Efficacy and safety of micafungin in unrelated cord blood transplant recipients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-09-07

AUTHORS

Takeo Yasu, Takaaki Konuma, Maki Oiwa-Monna, Mai Mizusawa, Masamichi Isobe, Seiko Kato, Satoshi Takahashi, Arinobu Tojo

ABSTRACT

Micafungin (MCFG) is an echinocandin antifungal drug used for prophylaxis and treatment of fungal infections after allogeneic hematopoietic cell transplantation (HCT). However, its efficacy and safety in patients undergoing cord blood transplantation (CBT) has not been clarified. We retrospectively analyzed the efficacy and safety of MCFG in 92 adult patients undergoing CBT in our institute. Of the entire cohort, 83 patients (90%) received MCFG for empirical or preemptive therapy. Documented breakthrough fungal infection occurred in 2 patients during MCFG treatment. Among the 49 patients who received MCFG as empirical therapy for febrile neutropenia, 41 (84%) patients had resolution of fever during neutropenia. Elevation of serum levels of hepatobiliary parameters during MCFG treatment was commonly observed, but grade 3 or higher elevation was rare. We also compared the efficacy and safety of 2 different initial daily doses of MCFG (150 mg vs. 300 mg). There were no significant differences of efficacy and safety between the two groups. These data suggest that MCFG was effective and safe for adult patients undergoing CBT. The optimal daily dose of MCFG treatment is a matter of future investigation for adult patients undergoing CBT. More... »

PAGES

2593-2600

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-019-03790-z

DOI

http://dx.doi.org/10.1007/s00277-019-03790-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1120923054

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31494737


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