Pre-conditioning intervention in patients with relapsed or refractory acute lymphoblastic leukemia who underwent allogeneic hematopoietic cell transplantation: a KSGCT multicenter ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-08-06

AUTHORS

Takayoshi Tachibana, Junya Kanda, Takuma Ishizaki, Yuho Najima, Masatsugu Tanaka, Noriko Doki, Shin-ichiro Fujiwara, Shun-ichi Kimura, Makoto Onizuka, Satoshi Takahashi, Takeshi Saito, Takehiko Mori, Shin Fujisawa, Emiko Sakaida, Takuya Miyazaki, Nobuyuki Aotsuka, Moritaka Gotoh, Reiko Watanabe, Katsuhiro Shono, Heiwa Kanamori, Yoshinobu Kanda, Shinichiro Okamoto

ABSTRACT

The efficacy and clinical significance of pre-conditioning intervention (PCI) before allogeneic hematopoietic cell transplantation (HCT) in patients with acute lymphoblastic leukemia (ALL) not in remission remain inconclusive. The purpose of this multicenter retrospective study was to clarify the clinical significance of PCI before HCT in patients with non-remission ALL. Patients with non-remission ALL who received HCT between 2005 and 2015 at 16 institutions were included. PCI was objectively defined and classified to three groups according to the intensity of PCI (no, intensive, or moderate). The study cohort consisted of 104 patients with a median age of 38 (range 17–68). A significant decrease of blast percentage in the peripheral blood (PB) was confirmed in both PCI groups, suggesting that PCIs were effective to stabilize the disease activity. The group with moderate PCI had higher nucleated cell count in the BM compared to the group with intensive PCI or the group without PCI. The overall survival (OS) rates of groups with intensive and no PCI showed comparable and significantly better compared to the group with moderate PCI (P = 0.009). Multivariate analysis demonstrated that the OS of moderate PCI group was significantly worse compared to that of intensive PCI group (HR = 2.43, 95% CI: 1.32–4.14, P = 0.004), while the OS of intensive PCI group was comparable to that of the group without PCI. These results suggest that the intensity of PCI rather than the response to PCI may contribute to improve the transplant outcome in patients with ALL not in remission. More... »

PAGES

2763-2771

References to SciGraph publications

  • 2020-02-27. T315I mutation exerts a dismal prognosis on adult BCR-ABL1-positive acute lymphoblastic leukemia, and salvage therapy with ponatinib or CAR-T cell and bridging to allogeneic hematopoietic stem cell transplantation can improve clinical outcomes in ANNALS OF HEMATOLOGY
  • 2019-09-27. Allogeneic stem-cell transplantation with sequential conditioning in adult patients with refractory or relapsed acute lymphoblastic leukemia: a report from the EBMT Acute Leukemia Working Party in BONE MARROW TRANSPLANTATION
  • 2006-06-26. Allogeneic hematopoietic stem cell transplantation after rituximab-containing myeloablative preparative regimen for acute lymphoblastic leukemia in BONE MARROW TRANSPLANTATION
  • 2011-08-31. Sequential chemotherapy and myeloablative allogeneic hematopoietic stem cell transplantation for refractory acute lymphoblastic leukemia in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2008-08-18. Allogeneic SCT in refractory or relapsed adult ALL is effective without prior reinduction chemotherapy in BONE MARROW TRANSPLANTATION
  • 2018-12-03. Salvage and bridging to allogeneic hematopoietic cell transplantation with ponatinib in patients with relapsed or refractory Philadelphia chromosome-positive leukemia in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2012-12-03. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics in BONE MARROW TRANSPLANTATION
  • 2000-04-26. Poor outcome in children with refractory/relapsed leukemia undergoing bone marrow transplantation with mismatched family member donors in BONE MARROW TRANSPLANTATION
  • 2005-10-31. Allogeneic stem-cell transplantation in patients with refractory acute leukemia: a long-term follow-up in BONE MARROW TRANSPLANTATION
  • 2015-12-15. Refractory acute lymphoblastic leukemia in Chinese children: bridging to stem cell transplantation with clofarabine, cyclophosphamide and etoposide in ANNALS OF HEMATOLOGY
  • Journal

    TITLE

    Annals of Hematology

    ISSUE

    11

    VOLUME

    100

    Author Affiliations

  • Department of Hematology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241 -8515, Yokohama, Japan
  • Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Japan
  • Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
  • Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan
  • Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
  • Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan
  • Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  • Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
  • Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
  • Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
  • Department of Hematology, Chiba University Hospital, Chiba, Japan
  • Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan
  • Division of Hematology-Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan
  • First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
  • Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
  • Department of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00277-021-04607-8

    DOI

    http://dx.doi.org/10.1007/s00277-021-04607-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1140245891

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34357435


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Allografts", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Combined Chemotherapy Protocols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Combined Modality Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclophosphamide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytarabine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dexamethasone", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Doxorubicin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Etoposide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hematopoietic Stem Cell Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kaplan-Meier Estimate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mitoxantrone", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Precursor Cell Lymphoblastic Leukemia-Lymphoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Recurrence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transplantation Conditioning", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vincristine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241 -8515, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414944.8", 
              "name": [
                "Department of Hematology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241 -8515, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tachibana", 
            "givenName": "Takayoshi", 
            "id": "sg:person.01074653417.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074653417.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258799.8", 
              "name": [
                "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan", 
                "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanda", 
            "givenName": "Junya", 
            "id": "sg:person.01100640630.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100640630.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.256642.1", 
              "name": [
                "Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishizaki", 
            "givenName": "Takuma", 
            "id": "sg:person.01122167503.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122167503.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415479.a", 
              "name": [
                "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Najima", 
            "givenName": "Yuho", 
            "id": "sg:person.01214267464.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214267464.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241 -8515, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414944.8", 
              "name": [
                "Department of Hematology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241 -8515, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tanaka", 
            "givenName": "Masatsugu", 
            "id": "sg:person.01171141246.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171141246.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415479.a", 
              "name": [
                "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Doki", 
            "givenName": "Noriko", 
            "id": "sg:person.01240752436.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240752436.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410804.9", 
              "name": [
                "Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fujiwara", 
            "givenName": "Shin-ichiro", 
            "id": "sg:person.01073536015.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073536015.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415020.2", 
              "name": [
                "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kimura", 
            "givenName": "Shun-ichi", 
            "id": "sg:person.0600361031.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600361031.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan", 
              "id": "http://www.grid.ac/institutes/grid.265061.6", 
              "name": [
                "Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Onizuka", 
            "givenName": "Makoto", 
            "id": "sg:person.01046262603.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046262603.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takahashi", 
            "givenName": "Satoshi", 
            "id": "sg:person.0721047700.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721047700.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411898.d", 
              "name": [
                "Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saito", 
            "givenName": "Takeshi", 
            "id": "sg:person.015754574322.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015754574322.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26091.3c", 
              "name": [
                "Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mori", 
            "givenName": "Takehiko", 
            "id": "sg:person.015512754302.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015512754302.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413045.7", 
              "name": [
                "Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fujisawa", 
            "givenName": "Shin", 
            "id": "sg:person.01145377314.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145377314.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Chiba University Hospital, Chiba, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411321.4", 
              "name": [
                "Department of Hematology, Chiba University Hospital, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sakaida", 
            "givenName": "Emiko", 
            "id": "sg:person.0775302360.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775302360.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.268441.d", 
              "name": [
                "Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miyazaki", 
            "givenName": "Takuya", 
            "id": "sg:person.01305756547.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305756547.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology-Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan", 
              "id": "http://www.grid.ac/institutes/grid.459661.9", 
              "name": [
                "Division of Hematology-Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aotsuka", 
            "givenName": "Nobuyuki", 
            "id": "sg:person.0577376767.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577376767.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410793.8", 
              "name": [
                "First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gotoh", 
            "givenName": "Moritaka", 
            "id": "sg:person.01256303666.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256303666.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watanabe", 
            "givenName": "Reiko", 
            "id": "sg:person.012637131732.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012637131732.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan", 
              "id": "http://www.grid.ac/institutes/grid.459433.c", 
              "name": [
                "Department of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shono", 
            "givenName": "Katsuhiro", 
            "id": "sg:person.01225510655.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225510655.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241 -8515, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414944.8", 
              "name": [
                "Department of Hematology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241 -8515, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanamori", 
            "givenName": "Heiwa", 
            "id": "sg:person.01060176576.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060176576.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410804.9", 
              "name": [
                "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan", 
                "Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanda", 
            "givenName": "Yoshinobu", 
            "id": "sg:person.0617055140.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617055140.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26091.3c", 
              "name": [
                "Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Okamoto", 
            "givenName": "Shinichiro", 
            "id": "sg:person.0715264147.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715264147.87"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.bmt.1705207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026148482", 
              "https://doi.org/10.1038/sj.bmt.1705207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2012.244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028358194", 
              "https://doi.org/10.1038/bmt.2012.244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-018-02571-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110344846", 
              "https://doi.org/10.1007/s12185-018-02571-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1705425", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028816747", 
              "https://doi.org/10.1038/sj.bmt.1705425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1702373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038683413", 
              "https://doi.org/10.1038/sj.bmt.1702373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-015-2577-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022653383", 
              "https://doi.org/10.1007/s00277-015-2577-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-020-03949-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1125134417", 
              "https://doi.org/10.1007/s00277-020-03949-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12185-011-0919-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021227781", 
              "https://doi.org/10.1007/s12185-011-0919-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2008.258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031232931", 
              "https://doi.org/10.1038/bmt.2008.258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41409-019-0702-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1121305376", 
              "https://doi.org/10.1038/s41409-019-0702-2"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2021-08-06", 
        "datePublishedReg": "2021-08-06", 
        "description": "The efficacy and clinical significance of pre-conditioning intervention (PCI) before allogeneic hematopoietic cell transplantation (HCT) in patients with acute lymphoblastic leukemia (ALL) not in remission remain inconclusive. The purpose of this multicenter retrospective study was to clarify the clinical significance of PCI before HCT in patients with non-remission ALL. Patients with non-remission ALL who received HCT between 2005 and 2015 at 16 institutions were included. PCI was objectively defined and classified to three groups according to the intensity of PCI (no, intensive, or moderate). The study cohort consisted of 104 patients with a median age of 38 (range 17\u201368). A significant decrease of blast percentage in the peripheral blood (PB) was confirmed in both PCI groups, suggesting that PCIs were effective to stabilize the disease activity. The group with moderate PCI had higher nucleated cell count in the BM compared to the group with intensive PCI or the group without PCI. The overall survival (OS) rates of groups with intensive and no PCI showed comparable and significantly better compared to the group with moderate PCI (P\u2009=\u20090.009). Multivariate analysis demonstrated that the OS of moderate PCI group was significantly worse compared to that of intensive PCI group (HR\u2009=\u20092.43, 95% CI: 1.32\u20134.14, P\u2009=\u20090.004), while the OS of intensive PCI group was comparable to that of the group without PCI. These results suggest that the intensity of PCI rather than the response to PCI may contribute to improve the transplant outcome in patients with ALL not in remission.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00277-021-04607-8", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1358129", 
            "issn": [
              "0939-5555", 
              "1432-0584"
            ], 
            "name": "Annals of Hematology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "11", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "100"
          }
        ], 
        "keywords": [
          "hematopoietic cell transplantation", 
          "acute lymphoblastic leukemia", 
          "allogeneic hematopoietic cell transplantation", 
          "PCI group", 
          "cell transplantation", 
          "peripheral blood", 
          "lymphoblastic leukemia", 
          "clinical significance", 
          "high nucleated cell counts", 
          "refractory acute lymphoblastic leukemia", 
          "multicenter retrospective analysis", 
          "multicenter retrospective study", 
          "overall survival rate", 
          "nucleated cell count", 
          "blast percentage", 
          "disease activity", 
          "transplant outcomes", 
          "median age", 
          "retrospective study", 
          "study cohort", 
          "retrospective analysis", 
          "patients", 
          "cell count", 
          "survival rate", 
          "multivariate analysis", 
          "significant decrease", 
          "remission", 
          "transplantation", 
          "leukemia", 
          "intervention", 
          "group", 
          "cohort", 
          "blood", 
          "efficacy", 
          "OS", 
          "age", 
          "outcomes", 
          "significance", 
          "BM", 
          "count", 
          "percentage", 
          "response", 
          "decrease", 
          "activity", 
          "study", 
          "rate", 
          "analysis", 
          "purpose", 
          "institutions", 
          "intensity", 
          "results"
        ], 
        "name": "Pre-conditioning intervention in patients with relapsed or refractory acute lymphoblastic leukemia who underwent allogeneic hematopoietic cell transplantation: a KSGCT multicenter retrospective analysis", 
        "pagination": "2763-2771", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1140245891"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00277-021-04607-8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "34357435"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00277-021-04607-8", 
          "https://app.dimensions.ai/details/publication/pub.1140245891"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-20T07:39", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_909.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00277-021-04607-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00277-021-04607-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00277-021-04607-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-021-04607-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-021-04607-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    446 TRIPLES      22 PREDICATES      111 URIs      93 LITERALS      31 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00277-021-04607-8 schema:about N08f78a01952f4146af4f29c46c19a9ab
    2 N0c153ce200fa45039e712786abd94f5e
    3 N10e66461010e4f5fac6c2e053e306a9c
    4 N1640de5a978944999f3003637fa3e06f
    5 N32e35bd93da546d29f0762c66d465ea0
    6 N37e9bc83072747959a5c87bdada9a6ae
    7 N7c75ea6d61944e54a2f1cb66636ed666
    8 N8122018d79b146ed8b7b9de182dccb0e
    9 N9a374632151f4aa7b2ade9a5191c7e7c
    10 Na2e57b51c0b7418e98575f1ee0d0dec6
    11 Naef09c2e037d4f0bbc3d8ac40fe72d15
    12 Nb623ede2e9954e89a3411622975f0b7a
    13 Nbb9b693b63bc4d51b7368df53184b754
    14 Nbca457e6ae62400eb076e8af3bdf1a77
    15 Nbe9854df80f84619ae37444e9c4a6353
    16 Nc5b0204340a04c7dbe2157051d758d74
    17 Nc5b0dc4cb3e44c2597e6f2b475ec80ee
    18 Nce211b05b4134e6093844e40586f253d
    19 Ne07f42abbc6e403287e90f6009b10910
    20 Ne696fce49ecb40f491670c07f99d1cdd
    21 Nef1b5400da2748448bc8766fa4fdb261
    22 Nf2e2691e6290473d9975181f67001e5b
    23 Nfafd3aa88d7a48b786a91ee892e529a1
    24 Nfb6f706055e24787b6983b15c28c1785
    25 anzsrc-for:11
    26 anzsrc-for:1102
    27 schema:author Naf140d4ef098426b940e8c415cfc3b14
    28 schema:citation sg:pub.10.1007/s00277-015-2577-7
    29 sg:pub.10.1007/s00277-020-03949-z
    30 sg:pub.10.1007/s12185-011-0919-3
    31 sg:pub.10.1007/s12185-018-02571-0
    32 sg:pub.10.1038/bmt.2008.258
    33 sg:pub.10.1038/bmt.2012.244
    34 sg:pub.10.1038/s41409-019-0702-2
    35 sg:pub.10.1038/sj.bmt.1702373
    36 sg:pub.10.1038/sj.bmt.1705207
    37 sg:pub.10.1038/sj.bmt.1705425
    38 schema:datePublished 2021-08-06
    39 schema:datePublishedReg 2021-08-06
    40 schema:description The efficacy and clinical significance of pre-conditioning intervention (PCI) before allogeneic hematopoietic cell transplantation (HCT) in patients with acute lymphoblastic leukemia (ALL) not in remission remain inconclusive. The purpose of this multicenter retrospective study was to clarify the clinical significance of PCI before HCT in patients with non-remission ALL. Patients with non-remission ALL who received HCT between 2005 and 2015 at 16 institutions were included. PCI was objectively defined and classified to three groups according to the intensity of PCI (no, intensive, or moderate). The study cohort consisted of 104 patients with a median age of 38 (range 17–68). A significant decrease of blast percentage in the peripheral blood (PB) was confirmed in both PCI groups, suggesting that PCIs were effective to stabilize the disease activity. The group with moderate PCI had higher nucleated cell count in the BM compared to the group with intensive PCI or the group without PCI. The overall survival (OS) rates of groups with intensive and no PCI showed comparable and significantly better compared to the group with moderate PCI (P = 0.009). Multivariate analysis demonstrated that the OS of moderate PCI group was significantly worse compared to that of intensive PCI group (HR = 2.43, 95% CI: 1.32–4.14, P = 0.004), while the OS of intensive PCI group was comparable to that of the group without PCI. These results suggest that the intensity of PCI rather than the response to PCI may contribute to improve the transplant outcome in patients with ALL not in remission.
    41 schema:genre article
    42 schema:inLanguage en
    43 schema:isAccessibleForFree false
    44 schema:isPartOf N975acaffcc6c4baca898fab26ab8c67a
    45 Nf3097c5567444b16abb4af7270360a08
    46 sg:journal.1358129
    47 schema:keywords BM
    48 OS
    49 PCI group
    50 activity
    51 acute lymphoblastic leukemia
    52 age
    53 allogeneic hematopoietic cell transplantation
    54 analysis
    55 blast percentage
    56 blood
    57 cell count
    58 cell transplantation
    59 clinical significance
    60 cohort
    61 count
    62 decrease
    63 disease activity
    64 efficacy
    65 group
    66 hematopoietic cell transplantation
    67 high nucleated cell counts
    68 institutions
    69 intensity
    70 intervention
    71 leukemia
    72 lymphoblastic leukemia
    73 median age
    74 multicenter retrospective analysis
    75 multicenter retrospective study
    76 multivariate analysis
    77 nucleated cell count
    78 outcomes
    79 overall survival rate
    80 patients
    81 percentage
    82 peripheral blood
    83 purpose
    84 rate
    85 refractory acute lymphoblastic leukemia
    86 remission
    87 response
    88 results
    89 retrospective analysis
    90 retrospective study
    91 significance
    92 significant decrease
    93 study
    94 study cohort
    95 survival rate
    96 transplant outcomes
    97 transplantation
    98 schema:name Pre-conditioning intervention in patients with relapsed or refractory acute lymphoblastic leukemia who underwent allogeneic hematopoietic cell transplantation: a KSGCT multicenter retrospective analysis
    99 schema:pagination 2763-2771
    100 schema:productId N3f256b27c3ba4bddbcd30d93dc8f0633
    101 N5f856b6df0d94a83a3fd8d759b0f358e
    102 N799ada3003644ad2bd22c69f9d2b489f
    103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1140245891
    104 https://doi.org/10.1007/s00277-021-04607-8
    105 schema:sdDatePublished 2022-05-20T07:39
    106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    107 schema:sdPublisher N15469a24ee1944949fcf4c814fb5df5f
    108 schema:url https://doi.org/10.1007/s00277-021-04607-8
    109 sgo:license sg:explorer/license/
    110 sgo:sdDataset articles
    111 rdf:type schema:ScholarlyArticle
    112 N03741e2ba8614e8f9c77f9f95279537d rdf:first sg:person.012637131732.19
    113 rdf:rest N80d104aafaab418e8f80d5c0e2b52031
    114 N08f78a01952f4146af4f29c46c19a9ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Antineoplastic Combined Chemotherapy Protocols
    116 rdf:type schema:DefinedTerm
    117 N099520ef08024847b1f0cfcf19140d07 rdf:first sg:person.01122167503.96
    118 rdf:rest Nc941499643af4671a0d0ecc6444da847
    119 N0b743e52f81c46f9a274a9def07d333a rdf:first sg:person.0600361031.85
    120 rdf:rest Na8d93252ab6240dfab7ec79d53ba3575
    121 N0c153ce200fa45039e712786abd94f5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Cytarabine
    123 rdf:type schema:DefinedTerm
    124 N10e66461010e4f5fac6c2e053e306a9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Adult
    126 rdf:type schema:DefinedTerm
    127 N15469a24ee1944949fcf4c814fb5df5f schema:name Springer Nature - SN SciGraph project
    128 rdf:type schema:Organization
    129 N1640de5a978944999f3003637fa3e06f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Combined Modality Therapy
    131 rdf:type schema:DefinedTerm
    132 N2ee0d7ef9d6d42b8996f653cd06172e3 rdf:first sg:person.01060176576.11
    133 rdf:rest Nf4cb46ab89874973a49a6d6e9b9b86d9
    134 N32e35bd93da546d29f0762c66d465ea0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Cyclophosphamide
    136 rdf:type schema:DefinedTerm
    137 N338fce414a76443296af388adb1f456c rdf:first sg:person.01073536015.79
    138 rdf:rest N0b743e52f81c46f9a274a9def07d333a
    139 N37e9bc83072747959a5c87bdada9a6ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Humans
    141 rdf:type schema:DefinedTerm
    142 N3f256b27c3ba4bddbcd30d93dc8f0633 schema:name doi
    143 schema:value 10.1007/s00277-021-04607-8
    144 rdf:type schema:PropertyValue
    145 N422eb82832bc4b52bc1b8f5abb68c54c rdf:first sg:person.0775302360.96
    146 rdf:rest Nbc02991ecc4446bb8b2946766109e316
    147 N5349495e528e445db149ee52f004b95c rdf:first sg:person.01145377314.06
    148 rdf:rest N422eb82832bc4b52bc1b8f5abb68c54c
    149 N5f856b6df0d94a83a3fd8d759b0f358e schema:name pubmed_id
    150 schema:value 34357435
    151 rdf:type schema:PropertyValue
    152 N75b15d47db9f4ef88b7db0a84d577c97 rdf:first sg:person.0721047700.17
    153 rdf:rest N97583b19d5294dd9804ce82530e0364a
    154 N799ada3003644ad2bd22c69f9d2b489f schema:name dimensions_id
    155 schema:value pub.1140245891
    156 rdf:type schema:PropertyValue
    157 N7c75ea6d61944e54a2f1cb66636ed666 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Adolescent
    159 rdf:type schema:DefinedTerm
    160 N80d104aafaab418e8f80d5c0e2b52031 rdf:first sg:person.01225510655.03
    161 rdf:rest N2ee0d7ef9d6d42b8996f653cd06172e3
    162 N8122018d79b146ed8b7b9de182dccb0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Young Adult
    164 rdf:type schema:DefinedTerm
    165 N845af18507654f06a9d95c09d24cfca1 rdf:first sg:person.01100640630.10
    166 rdf:rest N099520ef08024847b1f0cfcf19140d07
    167 N97583b19d5294dd9804ce82530e0364a rdf:first sg:person.015754574322.05
    168 rdf:rest Nc66b87355a1e44f5b56d9989a9dedc4d
    169 N975acaffcc6c4baca898fab26ab8c67a schema:volumeNumber 100
    170 rdf:type schema:PublicationVolume
    171 N997caa5020764c8e8068983918368f28 rdf:first sg:person.0715264147.87
    172 rdf:rest rdf:nil
    173 N9a374632151f4aa7b2ade9a5191c7e7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Precursor Cell Lymphoblastic Leukemia-Lymphoma
    175 rdf:type schema:DefinedTerm
    176 Na2e57b51c0b7418e98575f1ee0d0dec6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Female
    178 rdf:type schema:DefinedTerm
    179 Na8d93252ab6240dfab7ec79d53ba3575 rdf:first sg:person.01046262603.08
    180 rdf:rest N75b15d47db9f4ef88b7db0a84d577c97
    181 Naecd36e9f18a4aeeb874245ce802a6d1 rdf:first sg:person.0577376767.42
    182 rdf:rest Nba6e77ae0dc54e04afea2ae8731d2595
    183 Naef09c2e037d4f0bbc3d8ac40fe72d15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Kaplan-Meier Estimate
    185 rdf:type schema:DefinedTerm
    186 Naf140d4ef098426b940e8c415cfc3b14 rdf:first sg:person.01074653417.74
    187 rdf:rest N845af18507654f06a9d95c09d24cfca1
    188 Nb623ede2e9954e89a3411622975f0b7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Transplantation Conditioning
    190 rdf:type schema:DefinedTerm
    191 Nba6e77ae0dc54e04afea2ae8731d2595 rdf:first sg:person.01256303666.11
    192 rdf:rest N03741e2ba8614e8f9c77f9f95279537d
    193 Nbb9b693b63bc4d51b7368df53184b754 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    194 schema:name Male
    195 rdf:type schema:DefinedTerm
    196 Nbc02991ecc4446bb8b2946766109e316 rdf:first sg:person.01305756547.68
    197 rdf:rest Naecd36e9f18a4aeeb874245ce802a6d1
    198 Nbca457e6ae62400eb076e8af3bdf1a77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Mitoxantrone
    200 rdf:type schema:DefinedTerm
    201 Nbe9854df80f84619ae37444e9c4a6353 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Etoposide
    203 rdf:type schema:DefinedTerm
    204 Nc5b0204340a04c7dbe2157051d758d74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Doxorubicin
    206 rdf:type schema:DefinedTerm
    207 Nc5b0dc4cb3e44c2597e6f2b475ec80ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Recurrence
    209 rdf:type schema:DefinedTerm
    210 Nc66b87355a1e44f5b56d9989a9dedc4d rdf:first sg:person.015512754302.32
    211 rdf:rest N5349495e528e445db149ee52f004b95c
    212 Nc941499643af4671a0d0ecc6444da847 rdf:first sg:person.01214267464.19
    213 rdf:rest Ne384901ea1884c92937f975379e1f9ae
    214 Nce211b05b4134e6093844e40586f253d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Allografts
    216 rdf:type schema:DefinedTerm
    217 Ne07f42abbc6e403287e90f6009b10910 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Hematopoietic Stem Cell Transplantation
    219 rdf:type schema:DefinedTerm
    220 Ne384901ea1884c92937f975379e1f9ae rdf:first sg:person.01171141246.33
    221 rdf:rest Nfd4c5b65a1224543909e08e7206f2e61
    222 Ne696fce49ecb40f491670c07f99d1cdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    223 schema:name Middle Aged
    224 rdf:type schema:DefinedTerm
    225 Nef1b5400da2748448bc8766fa4fdb261 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    226 schema:name Dexamethasone
    227 rdf:type schema:DefinedTerm
    228 Nf2e2691e6290473d9975181f67001e5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name Vincristine
    230 rdf:type schema:DefinedTerm
    231 Nf3097c5567444b16abb4af7270360a08 schema:issueNumber 11
    232 rdf:type schema:PublicationIssue
    233 Nf4cb46ab89874973a49a6d6e9b9b86d9 rdf:first sg:person.0617055140.49
    234 rdf:rest N997caa5020764c8e8068983918368f28
    235 Nfafd3aa88d7a48b786a91ee892e529a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    236 schema:name Retrospective Studies
    237 rdf:type schema:DefinedTerm
    238 Nfb6f706055e24787b6983b15c28c1785 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    239 schema:name Aged
    240 rdf:type schema:DefinedTerm
    241 Nfd4c5b65a1224543909e08e7206f2e61 rdf:first sg:person.01240752436.35
    242 rdf:rest N338fce414a76443296af388adb1f456c
    243 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    244 schema:name Medical and Health Sciences
    245 rdf:type schema:DefinedTerm
    246 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    247 schema:name Cardiorespiratory Medicine and Haematology
    248 rdf:type schema:DefinedTerm
    249 sg:journal.1358129 schema:issn 0939-5555
    250 1432-0584
    251 schema:name Annals of Hematology
    252 schema:publisher Springer Nature
    253 rdf:type schema:Periodical
    254 sg:person.01046262603.08 schema:affiliation grid-institutes:grid.265061.6
    255 schema:familyName Onizuka
    256 schema:givenName Makoto
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046262603.08
    258 rdf:type schema:Person
    259 sg:person.01060176576.11 schema:affiliation grid-institutes:grid.414944.8
    260 schema:familyName Kanamori
    261 schema:givenName Heiwa
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060176576.11
    263 rdf:type schema:Person
    264 sg:person.01073536015.79 schema:affiliation grid-institutes:grid.410804.9
    265 schema:familyName Fujiwara
    266 schema:givenName Shin-ichiro
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073536015.79
    268 rdf:type schema:Person
    269 sg:person.01074653417.74 schema:affiliation grid-institutes:grid.414944.8
    270 schema:familyName Tachibana
    271 schema:givenName Takayoshi
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074653417.74
    273 rdf:type schema:Person
    274 sg:person.01100640630.10 schema:affiliation grid-institutes:grid.258799.8
    275 schema:familyName Kanda
    276 schema:givenName Junya
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100640630.10
    278 rdf:type schema:Person
    279 sg:person.01122167503.96 schema:affiliation grid-institutes:grid.256642.1
    280 schema:familyName Ishizaki
    281 schema:givenName Takuma
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122167503.96
    283 rdf:type schema:Person
    284 sg:person.01145377314.06 schema:affiliation grid-institutes:grid.413045.7
    285 schema:familyName Fujisawa
    286 schema:givenName Shin
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145377314.06
    288 rdf:type schema:Person
    289 sg:person.01171141246.33 schema:affiliation grid-institutes:grid.414944.8
    290 schema:familyName Tanaka
    291 schema:givenName Masatsugu
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171141246.33
    293 rdf:type schema:Person
    294 sg:person.01214267464.19 schema:affiliation grid-institutes:grid.415479.a
    295 schema:familyName Najima
    296 schema:givenName Yuho
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214267464.19
    298 rdf:type schema:Person
    299 sg:person.01225510655.03 schema:affiliation grid-institutes:grid.459433.c
    300 schema:familyName Shono
    301 schema:givenName Katsuhiro
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225510655.03
    303 rdf:type schema:Person
    304 sg:person.01240752436.35 schema:affiliation grid-institutes:grid.415479.a
    305 schema:familyName Doki
    306 schema:givenName Noriko
    307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240752436.35
    308 rdf:type schema:Person
    309 sg:person.01256303666.11 schema:affiliation grid-institutes:grid.410793.8
    310 schema:familyName Gotoh
    311 schema:givenName Moritaka
    312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256303666.11
    313 rdf:type schema:Person
    314 sg:person.012637131732.19 schema:affiliation grid-institutes:None
    315 schema:familyName Watanabe
    316 schema:givenName Reiko
    317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012637131732.19
    318 rdf:type schema:Person
    319 sg:person.01305756547.68 schema:affiliation grid-institutes:grid.268441.d
    320 schema:familyName Miyazaki
    321 schema:givenName Takuya
    322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305756547.68
    323 rdf:type schema:Person
    324 sg:person.015512754302.32 schema:affiliation grid-institutes:grid.26091.3c
    325 schema:familyName Mori
    326 schema:givenName Takehiko
    327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015512754302.32
    328 rdf:type schema:Person
    329 sg:person.015754574322.05 schema:affiliation grid-institutes:grid.411898.d
    330 schema:familyName Saito
    331 schema:givenName Takeshi
    332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015754574322.05
    333 rdf:type schema:Person
    334 sg:person.0577376767.42 schema:affiliation grid-institutes:grid.459661.9
    335 schema:familyName Aotsuka
    336 schema:givenName Nobuyuki
    337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577376767.42
    338 rdf:type schema:Person
    339 sg:person.0600361031.85 schema:affiliation grid-institutes:grid.415020.2
    340 schema:familyName Kimura
    341 schema:givenName Shun-ichi
    342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600361031.85
    343 rdf:type schema:Person
    344 sg:person.0617055140.49 schema:affiliation grid-institutes:grid.410804.9
    345 schema:familyName Kanda
    346 schema:givenName Yoshinobu
    347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617055140.49
    348 rdf:type schema:Person
    349 sg:person.0715264147.87 schema:affiliation grid-institutes:grid.26091.3c
    350 schema:familyName Okamoto
    351 schema:givenName Shinichiro
    352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715264147.87
    353 rdf:type schema:Person
    354 sg:person.0721047700.17 schema:affiliation grid-institutes:grid.26999.3d
    355 schema:familyName Takahashi
    356 schema:givenName Satoshi
    357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721047700.17
    358 rdf:type schema:Person
    359 sg:person.0775302360.96 schema:affiliation grid-institutes:grid.411321.4
    360 schema:familyName Sakaida
    361 schema:givenName Emiko
    362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775302360.96
    363 rdf:type schema:Person
    364 sg:pub.10.1007/s00277-015-2577-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022653383
    365 https://doi.org/10.1007/s00277-015-2577-7
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1007/s00277-020-03949-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1125134417
    368 https://doi.org/10.1007/s00277-020-03949-z
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1007/s12185-011-0919-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021227781
    371 https://doi.org/10.1007/s12185-011-0919-3
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1007/s12185-018-02571-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110344846
    374 https://doi.org/10.1007/s12185-018-02571-0
    375 rdf:type schema:CreativeWork
    376 sg:pub.10.1038/bmt.2008.258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031232931
    377 https://doi.org/10.1038/bmt.2008.258
    378 rdf:type schema:CreativeWork
    379 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
    380 https://doi.org/10.1038/bmt.2012.244
    381 rdf:type schema:CreativeWork
    382 sg:pub.10.1038/s41409-019-0702-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1121305376
    383 https://doi.org/10.1038/s41409-019-0702-2
    384 rdf:type schema:CreativeWork
    385 sg:pub.10.1038/sj.bmt.1702373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038683413
    386 https://doi.org/10.1038/sj.bmt.1702373
    387 rdf:type schema:CreativeWork
    388 sg:pub.10.1038/sj.bmt.1705207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026148482
    389 https://doi.org/10.1038/sj.bmt.1705207
    390 rdf:type schema:CreativeWork
    391 sg:pub.10.1038/sj.bmt.1705425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028816747
    392 https://doi.org/10.1038/sj.bmt.1705425
    393 rdf:type schema:CreativeWork
    394 grid-institutes:None schema:alternateName Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
    395 schema:name Department of Hematology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan
    396 rdf:type schema:Organization
    397 grid-institutes:grid.256642.1 schema:alternateName Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    398 schema:name Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    399 rdf:type schema:Organization
    400 grid-institutes:grid.258799.8 schema:alternateName Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    401 schema:name Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    402 Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
    403 rdf:type schema:Organization
    404 grid-institutes:grid.26091.3c schema:alternateName Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    405 schema:name Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    406 rdf:type schema:Organization
    407 grid-institutes:grid.265061.6 schema:alternateName Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan
    408 schema:name Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan
    409 rdf:type schema:Organization
    410 grid-institutes:grid.268441.d schema:alternateName Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan
    411 schema:name Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan
    412 rdf:type schema:Organization
    413 grid-institutes:grid.26999.3d schema:alternateName Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    414 schema:name Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    415 rdf:type schema:Organization
    416 grid-institutes:grid.410793.8 schema:alternateName First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    417 schema:name First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    418 rdf:type schema:Organization
    419 grid-institutes:grid.410804.9 schema:alternateName Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan
    420 schema:name Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan
    421 Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
    422 rdf:type schema:Organization
    423 grid-institutes:grid.411321.4 schema:alternateName Department of Hematology, Chiba University Hospital, Chiba, Japan
    424 schema:name Department of Hematology, Chiba University Hospital, Chiba, Japan
    425 rdf:type schema:Organization
    426 grid-institutes:grid.411898.d schema:alternateName Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    427 schema:name Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    428 rdf:type schema:Organization
    429 grid-institutes:grid.413045.7 schema:alternateName Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
    430 schema:name Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
    431 rdf:type schema:Organization
    432 grid-institutes:grid.414944.8 schema:alternateName Department of Hematology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241 -8515, Yokohama, Japan
    433 schema:name Department of Hematology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241 -8515, Yokohama, Japan
    434 rdf:type schema:Organization
    435 grid-institutes:grid.415020.2 schema:alternateName Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
    436 schema:name Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
    437 rdf:type schema:Organization
    438 grid-institutes:grid.415479.a schema:alternateName Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
    439 schema:name Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
    440 rdf:type schema:Organization
    441 grid-institutes:grid.459433.c schema:alternateName Department of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan
    442 schema:name Department of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan
    443 rdf:type schema:Organization
    444 grid-institutes:grid.459661.9 schema:alternateName Division of Hematology-Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan
    445 schema:name Division of Hematology-Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan
    446 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...