Clinical outcomes in patients with Philadelphia chromosome-positive leukemia treated with ponatinib in routine clinical practice—data from a Belgian registry View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-05-04

AUTHORS

Timothy Devos, Violaine Havelange, Koen Theunissen, Stef Meers, Fleur Samantha Benghiat, Alain Gadisseur, Gaëtan Vanstraelen, Hélène Vellemans, Benjamin Bailly, Nikki Granacher, Philippe Lewalle, Ann De Becker, Koen Van Eygen, Mia Janssen, Agnes Triffet, Inge Vrelust, Dries Deeren, Dominiek Mazure, Julie Bekaert, Michael Beck, Dominik Selleslag

ABSTRACT

Data on clinical use of ponatinib are limited. This prospective registry aimed to evaluate outcomes of ponatinib treatment in routine practice over 3 years (2016–2019) in Belgium (NCT03678454). Patients with chronic myeloid leukemia (CML) or Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) were treated with ponatinib per current label. Fifty patients (33 CML and 17 Ph+ ALL) were enrolled. Fifty-five percent of CML and 29% of Ph+ ALL patients had received ≥3 prior tyrosine kinase inhibitors (TKIs). Reasons for starting ponatinib were intolerance (40%), relapse or refractoriness (28%) to previous TKIs, progression (16%), or T315I mutation (16%). Median follow-up was 15 months for CML and 4.5 months for Ph+ ALL patients. Best response was a major molecular response in 58% of CML and 41% of Ph+ ALL patients. Of 20 patients who started ponatinib due to intolerance to previous TKIs, 9 (64%) CML and 4 (67%) Ph+ ALL achieved a major molecular response. Three-year estimates of overall survival were 85.3% and 85.6%, respectively, in CML and Ph+ ALL patients; estimated progression-free survival was 81.6% and 48.9%. Adverse reactions were reported in 34 patients (68%); rash (26%) and dry skin (10%) were most common. Reported cardiovascular adverse reactions included vascular stenosis (3), arterial hypertension (2), chest pain (1), palpitations (1), and vascular occlusion (1). This Belgian registry confirms results from the PACE clinical trial and supports routine ponatinib use in CML and Ph+ ALL patients who are resistant or intolerant to previous TKIs or with the T315I mutation. More... »

PAGES

1723-1732

Journal

TITLE

Annals of Hematology

ISSUE

7

VOLUME

100

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-021-04507-x

DOI

http://dx.doi.org/10.1007/s00277-021-04507-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1137745688

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33942128


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