Ontology type: schema:ScholarlyArticle
2021-02-23
AUTHORSMasamichi Isobe, Takaaki Konuma, Masayoshi Masuko, Naoyuki Uchida, Shigesaburo Miyakoshi, Yasuhiro Sugio, Shuro Yoshida, Masatsugu Tanaka, Yoshiko Matsuhashi, Norimichi Hattori, Makoto Onizuka, Nobuyuki Aotsuka, Yasushi Kouzai, Atsushi Wake, Takafumi Kimura, Tatsuo Ichinohe, Yoshiko Atsuta, Masamitsu Yanada
ABSTRACTThe availability of alternative donor sources could allow elderly patients to receive allogeneic hematopoietic cell transplantation (HCT). We retrospectively evaluated the outcomes of single-unit cord blood transplantation (CBT) in 1577 patients aged ≥60 years with acute myeloid leukemia (AML) in Japan between 2002 and 2017. In total, 990 (63%) patients were not in complete remission (CR) at the time of CBT. A myeloablative conditioning regimen (52%) and calcineurin inhibitor (CI) + mycophenolate mofetil (MMF)–based graft-versus-host disease (GVHD) prophylaxis (45%) were more commonly used. With a median follow-up for survivors of 31 months, the probability of overall survival and the cumulative incidence of leukemia-related mortality at 3 years was 31% and 29%, respectively. The cumulative incidence of non-relapse mortality (NRM) at 100 days and 3 years were 24% and 41%, respectively. The cumulative incidences of grade II–IV and grade III–IV acute GVHD at 100 days and extensive chronic GVHD at 2 years were 44%, 16%, and 14%, respectively. The cumulative incidence of neutrophil engraftment was 80% at 42 days. Results of multivariate analysis indicated that the following factors were significantly associated with higher overall mortality: performance status ≥1, hematopoietic cell transplantation-specific comorbidity index ≥3, adverse cytogenetics, extramedullary disease at diagnosis, and non-CR status at CBT. By contrast, female sex, HLA disparities ≥2, mycophenolate mofetil–based GVHD prophylaxis, and recent CBT were significantly associated with lower overall mortality. In conclusion, single CBT offers a curative option for AML patients aged ≥60 years with careful patient selection. More... »
PAGES1849-1861
http://scigraph.springernature.com/pub.10.1007/s00277-021-04464-5
DOIhttp://dx.doi.org/10.1007/s00277-021-04464-5
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1135660329
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/33624134
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Cardiorespiratory Medicine and Haematology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Combined Chemotherapy Protocols",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Calcineurin Inhibitors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Combined Modality Therapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cord Blood Stem Cell Transplantation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Disease-Free Survival",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Follow-Up Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Graft Survival",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Graft vs Host Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunosuppressive Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Incidence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Japan",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kaplan-Meier Estimate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Leukemia, Myeloid, Acute",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mycophenolic Acid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Myeloablative Agonists",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Risk Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transplantation Conditioning",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, 108-8639, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, 108-8639, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Isobe",
"givenName": "Masamichi",
"id": "sg:person.01242776507.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242776507.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, 108-8639, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, 108-8639, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Konuma",
"givenName": "Takaaki",
"id": "sg:person.01350075427.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350075427.97"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematopoietic Cell Transplantation, Niigata University Medical and Dental Hospital, Niigata, Japan",
"id": "http://www.grid.ac/institutes/grid.412181.f",
"name": [
"Department of Hematopoietic Cell Transplantation, Niigata University Medical and Dental Hospital, Niigata, Japan"
],
"type": "Organization"
},
"familyName": "Masuko",
"givenName": "Masayoshi",
"id": "sg:person.01274407522.85",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274407522.85"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Toranomon Hospital, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.410813.f",
"name": [
"Department of Hematology, Toranomon Hospital, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Uchida",
"givenName": "Naoyuki",
"id": "sg:person.01243564276.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243564276.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.417092.9",
"name": [
"Department of Hematology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Miyakoshi",
"givenName": "Shigesaburo",
"id": "sg:person.01137533644.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137533644.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Internal Medicine, Kitakyushu City Hospital Organization, Kitakyushu Municipal Medical Center, Kitakyushu, Japan",
"id": "http://www.grid.ac/institutes/grid.415388.3",
"name": [
"Department of Internal Medicine, Kitakyushu City Hospital Organization, Kitakyushu Municipal Medical Center, Kitakyushu, Japan"
],
"type": "Organization"
},
"familyName": "Sugio",
"givenName": "Yasuhiro",
"id": "sg:person.01370707364.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370707364.81"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan",
"id": "http://www.grid.ac/institutes/grid.413617.6",
"name": [
"Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan"
],
"type": "Organization"
},
"familyName": "Yoshida",
"givenName": "Shuro",
"id": "sg:person.0761427154.71",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761427154.71"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan",
"id": "http://www.grid.ac/institutes/grid.414944.8",
"name": [
"Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Tanaka",
"givenName": "Masatsugu",
"id": "sg:person.01171141246.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171141246.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Kawasaki Medical School Hospital, Kurashiki, Japan",
"id": "http://www.grid.ac/institutes/grid.415106.7",
"name": [
"Department of Hematology, Kawasaki Medical School Hospital, Kurashiki, Japan"
],
"type": "Organization"
},
"familyName": "Matsuhashi",
"givenName": "Yoshiko",
"id": "sg:person.01353734234.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353734234.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.410714.7",
"name": [
"Division of Hematology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Hattori",
"givenName": "Norimichi",
"id": "sg:person.01002213320.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002213320.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan",
"id": "http://www.grid.ac/institutes/grid.265061.6",
"name": [
"Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan"
],
"type": "Organization"
},
"familyName": "Onizuka",
"givenName": "Makoto",
"id": "sg:person.01046262603.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046262603.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Hematology-Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan",
"id": "http://www.grid.ac/institutes/grid.459661.9",
"name": [
"Division of Hematology-Oncology, Japanese Red Cross Society Narita Hospital, Narita, Japan"
],
"type": "Organization"
},
"familyName": "Aotsuka",
"givenName": "Nobuyuki",
"id": "sg:person.0577376767.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577376767.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Transfusion Medicine, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.417089.3",
"name": [
"Department of Transfusion Medicine, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Kouzai",
"givenName": "Yasushi",
"id": "sg:person.01355315570.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355315570.06"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Toranomon Hospital Kajigaya, Kawasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.410813.f",
"name": [
"Department of Hematology, Toranomon Hospital Kajigaya, Kawasaki, Japan"
],
"type": "Organization"
},
"familyName": "Wake",
"givenName": "Atsushi",
"id": "sg:person.01127335676.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127335676.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Preparation Department, Japanese Red Cross Kinki Block Blood Center, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.410775.0",
"name": [
"Preparation Department, Japanese Red Cross Kinki Block Blood Center, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Kimura",
"givenName": "Takafumi",
"id": "sg:person.013702352722.25",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013702352722.25"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan",
"id": "http://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Ichinohe",
"givenName": "Tatsuo",
"id": "sg:person.0623252373.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623252373.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan",
"id": "http://www.grid.ac/institutes/grid.27476.30",
"name": [
"Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan",
"Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan"
],
"type": "Organization"
},
"familyName": "Atsuta",
"givenName": "Yoshiko",
"id": "sg:person.01146754030.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan",
"id": "http://www.grid.ac/institutes/grid.410800.d",
"name": [
"Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan"
],
"type": "Organization"
},
"familyName": "Yanada",
"givenName": "Masamitsu",
"id": "sg:person.01024604275.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024604275.66"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1186/s13045-018-0598-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103392923",
"https://doi.org/10.1186/s13045-018-0598-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2017.116",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085985957",
"https://doi.org/10.1038/bmt.2017.116"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2016.255",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024061204",
"https://doi.org/10.1038/bmt.2016.255"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2013.48",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003881084",
"https://doi.org/10.1038/bmt.2013.48"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00277-015-2347-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037356938",
"https://doi.org/10.1007/s00277-015-2347-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2012.244",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028358194",
"https://doi.org/10.1038/bmt.2012.244"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41409-019-0539-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1113958970",
"https://doi.org/10.1038/s41409-019-0539-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1532/ijh97.06239",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1054504897",
"https://doi.org/10.1532/ijh97.06239"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41409-017-0021-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1100248955",
"https://doi.org/10.1038/s41409-017-0021-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41375-019-0477-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1114029076",
"https://doi.org/10.1038/s41375-019-0477-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2012.208",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012462407",
"https://doi.org/10.1038/bmt.2012.208"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12185-015-1894-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036307316",
"https://doi.org/10.1007/s12185-015-1894-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2016.99",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051320389",
"https://doi.org/10.1038/leu.2016.99"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2011.114",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050477961",
"https://doi.org/10.1038/bmt.2011.114"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12185-019-02688-w",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1117128343",
"https://doi.org/10.1007/s12185-019-02688-w"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2017.202",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1086386336",
"https://doi.org/10.1038/leu.2017.202"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12185-015-1907-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045343135",
"https://doi.org/10.1007/s12185-015-1907-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2013.120",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019724737",
"https://doi.org/10.1038/bmt.2013.120"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12185-012-1137-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034073951",
"https://doi.org/10.1007/s12185-012-1137-3"
],
"type": "CreativeWork"
}
],
"datePublished": "2021-02-23",
"datePublishedReg": "2021-02-23",
"description": "The availability of alternative donor sources could allow elderly patients to receive allogeneic hematopoietic cell transplantation (HCT). We retrospectively evaluated the outcomes of single-unit cord blood transplantation (CBT) in 1577 patients aged \u226560 years with acute myeloid leukemia (AML) in Japan between 2002 and 2017. In total, 990 (63%) patients were not in complete remission (CR) at the time of CBT. A myeloablative conditioning regimen (52%) and calcineurin inhibitor (CI) + mycophenolate mofetil (MMF)\u2013based graft-versus-host disease (GVHD) prophylaxis (45%) were more commonly used. With a median follow-up for survivors of 31 months, the probability of overall survival and the cumulative incidence of leukemia-related mortality at 3 years was 31% and 29%, respectively. The cumulative incidence of non-relapse mortality (NRM) at 100 days and 3 years were 24% and 41%, respectively. The cumulative incidences of grade II\u2013IV and grade III\u2013IV acute GVHD at 100 days and extensive chronic GVHD at 2 years were 44%, 16%, and 14%, respectively. The cumulative incidence of neutrophil engraftment was 80% at 42 days. Results of multivariate analysis indicated that the following factors were significantly associated with higher overall mortality: performance status \u22651, hematopoietic cell transplantation-specific comorbidity index \u22653, adverse cytogenetics, extramedullary disease at diagnosis, and non-CR status at CBT. By contrast, female sex, HLA disparities \u22652, mycophenolate mofetil\u2013based GVHD prophylaxis, and recent CBT were significantly associated with lower overall mortality. In conclusion, single CBT offers a curative option for AML patients aged \u226560 years with careful patient selection.",
"genre": "article",
"id": "sg:pub.10.1007/s00277-021-04464-5",
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.9199736",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1358129",
"issn": [
"0939-5555",
"1432-0584"
],
"name": "Annals of Hematology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "7",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "100"
}
],
"keywords": [
"cord blood transplantation",
"single cord blood transplantation",
"non-relapse mortality",
"hematopoietic cell transplantation",
"cumulative incidence",
"acute myeloid leukemia",
"blood transplantation",
"complete remission",
"mycophenolate mofetil",
"overall mortality",
"calcineurin inhibitors",
"hematopoietic cell transplantation-specific comorbidity index",
"single-unit cord blood transplantation",
"time of CBT",
"allogeneic hematopoietic cell transplantation",
"acute myeloid leukemia patients",
"host disease (GVHD) prophylaxis",
"extensive chronic GVHD",
"non-CR status",
"myeloablative conditioning regimen",
"alternative donor sources",
"careful patient selection",
"myeloid leukemia patients",
"lower overall mortality",
"higher overall mortality",
"leukemia-related mortality",
"acute GVHD",
"chronic GVHD",
"adverse cytogenetics",
"GVHD prophylaxis",
"conditioning regimen",
"neutrophil engraftment",
"comorbidity index",
"extramedullary disease",
"elderly patients",
"overall survival",
"performance status",
"curative option",
"disease prophylaxis",
"AML patients",
"patient selection",
"retrospective study",
"cell transplantation",
"grade III",
"female sex",
"grade II",
"myeloid leukemia",
"leukemia patients",
"patients",
"multivariate analysis",
"donor source",
"transplantation",
"mortality",
"incidence",
"GVHD",
"mofetil",
"prophylaxis",
"days",
"years",
"status",
"remission",
"regimen",
"HLA",
"engraftment",
"graft",
"leukemia",
"disease",
"survivors",
"diagnosis",
"months",
"survival",
"outcomes",
"sex",
"total",
"inhibitors",
"cytogenetics",
"conclusion",
"options",
"index",
"factors",
"study",
"contrast",
"Japan",
"time",
"analysis",
"results",
"availability",
"selection",
"probability",
"source"
],
"name": "Single cord blood transplantation for acute myeloid leukemia patients aged 60 years or older: a retrospective study in Japan",
"pagination": "1849-1861",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1135660329"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00277-021-04464-5"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"33624134"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00277-021-04464-5",
"https://app.dimensions.ai/details/publication/pub.1135660329"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T17:09",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_914.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00277-021-04464-5"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00277-021-04464-5'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00277-021-04464-5'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-021-04464-5'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-021-04464-5'
This table displays all metadata directly associated to this object as RDF triples.
496 TRIPLES
21 PREDICATES
159 URIs
132 LITERALS
32 BLANK NODES