A cross-sectional study on late taste disorders in survivors of allogeneic hematopoietic cell transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08-16

AUTHORS

Tomoko Sato, Takaaki Konuma, Yoriko Miwa, Nozomi Sugihara, Yukari Tsuru, Hatsuko Narita, Satomi Kiriyama, Seiko Kato, Maki Oiwa-Monna, Koji Kobayashi, Satoshi Takahashi, Arinobu Tojo

ABSTRACT

Taste disorders are one of the most common complications in patients undergoing allogeneic hematopoietic cell transplantation (HCT). They persist in some patients as a late complication 3 months or more after HCT. Therefore, we conducted a cross-sectional study to evaluate the prevalence and predictive factors of late taste disorders, with the help of a self-reporting and closed-ended questionnaire, which was distributed among 91 patients in our institute. The median age at this study was 50 (range, 25–69) years. The median follow-up period was 54 (range, 3–234) months after HCT. Taste disorders were observed in 43 patients (47%). The most frequent form of late taste disorders was reduced appetite in 18 patients (20%). The most frequent form of decline of basic taste was umami, which was observed in 12 patients (13%). Almost all taste disorders were mild in their severity. Multivariate logistic regression analyses showed that the duration of less than 1 year post HCT and the presence of oral chronic graft-versus-host disease are important risk factors for late taste disorders in survivors of HCT. These data suggested that taste disorders usually return to normal levels more than a year after HCT in most recipients. More... »

PAGES

1841-1847

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-017-3087-6

DOI

http://dx.doi.org/10.1007/s00277-017-3087-6

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28815326


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