Improved prognosis of extranodal NK/T cell lymphoma, nasal type of nasal origin but not extranasal origin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-19

AUTHORS

Motoko Yamaguchi, Ritsuro Suzuki, Kana Miyazaki, Jun Amaki, Jun Takizawa, Nodoka Sekiguchi, Shiori Kinoshita, Naoto Tomita, Hideho Wada, Yukio Kobayashi, Nozomi Niitsu, Toshihiko Ando, Takeshi Maeda, Bungo Saito, Hiroshi Matsuoka, Rika Sakai, Nobuko Kubota, Yasufumi Masaki, Yoshihiro Kameoka, Naoko Asano, Masahiko Oguchi, Naoyuki Katayama

ABSTRACT

Extranodal NK/T cell lymphoma (NKTCL), nasal type (ENKL) that shows no apparent nasal involvement, is termed extranasal NKTCL or non-nasal NKTCL. In this study, we aimed to explore therapeutic approaches and outcomes in patients with extranasal NKTCL in current clinical practice. A data set of patients with newly diagnosed NKTCL who were diagnosed at 31 institutes in Japan between 2000 and 2013 was used for analysis. The patients’ fitness for steroid, methotrexate, ifosfamide, l-asparaginase, and etoposide (SMILE) chemotherapy was assessed using the major inclusion criteria of the SMILE phase 2 study. Of 358 patients, 47 (13%) had extranasal NKTCL. The most frequent extranodal sites of involvement in extranasal NKTCL were skin/subcutaneous tissue (n = 18). Six (13%) of the patients with extranasal NKTCL had localized disease and were diagnosed before 2010. With a median follow-up of 5.8 years, the 2-year overall survival (OS) in patients with nasal and extranasal NKTCL was 70% (95% confidence interval [CI], 65–75%) and 34% (95% CI, 21–47%), respectively. OS in patients with nasal NKTCL had a trend toward better according to treatment era (P = 0.063). In contrast, no obvious improvement of OS was observed in extranasal NKTCL (P = 0.43). The major inclusion criteria of the SMILE-P2 were met in 21% (10/47) of patients with extranasal NKTCL and 60% (188/311) of those with nasal NKTCL (P < 0.001). Despite the advent of new treatments for ENKL, OS remains unfavorable in extranasal NKTCL. A more effective therapy is needed for extranasal NKTCL. More... »

PAGES

1647-1655

Journal

TITLE

Annals of Hematology

ISSUE

7

VOLUME

98

Author Affiliations

  • Department of Hematology and Oncology, Mie University Graduate School of Medicine, 2-174 Edobashi, 514-8507, Tsu, Mie, Japan
  • Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan
  • Division of Hematology & Oncology, Tokai University School of Medicine, Isehara, Japan
  • Department of Hematology, Endocrinology and Metabolism, Niigata University Faculty of Medicine, Niigata, Japan
  • Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, Matsumoto, Japan
  • Department of Hematology and Oncology, Nagoya City University School of Medicine, Nagoya, Japan
  • Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
  • Department of Hematology, Kawasaki Medical School, Kurashiki, Japan
  • Department of Hematology, International University of Health and Welfare Mita Hospital, Tokyo, Japan
  • International Medical Center, Saitama Medical University, Hidaka, Japan
  • Division of Hematology, Respiratory Medicine and Oncology, Saga University, Saga, Japan
  • Department of Haematology and Oncology, Kurashiki Center Hospital, Kurashiki, Japan
  • Division of Hematology, Showa University School of Medicine, Tokyo, Japan
  • Medical Oncology/Hematology, Kobe University, Kobe, Japan
  • Department of Medical Oncology, Kanagawa Cancer Center, Yokohama, Japan
  • Division of Hematology, Saitama Cancer Center, Ina, Japan
  • Division of Hematology and Immunology, Kanazawa Medical University, Uchinada, Japan
  • Department of Hematology, Akita University, Akita, Japan
  • Department of Molecular Diagnostics, Nagano Prefectural Shinshu Medical Center, Suzaka, Japan
  • Department of Radiation Oncology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00277-019-03689-9

    DOI

    http://dx.doi.org/10.1007/s00277-019-03689-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113574703

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31001658


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