Ontology type: schema:ScholarlyArticle
2003-07
AUTHORSG. J. Peters, P. Noordhuis, A. B. P. Van Kuilenburg, J. H. Schornagel, H. Gall, S. L. Turner, M. S. Swart, D. Voorn, A. H. Van Gennip, J. Wanders, U. Holwerda, K. Smid, G. Giaccone, P. Fumoleau, C. J. Van Groeningen
ABSTRACTS-1 is an oral formulation of ftorafur (FT), oxonic acid and 5-chloro-2,4-dihydroxypyridine (CDHP) at a molar ratio of 1:0.4:1. FT is a 5-fluorouracil (5-FU) prodrug, CDHP is a dihydropyrimidine dehydrogenase (DPD) inhibitor and oxonic acid is an inhibitor of 5-FU phosphoribosylation in the gastrointestinal mucosa and was included to prevent gastrointestinal toxicity. We determined the pharmacokinetics of S-1 in 28 patients at doses of 25, 35, 40 and 45 mg/m(2). The plasma C(max) values of FT, 5-FU, oxonic acid and CDHP increased dose-dependently and after 1-2 h were in the ranges 5.8-13 microM, 0.4-2.4 microM, 0.026-1.337 microM, and 1.1-3.6 microM, respectively. Uracil levels, indicative of DPD inhibition, also increased dose-dependently from basal levels of 0.03-0.25 microM to 3.6-9.4 microM after 2-4 h, and 0.09-0.9 microM was still present after 24 h. The pharmacokinetics of CDHP and uracil were linear over the dose range. The areas under the plasma concentration curves (AUC) for CDHP and uracil were in the ranges 418-1735 and 2281-8627 micromol x min/l, respectively. The t(1/2) values were in the ranges 213-692 and 216-354 min, respectively. Cumulative urinary excretion of FT was predominantly as 5-FU and was 2.2-11.9%; the urinary excretion of both fluoro-beta-alanine and uracil was generally maximal between 6 and 18 h. During 28-day courses with twice-daily S-1 administration, 5-FU and uracil generally increased. Before each intake of S-1, 5-FU varied between 0.5 and 1 microM and uracil was in the micromolar range (up to 7 microM), indicating that effective DPD inhibition was maintained during the course. In a biopsy of an esophageal adenocarcinoma metastasis that had regressed, thymidylate synthase, the target of 5-FU, was inhibited 50%, but increased four- to tenfold after relapse in subsequent biopsies. In conclusion, oral S-1 administration resulted in prolonged exposure to micromolar 5-FU concentrations due to DPD inhibition, and the decrease in uracil levels after 6 h followed the pattern of CDHP and indicates reversible DPD inhibition. More... »
PAGES1-12
http://scigraph.springernature.com/pub.10.1007/s00280-003-0617-9
DOIhttp://dx.doi.org/10.1007/s00280-003-0617-9
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1036282560
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/12739060
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Pharmacology and Pharmaceutical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antimetabolites, Antineoplastic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Area Under Curve",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biological Availability",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dose-Response Relationship, Drug",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Combinations",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fluorouracil",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Half-Life",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Metabolic Clearance Rate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oxonic Acid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pyridines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tegafur",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tissue Distribution",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Uracil",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "VU University Medical Center",
"id": "https://www.grid.ac/institutes/grid.16872.3a",
"name": [
"Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007\u00a0MB, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Peters",
"givenName": "G. J.",
"id": "sg:person.01255301342.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255301342.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "VU University Medical Center",
"id": "https://www.grid.ac/institutes/grid.16872.3a",
"name": [
"Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007\u00a0MB, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Noordhuis",
"givenName": "P.",
"id": "sg:person.01171546142.92",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171546142.92"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Academic Medical Center",
"id": "https://www.grid.ac/institutes/grid.5650.6",
"name": [
"Laboratory of Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Van Kuilenburg",
"givenName": "A. B. P.",
"id": "sg:person.010124200377.90",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010124200377.90"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Antoni van Leeuwenhoek Hospital",
"id": "https://www.grid.ac/institutes/grid.430814.a",
"name": [
"Department of Internal Medicine, Netherlands Cancer Institute, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Schornagel",
"givenName": "J. H.",
"id": "sg:person.0600513472.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600513472.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "VU University Medical Center",
"id": "https://www.grid.ac/institutes/grid.16872.3a",
"name": [
"Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007\u00a0MB, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Gall",
"givenName": "H.",
"id": "sg:person.01023051473.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023051473.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Antoni van Leeuwenhoek Hospital",
"id": "https://www.grid.ac/institutes/grid.430814.a",
"name": [
"Department of Internal Medicine, Netherlands Cancer Institute, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Turner",
"givenName": "S. L.",
"id": "sg:person.0606744057.67",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606744057.67"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Antoni van Leeuwenhoek Hospital",
"id": "https://www.grid.ac/institutes/grid.430814.a",
"name": [
"Department of Internal Medicine, Netherlands Cancer Institute, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Swart",
"givenName": "M. S.",
"id": "sg:person.01256606405.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256606405.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "VU University Medical Center",
"id": "https://www.grid.ac/institutes/grid.16872.3a",
"name": [
"Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007\u00a0MB, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Voorn",
"givenName": "D.",
"id": "sg:person.01346612643.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346612643.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Academic Medical Center",
"id": "https://www.grid.ac/institutes/grid.5650.6",
"name": [
"Laboratory of Genetic Metabolic Diseases, Academic Medical Center, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Van Gennip",
"givenName": "A. H.",
"id": "sg:person.01220376041.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220376041.48"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"NDDO Oncology, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Wanders",
"givenName": "J.",
"id": "sg:person.01307713100.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307713100.00"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "VU University Medical Center",
"id": "https://www.grid.ac/institutes/grid.16872.3a",
"name": [
"Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Holwerda",
"givenName": "U.",
"id": "sg:person.01347171204.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347171204.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "VU University Medical Center",
"id": "https://www.grid.ac/institutes/grid.16872.3a",
"name": [
"Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007\u00a0MB, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Smid",
"givenName": "K.",
"id": "sg:person.01232364243.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232364243.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "VU University Medical Center",
"id": "https://www.grid.ac/institutes/grid.16872.3a",
"name": [
"Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007\u00a0MB, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Giaccone",
"givenName": "G.",
"id": "sg:person.01304747074.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304747074.35"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"EORTC\u2014New Drug Development Group, Nantes, France"
],
"type": "Organization"
},
"familyName": "Fumoleau",
"givenName": "P.",
"id": "sg:person.01101667531.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101667531.56"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "VU University Medical Center",
"id": "https://www.grid.ac/institutes/grid.16872.3a",
"name": [
"Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007\u00a0MB, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Van Groeningen",
"givenName": "C. J.",
"id": "sg:person.016122500204.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016122500204.87"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1054/drup.1999.0089",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000143703"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(98)00058-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004034553"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(01)00371-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008444022"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-2952(94)00444-q",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012048074"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0378-4347(01)00203-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016987868"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00685670",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017013439",
"https://doi.org/10.1007/bf00685670"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00685670",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017013439",
"https://doi.org/10.1007/bf00685670"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1081/cnv-120000360",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018308252"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archneur.1970.00480260061008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024508314"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1517/13543784.5.6.637",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025883442"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00662639",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026508229",
"https://doi.org/10.1007/bf00662639"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00662639",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026508229",
"https://doi.org/10.1007/bf00662639"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0925-4439(02)00082-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026544769"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-2952(89)90187-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027438015"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-2952(89)90187-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027438015"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000138581",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027697939"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s002800050561",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028328879",
"https://doi.org/10.1007/s002800050561"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/00498259609046718",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029977116"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-59259-725-3_5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035390634",
"https://doi.org/10.1007/978-1-59259-725-3_5"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0277-5379(87)90053-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036522081"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19911101)68:9<1903::aid-cncr2820680910>3.0.co;2-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036845106"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0959-8049(95)00217-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041155362"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/clpt.1980.156",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041499966",
"https://doi.org/10.1038/clpt.1980.156"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0959-8049(93)90129-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044367856"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0378-4347(96)00429-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046560228"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074255186",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074515759",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1999.17.8.2439",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074549863"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074570373",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2000.18.14.2772",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074667570"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074733629",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074797879",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3727/096504001108747729",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074838513"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2001.19.22.4267",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074954342"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076942345",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079562315",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079597830",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079977592",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080114929",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081600900",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082466563",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1994.12.10.2035",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082570398"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082895728",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1998.16.1.301",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083201650"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1998.16.4.1450",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083246640"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083251777",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083320099",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083370636",
"type": "CreativeWork"
}
],
"datePublished": "2003-07",
"datePublishedReg": "2003-07-01",
"description": "S-1 is an oral formulation of ftorafur (FT), oxonic acid and 5-chloro-2,4-dihydroxypyridine (CDHP) at a molar ratio of 1:0.4:1. FT is a 5-fluorouracil (5-FU) prodrug, CDHP is a dihydropyrimidine dehydrogenase (DPD) inhibitor and oxonic acid is an inhibitor of 5-FU phosphoribosylation in the gastrointestinal mucosa and was included to prevent gastrointestinal toxicity. We determined the pharmacokinetics of S-1 in 28 patients at doses of 25, 35, 40 and 45 mg/m(2). The plasma C(max) values of FT, 5-FU, oxonic acid and CDHP increased dose-dependently and after 1-2 h were in the ranges 5.8-13 microM, 0.4-2.4 microM, 0.026-1.337 microM, and 1.1-3.6 microM, respectively. Uracil levels, indicative of DPD inhibition, also increased dose-dependently from basal levels of 0.03-0.25 microM to 3.6-9.4 microM after 2-4 h, and 0.09-0.9 microM was still present after 24 h. The pharmacokinetics of CDHP and uracil were linear over the dose range. The areas under the plasma concentration curves (AUC) for CDHP and uracil were in the ranges 418-1735 and 2281-8627 micromol x min/l, respectively. The t(1/2) values were in the ranges 213-692 and 216-354 min, respectively. Cumulative urinary excretion of FT was predominantly as 5-FU and was 2.2-11.9%; the urinary excretion of both fluoro-beta-alanine and uracil was generally maximal between 6 and 18 h. During 28-day courses with twice-daily S-1 administration, 5-FU and uracil generally increased. Before each intake of S-1, 5-FU varied between 0.5 and 1 microM and uracil was in the micromolar range (up to 7 microM), indicating that effective DPD inhibition was maintained during the course. In a biopsy of an esophageal adenocarcinoma metastasis that had regressed, thymidylate synthase, the target of 5-FU, was inhibited 50%, but increased four- to tenfold after relapse in subsequent biopsies. In conclusion, oral S-1 administration resulted in prolonged exposure to micromolar 5-FU concentrations due to DPD inhibition, and the decrease in uracil levels after 6 h followed the pattern of CDHP and indicates reversible DPD inhibition.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00280-003-0617-9",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1088364",
"issn": [
"0344-5704",
"1432-0843"
],
"name": "Cancer Chemotherapy and Pharmacology",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "52"
}
],
"name": "Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors",
"pagination": "1-12",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"acd5d5a931367e586fac1b0057274724d5a4c95028c01520f1b3c8ad66ba43ff"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"12739060"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"7806519"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00280-003-0617-9"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1036282560"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00280-003-0617-9",
"https://app.dimensions.ai/details/publication/pub.1036282560"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T18:21",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000514.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs00280-003-0617-9"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00280-003-0617-9'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00280-003-0617-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00280-003-0617-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00280-003-0617-9'
This table displays all metadata directly associated to this object as RDF triples.
382 TRIPLES
21 PREDICATES
94 URIs
41 LITERALS
29 BLANK NODES