Clinical dissection of thrombotic microangiopathy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-07-27

AUTHORS

Eunjeong Kang, Shin Hye Yoo, Doyeun Oh, Kwon Wook Joo, Yon Su Kim, Sung-Soo Yoon, Inho Kim, Seonyang Park, Hajeong Lee, Youngil Koh

ABSTRACT

Differential treatment strategies are applied in thrombotic microangiopathy (TMA) according to the sub-classifications. Hence, it is worthwhile to overview clinical manifestations and outcomes of overall TMA patients according to sub-classifications. We analyzed TMA patients whose serum lactate dehydrogenase levels >250 IU/L, with the presence of schistocytes in their peripheral blood smear, or with typical vascular pathologic abnormalities in their renal biopsy. We compared clinical manifestations including overall survival (OS) and renal survival according to TMA causes. A total of 117 TMA patients (57 primary and 60 secondary TMA) were analyzed. Renal symptom was the most common manifestation in whole patients, while renal function at diagnosis was worst in pregnancy-related TMA group. Primary TMA patients had more frequent CNS symptom and hematologic manifestation compared to secondary TMAs. Among secondary TMAs, pregnancy- and HSCT-related TMA patients showed prevalent hemolytic features. During 150.2 months of follow-up, 5-year OS rate was 64.8%. Poor prognostic factors included older age, combined hematologic and solid organ malignancies, lower hemoglobin levels, and lower serum albumin levels. There was no significant difference in OS between primary and secondary TMAs. Seventy-eight percent of patients experienced AKI during TMA. Five-year death-censored renal survival rate was poor with only 69.2%. However, excellent renal outcome was observed in pregnancy-associated TMA. TMA showed various clinical manifestations according to their etiology. Notably, both OS and renal survival were poor regardless of their etiologies except pregnancy-associated TMA. Physicians should differentiate a variety of TMA categories and properly manage this complex disease entity. More... »

PAGES

1715-1726

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-017-3063-1

DOI

http://dx.doi.org/10.1007/s00277-017-3063-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090909979

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28752391


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemoglobins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy Complications, Hematologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serum Albumin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thrombotic Microangiopathies", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kang", 
        "givenName": "Eunjeong", 
        "id": "sg:person.01146652051.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146652051.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoo", 
        "givenName": "Shin Hye", 
        "id": "sg:person.01345661302.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345661302.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology-oncology, Department of Internal Medicine, CHA University School of Medicine, Seongnam, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.410886.3", 
          "name": [
            "Division of Hematology-oncology, Department of Internal Medicine, CHA University School of Medicine, Seongnam, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oh", 
        "givenName": "Doyeun", 
        "id": "sg:person.011143750642.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011143750642.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kidney Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Nephrology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, South Korea", 
            "Kidney Research Institute, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Joo", 
        "givenName": "Kwon Wook", 
        "id": "sg:person.012034363542.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012034363542.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kidney Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Nephrology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, South Korea", 
            "Kidney Research Institute, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Yon Su", 
        "id": "sg:person.012310220365.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012310220365.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Hematology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoon", 
        "givenName": "Sung-Soo", 
        "id": "sg:person.01340117230.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340117230.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Hematology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Inho", 
        "id": "sg:person.01165011054.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165011054.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Hematology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Seonyang", 
        "id": "sg:person.01040743514.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040743514.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kidney Research Institute, Seoul National University College of Medicine, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Nephrology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, South Korea", 
            "Kidney Research Institute, Seoul National University College of Medicine, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hajeong", 
        "id": "sg:person.01250766430.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250766430.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, South Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Division of Hematology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koh", 
        "givenName": "Youngil", 
        "id": "sg:person.0606172266.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606172266.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00277-015-2411-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007296740", 
          "https://doi.org/10.1007/s00277-015-2411-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00467-012-2276-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008095801", 
          "https://doi.org/10.1007/s00467-012-2276-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2369-15-94", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006601420", 
          "https://doi.org/10.1186/1471-2369-15-94"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1705160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040938178", 
          "https://doi.org/10.1038/sj.bmt.1705160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12185-011-0771-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050662602", 
          "https://doi.org/10.1007/s12185-011-0771-5"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-07-27", 
    "datePublishedReg": "2017-07-27", 
    "description": "Differential treatment strategies are applied in thrombotic microangiopathy (TMA) according to the sub-classifications. Hence, it is worthwhile to overview clinical manifestations and outcomes of overall TMA patients according to sub-classifications. We analyzed TMA patients whose serum lactate dehydrogenase levels >250\u00a0IU/L, with the presence of schistocytes in their peripheral blood smear, or with typical vascular pathologic abnormalities in their renal biopsy. We compared clinical manifestations including overall survival (OS) and renal survival according to TMA causes. A total of 117 TMA patients (57 primary and 60 secondary TMA) were analyzed. Renal symptom was the most common manifestation in whole patients, while renal function at diagnosis was worst in pregnancy-related TMA group. Primary TMA patients had more frequent CNS symptom and hematologic manifestation compared to secondary TMAs. Among secondary TMAs, pregnancy- and HSCT-related TMA patients showed prevalent hemolytic features. During 150.2\u00a0months of follow-up, 5-year OS rate was 64.8%. Poor prognostic factors included older age, combined hematologic and solid organ malignancies, lower hemoglobin levels, and lower serum albumin levels. There was no significant difference in OS between primary and secondary TMAs. Seventy-eight percent of patients experienced AKI during TMA. Five-year death-censored renal survival rate was poor with only 69.2%. However, excellent renal outcome was observed in pregnancy-associated TMA. TMA showed various clinical manifestations according to their etiology. Notably, both OS and renal survival were poor regardless of their etiologies except pregnancy-associated TMA. Physicians should differentiate a variety of TMA categories and properly manage this complex disease entity.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00277-017-3063-1", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1358129", 
        "issn": [
          "0939-5555", 
          "1432-0584"
        ], 
        "name": "Annals of Hematology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "96"
      }
    ], 
    "keywords": [
      "secondary thrombotic microangiopathy", 
      "pregnancy-associated thrombotic microangiopathy", 
      "thrombotic microangiopathy", 
      "TMA patients", 
      "overall survival", 
      "clinical manifestations", 
      "renal survival", 
      "low serum albumin level", 
      "serum lactate dehydrogenase level", 
      "presence of schistocytes", 
      "renal survival rate", 
      "excellent renal outcome", 
      "percent of patients", 
      "solid organ malignancies", 
      "serum albumin level", 
      "poor prognostic factor", 
      "lower hemoglobin levels", 
      "lactate dehydrogenase levels", 
      "IU/L", 
      "complex disease entity", 
      "peripheral blood smear", 
      "differential treatment strategies", 
      "TMA causes", 
      "renal outcomes", 
      "CNS symptoms", 
      "renal symptoms", 
      "renal function", 
      "organ malignancies", 
      "renal biopsy", 
      "OS rates", 
      "prognostic factors", 
      "albumin levels", 
      "hemoglobin levels", 
      "hematologic manifestations", 
      "common manifestation", 
      "treatment strategies", 
      "disease entity", 
      "dehydrogenase levels", 
      "whole patient", 
      "pathologic abnormalities", 
      "patients", 
      "survival rate", 
      "blood smears", 
      "older age", 
      "clinical dissection", 
      "hemolytic features", 
      "manifestations", 
      "microangiopathy", 
      "significant differences", 
      "survival", 
      "etiology", 
      "symptoms", 
      "outcomes", 
      "TMA group", 
      "HSCT", 
      "schistocytes", 
      "biopsy", 
      "pregnancy", 
      "malignancy", 
      "AKI", 
      "abnormalities", 
      "levels", 
      "smears", 
      "physicians", 
      "diagnosis", 
      "dissection", 
      "months", 
      "age", 
      "total", 
      "cause", 
      "rate", 
      "percent", 
      "group", 
      "factors", 
      "differences", 
      "entities", 
      "presence", 
      "function", 
      "categories", 
      "strategies", 
      "features", 
      "variety"
    ], 
    "name": "Clinical dissection of thrombotic microangiopathy", 
    "pagination": "1715-1726", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1090909979"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00277-017-3063-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28752391"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00277-017-3063-1", 
      "https://app.dimensions.ai/details/publication/pub.1090909979"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T17:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_747.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00277-017-3063-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00277-017-3063-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00277-017-3063-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-017-3063-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-017-3063-1'


 

This table displays all metadata directly associated to this object as RDF triples.

302 TRIPLES      21 PREDICATES      129 URIs      116 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00277-017-3063-1 schema:about N19dd01a293fa420783f81de6cc35e98c
2 N1aa649478e4c4c1b9c0c560f6563d96d
3 N1d617b03fa91453d9f2f5021346e7cd7
4 N2e248a4f041e496b8771349dd4041b4d
5 N35ea8925e2184d1c81b08741e5da0336
6 N3df340caec8c46539eb9a089d4e18dd3
7 N4d1abd628fd54462846d54a1f1bac01e
8 N50c6a265c1874473afa3acf81d85f070
9 N59cb0ca83c4746209db4b16b34996c02
10 N5d5c661b18ef42eea92355421a6d9b9e
11 N8772d859dcc84590b1e5a16ea29705b9
12 Nc3cef348d9f5476fa1ac6a3fa5e74778
13 Nc518796f770a4a1aa9016142cbdd889d
14 Ndd765dfda8054890953c346c220d773e
15 Ndedb294efac14b7984bc29d0ef5d6434
16 Ne32bc126042f40ea85fcf16762ba3659
17 Nfed71b8099544f10b99d16acf5a704eb
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author Nc66ab4e4a39147b18eed328555863bad
21 schema:citation sg:pub.10.1007/s00277-015-2411-2
22 sg:pub.10.1007/s00467-012-2276-8
23 sg:pub.10.1007/s12185-011-0771-5
24 sg:pub.10.1038/sj.bmt.1705160
25 sg:pub.10.1186/1471-2369-15-94
26 schema:datePublished 2017-07-27
27 schema:datePublishedReg 2017-07-27
28 schema:description Differential treatment strategies are applied in thrombotic microangiopathy (TMA) according to the sub-classifications. Hence, it is worthwhile to overview clinical manifestations and outcomes of overall TMA patients according to sub-classifications. We analyzed TMA patients whose serum lactate dehydrogenase levels >250 IU/L, with the presence of schistocytes in their peripheral blood smear, or with typical vascular pathologic abnormalities in their renal biopsy. We compared clinical manifestations including overall survival (OS) and renal survival according to TMA causes. A total of 117 TMA patients (57 primary and 60 secondary TMA) were analyzed. Renal symptom was the most common manifestation in whole patients, while renal function at diagnosis was worst in pregnancy-related TMA group. Primary TMA patients had more frequent CNS symptom and hematologic manifestation compared to secondary TMAs. Among secondary TMAs, pregnancy- and HSCT-related TMA patients showed prevalent hemolytic features. During 150.2 months of follow-up, 5-year OS rate was 64.8%. Poor prognostic factors included older age, combined hematologic and solid organ malignancies, lower hemoglobin levels, and lower serum albumin levels. There was no significant difference in OS between primary and secondary TMAs. Seventy-eight percent of patients experienced AKI during TMA. Five-year death-censored renal survival rate was poor with only 69.2%. However, excellent renal outcome was observed in pregnancy-associated TMA. TMA showed various clinical manifestations according to their etiology. Notably, both OS and renal survival were poor regardless of their etiologies except pregnancy-associated TMA. Physicians should differentiate a variety of TMA categories and properly manage this complex disease entity.
29 schema:genre article
30 schema:isAccessibleForFree false
31 schema:isPartOf N818d08af299842afac1372f2a90df59c
32 N98f66b1a56a9405f9ac76e6e2e582a21
33 sg:journal.1358129
34 schema:keywords AKI
35 CNS symptoms
36 HSCT
37 IU/L
38 OS rates
39 TMA causes
40 TMA group
41 TMA patients
42 abnormalities
43 age
44 albumin levels
45 biopsy
46 blood smears
47 categories
48 cause
49 clinical dissection
50 clinical manifestations
51 common manifestation
52 complex disease entity
53 dehydrogenase levels
54 diagnosis
55 differences
56 differential treatment strategies
57 disease entity
58 dissection
59 entities
60 etiology
61 excellent renal outcome
62 factors
63 features
64 function
65 group
66 hematologic manifestations
67 hemoglobin levels
68 hemolytic features
69 lactate dehydrogenase levels
70 levels
71 low serum albumin level
72 lower hemoglobin levels
73 malignancy
74 manifestations
75 microangiopathy
76 months
77 older age
78 organ malignancies
79 outcomes
80 overall survival
81 pathologic abnormalities
82 patients
83 percent
84 percent of patients
85 peripheral blood smear
86 physicians
87 poor prognostic factor
88 pregnancy
89 pregnancy-associated thrombotic microangiopathy
90 presence
91 presence of schistocytes
92 prognostic factors
93 rate
94 renal biopsy
95 renal function
96 renal outcomes
97 renal survival
98 renal survival rate
99 renal symptoms
100 schistocytes
101 secondary thrombotic microangiopathy
102 serum albumin level
103 serum lactate dehydrogenase level
104 significant differences
105 smears
106 solid organ malignancies
107 strategies
108 survival
109 survival rate
110 symptoms
111 thrombotic microangiopathy
112 total
113 treatment strategies
114 variety
115 whole patient
116 schema:name Clinical dissection of thrombotic microangiopathy
117 schema:pagination 1715-1726
118 schema:productId N10a234452b4046b98ec063fea71f0cef
119 N4022e04534464adaabf40d37fb1d5396
120 Nad9a41135d5249cd871759bd2bc2692e
121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090909979
122 https://doi.org/10.1007/s00277-017-3063-1
123 schema:sdDatePublished 2022-08-04T17:05
124 schema:sdLicense https://scigraph.springernature.com/explorer/license/
125 schema:sdPublisher N49b732920d724ed19fe255a9ff2bf530
126 schema:url https://doi.org/10.1007/s00277-017-3063-1
127 sgo:license sg:explorer/license/
128 sgo:sdDataset articles
129 rdf:type schema:ScholarlyArticle
130 N10a234452b4046b98ec063fea71f0cef schema:name pubmed_id
131 schema:value 28752391
132 rdf:type schema:PropertyValue
133 N19dd01a293fa420783f81de6cc35e98c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Aged
135 rdf:type schema:DefinedTerm
136 N1aa649478e4c4c1b9c0c560f6563d96d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Retrospective Studies
138 rdf:type schema:DefinedTerm
139 N1d617b03fa91453d9f2f5021346e7cd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Adult
141 rdf:type schema:DefinedTerm
142 N2907fc1e8f9f4363ad31859b40c27199 rdf:first sg:person.011143750642.33
143 rdf:rest Nf9ce005891c94b33ae134b61d5be5c0d
144 N2e248a4f041e496b8771349dd4041b4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Middle Aged
146 rdf:type schema:DefinedTerm
147 N32ff892a5f224a6ab3869e6ba56a5643 rdf:first sg:person.012310220365.89
148 rdf:rest N63556909d82e4f8a889fd42ac0d3ee08
149 N35ea8925e2184d1c81b08741e5da0336 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Pregnancy
151 rdf:type schema:DefinedTerm
152 N3df340caec8c46539eb9a089d4e18dd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Risk Factors
154 rdf:type schema:DefinedTerm
155 N4022e04534464adaabf40d37fb1d5396 schema:name dimensions_id
156 schema:value pub.1090909979
157 rdf:type schema:PropertyValue
158 N49b732920d724ed19fe255a9ff2bf530 schema:name Springer Nature - SN SciGraph project
159 rdf:type schema:Organization
160 N4d1abd628fd54462846d54a1f1bac01e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Male
162 rdf:type schema:DefinedTerm
163 N50c6a265c1874473afa3acf81d85f070 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Survival Rate
165 rdf:type schema:DefinedTerm
166 N59cb0ca83c4746209db4b16b34996c02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Humans
168 rdf:type schema:DefinedTerm
169 N5d0bd8f301764b69bc438d14426794d1 rdf:first sg:person.01250766430.64
170 rdf:rest Nda3a18e3fe48453fa02c08ae73773e37
171 N5d5c661b18ef42eea92355421a6d9b9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Serum Albumin
173 rdf:type schema:DefinedTerm
174 N63556909d82e4f8a889fd42ac0d3ee08 rdf:first sg:person.01340117230.25
175 rdf:rest Ne8e54b033ef54d58a507ce20988b553b
176 N818d08af299842afac1372f2a90df59c schema:volumeNumber 96
177 rdf:type schema:PublicationVolume
178 N8772d859dcc84590b1e5a16ea29705b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Pregnancy Complications, Hematologic
180 rdf:type schema:DefinedTerm
181 N98f66b1a56a9405f9ac76e6e2e582a21 schema:issueNumber 10
182 rdf:type schema:PublicationIssue
183 Naafcfecb5e584ea9865506e5ff9a7d4d rdf:first sg:person.01040743514.14
184 rdf:rest N5d0bd8f301764b69bc438d14426794d1
185 Nad9a41135d5249cd871759bd2bc2692e schema:name doi
186 schema:value 10.1007/s00277-017-3063-1
187 rdf:type schema:PropertyValue
188 Nb36ed95cc0074f5c863d44b1b317fb11 rdf:first sg:person.01345661302.02
189 rdf:rest N2907fc1e8f9f4363ad31859b40c27199
190 Nc3cef348d9f5476fa1ac6a3fa5e74778 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Disease-Free Survival
192 rdf:type schema:DefinedTerm
193 Nc518796f770a4a1aa9016142cbdd889d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Aged, 80 and over
195 rdf:type schema:DefinedTerm
196 Nc66ab4e4a39147b18eed328555863bad rdf:first sg:person.01146652051.10
197 rdf:rest Nb36ed95cc0074f5c863d44b1b317fb11
198 Nda3a18e3fe48453fa02c08ae73773e37 rdf:first sg:person.0606172266.96
199 rdf:rest rdf:nil
200 Ndd765dfda8054890953c346c220d773e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Thrombotic Microangiopathies
202 rdf:type schema:DefinedTerm
203 Ndedb294efac14b7984bc29d0ef5d6434 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Female
205 rdf:type schema:DefinedTerm
206 Ne32bc126042f40ea85fcf16762ba3659 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Hemoglobins
208 rdf:type schema:DefinedTerm
209 Ne8e54b033ef54d58a507ce20988b553b rdf:first sg:person.01165011054.41
210 rdf:rest Naafcfecb5e584ea9865506e5ff9a7d4d
211 Nf9ce005891c94b33ae134b61d5be5c0d rdf:first sg:person.012034363542.01
212 rdf:rest N32ff892a5f224a6ab3869e6ba56a5643
213 Nfed71b8099544f10b99d16acf5a704eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Adolescent
215 rdf:type schema:DefinedTerm
216 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
217 schema:name Medical and Health Sciences
218 rdf:type schema:DefinedTerm
219 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
220 schema:name Clinical Sciences
221 rdf:type schema:DefinedTerm
222 sg:journal.1358129 schema:issn 0939-5555
223 1432-0584
224 schema:name Annals of Hematology
225 schema:publisher Springer Nature
226 rdf:type schema:Periodical
227 sg:person.01040743514.14 schema:affiliation grid-institutes:grid.31501.36
228 schema:familyName Park
229 schema:givenName Seonyang
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040743514.14
231 rdf:type schema:Person
232 sg:person.011143750642.33 schema:affiliation grid-institutes:grid.410886.3
233 schema:familyName Oh
234 schema:givenName Doyeun
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011143750642.33
236 rdf:type schema:Person
237 sg:person.01146652051.10 schema:affiliation grid-institutes:grid.31501.36
238 schema:familyName Kang
239 schema:givenName Eunjeong
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146652051.10
241 rdf:type schema:Person
242 sg:person.01165011054.41 schema:affiliation grid-institutes:grid.31501.36
243 schema:familyName Kim
244 schema:givenName Inho
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165011054.41
246 rdf:type schema:Person
247 sg:person.012034363542.01 schema:affiliation grid-institutes:grid.31501.36
248 schema:familyName Joo
249 schema:givenName Kwon Wook
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012034363542.01
251 rdf:type schema:Person
252 sg:person.012310220365.89 schema:affiliation grid-institutes:grid.31501.36
253 schema:familyName Kim
254 schema:givenName Yon Su
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012310220365.89
256 rdf:type schema:Person
257 sg:person.01250766430.64 schema:affiliation grid-institutes:grid.31501.36
258 schema:familyName Lee
259 schema:givenName Hajeong
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250766430.64
261 rdf:type schema:Person
262 sg:person.01340117230.25 schema:affiliation grid-institutes:grid.31501.36
263 schema:familyName Yoon
264 schema:givenName Sung-Soo
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340117230.25
266 rdf:type schema:Person
267 sg:person.01345661302.02 schema:affiliation grid-institutes:grid.31501.36
268 schema:familyName Yoo
269 schema:givenName Shin Hye
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345661302.02
271 rdf:type schema:Person
272 sg:person.0606172266.96 schema:affiliation grid-institutes:grid.31501.36
273 schema:familyName Koh
274 schema:givenName Youngil
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606172266.96
276 rdf:type schema:Person
277 sg:pub.10.1007/s00277-015-2411-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007296740
278 https://doi.org/10.1007/s00277-015-2411-2
279 rdf:type schema:CreativeWork
280 sg:pub.10.1007/s00467-012-2276-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008095801
281 https://doi.org/10.1007/s00467-012-2276-8
282 rdf:type schema:CreativeWork
283 sg:pub.10.1007/s12185-011-0771-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050662602
284 https://doi.org/10.1007/s12185-011-0771-5
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/sj.bmt.1705160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040938178
287 https://doi.org/10.1038/sj.bmt.1705160
288 rdf:type schema:CreativeWork
289 sg:pub.10.1186/1471-2369-15-94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006601420
290 https://doi.org/10.1186/1471-2369-15-94
291 rdf:type schema:CreativeWork
292 grid-institutes:grid.31501.36 schema:alternateName Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
293 Division of Hematology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, South Korea
294 Kidney Research Institute, Seoul National University College of Medicine, Seoul, South Korea
295 schema:name Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
296 Division of Hematology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, South Korea
297 Division of Nephrology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, South Korea
298 Kidney Research Institute, Seoul National University College of Medicine, Seoul, South Korea
299 rdf:type schema:Organization
300 grid-institutes:grid.410886.3 schema:alternateName Division of Hematology-oncology, Department of Internal Medicine, CHA University School of Medicine, Seongnam, South Korea
301 schema:name Division of Hematology-oncology, Department of Internal Medicine, CHA University School of Medicine, Seongnam, South Korea
302 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...