
155 rdf:type schema:DefinedTerm
156 N7b2befc7088d4b4fb0eb9951fcdf42ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Receptors, Cell Surface
158 rdf:type schema:DefinedTerm
159 N7ff2b866f6694673814e971e4e7b846d rdf:first sg:person.0600545135.26
160 rdf:rest Nd385d85bf74040a3b7792d8f2147cfcb
161 N81186839e40046709b40c39ca2558fc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Folic Acid Antagonists
163 rdf:type schema:DefinedTerm
164 N8fbed97d820d433088188efb05817de3 schema:volumeNumber 62
165 rdf:type schema:PublicationVolume
166 N939a98377c4849c4aa45bc5d17457a3f schema:issueNumber 6
167 rdf:type schema:PublicationIssue
168 Na1e1411cc8334073903fc5aa6337d23d schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
169 schema:familyName Teshale
170 schema:givenName Habte
171 rdf:type schema:Person
172 Na7ee574071fc4368ab6429a859678d93 schema:name pubmed_id
173 schema:value 18283461
174 rdf:type schema:PropertyValue
175 Nb0784cac033740ae94d511934914997a rdf:first sg:person.01273433134.01
176 rdf:rest rdf:nil
177 Nb127b8780af94d7d813656b0ce9d420e rdf:first sg:person.01255301342.17
178 rdf:rest N7ff2b866f6694673814e971e4e7b846d
179 Nb14867b0c2ab431bb02727147fab78e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Neoplasm Proteins
181 rdf:type schema:DefinedTerm
182 Nbe09a3b62a1c413fba0f54d7855dbda7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Polyglutamic Acid
184 rdf:type schema:DefinedTerm
185 Nc4e905a79b8a42fcb2296f1472fe3246 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Animals
187 rdf:type schema:DefinedTerm
188 Nc97bf9be0e7f4e44982bb06126034a24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Folic Acid Deficiency
190 rdf:type schema:DefinedTerm
191 Ncd9e636c0d4a4d1fb762bc3d2b0d363e rdf:first sg:person.0645332635.23
192 rdf:rest Nb127b8780af94d7d813656b0ce9d420e
193 Nce97225f79544dc08bc934986ac3204c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Mice, Inbred DBA
195 rdf:type schema:DefinedTerm
196 Ncf2741d2afca40ac974529f6d432118a schema:name dimensions_id
197 schema:value pub.1053743201
198 rdf:type schema:PropertyValue
199 Nd385d85bf74040a3b7792d8f2147cfcb rdf:first Na1e1411cc8334073903fc5aa6337d23d
200 rdf:rest N0f8bef1bb0114883857e3c1cbb070f1d
201 Nd9189719600b48978bbb6fb6e29548e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Thymidylate Synthase
203 rdf:type schema:DefinedTerm
204 Nd99acea2682b4f688f1396f4247c5a1b schema:name Springer Nature - SN SciGraph project
205 rdf:type schema:Organization
206 Ne47a1632ba52442a97e37042b74d8219 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Leukemia L1210
208 rdf:type schema:DefinedTerm
209 Ne8f8b699d3f74a5eb0d999e32f188458 schema:name doi
210 schema:value 10.1007/s00280-008-0683-0
211 rdf:type schema:PropertyValue
212 Neb3a5ed86c7449d1974dd31e4af7c9ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Folate Receptors, GPI-Anchored
214 rdf:type schema:DefinedTerm
215 Neff6e59fbbda4547b167d38f22f0f40b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Carrier Proteins
217 rdf:type schema:DefinedTerm
218 Nf3bf6f74b4884e88a113133a4fff9202 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Maximum Tolerated Dose
220 rdf:type schema:DefinedTerm
221 Nf676c1e99e4b42f9b95cb0e7291a1751 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Female
223 rdf:type schema:DefinedTerm
224 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
225 schema:name Biological Sciences
226 rdf:type schema:DefinedTerm
227 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
228 schema:name Biochemistry and Cell Biology
229 rdf:type schema:DefinedTerm
230 sg:journal.1088364 schema:issn 0344-5704
231 1432-0843
232 schema:name Cancer Chemotherapy and Pharmacology
233 rdf:type schema:Periodical
234 sg:person.01016732673.95 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
235 schema:familyName Pinedo
236 schema:givenName Herbert M.
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016732673.95
238 rdf:type schema:Person
239 sg:person.01171546142.92 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
240 schema:familyName Noordhuis
241 schema:givenName Paul
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171546142.92
243 rdf:type schema:Person
244 sg:person.01255301342.17 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
245 schema:familyName Peters
246 schema:givenName Godefridus J.
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255301342.17
248 rdf:type schema:Person
249 sg:person.01273433134.01 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
250 schema:familyName Jansen
251 schema:givenName Gerrit
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273433134.01
253 rdf:type schema:Person
254 sg:person.013473012337.33 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
255 schema:familyName Comijn
256 schema:givenName Elizabeth M.
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013473012337.33
258 rdf:type schema:Person
259 sg:person.0600545135.26 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
260 schema:familyName Kathmann
261 schema:givenName Ietje
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600545135.26
263 rdf:type schema:Person
264 sg:person.0645332635.23 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
265 schema:familyName Mauritz
266 schema:givenName Robert
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645332635.23
268 rdf:type schema:Person
269 sg:pub.10.1007/978-1-4615-2960-6_93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012282808
270 https://doi.org/10.1007/978-1-4615-2960-6_93
271 rdf:type schema:CreativeWork
272 sg:pub.10.1007/978-1-59259-725-3_14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011665662
273 https://doi.org/10.1007/978-1-59259-725-3_14
274 rdf:type schema:CreativeWork
275 sg:pub.10.1007/978-1-59259-725-3_20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017540635
276 https://doi.org/10.1007/978-1-59259-725-3_20
277 rdf:type schema:CreativeWork
278 sg:pub.10.1007/s00280-003-0625-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045241343
279 https://doi.org/10.1007/s00280-003-0625-9
280 rdf:type schema:CreativeWork
281 sg:pub.10.1007/s00280-005-0115-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008530951
282 https://doi.org/10.1007/s00280-005-0115-3
283 rdf:type schema:CreativeWork
284 sg:pub.10.1007/s10555-007-9048-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031189710
285 https://doi.org/10.1007/s10555-007-9048-0
286 rdf:type schema:CreativeWork
287 sg:pub.10.1007/s10555-007-9049-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1003553463
288 https://doi.org/10.1007/s10555-007-9049-z
289 rdf:type schema:CreativeWork
290 sg:pub.10.1007/s10637-005-4541-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016798569
291 https://doi.org/10.1007/s10637-005-4541-1
292 rdf:type schema:CreativeWork
293 https://app.dimensions.ai/details/publication/pub.1074254081 schema:CreativeWork
294 https://app.dimensions.ai/details/publication/pub.1074273176 schema:CreativeWork
295 https://app.dimensions.ai/details/publication/pub.1074474441 schema:CreativeWork
296 https://app.dimensions.ai/details/publication/pub.1074563014 schema:CreativeWork
297 https://app.dimensions.ai/details/publication/pub.1074805958 schema:CreativeWork
298 https://app.dimensions.ai/details/publication/pub.1075309841 schema:CreativeWork
299 https://app.dimensions.ai/details/publication/pub.1077007485 schema:CreativeWork
300 https://app.dimensions.ai/details/publication/pub.1077069081 schema:CreativeWork
301 https://app.dimensions.ai/details/publication/pub.1077206566 schema:CreativeWork
302 https://app.dimensions.ai/details/publication/pub.1077833310 schema:CreativeWork
303 https://app.dimensions.ai/details/publication/pub.1078035410 schema:CreativeWork
304 https://app.dimensions.ai/details/publication/pub.1078733707 schema:CreativeWork
305 https://app.dimensions.ai/details/publication/pub.1079250634 schema:CreativeWork
306 https://app.dimensions.ai/details/publication/pub.1079469206 schema:CreativeWork
307 https://app.dimensions.ai/details/publication/pub.1079995109 schema:CreativeWork
308 https://app.dimensions.ai/details/publication/pub.1081908522 schema:CreativeWork
309 https://app.dimensions.ai/details/publication/pub.1082015539 schema:CreativeWork
310 https://app.dimensions.ai/details/publication/pub.1082132799 schema:CreativeWork
311 https://app.dimensions.ai/details/publication/pub.1082393884 schema:CreativeWork
312 https://app.dimensions.ai/details/publication/pub.1082415552 schema:CreativeWork
313 https://app.dimensions.ai/details/publication/pub.1082446082 schema:CreativeWork
314 https://app.dimensions.ai/details/publication/pub.1082802906 schema:CreativeWork
315 https://app.dimensions.ai/details/publication/pub.1083060235 schema:CreativeWork
316 https://app.dimensions.ai/details/publication/pub.1083339597 schema:CreativeWork
317 https://app.dimensions.ai/details/publication/pub.1083347234 schema:CreativeWork
318 https://app.dimensions.ai/details/publication/pub.1083347573 schema:CreativeWork
319 https://doi.org/10.1002/(sici)1097-0215(19980105)75:1<125::aid-ijc19>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1010329026
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/0006-2952(84)90089-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053719614
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/0006-2952(85)90788-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049215064
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/0006-2952(92)90089-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047682989
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/0006-2952(93)90604-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1047478112
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/0006-2952(94)90103-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011276203
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/0006-2952(96)00347-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015171581
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/0959-8049(95)00172-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1017099685
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/j.addr.2004.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041904527
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/j.addr.2004.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024317773
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/j.cell.2006.09.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034570301
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/j.drup.2006.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004515166
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/s0083-6729(03)01012-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020010647
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/s0899-9007(01)00618-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014958722
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1016/s0959-8049(97)84450-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045357440
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1021/bi00446a042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055176575
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1042/bst0230884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038930893
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1046/j.1365-2141.2000.02071.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015436846
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1053/sonc.2002.37465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057078615
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1073/pnas.83.16.5983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016863685
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1074/jbc.270.14.7842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018428858
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1074/jbc.270.39.22974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006007206
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1074/jbc.273.46.30189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024128522
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1083/jcb.132.1.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004848209
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1093/oxfordjournals.annonc.a059353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082883751
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1097/00001813-200501000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028681767
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1126/science.1310359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062474502
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1152/ajpcell.00202.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040033882
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1158/0008-5472.can-05-2034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010187263
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1158/0008-5472.can-05-4048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028114996
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1158/1078-0432.ccr-05-0355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040881104
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1158/1078-0432.ccr-05-9009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002631220
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1158/1078-0432.ccr-1066-03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009592571
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1200/jco.1995.13.7.1649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082430897
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1200/jco.1998.16.9.2943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083316814
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1517/13543784.5.6.719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012565716
390 rdf:type schema:CreativeWork
391 https://www.grid.ac/institutes/grid.16872.3a schema:alternateName VU University Medical Center
392 schema:name Department of Medical Oncology, VU University Medical Center, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands
393 Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
394 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...