Irofulven as first line therapy in recurrent or metastatic gastric cancer: a phase II multicenter study by the Cancer Therapeutics ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-06-17

AUTHORS

W. Yeo, M. Boyer, H. C. Chung, S. Y. K. Ong, R. Lim, Benny Zee, B. Ma, K. C. Lam, F. K. F. Mo, E. K. W. Ng, R. Ho, S. Clarke, J. K. Roh, P. Beale, S. Y. Rha, H. C. Jeung, R. Soo, B. C. Goh, A. T. C. Chan

ABSTRACT

BackgroundThe purpose of this study was to evaluate the tolerability and efficacy of irofulven, a DNA interacting acylfulvene analog, as first line therapy for patients with recurrent or metastatic gastric cancer.Patients and methodsTwenty-three patients with recurrent or metastatic gastric cancer received irofulven at a dose of 0.45 mg/kg administered intravenously over 30-min infusion (up to a maximum of 50 mg), on days 1 and 8, every 3 weeks.ResultsThe median number of cycles delivered per patient was 2 (range 1–6). Two patients (9%) had ≥ 1-week delay in administration of subsequent cycle of chemotherapy. For the day 8 chemotherapy, dose reductions were required in seven patients (30%); dose omitting occurred in five patients (22%). Grade 3/4 anemia and neutropenia occurred in 22 and 17% of patients, respectively. There was no grade 4 thrombocytopenia and no neutropenic fever was observed. Of the 20 evaluable patients, there were no responses observed, 3 patients had stable disease after 2 cycles of treatment which was not confirmed by a further assessment. Median overall survival was 6.05 months (95% CI 4.55–9.39).ConclusionsIrofulven was tolerated at the dose of 0.45 mg/kg on days 1 and 8, every 3 weeks but showed no evidence of antitumor activity in patients with advanced gastric cancer. More... »

PAGES

295-300

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00280-006-0270-1

DOI

http://dx.doi.org/10.1007/s00280-006-0270-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012453275

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16783579


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