Possible nosocomial transmission of virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-01-13

AUTHORS

Yoshiyuki Onda, Junya Kanda, Nozomu Hanaoka, Mizuki Watanabe, Yasuyuki Arai, Masakatsu Hishizawa, Tadakazu Kondo, Kouhei Yamashita, Miki Nagao, Tsuguto Fujimoto, Akifumi Takaori-Kondo

ABSTRACT

Adenovirus (ADV)- or BK virus (BKV)-associated hemorrhagic cystitis (HC) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Several risk factors have been previously reported; however, it is unclear whether virus-associated HC can be transmitted. To clarify this point, we performed a retrospective cohort study on 207 consecutive patients who underwent allo-HSCT at Kyoto University Hospital between 2012 and 2018. We evaluated the incidence and risk factors of virus-associated HC and performed a phylogenetic analysis of the ADV partial sequence. The median age at transplantation was 50 (range, 17–68) years. Fifty-eight patients (28%) developed HC. ADVs were detected in 18 cases, BKVs were detected in 51, both were detected in 12, and only John Cunningham virus (JCV) was detected in 1 case. No factor was significantly associated with HC. However, both ADV- and BKV-HC occurred intensively between April 2016 and September 2017, which suggested possible nosocomial transmission of ADV and BKV. Genome sequencing of the hexon, E3, and penton regions of detected ADVs identified 7 cases of ADV type 11, 2 cases of type 35, and 3 cases of a type 79-related strain. A sequence analysis revealed that these strains in each type were almost identical, except for one case of a type 79-related strain. In conclusion, ADV-HCs with possible nosocomial transmission were described based on genotyping of the virus and partial sequencing of the viral genome. Although viral HC after allo-HSCT is thought to mainly be due to reactivation of a latent virus, nosocomial transmission of ADV or BKV should also be considered. More... »

PAGES

753-761

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-021-04414-1

DOI

http://dx.doi.org/10.1007/s00277-021-04414-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1134527180

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33439306


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35 schema:description Adenovirus (ADV)- or BK virus (BKV)-associated hemorrhagic cystitis (HC) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Several risk factors have been previously reported; however, it is unclear whether virus-associated HC can be transmitted. To clarify this point, we performed a retrospective cohort study on 207 consecutive patients who underwent allo-HSCT at Kyoto University Hospital between 2012 and 2018. We evaluated the incidence and risk factors of virus-associated HC and performed a phylogenetic analysis of the ADV partial sequence. The median age at transplantation was 50 (range, 17–68) years. Fifty-eight patients (28%) developed HC. ADVs were detected in 18 cases, BKVs were detected in 51, both were detected in 12, and only John Cunningham virus (JCV) was detected in 1 case. No factor was significantly associated with HC. However, both ADV- and BKV-HC occurred intensively between April 2016 and September 2017, which suggested possible nosocomial transmission of ADV and BKV. Genome sequencing of the hexon, E3, and penton regions of detected ADVs identified 7 cases of ADV type 11, 2 cases of type 35, and 3 cases of a type 79-related strain. A sequence analysis revealed that these strains in each type were almost identical, except for one case of a type 79-related strain. In conclusion, ADV-HCs with possible nosocomial transmission were described based on genotyping of the virus and partial sequencing of the viral genome. Although viral HC after allo-HSCT is thought to mainly be due to reactivation of a latent virus, nosocomial transmission of ADV or BKV should also be considered.
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42 BK virus
43 BKV
44 BKV-HC
45 E3
46 John Cunningham virus
47 Kyoto University Hospital
48 University Hospital
49 adenovirus
50 age
51 allo-HSCT
52 allogeneic hematopoietic stem cell transplantation
53 analysis
54 cases
55 cell transplantation
56 cohort study
57 common complication
58 complications
59 conclusion
60 consecutive patients
61 cystitis
62 factors
63 genome
64 genome sequencing
65 genotyping
66 hematopoietic stem cell transplantation
67 hemorrhagic cystitis
68 hexon
69 hospital
70 incidence
71 latent virus
72 median age
73 nosocomial transmission
74 partial sequences
75 partial sequencing
76 patients
77 phylogenetic analysis
78 point
79 possible nosocomial transmission
80 reactivation
81 region
82 retrospective cohort study
83 risk factors
84 sequence
85 sequence analysis
86 sequencing
87 stem cell transplantation
88 strains
89 study
90 transmission
91 transplantation
92 type 11
93 type 35
94 types
95 viral genome
96 viral hemorrhagic cystitis
97 virus
98 virus-associated hemorrhagic cystitis
99 years
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