Impact of comorbidities and body mass index in patients with myelofibrosis treated with ruxolitinib View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Massimo Breccia, Daniela Bartoletti, Massimiliano Bonifacio, Giuseppe A. Palumbo, Nicola Polverelli, Elisabetta Abruzzese, Micaela Bergamaschi, Alessia Tieghi, Mario Tiribelli, Alessandra Iurlo, Francesco Cavazzini, Nicola Sgherza, Gianni Binotto, Alessandro Isidori, Mariella D’Adda, Monica Crugnola, Costanza Bosi, Florian Heidel, Matteo Molica, Luigi Scaffidi, Daniele Cattaneo, Roberto Latagliata, Giuseppe Auteri, Roberto M. Lemoli, Renato Fanin, Domenico Russo, Franco Aversa, Antonio Cuneo, Gianpietro Semenzato, Lucia Catani, Michele Cavo, Nicola Vianelli, Robin Foà, Francesca Palandri

ABSTRACT

Comorbidities defined by the Charlson comorbidity index (CCI) and body mass index (BMI) are significantly associated with outcome in patients who receive continuous treatment with tyrosine kinase inhibitors. We evaluated the impact of CCI and BMI on responses, drug-related toxicities, and outcome in a cohort of 402 patients with myelofibrosis (MF) treated with ruxolitinib in 23 European Hematology Centers. Comorbidities were evaluable in all 402 patients. A higher (≥ 3) CCI did not correlate with a lower spleen reduction at any time (p = 0.68) or symptoms' response (p = 0.11), but influenced the onset of anemia during the first 3 months of treatment and later (p = 0.02 and p = 0.03, respectively) in patients without anemia baseline. BMI was evaluable in 380 patients and did not correlate with differences in spleen and symptoms response (p = 0.57 and p = 0.49, respectively). A higher CCI and a lower BMI correlated also with a reduced overall survival (p < 0.001 and p = 0.02, respectively). The achievement of a spleen response at 6 months could counterbalance the negative impact of comorbidities, while patients who were underweight when starting ruxolitinib and did not achieve a spleen response at 6 months were projected to the worse outcome. In MF patients treated with ruxolitinib, BMI and comorbidities did not influence the achievement of spleen/symptom responses, but they contributed to the early identification of patients who deserve a strict monitoring during treatment. More... »

PAGES

889-896

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-018-3569-1

DOI

http://dx.doi.org/10.1007/s00277-018-3569-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110377849

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30515542


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469 schema:name Department of Hematology, University of Verona, Verona, Italy
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471 https://www.grid.ac/institutes/grid.7637.5 schema:alternateName University of Brescia
472 schema:name Unit of Blood Diseases and Stem Cells Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili of Brescia, Brescia, Italy
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474 https://www.grid.ac/institutes/grid.7841.a schema:alternateName Sapienza University of Rome
475 schema:name Division of Cellular Biotechnologies and Hematology, University Sapienza, Via Benevento 6, 00161, Rome, Italy
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477 https://www.grid.ac/institutes/grid.8158.4 schema:alternateName University of Catania
478 schema:name Division of Hematology, AOU “Policlinico-V. Emanuele”, University of Catania, Catania, Italy
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480 https://www.grid.ac/institutes/grid.8484.0 schema:alternateName University of Ferrara
481 schema:name Division of Hematology, University of Ferrara, Ferrara, Italy
482 rdf:type schema:Organization
 




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