Brentuximab vedotin prior to allogeneic stem cell transplantation increases survival in chemorefractory Hodgkin’s lymphoma patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-14

AUTHORS

Francesco Gaudio, Patrizio Mazza, Anna Mele, Giulia Palazzo, Angelo Michele Carella, Mario Delia, Giovanni Pisapia, Domenico Pastore, Nicola Cascavilla, Vincenzo Pavone, Giorgina Specchia

ABSTRACT

This study reports a retrospective multicenter experience by the Rete Ematologica Pugliese (REP) over the past 16 years, aiming to compare the patients characteristics and outcomes of 21 brentuximab vedotin (BV)–pre-treated patients to 51 patients who received reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (SCT) without prior BV. In total, 72 patients with classical Hodgkin’s lymphomas who received allogeneic SCT were retrospectively studied. Prior use of BV had no effect on either engraftment or the incidence and severity of acute graft versus host disease (GVHD). Indeed, a lower incidence of chronic GVHD was observed in the BV group, with a 43% cumulative incidence at 3 years versus 47% in the no BV group, although this was not statistically significant. Despite the low incidence of chronic GVHD, survival was not worse in the BV-treated group: 3-year progression-free survival (PFS) was 53%, 3-year overall survival (OS) was 62%, 3-year non-relapse mortality (NRM) was 24%. In the no BV group, the 3-year PFS was 33%, 3-year OS was 44%, and 3-year NRM was 14%. In chemorefractory patients at the time of transplant, we found a statistically significant difference in PFS between the BV and no BV groups (51% vs. 10%, p = 0.013). More... »

PAGES

1449-1455

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-019-03662-6

DOI

http://dx.doi.org/10.1007/s00277-019-03662-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112731542

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30868307


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46 GVHD
47 Hodgkin's lymphoma
48 Hodgkin's lymphoma patients
49 Pugliese
50 Rete Ematologica Pugliese
51 acute graft
52 allogeneic stem cell transplantation
53 brentuximab vedotin
54 cell transplantation
55 characteristics
56 chemorefractory Hodgkin’s lymphoma patients
57 chemorefractory patients
58 chronic GVHD
59 classical Hodgkin lymphoma
60 conditioning (RIC) allogeneic stem cell transplantation
61 cumulative incidence
62 differences
63 disease
64 effect
65 engraftment
66 experience
67 graft
68 group
69 host disease
70 incidence
71 lower incidence
72 lymphoma
73 lymphoma patients
74 mortality
75 multicenter experience
76 non-relapse mortality
77 outcomes
78 overall survival
79 patient characteristics
80 patients
81 pre-treated patients
82 prior BV
83 prior use
84 progression-free survival
85 reduced-intensity conditioning allogeneic stem cell transplantation
86 retrospective multicenter experience
87 severity
88 significant differences
89 stem cell transplantation
90 study
91 survival
92 time
93 time of transplant
94 transplant
95 transplantation
96 use
97 vedotin
98 years
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