The impacts of BCR-ABL1 mutations in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia who underwent allogeneic hematopoietic cell transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-08-15

AUTHORS

Takayoshi Tachibana, Yuho Najima, Yu Akahoshi, Shigeki Hirabayashi, Kaito Harada, Noriko Doki, Naoyuki Uchida, Takahiro Fukuda, Masashi Sawa, Masao Ogata, Satoru Takada, Masatsugu Tanaka, Yoshiko Matsuhashi, Junji Tanaka, Makoto Onizuka, Tatsuo Ichinohe, Yoshiko Atsuta, Shinichi Kako

ABSTRACT

The prognostic impacts of BCR-ABL1 fusion gene mutations in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) remain unknown. Using data from a nationwide Japanese registry, we have evaluated the prognostic impact of BCR-ABL1 mutations prior to the first allogeneic hematopoietic cell transplantation (HCT). The cohort included 289 patients with a median of 48 years of age (range: 16–70). Point mutations were detected in 110 patients. Of these, 90 (82%) harbored T315I mutations, while 20 had other mutations. With a median follow-up period of 29 months (range: 1–125), outcomes after 2 years were worse with mutations than without (overall survival [OS]: 34% vs 68%, p < 0.001; relapse rate [RR]: 48% vs 18%, p < 0.001), particularly with the presence of the T315I mutation (OS: 29% vs 68%, p < 0.001; RR: 54% vs 18%, p < 0.001). OS was significantly worse in the T315I group even among the cohort with hematological (p < 0.001) or molecular complete remission (p = 0.025) as compared to the no mutation group. Multivariate analysis determined the prognostic impact of the T315I mutation (OS: hazard ratio [HR] = 2.19, 95% confidence interval [CI]: 1.5–3.3, p < 0.001; RR: HR = 2.51, 95% CI: 1.5–4.2, p < 0.001). This study is the first to report on the prognostic significance of BCR-ABL1 mutations in Ph + ALL. More... »

PAGES

2393-2404

Journal

TITLE

Annals of Hematology

ISSUE

10

VOLUME

99

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-020-04212-1

DOI

http://dx.doi.org/10.1007/s00277-020-04212-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1130138860

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32803312


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Allografts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fusion Proteins, bcr-abl", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Japan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation, Missense", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Philadelphia Chromosome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Point Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precursor Cell Lymphoblastic Leukemia-Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recurrence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Registries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414944.8", 
          "name": [
            "Department of Hematology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tachibana", 
        "givenName": "Takayoshi", 
        "id": "sg:person.01074653417.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074653417.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415479.a", 
          "name": [
            "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Najima", 
        "givenName": "Yuho", 
        "id": "sg:person.01214267464.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214267464.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415020.2", 
          "name": [
            "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akahoshi", 
        "givenName": "Yu", 
        "id": "sg:person.01103006416.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103006416.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirabayashi", 
        "givenName": "Shigeki", 
        "id": "sg:person.0670101762.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670101762.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harada", 
        "givenName": "Kaito", 
        "id": "sg:person.01251211405.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251211405.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415479.a", 
          "name": [
            "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Doki", 
        "givenName": "Noriko", 
        "id": "sg:person.01240752436.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240752436.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations, Toranomon Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410813.f", 
          "name": [
            "Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations, Toranomon Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uchida", 
        "givenName": "Naoyuki", 
        "id": "sg:person.01243564276.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243564276.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukuda", 
        "givenName": "Takahiro", 
        "id": "sg:person.016452523632.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.413779.f", 
          "name": [
            "Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sawa", 
        "givenName": "Masashi", 
        "id": "sg:person.0635043607.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635043607.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Oita University Hospital, Oita, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412337.0", 
          "name": [
            "Department of Hematology, Oita University Hospital, Oita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ogata", 
        "givenName": "Masao", 
        "id": "sg:person.01022762045.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022762045.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leukemia Research Center, Saiseikai Mabashi Hospital, Gunma, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Leukemia Research Center, Saiseikai Mabashi Hospital, Gunma, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takada", 
        "givenName": "Satoru", 
        "id": "sg:person.0624156521.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624156521.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414944.8", 
          "name": [
            "Department of Hematology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanaka", 
        "givenName": "Masatsugu", 
        "id": "sg:person.01171141246.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171141246.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Kawasaki Medical School Hospital, Kurashiki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415106.7", 
          "name": [
            "Department of Hematology, Kawasaki Medical School Hospital, Kurashiki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsuhashi", 
        "givenName": "Yoshiko", 
        "id": "sg:person.01353734234.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353734234.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Tokyo Women\u2019s Medical University, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410818.4", 
          "name": [
            "Department of Hematology, Tokyo Women\u2019s Medical University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanaka", 
        "givenName": "Junji", 
        "id": "sg:person.0714107337.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714107337.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Onizuka", 
        "givenName": "Makoto", 
        "id": "sg:person.01046262603.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046262603.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan", 
          "id": "http://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ichinohe", 
        "givenName": "Tatsuo", 
        "id": "sg:person.0623252373.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623252373.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.511247.4", 
          "name": [
            "Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Atsuta", 
        "givenName": "Yoshiko", 
        "id": "sg:person.01146754030.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415020.2", 
          "name": [
            "Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kako", 
        "givenName": "Shinichi", 
        "id": "sg:person.0675760325.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675760325.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bmt.2012.244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028358194", 
          "https://doi.org/10.1038/bmt.2012.244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12185-018-02571-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1110344846", 
          "https://doi.org/10.1007/s12185-018-02571-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2402526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005965862", 
          "https://doi.org/10.1038/sj.leu.2402526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2012.352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021091201", 
          "https://doi.org/10.1038/leu.2012.352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2015.217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013878219", 
          "https://doi.org/10.1038/bmt.2015.217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2010.228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018775968", 
          "https://doi.org/10.1038/leu.2010.228"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-08-15", 
    "datePublishedReg": "2020-08-15", 
    "description": "The prognostic impacts of BCR-ABL1 fusion gene mutations in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) remain unknown. Using data from a nationwide Japanese registry, we have evaluated the prognostic impact of BCR-ABL1 mutations prior to the first allogeneic hematopoietic cell transplantation (HCT). The cohort included 289 patients with a median of 48 years of age (range: 16\u201370). Point mutations were detected in 110 patients. Of these, 90 (82%) harbored T315I mutations, while 20 had other mutations. With a median follow-up period of 29 months (range: 1\u2013125), outcomes after 2 years were worse with mutations than without (overall survival [OS]: 34% vs 68%, p < 0.001; relapse rate [RR]: 48% vs 18%, p < 0.001), particularly with the presence of the T315I mutation (OS: 29% vs 68%, p < 0.001; RR: 54% vs 18%, p < 0.001). OS was significantly worse in the T315I group even among the cohort with hematological (p < 0.001) or molecular complete remission (p = 0.025) as compared to the no mutation group. Multivariate analysis determined the prognostic impact of the T315I mutation (OS: hazard ratio [HR] = 2.19, 95% confidence interval [CI]: 1.5\u20133.3, p < 0.001; RR: HR = 2.51, 95% CI: 1.5\u20134.2, p < 0.001). This study is the first to report on the prognostic significance of BCR-ABL1 mutations in Ph + ALL.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00277-020-04212-1", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1358129", 
        "issn": [
          "0939-5555", 
          "1432-0584"
        ], 
        "name": "Annals of Hematology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "99"
      }
    ], 
    "keywords": [
      "hematopoietic cell transplantation", 
      "BCR-ABL1 mutations", 
      "Philadelphia chromosome-positive acute lymphoblastic leukemia", 
      "allogeneic hematopoietic cell transplantation", 
      "acute lymphoblastic leukemia", 
      "prognostic impact", 
      "T315I mutation", 
      "cell transplantation", 
      "lymphoblastic leukemia", 
      "first allogeneic hematopoietic cell transplantation", 
      "nationwide Japanese registry", 
      "molecular complete remission", 
      "years of age", 
      "fusion gene mutations", 
      "median follow", 
      "complete remission", 
      "prognostic significance", 
      "Japanese Registry", 
      "multivariate analysis", 
      "mutation group", 
      "patients", 
      "gene mutations", 
      "transplantation", 
      "leukemia", 
      "cohort", 
      "mutations", 
      "remission", 
      "point mutations", 
      "group", 
      "registry", 
      "follow", 
      "years", 
      "months", 
      "median", 
      "age", 
      "outcomes", 
      "OS", 
      "impact", 
      "period", 
      "significance", 
      "study", 
      "presence", 
      "data", 
      "analysis", 
      "pH"
    ], 
    "name": "The impacts of BCR-ABL1 mutations in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia who underwent allogeneic hematopoietic cell transplantation", 
    "pagination": "2393-2404", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1130138860"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00277-020-04212-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "32803312"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00277-020-04212-1", 
      "https://app.dimensions.ai/details/publication/pub.1130138860"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_860.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00277-020-04212-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00277-020-04212-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00277-020-04212-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-020-04212-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-020-04212-1'


 

This table displays all metadata directly associated to this object as RDF triples.

397 TRIPLES      22 PREDICATES      104 URIs      90 LITERALS      34 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00277-020-04212-1 schema:about N097098b617a94c1bbae6af121424d755
2 N0e342a293e324a1f9e1d1e31205b0ee5
3 N26cde8bda64e4882a76a4e66e055b3d6
4 N2af2c0b0bb754aa8808333762df0138f
5 N2d91cedbcbe2446fa98d209c046aa54f
6 N317490e1625742cda2f7eb048843e1bf
7 N341ad9da64ed407bb88f26dbb8145627
8 N4a1d611c8eb9478594f0654b4f221215
9 N50d36f7a0d3041f2945c570c1af405d2
10 N644e54903e8c423b93ab90bc8bb77301
11 N6b067459dd664f15ac577e785b892e5e
12 N76b8377e7bb2407782f70314de9926f6
13 N83a1139eeaf04f969c0b3d66884bdcab
14 N94a5f83bb9da4e59857c07346fdce2d9
15 N9adf4b0a69274f5a9f2db2c5bed38f67
16 Na1b5475f037449e2abb21c2d79d6c558
17 Na9875f5bf8764d729a5dd92f4852b3f1
18 Nb1ce93d0053a4109b456082fa536d1eb
19 Nbb46b9e3e8a94fd9b83cad782f1f536a
20 Nd166bf03817c4e819dde7ad4c23d3949
21 Nd385757792c8460ea1c272f5c0c0ac9b
22 Nd73d831cde104b1e8b6180462ef614ee
23 Ndf8fabf071ed43e0b33e6119839dcf20
24 Ne0a166524b5947d192dec6662d72b09f
25 Nebacd639583f4cfbabef9dfe511ea6db
26 Nf20c520ba1af414c8325b2c35f66f2de
27 Nf4f7614eb7d64caaa14b5b926255c11f
28 anzsrc-for:11
29 anzsrc-for:1117
30 schema:author N970e448581354de9ade59487c23706ad
31 schema:citation sg:pub.10.1007/s12185-018-02571-0
32 sg:pub.10.1038/bmt.2012.244
33 sg:pub.10.1038/bmt.2015.217
34 sg:pub.10.1038/leu.2010.228
35 sg:pub.10.1038/leu.2012.352
36 sg:pub.10.1038/sj.leu.2402526
37 schema:datePublished 2020-08-15
38 schema:datePublishedReg 2020-08-15
39 schema:description The prognostic impacts of BCR-ABL1 fusion gene mutations in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) remain unknown. Using data from a nationwide Japanese registry, we have evaluated the prognostic impact of BCR-ABL1 mutations prior to the first allogeneic hematopoietic cell transplantation (HCT). The cohort included 289 patients with a median of 48 years of age (range: 16–70). Point mutations were detected in 110 patients. Of these, 90 (82%) harbored T315I mutations, while 20 had other mutations. With a median follow-up period of 29 months (range: 1–125), outcomes after 2 years were worse with mutations than without (overall survival [OS]: 34% vs 68%, p < 0.001; relapse rate [RR]: 48% vs 18%, p < 0.001), particularly with the presence of the T315I mutation (OS: 29% vs 68%, p < 0.001; RR: 54% vs 18%, p < 0.001). OS was significantly worse in the T315I group even among the cohort with hematological (p < 0.001) or molecular complete remission (p = 0.025) as compared to the no mutation group. Multivariate analysis determined the prognostic impact of the T315I mutation (OS: hazard ratio [HR] = 2.19, 95% confidence interval [CI]: 1.5–3.3, p < 0.001; RR: HR = 2.51, 95% CI: 1.5–4.2, p < 0.001). This study is the first to report on the prognostic significance of BCR-ABL1 mutations in Ph + ALL.
40 schema:genre article
41 schema:inLanguage en
42 schema:isAccessibleForFree false
43 schema:isPartOf Nbae0b98d27f140b5b546af41fb661f74
44 Nd05e0b227d6045ada62f430b390bf2dd
45 sg:journal.1358129
46 schema:keywords BCR-ABL1 mutations
47 Japanese Registry
48 OS
49 Philadelphia chromosome-positive acute lymphoblastic leukemia
50 T315I mutation
51 acute lymphoblastic leukemia
52 age
53 allogeneic hematopoietic cell transplantation
54 analysis
55 cell transplantation
56 cohort
57 complete remission
58 data
59 first allogeneic hematopoietic cell transplantation
60 follow
61 fusion gene mutations
62 gene mutations
63 group
64 hematopoietic cell transplantation
65 impact
66 leukemia
67 lymphoblastic leukemia
68 median
69 median follow
70 molecular complete remission
71 months
72 multivariate analysis
73 mutation group
74 mutations
75 nationwide Japanese registry
76 outcomes
77 pH
78 patients
79 period
80 point mutations
81 presence
82 prognostic impact
83 prognostic significance
84 registry
85 remission
86 significance
87 study
88 transplantation
89 years
90 years of age
91 schema:name The impacts of BCR-ABL1 mutations in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia who underwent allogeneic hematopoietic cell transplantation
92 schema:pagination 2393-2404
93 schema:productId N556192d40cc74b54ba4f220060d7b5cf
94 N71a4b131e4644cdf9716934158a6b878
95 Nae171dd8d4604fb0a401ee6218f7c38d
96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1130138860
97 https://doi.org/10.1007/s00277-020-04212-1
98 schema:sdDatePublished 2022-05-20T07:37
99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
100 schema:sdPublisher Nbf079719292a4024b90429d48652d601
101 schema:url https://doi.org/10.1007/s00277-020-04212-1
102 sgo:license sg:explorer/license/
103 sgo:sdDataset articles
104 rdf:type schema:ScholarlyArticle
105 N063f23ab96db4f7d95bc5acfaab29389 rdf:first sg:person.016452523632.46
106 rdf:rest Nfd19dcd253ab426ca2643a8a76f5b1e9
107 N06879fac89264ec2bfbe8f353de2c8eb rdf:first sg:person.01103006416.55
108 rdf:rest N250f8146e5444ddf93950ce235f33a43
109 N097098b617a94c1bbae6af121424d755 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Fusion Proteins, bcr-abl
111 rdf:type schema:DefinedTerm
112 N0e342a293e324a1f9e1d1e31205b0ee5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Follow-Up Studies
114 rdf:type schema:DefinedTerm
115 N147a61402170424fadee9d28deddd989 rdf:first sg:person.01146754030.08
116 rdf:rest N1e5bf0baf2504b09b390b976ec99b2a0
117 N1e5bf0baf2504b09b390b976ec99b2a0 rdf:first sg:person.0675760325.07
118 rdf:rest rdf:nil
119 N250f8146e5444ddf93950ce235f33a43 rdf:first sg:person.0670101762.46
120 rdf:rest Na43d4621c8c44b13853d5866f0d9e0f1
121 N26cde8bda64e4882a76a4e66e055b3d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Registries
123 rdf:type schema:DefinedTerm
124 N287a36324aff4e37a20b2c17bd3a71f4 rdf:first sg:person.01353734234.28
125 rdf:rest Nda2db135c9544bf095f4d6f2d7711276
126 N2af2c0b0bb754aa8808333762df0138f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Adolescent
128 rdf:type schema:DefinedTerm
129 N2d91cedbcbe2446fa98d209c046aa54f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Disease-Free Survival
131 rdf:type schema:DefinedTerm
132 N30cb6ceac41549c8bab028b3fb2dc6dd rdf:first sg:person.01046262603.08
133 rdf:rest N75596f3ae07c450c8fc0c863fa504b24
134 N317490e1625742cda2f7eb048843e1bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Hematopoietic Stem Cell Transplantation
136 rdf:type schema:DefinedTerm
137 N341ad9da64ed407bb88f26dbb8145627 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Protein Kinase Inhibitors
139 rdf:type schema:DefinedTerm
140 N3d1f9fee0920418187bf37fc3caa69d5 rdf:first sg:person.01022762045.56
141 rdf:rest Ne0b6c4a0bf194d30aa72f0464a94c558
142 N4a1d611c8eb9478594f0654b4f221215 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Mutation, Missense
144 rdf:type schema:DefinedTerm
145 N50d36f7a0d3041f2945c570c1af405d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Recurrence
147 rdf:type schema:DefinedTerm
148 N556192d40cc74b54ba4f220060d7b5cf schema:name dimensions_id
149 schema:value pub.1130138860
150 rdf:type schema:PropertyValue
151 N644e54903e8c423b93ab90bc8bb77301 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Humans
153 rdf:type schema:DefinedTerm
154 N69178708723b467b9b4819a5a5a81917 rdf:first sg:person.01243564276.76
155 rdf:rest N063f23ab96db4f7d95bc5acfaab29389
156 N6b067459dd664f15ac577e785b892e5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Kaplan-Meier Estimate
158 rdf:type schema:DefinedTerm
159 N71a4b131e4644cdf9716934158a6b878 schema:name pubmed_id
160 schema:value 32803312
161 rdf:type schema:PropertyValue
162 N744279a024484ae290d40d32ae4ba936 rdf:first sg:person.01240752436.35
163 rdf:rest N69178708723b467b9b4819a5a5a81917
164 N75596f3ae07c450c8fc0c863fa504b24 rdf:first sg:person.0623252373.33
165 rdf:rest N147a61402170424fadee9d28deddd989
166 N76b8377e7bb2407782f70314de9926f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Treatment Outcome
168 rdf:type schema:DefinedTerm
169 N83a1139eeaf04f969c0b3d66884bdcab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Retrospective Studies
171 rdf:type schema:DefinedTerm
172 N94a5f83bb9da4e59857c07346fdce2d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Middle Aged
174 rdf:type schema:DefinedTerm
175 N970e448581354de9ade59487c23706ad rdf:first sg:person.01074653417.74
176 rdf:rest Ne6111d80209d4fc39103c0bb5c86e5f8
177 N9adf4b0a69274f5a9f2db2c5bed38f67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Female
179 rdf:type schema:DefinedTerm
180 Na1b5475f037449e2abb21c2d79d6c558 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Prognosis
182 rdf:type schema:DefinedTerm
183 Na43d4621c8c44b13853d5866f0d9e0f1 rdf:first sg:person.01251211405.80
184 rdf:rest N744279a024484ae290d40d32ae4ba936
185 Na9875f5bf8764d729a5dd92f4852b3f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Precursor Cell Lymphoblastic Leukemia-Lymphoma
187 rdf:type schema:DefinedTerm
188 Nae171dd8d4604fb0a401ee6218f7c38d schema:name doi
189 schema:value 10.1007/s00277-020-04212-1
190 rdf:type schema:PropertyValue
191 Nb1ce93d0053a4109b456082fa536d1eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Allografts
193 rdf:type schema:DefinedTerm
194 Nbae0b98d27f140b5b546af41fb661f74 schema:issueNumber 10
195 rdf:type schema:PublicationIssue
196 Nbb46b9e3e8a94fd9b83cad782f1f536a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Male
198 rdf:type schema:DefinedTerm
199 Nbf079719292a4024b90429d48652d601 schema:name Springer Nature - SN SciGraph project
200 rdf:type schema:Organization
201 Nd05e0b227d6045ada62f430b390bf2dd schema:volumeNumber 99
202 rdf:type schema:PublicationVolume
203 Nd166bf03817c4e819dde7ad4c23d3949 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Antineoplastic Agents
205 rdf:type schema:DefinedTerm
206 Nd385757792c8460ea1c272f5c0c0ac9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Point Mutation
208 rdf:type schema:DefinedTerm
209 Nd73d831cde104b1e8b6180462ef614ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Philadelphia Chromosome
211 rdf:type schema:DefinedTerm
212 Nda2db135c9544bf095f4d6f2d7711276 rdf:first sg:person.0714107337.54
213 rdf:rest N30cb6ceac41549c8bab028b3fb2dc6dd
214 Ndf8fabf071ed43e0b33e6119839dcf20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Combined Modality Therapy
216 rdf:type schema:DefinedTerm
217 Ne0a166524b5947d192dec6662d72b09f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Japan
219 rdf:type schema:DefinedTerm
220 Ne0b6c4a0bf194d30aa72f0464a94c558 rdf:first sg:person.0624156521.99
221 rdf:rest Nf35ea32fefbd4aea82746037abd9b107
222 Ne6111d80209d4fc39103c0bb5c86e5f8 rdf:first sg:person.01214267464.19
223 rdf:rest N06879fac89264ec2bfbe8f353de2c8eb
224 Nebacd639583f4cfbabef9dfe511ea6db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Adult
226 rdf:type schema:DefinedTerm
227 Nf20c520ba1af414c8325b2c35f66f2de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
228 schema:name Young Adult
229 rdf:type schema:DefinedTerm
230 Nf35ea32fefbd4aea82746037abd9b107 rdf:first sg:person.01171141246.33
231 rdf:rest N287a36324aff4e37a20b2c17bd3a71f4
232 Nf4f7614eb7d64caaa14b5b926255c11f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name Aged
234 rdf:type schema:DefinedTerm
235 Nfd19dcd253ab426ca2643a8a76f5b1e9 rdf:first sg:person.0635043607.22
236 rdf:rest N3d1f9fee0920418187bf37fc3caa69d5
237 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
238 schema:name Medical and Health Sciences
239 rdf:type schema:DefinedTerm
240 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
241 schema:name Public Health and Health Services
242 rdf:type schema:DefinedTerm
243 sg:journal.1358129 schema:issn 0939-5555
244 1432-0584
245 schema:name Annals of Hematology
246 schema:publisher Springer Nature
247 rdf:type schema:Periodical
248 sg:person.01022762045.56 schema:affiliation grid-institutes:grid.412337.0
249 schema:familyName Ogata
250 schema:givenName Masao
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022762045.56
252 rdf:type schema:Person
253 sg:person.01046262603.08 schema:affiliation grid-institutes:grid.265061.6
254 schema:familyName Onizuka
255 schema:givenName Makoto
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046262603.08
257 rdf:type schema:Person
258 sg:person.01074653417.74 schema:affiliation grid-institutes:grid.414944.8
259 schema:familyName Tachibana
260 schema:givenName Takayoshi
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074653417.74
262 rdf:type schema:Person
263 sg:person.01103006416.55 schema:affiliation grid-institutes:grid.415020.2
264 schema:familyName Akahoshi
265 schema:givenName Yu
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103006416.55
267 rdf:type schema:Person
268 sg:person.01146754030.08 schema:affiliation grid-institutes:grid.511247.4
269 schema:familyName Atsuta
270 schema:givenName Yoshiko
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08
272 rdf:type schema:Person
273 sg:person.01171141246.33 schema:affiliation grid-institutes:grid.414944.8
274 schema:familyName Tanaka
275 schema:givenName Masatsugu
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171141246.33
277 rdf:type schema:Person
278 sg:person.01214267464.19 schema:affiliation grid-institutes:grid.415479.a
279 schema:familyName Najima
280 schema:givenName Yuho
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214267464.19
282 rdf:type schema:Person
283 sg:person.01240752436.35 schema:affiliation grid-institutes:grid.415479.a
284 schema:familyName Doki
285 schema:givenName Noriko
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240752436.35
287 rdf:type schema:Person
288 sg:person.01243564276.76 schema:affiliation grid-institutes:grid.410813.f
289 schema:familyName Uchida
290 schema:givenName Naoyuki
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243564276.76
292 rdf:type schema:Person
293 sg:person.01251211405.80 schema:affiliation grid-institutes:grid.265061.6
294 schema:familyName Harada
295 schema:givenName Kaito
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251211405.80
297 rdf:type schema:Person
298 sg:person.01353734234.28 schema:affiliation grid-institutes:grid.415106.7
299 schema:familyName Matsuhashi
300 schema:givenName Yoshiko
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353734234.28
302 rdf:type schema:Person
303 sg:person.016452523632.46 schema:affiliation grid-institutes:grid.272242.3
304 schema:familyName Fukuda
305 schema:givenName Takahiro
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46
307 rdf:type schema:Person
308 sg:person.0623252373.33 schema:affiliation grid-institutes:grid.257022.0
309 schema:familyName Ichinohe
310 schema:givenName Tatsuo
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623252373.33
312 rdf:type schema:Person
313 sg:person.0624156521.99 schema:affiliation grid-institutes:None
314 schema:familyName Takada
315 schema:givenName Satoru
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624156521.99
317 rdf:type schema:Person
318 sg:person.0635043607.22 schema:affiliation grid-institutes:grid.413779.f
319 schema:familyName Sawa
320 schema:givenName Masashi
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635043607.22
322 rdf:type schema:Person
323 sg:person.0670101762.46 schema:affiliation grid-institutes:grid.258799.8
324 schema:familyName Hirabayashi
325 schema:givenName Shigeki
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670101762.46
327 rdf:type schema:Person
328 sg:person.0675760325.07 schema:affiliation grid-institutes:grid.415020.2
329 schema:familyName Kako
330 schema:givenName Shinichi
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675760325.07
332 rdf:type schema:Person
333 sg:person.0714107337.54 schema:affiliation grid-institutes:grid.410818.4
334 schema:familyName Tanaka
335 schema:givenName Junji
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714107337.54
337 rdf:type schema:Person
338 sg:pub.10.1007/s12185-018-02571-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110344846
339 https://doi.org/10.1007/s12185-018-02571-0
340 rdf:type schema:CreativeWork
341 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
342 https://doi.org/10.1038/bmt.2012.244
343 rdf:type schema:CreativeWork
344 sg:pub.10.1038/bmt.2015.217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013878219
345 https://doi.org/10.1038/bmt.2015.217
346 rdf:type schema:CreativeWork
347 sg:pub.10.1038/leu.2010.228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018775968
348 https://doi.org/10.1038/leu.2010.228
349 rdf:type schema:CreativeWork
350 sg:pub.10.1038/leu.2012.352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021091201
351 https://doi.org/10.1038/leu.2012.352
352 rdf:type schema:CreativeWork
353 sg:pub.10.1038/sj.leu.2402526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005965862
354 https://doi.org/10.1038/sj.leu.2402526
355 rdf:type schema:CreativeWork
356 grid-institutes:None schema:alternateName Leukemia Research Center, Saiseikai Mabashi Hospital, Gunma, Japan
357 schema:name Leukemia Research Center, Saiseikai Mabashi Hospital, Gunma, Japan
358 rdf:type schema:Organization
359 grid-institutes:grid.257022.0 schema:alternateName Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
360 schema:name Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
361 rdf:type schema:Organization
362 grid-institutes:grid.258799.8 schema:alternateName Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
363 schema:name Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
364 rdf:type schema:Organization
365 grid-institutes:grid.265061.6 schema:alternateName Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan
366 schema:name Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan
367 rdf:type schema:Organization
368 grid-institutes:grid.272242.3 schema:alternateName Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
369 schema:name Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
370 rdf:type schema:Organization
371 grid-institutes:grid.410813.f schema:alternateName Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations, Toranomon Hospital, Tokyo, Japan
372 schema:name Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations, Toranomon Hospital, Tokyo, Japan
373 rdf:type schema:Organization
374 grid-institutes:grid.410818.4 schema:alternateName Department of Hematology, Tokyo Women’s Medical University, Tokyo, Japan
375 schema:name Department of Hematology, Tokyo Women’s Medical University, Tokyo, Japan
376 rdf:type schema:Organization
377 grid-institutes:grid.412337.0 schema:alternateName Department of Hematology, Oita University Hospital, Oita, Japan
378 schema:name Department of Hematology, Oita University Hospital, Oita, Japan
379 rdf:type schema:Organization
380 grid-institutes:grid.413779.f schema:alternateName Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan
381 schema:name Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan
382 rdf:type schema:Organization
383 grid-institutes:grid.414944.8 schema:alternateName Department of Hematology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan
384 schema:name Department of Hematology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Japan
385 rdf:type schema:Organization
386 grid-institutes:grid.415020.2 schema:alternateName Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
387 schema:name Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
388 rdf:type schema:Organization
389 grid-institutes:grid.415106.7 schema:alternateName Department of Hematology, Kawasaki Medical School Hospital, Kurashiki, Japan
390 schema:name Department of Hematology, Kawasaki Medical School Hospital, Kurashiki, Japan
391 rdf:type schema:Organization
392 grid-institutes:grid.415479.a schema:alternateName Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
393 schema:name Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
394 rdf:type schema:Organization
395 grid-institutes:grid.511247.4 schema:alternateName Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
396 schema:name Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
397 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...