Drug-to-drug interactions of tyrosine kinase inhibitors in chronic myeloid leukemia patients. Is it a real problem? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11

AUTHORS

Santiago Osorio, Vicente Escudero-Vilaplana, Ignacio Gómez-Centurión, Raúl Pérez-López, Rosa Ayala, Ferrán Vall-Llovera, Valentín García-Gutierrez, María Teresa Gómez Casares, José David González San Miguel, José-Ángel Hernández-Rivas, Fermín Sánchez-Guijo, Ana Belén Martínez-García, Lucia Villalón, Venancio Conesa-García, Alicia Rodriguez, Felipe Casado, Xandra Garcia-Gonzalez, María Nieves Sáez Perdomo, Úrsula Baños, Juan Luis Steegmann, On behalf of the CML Spanish Group (GELMC)

ABSTRACT

With tyrosine kinase inhibitors (TKI), chronic myeloid leukemia (CML) patients are achieving similar rates of survival to the general population and some treatment aspects such as adherence and drug-to-drug interactions (DDI) are becoming increasingly important. Our aim was to investigate the frequency and real clinical consequences of DDI between TKI and concurrent medications in CML. We performed a retrospective multicenter study including 105 patients receiving 134 TKI treatments. Sixty-three patients (60%) had at least one potential DDI. The mean number of concomitant medications was 4.8 (0-19). The mean number of DDI by TKI treatment was 1.2 (0-8); it increased with the number of concomitant medications and age in a significant manner. A total of 159 DDI were detected, involving 55 different drugs. The most common drug classes involved were proton pump inhibitors, statins, and antidepressants. A DDI-related clinical effect (toxicity and/or lack of efficacy) was suspected during the common course of patient follow-up in only five patients (4.7%). This number increased to 20% when data were centrally reviewed. Most of the adverse events (AE) attributed to DDIs were mild. The most common were diarrhea, vomiting, edema, cramps, and transaminitis. Nilotinib and dasatinib showed a tendency towards a higher risk of DDI compared with imatinib. There were no significant differences in AE frequency or in treatment response between patients with or without DDI. Due to their frequency, and their potential to cause clinically relevant effects, DDI are an important aspect of CML management. More... »

PAGES

2089-2098

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-018-3413-7

DOI

http://dx.doi.org/10.1007/s00277-018-3413-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105169750

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29955943


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