A phase II study of paclitaxel combined with infusional 5-fluorouracil and low-dose leucovorin for advanced gastric cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-06-02

AUTHORS

Chong Kun Im, Hei-Cheul Jeung, Sun Young Rha, Nae Choon Yoo, Sung Hoon Noh, Jae Kyung Roh, Hyun Cheol Chung

ABSTRACT

PurposeThe aim of this study was to investigate the efficacy and safety of the combination chemotherapy of paclitaxel, infusional 5-fluorouracil (5-FU) and leucovorin (FLT regimen) in advanced gastric cancer. The primary end point was the time to progression (TTP).MethodsPatients with evaluable disease with or without measurable lesions received 175 mg/m2 paclitaxel on day 1 followed by 20 mg/m2 leucovorin and 24-h infusion of 5-FU 1,000 mg/m2 (day 1-3) repeated every 3 weeks.ResultsSixty patients were enrolled. The median TTP and overall survival duration were 13 and 60 weeks, respectively. One-year survival rate was 53.3%. Of the 50 patients with measurable lesion, the overall response rate was 31.7%. The most common grade 3–4 adverse event was neutropenia (61.7%).ConclusionThe FLT regimen showed an efficacy comparable to other regimens of cisplatin or anthracycline combinations with the advantage of remarkably low non-hematological toxicity. These data about the efficacy of this regimen need confirmation in a phase III trial. More... »

PAGES

315-321

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00280-007-0508-6

DOI

http://dx.doi.org/10.1007/s00280-007-0508-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036594365

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18026677


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