Ontology type: schema:ScholarlyArticle
2017-11-18
AUTHORSThomas Schroeder, Christina Rautenberg, William Krüger, Uwe Platzbecker, Gesine Bug, Juliane Steinmann, Stefan Klein, Olaf Hopfer, Kathrin Nachtkamp, Mustafa Kondakci, Stefanie Geyh, Rainer Haas, Ulrich Germing, Martin Bornhäuser, Guido Kobbe
ABSTRACTIn contrast to the evidence regarding azacitidine (Aza), there is limited knowledge about the combination of decitabine (DAC) and donor lymphocyte infusions as salvage therapy for relapse after allogeneic stem cell transplantation (allo-SCT) so far. We retrospectively analyzed data of 36 patients with hematological (n = 35) or molecular relapse (n = 1) of acute myeloid leukemia (AML, n = 29) or myelodysplastic syndrome (MDS, n = 7) collected from 6 German transplant centers. Patients were treated with a median of 2 cycles DAC (range, 1 to 11). DAC was the first salvage therapy in 16 patients (44%), whereas 20 patients (56%) had previously received 1 to 5 lines of salvage therapy including 16 of them had been treated with Aza. In 22 patients (61%), a median of 2 DLI per patient (range, 1 to 5) was administered in addition to DAC. As a result, overall response rate was 25% including 6 complete remissions (CR, 17%) and 3 partial remissions (PR, 8%). Three patients within the first-line group achieved CR, while also 3 patients receiving DAC as second-line treatment reached CR including 2 patients with previous Aza failure. Median duration of CR was 10 months (range, 2 to 33) and no patient relapsed so far. The 2-year OS rate was 11% (± 6%) without any difference between first-line and pretreated patients. Incidence of acute and chronic graft-versus-host disease was 19 and 5%. Taken together, DAC exerts clinical efficacy in patients with AML or MDS relapsing after allo-SCT and is able to induce durable remissions in individual patients suggesting that DAC may be an alternative to Aza or even a second choice after Aza failure. More... »
PAGES335-342
http://scigraph.springernature.com/pub.10.1007/s00277-017-3185-5
DOIhttp://dx.doi.org/10.1007/s00277-017-3185-5
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1092764909
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29151133
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Cardiorespiratory Medicine and Haematology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antimetabolites, Antineoplastic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Azacitidine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Decitabine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Graft vs Host Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hematopoietic Stem Cell Transplantation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Leukemia, Myeloid, Acute",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphocyte Transfusion",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Myelodysplastic Syndromes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Recurrence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Remission Induction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Salvage Therapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Analysis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transplantation, Homologous",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, D\u00fcsseldorf, Germany",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, D\u00fcsseldorf, Germany"
],
"type": "Organization"
},
"familyName": "Schroeder",
"givenName": "Thomas",
"id": "sg:person.01271136615.68",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271136615.68"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, D\u00fcsseldorf, Germany",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, D\u00fcsseldorf, Germany"
],
"type": "Organization"
},
"familyName": "Rautenberg",
"givenName": "Christina",
"id": "sg:person.014702750321.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014702750321.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Clinic and Policlinic for Internal Medicine C, Hematology and Oncology, University of Greifswald, Greifswald, Germany",
"id": "http://www.grid.ac/institutes/grid.5603.0",
"name": [
"Clinic and Policlinic for Internal Medicine C, Hematology and Oncology, University of Greifswald, Greifswald, Germany"
],
"type": "Organization"
},
"familyName": "Kr\u00fcger",
"givenName": "William",
"id": "sg:person.01121306556.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121306556.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Medical Clinic and Policlinic I, University Hospital Carl Gustav Carus, Dresden, Germany",
"id": "http://www.grid.ac/institutes/grid.412282.f",
"name": [
"Medical Clinic and Policlinic I, University Hospital Carl Gustav Carus, Dresden, Germany"
],
"type": "Organization"
},
"familyName": "Platzbecker",
"givenName": "Uwe",
"id": "sg:person.0670313557.25",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670313557.25"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Medicine II, University Hospital Frankfurt, Frankfurt am Main, Germany",
"id": "http://www.grid.ac/institutes/grid.411088.4",
"name": [
"Department of Medicine II, University Hospital Frankfurt, Frankfurt am Main, Germany"
],
"type": "Organization"
},
"familyName": "Bug",
"givenName": "Gesine",
"id": "sg:person.0660354231.27",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660354231.27"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Medicine II, University Hospital Frankfurt, Frankfurt am Main, Germany",
"id": "http://www.grid.ac/institutes/grid.411088.4",
"name": [
"Department of Medicine II, University Hospital Frankfurt, Frankfurt am Main, Germany"
],
"type": "Organization"
},
"familyName": "Steinmann",
"givenName": "Juliane",
"id": "sg:person.016431005447.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016431005447.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Med. Clinic III, University Medicine Mannheim, Mannheim, Germany",
"id": "http://www.grid.ac/institutes/grid.411778.c",
"name": [
"Med. Clinic III, University Medicine Mannheim, Mannheim, Germany"
],
"type": "Organization"
},
"familyName": "Klein",
"givenName": "Stefan",
"id": "sg:person.01007205467.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007205467.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Klinikum Frankfurt (Oder) GmbH, Med. Clinic I, Frankfurt (Oder), Frankfurt, Germany",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Klinikum Frankfurt (Oder) GmbH, Med. Clinic I, Frankfurt (Oder), Frankfurt, Germany"
],
"type": "Organization"
},
"familyName": "Hopfer",
"givenName": "Olaf",
"id": "sg:person.01200517504.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200517504.74"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, D\u00fcsseldorf, Germany",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, D\u00fcsseldorf, Germany"
],
"type": "Organization"
},
"familyName": "Nachtkamp",
"givenName": "Kathrin",
"id": "sg:person.01367010764.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367010764.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, D\u00fcsseldorf, Germany",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, D\u00fcsseldorf, Germany"
],
"type": "Organization"
},
"familyName": "Kondakci",
"givenName": "Mustafa",
"id": "sg:person.01150516001.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150516001.45"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, D\u00fcsseldorf, Germany",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, D\u00fcsseldorf, Germany"
],
"type": "Organization"
},
"familyName": "Geyh",
"givenName": "Stefanie",
"id": "sg:person.0766505315.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766505315.56"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, D\u00fcsseldorf, Germany",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, D\u00fcsseldorf, Germany"
],
"type": "Organization"
},
"familyName": "Haas",
"givenName": "Rainer",
"id": "sg:person.01127414674.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127414674.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, D\u00fcsseldorf, Germany",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, D\u00fcsseldorf, Germany"
],
"type": "Organization"
},
"familyName": "Germing",
"givenName": "Ulrich",
"id": "sg:person.01362464041.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362464041.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Medical Clinic and Policlinic I, University Hospital Carl Gustav Carus, Dresden, Germany",
"id": "http://www.grid.ac/institutes/grid.412282.f",
"name": [
"Medical Clinic and Policlinic I, University Hospital Carl Gustav Carus, Dresden, Germany"
],
"type": "Organization"
},
"familyName": "Bornh\u00e4user",
"givenName": "Martin",
"id": "sg:person.01036310055.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036310055.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, D\u00fcsseldorf, Germany",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, D\u00fcsseldorf, Germany"
],
"type": "Organization"
},
"familyName": "Kobbe",
"givenName": "Guido",
"id": "sg:person.01164073234.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164073234.53"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s00277-012-1607-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021337269",
"https://doi.org/10.1007/s00277-012-1607-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2009.266",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026051000",
"https://doi.org/10.1038/bmt.2009.266"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2013.233",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048090912",
"https://doi.org/10.1038/bmt.2013.233"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2013.64",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051101519",
"https://doi.org/10.1038/leu.2013.64"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2009.222",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042146563",
"https://doi.org/10.1038/bmt.2009.222"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2013.7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019069739",
"https://doi.org/10.1038/leu.2013.7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2011.234",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037902470",
"https://doi.org/10.1038/leu.2011.234"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bmt.2015.10",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034490318",
"https://doi.org/10.1038/bmt.2015.10"
],
"type": "CreativeWork"
}
],
"datePublished": "2017-11-18",
"datePublishedReg": "2017-11-18",
"description": "In contrast to the evidence regarding azacitidine (Aza), there is limited knowledge about the combination of decitabine (DAC) and donor lymphocyte infusions as salvage therapy for relapse after allogeneic stem cell transplantation (allo-SCT) so far. We retrospectively analyzed data of 36 patients with hematological (n\u2009=\u200935) or molecular relapse (n\u2009=\u20091) of acute myeloid leukemia (AML, n\u2009=\u200929) or myelodysplastic syndrome (MDS, n\u2009=\u20097) collected from 6 German transplant centers. Patients were treated with a median of 2 cycles DAC (range, 1 to 11). DAC was the first salvage therapy in 16 patients (44%), whereas 20 patients (56%) had previously received 1 to 5 lines of salvage therapy including 16 of them had been treated with Aza. In 22 patients (61%), a median of 2\u00a0DLI per patient (range, 1 to 5) was administered in addition to DAC. As a result, overall response rate was 25% including 6 complete remissions (CR, 17%) and 3 partial remissions (PR, 8%). Three patients within the first-line group achieved CR, while also 3 patients receiving DAC as second-line treatment reached CR including 2 patients with previous Aza failure. Median duration of CR was 10\u00a0months (range, 2 to 33) and no patient relapsed so far. The 2-year OS rate was 11% (\u00b1\u20096%) without any difference between first-line and pretreated patients. Incidence of acute and chronic graft-versus-host disease was 19 and 5%. Taken together, DAC exerts clinical efficacy in patients with AML or MDS relapsing after allo-SCT and is able to induce durable remissions in individual patients suggesting that DAC may be an alternative to Aza or even a second choice after Aza failure.",
"genre": "article",
"id": "sg:pub.10.1007/s00277-017-3185-5",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1358129",
"issn": [
"0939-5555",
"1432-0584"
],
"name": "Annals of Hematology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "97"
}
],
"keywords": [
"allogeneic stem cell transplantation",
"stem cell transplantation",
"salvage therapy",
"cell transplantation",
"first salvage therapy",
"first-line group",
"donor lymphocyte infusion",
"second-line treatment",
"retrospective multicenter analysis",
"German transplant centers",
"overall response rate",
"acute myeloid leukemia",
"combination of decitabine",
"molecular relapse",
"chronic graft",
"lymphocyte infusion",
"complete remission",
"partial remission",
"host disease",
"allo-SCT",
"durable remissions",
"median duration",
"transplant centers",
"OS rates",
"multicenter analysis",
"myelodysplastic syndrome",
"clinical efficacy",
"myeloid leukemia",
"individual patients",
"study group",
"patients",
"response rate",
"remission",
"therapy",
"relapse",
"transplantation",
"AML",
"decitabine",
"median",
"treatment",
"second choice",
"relapsing",
"DLI",
"limited knowledge",
"failure",
"group",
"infusion",
"syndrome",
"graft",
"leukemia",
"incidence",
"disease",
"months",
"efficacy",
"duration",
"rate",
"AZA",
"MDS",
"evidence",
"differences",
"center",
"contrast",
"combination",
"data",
"addition",
"lines",
"knowledge",
"alternative",
"choice",
"analysis",
"results",
"Cr",
"behalf",
"DAC"
],
"name": "Treatment of relapsed AML and MDS after allogeneic stem cell transplantation with decitabine and DLI\u2014a retrospective multicenter analysis on behalf of the German Cooperative Transplant Study Group",
"pagination": "335-342",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1092764909"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00277-017-3185-5"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29151133"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00277-017-3185-5",
"https://app.dimensions.ai/details/publication/pub.1092764909"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T17:05",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_754.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00277-017-3185-5"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00277-017-3185-5'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00277-017-3185-5'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-017-3185-5'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-017-3185-5'
This table displays all metadata directly associated to this object as RDF triples.
363 TRIPLES
21 PREDICATES
128 URIs
112 LITERALS
28 BLANK NODES