Allogeneic hematopoietic cell transplantation in adult acute myeloid leukemia with 11q23 abnormality: a retrospective study of the Adult Acute Myeloid ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-07-06

AUTHORS

Takaaki Konuma, Shohei Mizuno, Tadakazu Kondo, Hiroki Yamaguchi, Takahiro Fukuda, Naoyuki Uchida, Yuho Najima, Heiwa Kanamori, Shuichi Ota, Hirohisa Nakamae, Mika Nakamae, Ishikazu Mizuno, Junichi Sugita, Yasushi Onishi, Akira Yokota, Satoshi Takahashi, Yoshinobu Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Shingo Yano, Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation

ABSTRACT

An 11q23 abnormality presents in approximately 5% of adults with acute myeloid leukemia (AML) and is associated with adverse outcomes even after allogeneic hematopoietic cell transplantation (allo-HCT). To evaluate the outcomes and prognostic factors following allo-HCT for adult AML with 11q23 abnormality, we retrospectively analyzed the Japanese registration data of 322 adult AML patients with 11q23 abnormality who had received allo-HCT between 1990 and 2014. In total, the disease status at HCT was first complete remission (CR1) in 159 (49%) patients. The probability of overall survival and the cumulative incidence of relapse at 3 years were 44 and 44%, respectively. In the multivariate analysis, disease status beyond CR1 at the time of HCT was significantly associated with a higher overall mortality and relapse. The 11q23 fusion partner did not have a significant impact on survival. We also evaluated the prognostic value of minimal residual disease (MRD) status at HCT on transplant outcomes among hematological CR patients. MRD status at HCT was the significant prognostic indicator for hematological relapse and survival. These data suggested that allo-HCT offered a curative option for adult AML with 11q23 abnormality. Pretransplant MRD status was the significant prognostic indicator for relapse and survival in CR patients. More... »

PAGES

2173-2183

Journal

TITLE

Annals of Hematology

ISSUE

11

VOLUME

97

Author Affiliations

  • Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, 108-8639, Tokyo, Japan
  • Division of Hematology, Department of Internal Medicine, School of Medicine, Aichi Medical University, Nagakute, Japan
  • Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • Department of Hematology, Nippon Medical School, Tokyo, Japan
  • Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
  • Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan
  • Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
  • Department of Hematology, Kanagawa Cancer Center, Kanagawa, Japan
  • Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan
  • Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan
  • Department of Hematology, Hyogo Cancer Center, Akashi, Japan
  • Department of Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  • Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai, Japan
  • Department of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan
  • Division of Molecular Therapy, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  • Division of Hematology, Jichi Medical University, Saitama Medical Center, Saitama, Japan
  • Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
  • Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00277-018-3419-1

    DOI

    http://dx.doi.org/10.1007/s00277-018-3419-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105315248

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29978286


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