Disease management of patients with immune thrombocytopenia—results of a representative retrospective survey in Germany View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-07-25

AUTHORS

Anne Sophie Kubasch, Jens Kisro, Jörg Heßling, Holger Schulz, Hans-Jürgen Hurtz, Martine Klausmann, Achim Ehrnsperger, Claudia Willy, Uwe Platzbecker

ABSTRACT

Clinical research has resulted in an improvement of treatment options for patients with immune thrombocytopenia (ITP) over the last years. However, only few data exist on the real-life management of patients with ITP. To expand the knowledge, a multicenter, national survey was undertaken in 26 hematology practices distributed all over Germany. All patients with a diagnosis of ITP were documented using questionnaires, irrespective of the diagnosis date over a period of 2 years. Overall, data of 1023 patients were evaluated with 56% of patients being older than 60 years. Seventy-nine percent of the patients had chronic (> 12 months), 16% persistent (> 3–12 months), and 5% newly diagnosed (0–3 months) ITP. In 61% of cases, the disease lasted 3 or more years before survey documentation started. Main strategies applied as first-line therapy consisted of steroids in 45% and a “watch and wait” approach in 41% of patients. During second- and third-line strategies, treatment with steroids decreased (36% and 28%, respectively), while treatment modalities such as TPO-RAs increased (19% and 26%, respectively). As expected, patients with a low platelet count and thus a higher risk for bleeding and mortality received treatment (esp. steroids) more frequently during first line than those with a higher platelet count. Up to a third of patients were treated with steroids for more than a year. Overall, our study provides a cross-section overview about the current therapeutic treatment landscape in German ITP patients. The results will help to improve therapeutic management of ITP patients. More... »

PAGES

2085-2093

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-020-04173-5

DOI

http://dx.doi.org/10.1007/s00277-020-04173-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1129638319

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32710167


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