Donor lymphocyte infusion after haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-01-06

AUTHORS

Kaito Harada, Shohei Mizuno, Shingo Yano, Akiyoshi Takami, Hiroto Ishii, Kazuhiro Ikegame, Yuho Najima, Shinichi Kako, Takashi Ashida, Souichi Shiratori, Shuichi Ota, Makoto Onizuka, Kentaro Fukushima, Takahiro Fukuda, Tatsuo Ichinohe, Yoshiko Atsuta, Masamitsu Yanada

ABSTRACT

Although haploidentical donor lymphocyte infusion (DLI) is a valid treatment option for relapsed acute myeloid leukemia (AML), the incidence and risk factors for graft-versus-host disease (GVHD) and the efficacy of haploidentical DLI have not been fully evaluated. We retrospectively analyzed the outcomes after haploidentical DLI for 84 patients with AML using a nationwide database and additional questionnaires. The median number of DLI cycles and infused CD3+ cell dose was 1 and 1.0 × 106/kg, respectively. The infused CD3+ cell count of 5.0 × 105/kg or higher was associated with acute GVHD (grade II–IV, 32.1% vs. 10.5%, p = 0.03; grade III–IV, 21.4% vs. 5.3%, p = 0.10). Patients who developed grade III–IV acute GVHD more frequently succumbed to treatment-related mortality (46.7% vs. 15.8% at 1 year, p = 0.002), although the relapse-related mortality was significantly low (40.0% vs. 72.2% at 1 year, p = 0.025). The overall response to DLI was significantly higher in the preemptive DLI group (47.4%) than in the therapeutic group (13.9%, p = 0.002). In the multivariate analysis, preemptive DLI was the predictive factor for overall response (odds ratio, 5.58; p = 0.003). Our results indicated the substantial risk of acute GVHD after haploidentical DLI with CD3+ cell count of 5.0×105/kg or higher and the favorable outcomes after preemptive DLI. More... »

PAGES

643-653

References to SciGraph publications

  • 2019-02-12. Comparison of the safety and efficacy of prophylactic donor lymphocyte infusion after haploidentical versus matched-sibling PBSCT in very high-risk acute myeloid leukemia in ANNALS OF HEMATOLOGY
  • 2015-11-07. Introduction of Transplant Registry Unified Management Program 2 (TRUMP2): scripts for TRUMP data analyses, part I (variables other than HLA-related data) in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2014-10-13. DLI after haploidentical BMT with post-transplant CY in BONE MARROW TRANSPLANTATION
  • 2015-11-20. Scripts for TRUMP data analyses. Part II (HLA-related data): statistical analyses specific for hematopoietic stem cell transplantation in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2019-05-14. Prospective phase II study of prophylactic low-dose azacitidine and donor lymphocyte infusions following allogeneic hematopoietic stem cell transplantation for high-risk acute myeloid leukemia and myelodysplastic syndrome in BONE MARROW TRANSPLANTATION
  • 2019-05-18. HLA-haploidentical stem cell transplantation using posttransplant cyclophosphamide in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2017-10-16. Donor-lymphocyte infusion following haploidentical hematopoietic cell transplantation with peripheral blood stem cell grafts and PTCy in BONE MARROW TRANSPLANTATION
  • 2009-07-27. Outcome of patients developing GVHD after DLI given to treat CML relapse: a study by the chronic leukemia working party of the EBMT in BONE MARROW TRANSPLANTATION
  • 2012-12-03. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics in BONE MARROW TRANSPLANTATION
  • Journal

    TITLE

    Annals of Hematology

    ISSUE

    3

    VOLUME

    101

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00277-021-04731-5

    DOI

    http://dx.doi.org/10.1007/s00277-021-04731-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1144439988

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34988692


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blood Donors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Graft vs Host Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hematopoietic Stem Cell Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukemia, Myeloid, Acute", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphocyte Transfusion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, Tokai University School of Medicine, 143 Shimokasuya, 259-1143, Isehara, Kanagawa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.265061.6", 
              "name": [
                "Department of Hematology and Oncology, Tokai University School of Medicine, 143 Shimokasuya, 259-1143, Isehara, Kanagawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Harada", 
            "givenName": "Kaito", 
            "id": "sg:person.01251211405.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251211405.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411234.1", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mizuno", 
            "givenName": "Shohei", 
            "id": "sg:person.0677731025.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677731025.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinical Oncology and Hematology, The Jikei University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411898.d", 
              "name": [
                "Clinical Oncology and Hematology, The Jikei University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yano", 
            "givenName": "Shingo", 
            "id": "sg:person.01265010246.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411234.1", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takami", 
            "givenName": "Akiyoshi", 
            "id": "sg:person.0577702220.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577702220.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinical Oncology and Hematology, The Jikei University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411898.d", 
              "name": [
                "Clinical Oncology and Hematology, The Jikei University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishii", 
            "givenName": "Hiroto", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Hyogo College of Medicine Hospital, Nishinomiya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272264.7", 
              "name": [
                "Department of Hematology, Hyogo College of Medicine Hospital, Nishinomiya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ikegame", 
            "givenName": "Kazuhiro", 
            "id": "sg:person.01126146426.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126146426.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415479.a", 
              "name": [
                "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Najima", 
            "givenName": "Yuho", 
            "id": "sg:person.01214267464.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214267464.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415020.2", 
              "name": [
                "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kako", 
            "givenName": "Shinichi", 
            "id": "sg:person.0675760325.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675760325.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Hospital, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413111.7", 
              "name": [
                "Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Hospital, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ashida", 
            "givenName": "Takashi", 
            "id": "sg:person.0740242433.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740242433.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Hokkaido University Hospital, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412167.7", 
              "name": [
                "Department of Hematology, Hokkaido University Hospital, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shiratori", 
            "givenName": "Souichi", 
            "id": "sg:person.0653535643.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653535643.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415262.6", 
              "name": [
                "Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ota", 
            "givenName": "Shuichi", 
            "id": "sg:person.011176077202.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011176077202.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, Tokai University School of Medicine, 143 Shimokasuya, 259-1143, Isehara, Kanagawa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.265061.6", 
              "name": [
                "Department of Hematology and Oncology, Tokai University School of Medicine, 143 Shimokasuya, 259-1143, Isehara, Kanagawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Onizuka", 
            "givenName": "Makoto", 
            "id": "sg:person.01046262603.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046262603.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan", 
              "id": "http://www.grid.ac/institutes/grid.136593.b", 
              "name": [
                "Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukushima", 
            "givenName": "Kentaro", 
            "id": "sg:person.0603726437.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603726437.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematopoietic Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Hematopoietic Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukuda", 
            "givenName": "Takahiro", 
            "id": "sg:person.016452523632.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan", 
              "id": "http://www.grid.ac/institutes/grid.257022.0", 
              "name": [
                "Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ichinohe", 
            "givenName": "Tatsuo", 
            "id": "sg:person.0623252373.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623252373.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.27476.30", 
              "name": [
                "Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan", 
                "Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Atsuta", 
            "givenName": "Yoshiko", 
            "id": "sg:person.01146754030.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410800.d", 
              "name": [
                "Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yanada", 
            "givenName": "Masamitsu", 
            "id": "sg:person.01024604275.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024604275.66"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/bmt.2017.193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092233219", 
              "https://doi.org/10.1038/bmt.2017.193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-019-02660-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1114768290", 
              "https://doi.org/10.1007/s12185-019-02660-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-015-1894-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036307316", 
              "https://doi.org/10.1007/s12185-015-1894-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2012.244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028358194", 
              "https://doi.org/10.1038/bmt.2012.244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-019-03636-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112073879", 
              "https://doi.org/10.1007/s00277-019-03636-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2014.217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007553794", 
              "https://doi.org/10.1038/bmt.2014.217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2009.177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039356090", 
              "https://doi.org/10.1038/bmt.2009.177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41409-019-0536-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1114225724", 
              "https://doi.org/10.1038/s41409-019-0536-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-015-1907-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045343135", 
              "https://doi.org/10.1007/s12185-015-1907-9"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2022-01-06", 
        "datePublishedReg": "2022-01-06", 
        "description": "Although haploidentical donor lymphocyte infusion (DLI) is a valid treatment option for relapsed acute myeloid leukemia (AML), the incidence and risk factors for graft-versus-host disease (GVHD) and the efficacy of haploidentical DLI have not been fully evaluated. We retrospectively analyzed the outcomes after haploidentical DLI for 84 patients with AML using a nationwide database and additional questionnaires. The median number of DLI cycles and infused CD3+ cell dose was 1 and 1.0 \u00d7 106/kg, respectively. The infused CD3+ cell count of 5.0 \u00d7 105/kg or higher was associated with acute GVHD (grade II\u2013IV, 32.1% vs. 10.5%, p = 0.03; grade III\u2013IV, 21.4% vs. 5.3%, p = 0.10). Patients who developed grade III\u2013IV acute GVHD more frequently succumbed to treatment-related mortality (46.7% vs. 15.8% at 1 year, p = 0.002), although the relapse-related mortality was significantly low (40.0% vs. 72.2% at 1 year, p = 0.025). The overall response to DLI was significantly higher in the preemptive DLI group (47.4%) than in the therapeutic group (13.9%, p = 0.002). In the multivariate analysis, preemptive DLI was the predictive factor for overall response (odds ratio, 5.58; p = 0.003). Our results indicated the substantial risk of acute GVHD after haploidentical DLI with CD3+ cell count of 5.0\u00d7105/kg or higher and the favorable outcomes after preemptive DLI.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00277-021-04731-5", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1358129", 
            "issn": [
              "0939-5555", 
              "1432-0584"
            ], 
            "name": "Annals of Hematology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "101"
          }
        ], 
        "keywords": [
          "donor lymphocyte infusion", 
          "acute myeloid leukemia", 
          "preemptive donor lymphocyte infusion", 
          "acute GVHD", 
          "lymphocyte infusion", 
          "myeloid leukemia", 
          "haploidentical hematopoietic stem cell transplantation", 
          "cell count", 
          "hematopoietic stem cell transplantation", 
          "relapse-related mortality", 
          "treatment-related mortality", 
          "valid treatment option", 
          "stem cell transplantation", 
          "overall response", 
          "infused CD3", 
          "DLI group", 
          "host disease", 
          "predictive factors", 
          "treatment options", 
          "grade III", 
          "cell transplantation", 
          "risk factors", 
          "cell dose", 
          "nationwide database", 
          "favorable outcome", 
          "median number", 
          "therapeutic groups", 
          "multivariate analysis", 
          "GVHD", 
          "substantial risk", 
          "additional questionnaire", 
          "CD3", 
          "patients", 
          "infusion", 
          "leukemia", 
          "mortality", 
          "outcomes", 
          "count", 
          "transplantation", 
          "group", 
          "graft", 
          "incidence", 
          "disease", 
          "dose", 
          "response", 
          "efficacy", 
          "factors", 
          "risk", 
          "questionnaire", 
          "options", 
          "database", 
          "number", 
          "analysis", 
          "results", 
          "cycle"
        ], 
        "name": "Donor lymphocyte infusion after haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia", 
        "pagination": "643-653", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1144439988"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00277-021-04731-5"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "34988692"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00277-021-04731-5", 
          "https://app.dimensions.ai/details/publication/pub.1144439988"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:13", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_939.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00277-021-04731-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00277-021-04731-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00277-021-04731-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-021-04731-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-021-04731-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    355 TRIPLES      21 PREDICATES      102 URIs      85 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00277-021-04731-5 schema:about N08e739df2d4246b5b876e8e9bc6d6d5e
    2 N0cf6d4d9f0aa4a9a8b148485f0a25a4c
    3 N2cc6dc8944b149fcb5aee03bf2e8665a
    4 N2e5f64d5974c4380aa805abf6055b886
    5 N47dc2f17dd93490db9a4b9cf1a82d089
    6 N578fe07d9d554ed4b30fd8b42e331e71
    7 N7b81204abbf8416a9b0c9101a33985e8
    8 N840ec1d631024bcaa6b6a4d14c2d29df
    9 N8ecd7bf5d92841e4a59ce7bc118f1a13
    10 N9a23b59f9f46494a855955de10c41a22
    11 N9d1d4de2303a4a1aba96864254e33b91
    12 N9f436c42d18b4df7bc777d2da35eb7ea
    13 Na59bef59d7fa4ba98ef9a90b5ffca649
    14 anzsrc-for:11
    15 anzsrc-for:1102
    16 schema:author Nf39b50f5672d47bd9e4eebe61dc5852f
    17 schema:citation sg:pub.10.1007/s00277-019-03636-8
    18 sg:pub.10.1007/s12185-015-1894-x
    19 sg:pub.10.1007/s12185-015-1907-9
    20 sg:pub.10.1007/s12185-019-02660-8
    21 sg:pub.10.1038/bmt.2009.177
    22 sg:pub.10.1038/bmt.2012.244
    23 sg:pub.10.1038/bmt.2014.217
    24 sg:pub.10.1038/bmt.2017.193
    25 sg:pub.10.1038/s41409-019-0536-y
    26 schema:datePublished 2022-01-06
    27 schema:datePublishedReg 2022-01-06
    28 schema:description Although haploidentical donor lymphocyte infusion (DLI) is a valid treatment option for relapsed acute myeloid leukemia (AML), the incidence and risk factors for graft-versus-host disease (GVHD) and the efficacy of haploidentical DLI have not been fully evaluated. We retrospectively analyzed the outcomes after haploidentical DLI for 84 patients with AML using a nationwide database and additional questionnaires. The median number of DLI cycles and infused CD3+ cell dose was 1 and 1.0 × 106/kg, respectively. The infused CD3+ cell count of 5.0 × 105/kg or higher was associated with acute GVHD (grade II–IV, 32.1% vs. 10.5%, p = 0.03; grade III–IV, 21.4% vs. 5.3%, p = 0.10). Patients who developed grade III–IV acute GVHD more frequently succumbed to treatment-related mortality (46.7% vs. 15.8% at 1 year, p = 0.002), although the relapse-related mortality was significantly low (40.0% vs. 72.2% at 1 year, p = 0.025). The overall response to DLI was significantly higher in the preemptive DLI group (47.4%) than in the therapeutic group (13.9%, p = 0.002). In the multivariate analysis, preemptive DLI was the predictive factor for overall response (odds ratio, 5.58; p = 0.003). Our results indicated the substantial risk of acute GVHD after haploidentical DLI with CD3+ cell count of 5.0×105/kg or higher and the favorable outcomes after preemptive DLI.
    29 schema:genre article
    30 schema:isAccessibleForFree false
    31 schema:isPartOf N2158f6367bab4d78a7835b37963dc24a
    32 Na18d8b0784fe4b739c8f2e760a538fad
    33 sg:journal.1358129
    34 schema:keywords CD3
    35 DLI group
    36 GVHD
    37 acute GVHD
    38 acute myeloid leukemia
    39 additional questionnaire
    40 analysis
    41 cell count
    42 cell dose
    43 cell transplantation
    44 count
    45 cycle
    46 database
    47 disease
    48 donor lymphocyte infusion
    49 dose
    50 efficacy
    51 factors
    52 favorable outcome
    53 grade III
    54 graft
    55 group
    56 haploidentical hematopoietic stem cell transplantation
    57 hematopoietic stem cell transplantation
    58 host disease
    59 incidence
    60 infused CD3
    61 infusion
    62 leukemia
    63 lymphocyte infusion
    64 median number
    65 mortality
    66 multivariate analysis
    67 myeloid leukemia
    68 nationwide database
    69 number
    70 options
    71 outcomes
    72 overall response
    73 patients
    74 predictive factors
    75 preemptive donor lymphocyte infusion
    76 questionnaire
    77 relapse-related mortality
    78 response
    79 results
    80 risk
    81 risk factors
    82 stem cell transplantation
    83 substantial risk
    84 therapeutic groups
    85 transplantation
    86 treatment options
    87 treatment-related mortality
    88 valid treatment option
    89 schema:name Donor lymphocyte infusion after haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia
    90 schema:pagination 643-653
    91 schema:productId N32dbc8211fb44bb49830d7f99d94e8d5
    92 N82951a908e224c3ab2b61ac04fa6e36c
    93 Nb005763e9a334845868998b9cc3d6ddc
    94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1144439988
    95 https://doi.org/10.1007/s00277-021-04731-5
    96 schema:sdDatePublished 2022-08-04T17:13
    97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    98 schema:sdPublisher Ncd1d97bc7c4c4c33bacb8a66fb268d86
    99 schema:url https://doi.org/10.1007/s00277-021-04731-5
    100 sgo:license sg:explorer/license/
    101 sgo:sdDataset articles
    102 rdf:type schema:ScholarlyArticle
    103 N08e739df2d4246b5b876e8e9bc6d6d5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Blood Donors
    105 rdf:type schema:DefinedTerm
    106 N0cf6d4d9f0aa4a9a8b148485f0a25a4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Male
    108 rdf:type schema:DefinedTerm
    109 N1cd05fa5224d4780b05ca041f1986c2a schema:affiliation grid-institutes:grid.411898.d
    110 schema:familyName Ishii
    111 schema:givenName Hiroto
    112 rdf:type schema:Person
    113 N2158f6367bab4d78a7835b37963dc24a schema:issueNumber 3
    114 rdf:type schema:PublicationIssue
    115 N2cc6dc8944b149fcb5aee03bf2e8665a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Humans
    117 rdf:type schema:DefinedTerm
    118 N2e5f64d5974c4380aa805abf6055b886 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Adolescent
    120 rdf:type schema:DefinedTerm
    121 N32dbc8211fb44bb49830d7f99d94e8d5 schema:name doi
    122 schema:value 10.1007/s00277-021-04731-5
    123 rdf:type schema:PropertyValue
    124 N3f7ae9ea84784f94944319ba30509cab rdf:first sg:person.01214267464.19
    125 rdf:rest N52a9087e6aaa490aa586d190363fa9e5
    126 N47dc2f17dd93490db9a4b9cf1a82d089 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Lymphocyte Transfusion
    128 rdf:type schema:DefinedTerm
    129 N52a9087e6aaa490aa586d190363fa9e5 rdf:first sg:person.0675760325.07
    130 rdf:rest Nb3a58bd74da14433b60cbe61b8174e42
    131 N578fe07d9d554ed4b30fd8b42e331e71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Retrospective Studies
    133 rdf:type schema:DefinedTerm
    134 N608a6d5e63604d0283392f766be719bf rdf:first sg:person.0653535643.01
    135 rdf:rest Ne3afec60530d46af97bbcfb91b432361
    136 N72c4ce2e770c4d6bb712f709d1a6b655 rdf:first sg:person.01024604275.66
    137 rdf:rest rdf:nil
    138 N7b81204abbf8416a9b0c9101a33985e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Middle Aged
    140 rdf:type schema:DefinedTerm
    141 N82951a908e224c3ab2b61ac04fa6e36c schema:name pubmed_id
    142 schema:value 34988692
    143 rdf:type schema:PropertyValue
    144 N840ec1d631024bcaa6b6a4d14c2d29df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Female
    146 rdf:type schema:DefinedTerm
    147 N891cfd7494ff421c9b9e92614732a55e rdf:first sg:person.0623252373.33
    148 rdf:rest Nf180d6c1975b44d5ae396e9efbf82784
    149 N8ecd7bf5d92841e4a59ce7bc118f1a13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Hematopoietic Stem Cell Transplantation
    151 rdf:type schema:DefinedTerm
    152 N9a23b59f9f46494a855955de10c41a22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Young Adult
    154 rdf:type schema:DefinedTerm
    155 N9d1d4de2303a4a1aba96864254e33b91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Leukemia, Myeloid, Acute
    157 rdf:type schema:DefinedTerm
    158 N9f436c42d18b4df7bc777d2da35eb7ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Graft vs Host Disease
    160 rdf:type schema:DefinedTerm
    161 Na12308861a91435eacace559247235c1 rdf:first sg:person.01126146426.77
    162 rdf:rest N3f7ae9ea84784f94944319ba30509cab
    163 Na18d8b0784fe4b739c8f2e760a538fad schema:volumeNumber 101
    164 rdf:type schema:PublicationVolume
    165 Na59bef59d7fa4ba98ef9a90b5ffca649 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Adult
    167 rdf:type schema:DefinedTerm
    168 Na8876adc1a3b44d78ebb1d76109b05ea rdf:first sg:person.01265010246.42
    169 rdf:rest Nbdb538609b7c483b963758cb95423500
    170 Nab27ff63d8cf4dba8da0ec2655d83e5d rdf:first sg:person.016452523632.46
    171 rdf:rest N891cfd7494ff421c9b9e92614732a55e
    172 Nb005763e9a334845868998b9cc3d6ddc schema:name dimensions_id
    173 schema:value pub.1144439988
    174 rdf:type schema:PropertyValue
    175 Nb3a58bd74da14433b60cbe61b8174e42 rdf:first sg:person.0740242433.64
    176 rdf:rest N608a6d5e63604d0283392f766be719bf
    177 Nbc70fdc5970d426898dae32546a1d4db rdf:first sg:person.01046262603.08
    178 rdf:rest Nf45d27c044c9407ba5112f955a27dcd0
    179 Nbdb538609b7c483b963758cb95423500 rdf:first sg:person.0577702220.98
    180 rdf:rest Nfc923540e90d4ae487287a7cc22f8dc8
    181 Ncd1d97bc7c4c4c33bacb8a66fb268d86 schema:name Springer Nature - SN SciGraph project
    182 rdf:type schema:Organization
    183 Nd446a00ea0254c19b286676908e12936 rdf:first sg:person.0677731025.26
    184 rdf:rest Na8876adc1a3b44d78ebb1d76109b05ea
    185 Ne3afec60530d46af97bbcfb91b432361 rdf:first sg:person.011176077202.18
    186 rdf:rest Nbc70fdc5970d426898dae32546a1d4db
    187 Nf180d6c1975b44d5ae396e9efbf82784 rdf:first sg:person.01146754030.08
    188 rdf:rest N72c4ce2e770c4d6bb712f709d1a6b655
    189 Nf39b50f5672d47bd9e4eebe61dc5852f rdf:first sg:person.01251211405.80
    190 rdf:rest Nd446a00ea0254c19b286676908e12936
    191 Nf45d27c044c9407ba5112f955a27dcd0 rdf:first sg:person.0603726437.48
    192 rdf:rest Nab27ff63d8cf4dba8da0ec2655d83e5d
    193 Nfc923540e90d4ae487287a7cc22f8dc8 rdf:first N1cd05fa5224d4780b05ca041f1986c2a
    194 rdf:rest Na12308861a91435eacace559247235c1
    195 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    196 schema:name Medical and Health Sciences
    197 rdf:type schema:DefinedTerm
    198 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    199 schema:name Cardiorespiratory Medicine and Haematology
    200 rdf:type schema:DefinedTerm
    201 sg:journal.1358129 schema:issn 0939-5555
    202 1432-0584
    203 schema:name Annals of Hematology
    204 schema:publisher Springer Nature
    205 rdf:type schema:Periodical
    206 sg:person.01024604275.66 schema:affiliation grid-institutes:grid.410800.d
    207 schema:familyName Yanada
    208 schema:givenName Masamitsu
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024604275.66
    210 rdf:type schema:Person
    211 sg:person.01046262603.08 schema:affiliation grid-institutes:grid.265061.6
    212 schema:familyName Onizuka
    213 schema:givenName Makoto
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046262603.08
    215 rdf:type schema:Person
    216 sg:person.011176077202.18 schema:affiliation grid-institutes:grid.415262.6
    217 schema:familyName Ota
    218 schema:givenName Shuichi
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011176077202.18
    220 rdf:type schema:Person
    221 sg:person.01126146426.77 schema:affiliation grid-institutes:grid.272264.7
    222 schema:familyName Ikegame
    223 schema:givenName Kazuhiro
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126146426.77
    225 rdf:type schema:Person
    226 sg:person.01146754030.08 schema:affiliation grid-institutes:grid.27476.30
    227 schema:familyName Atsuta
    228 schema:givenName Yoshiko
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08
    230 rdf:type schema:Person
    231 sg:person.01214267464.19 schema:affiliation grid-institutes:grid.415479.a
    232 schema:familyName Najima
    233 schema:givenName Yuho
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214267464.19
    235 rdf:type schema:Person
    236 sg:person.01251211405.80 schema:affiliation grid-institutes:grid.265061.6
    237 schema:familyName Harada
    238 schema:givenName Kaito
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251211405.80
    240 rdf:type schema:Person
    241 sg:person.01265010246.42 schema:affiliation grid-institutes:grid.411898.d
    242 schema:familyName Yano
    243 schema:givenName Shingo
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42
    245 rdf:type schema:Person
    246 sg:person.016452523632.46 schema:affiliation grid-institutes:grid.272242.3
    247 schema:familyName Fukuda
    248 schema:givenName Takahiro
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46
    250 rdf:type schema:Person
    251 sg:person.0577702220.98 schema:affiliation grid-institutes:grid.411234.1
    252 schema:familyName Takami
    253 schema:givenName Akiyoshi
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577702220.98
    255 rdf:type schema:Person
    256 sg:person.0603726437.48 schema:affiliation grid-institutes:grid.136593.b
    257 schema:familyName Fukushima
    258 schema:givenName Kentaro
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603726437.48
    260 rdf:type schema:Person
    261 sg:person.0623252373.33 schema:affiliation grid-institutes:grid.257022.0
    262 schema:familyName Ichinohe
    263 schema:givenName Tatsuo
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623252373.33
    265 rdf:type schema:Person
    266 sg:person.0653535643.01 schema:affiliation grid-institutes:grid.412167.7
    267 schema:familyName Shiratori
    268 schema:givenName Souichi
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653535643.01
    270 rdf:type schema:Person
    271 sg:person.0675760325.07 schema:affiliation grid-institutes:grid.415020.2
    272 schema:familyName Kako
    273 schema:givenName Shinichi
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675760325.07
    275 rdf:type schema:Person
    276 sg:person.0677731025.26 schema:affiliation grid-institutes:grid.411234.1
    277 schema:familyName Mizuno
    278 schema:givenName Shohei
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677731025.26
    280 rdf:type schema:Person
    281 sg:person.0740242433.64 schema:affiliation grid-institutes:grid.413111.7
    282 schema:familyName Ashida
    283 schema:givenName Takashi
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740242433.64
    285 rdf:type schema:Person
    286 sg:pub.10.1007/s00277-019-03636-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112073879
    287 https://doi.org/10.1007/s00277-019-03636-8
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1007/s12185-015-1894-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036307316
    290 https://doi.org/10.1007/s12185-015-1894-x
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1007/s12185-015-1907-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045343135
    293 https://doi.org/10.1007/s12185-015-1907-9
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1007/s12185-019-02660-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1114768290
    296 https://doi.org/10.1007/s12185-019-02660-8
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1038/bmt.2009.177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039356090
    299 https://doi.org/10.1038/bmt.2009.177
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
    302 https://doi.org/10.1038/bmt.2012.244
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1038/bmt.2014.217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007553794
    305 https://doi.org/10.1038/bmt.2014.217
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1038/bmt.2017.193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092233219
    308 https://doi.org/10.1038/bmt.2017.193
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1038/s41409-019-0536-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1114225724
    311 https://doi.org/10.1038/s41409-019-0536-y
    312 rdf:type schema:CreativeWork
    313 grid-institutes:grid.136593.b schema:alternateName Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan
    314 schema:name Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan
    315 rdf:type schema:Organization
    316 grid-institutes:grid.257022.0 schema:alternateName Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    317 schema:name Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    318 rdf:type schema:Organization
    319 grid-institutes:grid.265061.6 schema:alternateName Department of Hematology and Oncology, Tokai University School of Medicine, 143 Shimokasuya, 259-1143, Isehara, Kanagawa, Japan
    320 schema:name Department of Hematology and Oncology, Tokai University School of Medicine, 143 Shimokasuya, 259-1143, Isehara, Kanagawa, Japan
    321 rdf:type schema:Organization
    322 grid-institutes:grid.272242.3 schema:alternateName Hematopoietic Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan
    323 schema:name Hematopoietic Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan
    324 rdf:type schema:Organization
    325 grid-institutes:grid.272264.7 schema:alternateName Department of Hematology, Hyogo College of Medicine Hospital, Nishinomiya, Japan
    326 schema:name Department of Hematology, Hyogo College of Medicine Hospital, Nishinomiya, Japan
    327 rdf:type schema:Organization
    328 grid-institutes:grid.27476.30 schema:alternateName Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
    329 schema:name Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
    330 Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
    331 rdf:type schema:Organization
    332 grid-institutes:grid.410800.d schema:alternateName Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan
    333 schema:name Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan
    334 rdf:type schema:Organization
    335 grid-institutes:grid.411234.1 schema:alternateName Division of Hematology, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan
    336 schema:name Division of Hematology, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan
    337 rdf:type schema:Organization
    338 grid-institutes:grid.411898.d schema:alternateName Clinical Oncology and Hematology, The Jikei University School of Medicine, Tokyo, Japan
    339 schema:name Clinical Oncology and Hematology, The Jikei University School of Medicine, Tokyo, Japan
    340 rdf:type schema:Organization
    341 grid-institutes:grid.412167.7 schema:alternateName Department of Hematology, Hokkaido University Hospital, Sapporo, Japan
    342 schema:name Department of Hematology, Hokkaido University Hospital, Sapporo, Japan
    343 rdf:type schema:Organization
    344 grid-institutes:grid.413111.7 schema:alternateName Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Hospital, Osaka, Japan
    345 schema:name Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Hospital, Osaka, Japan
    346 rdf:type schema:Organization
    347 grid-institutes:grid.415020.2 schema:alternateName Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
    348 schema:name Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
    349 rdf:type schema:Organization
    350 grid-institutes:grid.415262.6 schema:alternateName Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
    351 schema:name Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
    352 rdf:type schema:Organization
    353 grid-institutes:grid.415479.a schema:alternateName Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
    354 schema:name Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
    355 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...