Impact of second decline rate of BCR-ABL1 transcript on clinical outcome of chronic phase chronic myeloid leukemia patients on imatinib ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02-23

AUTHORS

Stephanie Dulucq, Gabriel Etienne, Stephane Morisset, Emilie Klein, Claudine Chollet, Fanny Robbesyn, Beatrice Turcq, Isabelle Tigaud, Sandrine Hayette, Franck E. Nicolini, François-Xavier Mahon

ABSTRACT

Early molecular response has been associated with clinical outcome in chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors. The BCR-ABL1 transcript rate decline from baseline to 3 months has been demonstrated to be more predictive than a single BCR-ABL1 level at 3 months (M3). However, it cannot be used routinely because ABL1, as an internal gene control, is not reliable for BCR-ABL1 quantification above 10%. This study aimed to compare clinical outcome and molecular response of chronic phase CML patients, depending on the percentage of BCR-ABL1 transcript decrease from month 3 to month 6 using ABL1 as an internal control gene. Two hundred sixteen chronic phase CML patients treated with imatinib 400 mg for whom M3 and month 6 molecular data were available were included in the study. Associations with event-free (EFS), failure-free (FFS), progression-free (PFS), and overall survivals (OS) molecular response 4 log and 4.5 log were assessed. The percentage of BCR-ABL1 decline from month 3 to month 6 was significantly linked to the EFS and the FFS (p < 0.001). A common cut-off of 67% of decline predicted the better risk of event. Patients with a decrease below 67% have worse EFS and FFS as compared to those having a higher decrease (p < 0.001). The impact was confirmed by multivariate analysis. Since the slope between diagnosis and 3 months cannot be reliable using ABL1 as an internal gene control, the second decline rate of BCR-ABL1 transcript between month 3 and month 6 could efficiently identify patients at higher risk of event. More... »

PAGES

1-10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-019-03633-x

DOI

http://dx.doi.org/10.1007/s00277-019-03633-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112362476

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30798348


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institut Bergoni\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.476460.7", 
          "name": [
            "Laboratory of Hematology, Bordeaux University Hospital, Avenue de Magellan, 33604, Pessac Cedex, France", 
            "INSERM U1218, University of Bordeaux, 146 rue L\u00e9o Saignat CS 61292, 33076, Bordeaux Cedex, France", 
            "French Group of CML (Fi-LMC), Bergoni\u00e9 Cancer Institute, 229 Cours de l\u2019Argonne, CS61283, 33076, Bordeaux Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dulucq", 
        "givenName": "Stephanie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Bergoni\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.476460.7", 
          "name": [
            "French Group of CML (Fi-LMC), Bergoni\u00e9 Cancer Institute, 229 Cours de l\u2019Argonne, CS61283, 33076, Bordeaux Cedex, France", 
            "Bergoni\u00e9 Cancer Institute, 229 Cours de l\u2019Argonne, CS61283, 33076, Bordeaux Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Etienne", 
        "givenName": "Gabriel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Lieu\u2013dit La Caillatte, 01150, Chazey sur Ain, France", 
            "L\u00e9on B\u00e9rard Cancer Institute and INSERM U1052, 28, rue Laennec, 69373, Lyon Cedex 08, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morisset", 
        "givenName": "Stephane", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Bordeaux", 
          "id": "https://www.grid.ac/institutes/grid.42399.35", 
          "name": [
            "Laboratory of Hematology, Bordeaux University Hospital, Avenue de Magellan, 33604, Pessac Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klein", 
        "givenName": "Emilie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Bordeaux", 
          "id": "https://www.grid.ac/institutes/grid.42399.35", 
          "name": [
            "Laboratory of Hematology, Bordeaux University Hospital, Avenue de Magellan, 33604, Pessac Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chollet", 
        "givenName": "Claudine", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Bordeaux", 
          "id": "https://www.grid.ac/institutes/grid.42399.35", 
          "name": [
            "Laboratory of Hematology, Bordeaux University Hospital, Avenue de Magellan, 33604, Pessac Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Robbesyn", 
        "givenName": "Fanny", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bordeaux", 
          "id": "https://www.grid.ac/institutes/grid.412041.2", 
          "name": [
            "INSERM U1218, University of Bordeaux, 146 rue L\u00e9o Saignat CS 61292, 33076, Bordeaux Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turcq", 
        "givenName": "Beatrice", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Lyon Sud", 
          "id": "https://www.grid.ac/institutes/grid.411430.3", 
          "name": [
            "Laboratory of Hematology, Centre Hospitalier Lyon Sud, 165 chemin du Grand Revoyet, 69495, Pierre B\u00e9nite Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tigaud", 
        "givenName": "Isabelle", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Lyon Sud", 
          "id": "https://www.grid.ac/institutes/grid.411430.3", 
          "name": [
            "French Group of CML (Fi-LMC), Bergoni\u00e9 Cancer Institute, 229 Cours de l\u2019Argonne, CS61283, 33076, Bordeaux Cedex, France", 
            "Laboratory of Hematology, Centre Hospitalier Lyon Sud, 165 chemin du Grand Revoyet, 69495, Pierre B\u00e9nite Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hayette", 
        "givenName": "Sandrine", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Bergoni\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.476460.7", 
          "name": [
            "French Group of CML (Fi-LMC), Bergoni\u00e9 Cancer Institute, 229 Cours de l\u2019Argonne, CS61283, 33076, Bordeaux Cedex, France", 
            "L\u00e9on B\u00e9rard Cancer Institute and INSERM U1052, 28, rue Laennec, 69373, Lyon Cedex 08, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nicolini", 
        "givenName": "Franck E.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Bergoni\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.476460.7", 
          "name": [
            "INSERM U1218, University of Bordeaux, 146 rue L\u00e9o Saignat CS 61292, 33076, Bordeaux Cedex, France", 
            "French Group of CML (Fi-LMC), Bergoni\u00e9 Cancer Institute, 229 Cours de l\u2019Argonne, CS61283, 33076, Bordeaux Cedex, France", 
            "Bergoni\u00e9 Cancer Institute, 229 Cours de l\u2019Argonne, CS61283, 33076, Bordeaux Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mahon", 
        "givenName": "Fran\u00e7ois-Xavier", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1046/j.1365-2141.2003.04200.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004027299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.38.6565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005602119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2012.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006724216", 
          "https://doi.org/10.1038/leu.2012.85"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ejh.12743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008878511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajh.23707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009950781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/243290a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012018569", 
          "https://doi.org/10.1038/243290a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-10-462291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012037694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.5958", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013078756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10428194.2014.974047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014479623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2015.64.8899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015564810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-11-466037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020253893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bjh.13108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020756900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-03-273979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023043587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2015.29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023059213", 
          "https://doi.org/10.1038/leu.2015.29"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2013-06-510396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023888886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2013-06-511592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024126321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clml.2016.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026498025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2014-05-578567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029002222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2014.153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032603709", 
          "https://doi.org/10.1038/leu.2014.153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2014.153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032603709", 
          "https://doi.org/10.1038/leu.2014.153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0106250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033608550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.beha.2009.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033981583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2013-03-490128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037321453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2013-05-501569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037386922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2014-03-566323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038079362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042288603", 
          "https://doi.org/10.1038/sj.leu.2403135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042288603", 
          "https://doi.org/10.1038/sj.leu.2403135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2011-10-383711", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043265594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10428194.2016.1239260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044172444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2012-01-407486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046461239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.40.5217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048842023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajh.23923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052815294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2406902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062536343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.11622/smedj.2016063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063354784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-017-2445-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085613860", 
          "https://doi.org/10.1007/s00432-017-2445-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-017-2445-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085613860", 
          "https://doi.org/10.1007/s00432-017-2445-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/asheducation-2017.1.102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100445144"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02-23", 
    "datePublishedReg": "2019-02-23", 
    "description": "Early molecular response has been associated with clinical outcome in chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors. The BCR-ABL1 transcript rate decline from baseline to 3\u00a0months has been demonstrated to be more predictive than a single BCR-ABL1 level at 3\u00a0months (M3). However, it cannot be used routinely because ABL1, as an internal gene control, is not reliable for BCR-ABL1 quantification above 10%. This study aimed to compare clinical outcome and molecular response of chronic phase CML patients, depending on the percentage of BCR-ABL1 transcript decrease from month 3 to month 6 using ABL1 as an internal control gene. Two hundred sixteen chronic phase CML patients treated with imatinib 400\u00a0mg for whom M3 and month 6 molecular data were available were included in the study. Associations with event-free (EFS), failure-free (FFS), progression-free (PFS), and overall survivals (OS) molecular response 4 log and 4.5 log were assessed. The percentage of BCR-ABL1 decline from month 3 to month 6 was significantly linked to the EFS and the FFS (p\u2009<\u20090.001). A common cut-off of 67% of decline predicted the better risk of event. Patients with a decrease below 67% have worse EFS and FFS as compared to those having a higher decrease (p\u2009<\u20090.001). The impact was confirmed by multivariate analysis. Since the slope between diagnosis and 3\u00a0months cannot be reliable using ABL1 as an internal gene control, the second decline rate of BCR-ABL1 transcript between month 3 and month 6 could efficiently identify patients at higher risk of event.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00277-019-03633-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018247", 
        "issn": [
          "1269-3286", 
          "1279-8509"
        ], 
        "name": "Annals of Hematology", 
        "type": "Periodical"
      }
    ], 
    "name": "Impact of second decline rate of BCR-ABL1 transcript on clinical outcome of chronic phase chronic myeloid leukemia patients on imatinib first-line", 
    "pagination": "1-10", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ff84f5dbb621ccddef847b49a6a45797b94ba0cad3edfd542f535e1d51824a15"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30798348"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9107334"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00277-019-03633-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112362476"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00277-019-03633-x", 
      "https://app.dimensions.ai/details/publication/pub.1112362476"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99832_00000005.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00277-019-03633-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00277-019-03633-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00277-019-03633-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-019-03633-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-019-03633-x'


 

This table displays all metadata directly associated to this object as RDF triples.

247 TRIPLES      21 PREDICATES      60 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00277-019-03633-x schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Na706c90b46684c37ac5872f77c06cf30
4 schema:citation sg:pub.10.1007/s00432-017-2445-z
5 sg:pub.10.1038/243290a0
6 sg:pub.10.1038/leu.2012.85
7 sg:pub.10.1038/leu.2014.153
8 sg:pub.10.1038/leu.2015.29
9 sg:pub.10.1038/sj.leu.2403135
10 https://doi.org/10.1002/ajh.23707
11 https://doi.org/10.1002/ajh.23923
12 https://doi.org/10.1002/sim.5958
13 https://doi.org/10.1016/j.beha.2009.04.001
14 https://doi.org/10.1016/j.clml.2016.03.008
15 https://doi.org/10.1046/j.1365-2141.2003.04200.x
16 https://doi.org/10.1080/10428194.2016.1239260
17 https://doi.org/10.1111/bjh.13108
18 https://doi.org/10.1111/ejh.12743
19 https://doi.org/10.1126/science.2406902
20 https://doi.org/10.11622/smedj.2016063
21 https://doi.org/10.1182/asheducation-2017.1.102
22 https://doi.org/10.1182/blood-2010-03-273979
23 https://doi.org/10.1182/blood-2011-10-383711
24 https://doi.org/10.1182/blood-2012-01-407486
25 https://doi.org/10.1182/blood-2012-10-462291
26 https://doi.org/10.1182/blood-2012-11-466037
27 https://doi.org/10.1182/blood-2013-03-490128
28 https://doi.org/10.1182/blood-2013-05-501569
29 https://doi.org/10.1182/blood-2013-06-510396
30 https://doi.org/10.1182/blood-2013-06-511592
31 https://doi.org/10.1182/blood-2014-03-566323
32 https://doi.org/10.1182/blood-2014-05-578567
33 https://doi.org/10.1200/jco.2011.38.6565
34 https://doi.org/10.1200/jco.2011.40.5217
35 https://doi.org/10.1200/jco.2015.64.8899
36 https://doi.org/10.1371/journal.pone.0106250
37 https://doi.org/10.3109/10428194.2014.974047
38 schema:datePublished 2019-02-23
39 schema:datePublishedReg 2019-02-23
40 schema:description Early molecular response has been associated with clinical outcome in chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors. The BCR-ABL1 transcript rate decline from baseline to 3 months has been demonstrated to be more predictive than a single BCR-ABL1 level at 3 months (M3). However, it cannot be used routinely because ABL1, as an internal gene control, is not reliable for BCR-ABL1 quantification above 10%. This study aimed to compare clinical outcome and molecular response of chronic phase CML patients, depending on the percentage of BCR-ABL1 transcript decrease from month 3 to month 6 using ABL1 as an internal control gene. Two hundred sixteen chronic phase CML patients treated with imatinib 400 mg for whom M3 and month 6 molecular data were available were included in the study. Associations with event-free (EFS), failure-free (FFS), progression-free (PFS), and overall survivals (OS) molecular response 4 log and 4.5 log were assessed. The percentage of BCR-ABL1 decline from month 3 to month 6 was significantly linked to the EFS and the FFS (p < 0.001). A common cut-off of 67% of decline predicted the better risk of event. Patients with a decrease below 67% have worse EFS and FFS as compared to those having a higher decrease (p < 0.001). The impact was confirmed by multivariate analysis. Since the slope between diagnosis and 3 months cannot be reliable using ABL1 as an internal gene control, the second decline rate of BCR-ABL1 transcript between month 3 and month 6 could efficiently identify patients at higher risk of event.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree false
44 schema:isPartOf sg:journal.1018247
45 schema:name Impact of second decline rate of BCR-ABL1 transcript on clinical outcome of chronic phase chronic myeloid leukemia patients on imatinib first-line
46 schema:pagination 1-10
47 schema:productId N1a27504fd5d04cebbf8a98f9b4027952
48 N8128beb66ed84474b5deb34b5d2aa0af
49 Naca22a4abd5542c5b9c539b70ec026d6
50 Nd70a5cbe492d4ef5ae38aca1d49bd6a0
51 Nf912239973424f6497ea47db5f9389ce
52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112362476
53 https://doi.org/10.1007/s00277-019-03633-x
54 schema:sdDatePublished 2019-04-11T09:38
55 schema:sdLicense https://scigraph.springernature.com/explorer/license/
56 schema:sdPublisher N05a29bb37f964f35953ddc8e4719af31
57 schema:url https://link.springer.com/10.1007%2Fs00277-019-03633-x
58 sgo:license sg:explorer/license/
59 sgo:sdDataset articles
60 rdf:type schema:ScholarlyArticle
61 N05a29bb37f964f35953ddc8e4719af31 schema:name Springer Nature - SN SciGraph project
62 rdf:type schema:Organization
63 N075e84e6a44d4e309082bcac728152e8 schema:affiliation https://www.grid.ac/institutes/grid.476460.7
64 schema:familyName Nicolini
65 schema:givenName Franck E.
66 rdf:type schema:Person
67 N1a18d88f34fc49dfa4fa8b206ca7c117 schema:affiliation https://www.grid.ac/institutes/grid.411430.3
68 schema:familyName Hayette
69 schema:givenName Sandrine
70 rdf:type schema:Person
71 N1a27504fd5d04cebbf8a98f9b4027952 schema:name doi
72 schema:value 10.1007/s00277-019-03633-x
73 rdf:type schema:PropertyValue
74 N221bcdc8d10d42c99ebab8cc7cccc582 rdf:first N36aae4bd773347f0a042073c6414997c
75 rdf:rest Na61e696890404a1ba3dfbabb95dfe44a
76 N25103c744dd64fec99b2b5df22106694 schema:affiliation https://www.grid.ac/institutes/grid.42399.35
77 schema:familyName Robbesyn
78 schema:givenName Fanny
79 rdf:type schema:Person
80 N252f9e9be8214f8580cb6cc93c67e591 rdf:first N25103c744dd64fec99b2b5df22106694
81 rdf:rest N221bcdc8d10d42c99ebab8cc7cccc582
82 N36aae4bd773347f0a042073c6414997c schema:affiliation https://www.grid.ac/institutes/grid.412041.2
83 schema:familyName Turcq
84 schema:givenName Beatrice
85 rdf:type schema:Person
86 N37ff9177f68442b68d56fa47104a99d9 schema:affiliation https://www.grid.ac/institutes/grid.476460.7
87 schema:familyName Etienne
88 schema:givenName Gabriel
89 rdf:type schema:Person
90 N65ffcf1d0a874639aef3cbcd8920b8b7 schema:affiliation https://www.grid.ac/institutes/grid.411430.3
91 schema:familyName Tigaud
92 schema:givenName Isabelle
93 rdf:type schema:Person
94 N6ca95651498e4657b9070dda6cd905dd rdf:first Na14265513d5847ae9a3b6ff9905b076c
95 rdf:rest N7320dd2cab2545b5bc7104fbc4e793e4
96 N73052caf1af84bc1977bfe4d5be6806a rdf:first N88c420eebe534539a46472712126738c
97 rdf:rest rdf:nil
98 N7320dd2cab2545b5bc7104fbc4e793e4 rdf:first Naee248474a744634b68c804e854280e7
99 rdf:rest Ne1879b5dac9d424bba8f31f5b56732c4
100 N78d699f6c781431ca0dd4577fb170914 rdf:first N075e84e6a44d4e309082bcac728152e8
101 rdf:rest N73052caf1af84bc1977bfe4d5be6806a
102 N8128beb66ed84474b5deb34b5d2aa0af schema:name pubmed_id
103 schema:value 30798348
104 rdf:type schema:PropertyValue
105 N88c420eebe534539a46472712126738c schema:affiliation https://www.grid.ac/institutes/grid.476460.7
106 schema:familyName Mahon
107 schema:givenName François-Xavier
108 rdf:type schema:Person
109 N898f23d83b3f42d8aedd6b1c7975aba5 rdf:first N37ff9177f68442b68d56fa47104a99d9
110 rdf:rest N6ca95651498e4657b9070dda6cd905dd
111 Na14265513d5847ae9a3b6ff9905b076c schema:affiliation Ndd4589f54ee64d6aafd4d52fbfefd044
112 schema:familyName Morisset
113 schema:givenName Stephane
114 rdf:type schema:Person
115 Na61e696890404a1ba3dfbabb95dfe44a rdf:first N65ffcf1d0a874639aef3cbcd8920b8b7
116 rdf:rest Nadd2821595874afc9862e25456b8a7d4
117 Na6896cae7a6b4b51981311acc2dc2428 schema:affiliation https://www.grid.ac/institutes/grid.476460.7
118 schema:familyName Dulucq
119 schema:givenName Stephanie
120 rdf:type schema:Person
121 Na706c90b46684c37ac5872f77c06cf30 rdf:first Na6896cae7a6b4b51981311acc2dc2428
122 rdf:rest N898f23d83b3f42d8aedd6b1c7975aba5
123 Naca22a4abd5542c5b9c539b70ec026d6 schema:name dimensions_id
124 schema:value pub.1112362476
125 rdf:type schema:PropertyValue
126 Nadd2821595874afc9862e25456b8a7d4 rdf:first N1a18d88f34fc49dfa4fa8b206ca7c117
127 rdf:rest N78d699f6c781431ca0dd4577fb170914
128 Naee248474a744634b68c804e854280e7 schema:affiliation https://www.grid.ac/institutes/grid.42399.35
129 schema:familyName Klein
130 schema:givenName Emilie
131 rdf:type schema:Person
132 Nd70a5cbe492d4ef5ae38aca1d49bd6a0 schema:name nlm_unique_id
133 schema:value 9107334
134 rdf:type schema:PropertyValue
135 Ndd4589f54ee64d6aafd4d52fbfefd044 schema:name Lieu–dit La Caillatte, 01150, Chazey sur Ain, France
136 Léon Bérard Cancer Institute and INSERM U1052, 28, rue Laennec, 69373, Lyon Cedex 08, France
137 rdf:type schema:Organization
138 Ne1879b5dac9d424bba8f31f5b56732c4 rdf:first Ned75f9a396d7408ebed80e33e94b5f09
139 rdf:rest N252f9e9be8214f8580cb6cc93c67e591
140 Ned75f9a396d7408ebed80e33e94b5f09 schema:affiliation https://www.grid.ac/institutes/grid.42399.35
141 schema:familyName Chollet
142 schema:givenName Claudine
143 rdf:type schema:Person
144 Nf912239973424f6497ea47db5f9389ce schema:name readcube_id
145 schema:value ff84f5dbb621ccddef847b49a6a45797b94ba0cad3edfd542f535e1d51824a15
146 rdf:type schema:PropertyValue
147 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
148 schema:name Medical and Health Sciences
149 rdf:type schema:DefinedTerm
150 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
151 schema:name Clinical Sciences
152 rdf:type schema:DefinedTerm
153 sg:journal.1018247 schema:issn 1269-3286
154 1279-8509
155 schema:name Annals of Hematology
156 rdf:type schema:Periodical
157 sg:pub.10.1007/s00432-017-2445-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1085613860
158 https://doi.org/10.1007/s00432-017-2445-z
159 rdf:type schema:CreativeWork
160 sg:pub.10.1038/243290a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012018569
161 https://doi.org/10.1038/243290a0
162 rdf:type schema:CreativeWork
163 sg:pub.10.1038/leu.2012.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006724216
164 https://doi.org/10.1038/leu.2012.85
165 rdf:type schema:CreativeWork
166 sg:pub.10.1038/leu.2014.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032603709
167 https://doi.org/10.1038/leu.2014.153
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/leu.2015.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023059213
170 https://doi.org/10.1038/leu.2015.29
171 rdf:type schema:CreativeWork
172 sg:pub.10.1038/sj.leu.2403135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042288603
173 https://doi.org/10.1038/sj.leu.2403135
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1002/ajh.23707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009950781
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1002/ajh.23923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052815294
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1002/sim.5958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013078756
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.beha.2009.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033981583
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.clml.2016.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026498025
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1046/j.1365-2141.2003.04200.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004027299
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1080/10428194.2016.1239260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044172444
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1111/bjh.13108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020756900
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1111/ejh.12743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008878511
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1126/science.2406902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062536343
194 rdf:type schema:CreativeWork
195 https://doi.org/10.11622/smedj.2016063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063354784
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1182/asheducation-2017.1.102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100445144
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1182/blood-2010-03-273979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023043587
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1182/blood-2011-10-383711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043265594
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1182/blood-2012-01-407486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046461239
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1182/blood-2012-10-462291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012037694
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1182/blood-2012-11-466037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020253893
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1182/blood-2013-03-490128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037321453
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1182/blood-2013-05-501569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037386922
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1182/blood-2013-06-510396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023888886
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1182/blood-2013-06-511592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024126321
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1182/blood-2014-03-566323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038079362
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1182/blood-2014-05-578567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029002222
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1200/jco.2011.38.6565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005602119
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1200/jco.2011.40.5217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048842023
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1200/jco.2015.64.8899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015564810
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1371/journal.pone.0106250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033608550
228 rdf:type schema:CreativeWork
229 https://doi.org/10.3109/10428194.2014.974047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014479623
230 rdf:type schema:CreativeWork
231 https://www.grid.ac/institutes/grid.411430.3 schema:alternateName Centre Hospitalier Lyon Sud
232 schema:name French Group of CML (Fi-LMC), Bergonié Cancer Institute, 229 Cours de l’Argonne, CS61283, 33076, Bordeaux Cedex, France
233 Laboratory of Hematology, Centre Hospitalier Lyon Sud, 165 chemin du Grand Revoyet, 69495, Pierre Bénite Cedex, France
234 rdf:type schema:Organization
235 https://www.grid.ac/institutes/grid.412041.2 schema:alternateName University of Bordeaux
236 schema:name INSERM U1218, University of Bordeaux, 146 rue Léo Saignat CS 61292, 33076, Bordeaux Cedex, France
237 rdf:type schema:Organization
238 https://www.grid.ac/institutes/grid.42399.35 schema:alternateName Centre Hospitalier Universitaire de Bordeaux
239 schema:name Laboratory of Hematology, Bordeaux University Hospital, Avenue de Magellan, 33604, Pessac Cedex, France
240 rdf:type schema:Organization
241 https://www.grid.ac/institutes/grid.476460.7 schema:alternateName Institut Bergonié
242 schema:name Bergonié Cancer Institute, 229 Cours de l’Argonne, CS61283, 33076, Bordeaux Cedex, France
243 French Group of CML (Fi-LMC), Bergonié Cancer Institute, 229 Cours de l’Argonne, CS61283, 33076, Bordeaux Cedex, France
244 INSERM U1218, University of Bordeaux, 146 rue Léo Saignat CS 61292, 33076, Bordeaux Cedex, France
245 Laboratory of Hematology, Bordeaux University Hospital, Avenue de Magellan, 33604, Pessac Cedex, France
246 Léon Bérard Cancer Institute and INSERM U1052, 28, rue Laennec, 69373, Lyon Cedex 08, France
247 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...