Cytomorphology review of 100 newly diagnosed lower-risk MDS patients in the European LeukemiaNet MDS (EUMDS) registry reveals a high inter-observer ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-05-20

AUTHORS

Louise de Swart, Alex Smith, Marius MacKenzie, Argiris Symeonidis, Judith Neukirchen, Dana Mikulenková, Teresa Vallespí, Gina Zini, Malgorzata Paszkowska-Kowalewska, Anton Kruger, Leonie Saft, Pierre Fenaux, David Bowen, Eva Hellström-Lindberg, Jaroslav Čermák, Reinhard Stauder, Aurelia Tatic, Mette Skov Holm, Luca Malcovati, Krzysztof Mądry, Jackie Droste, Nicole Blijlevens, Theo de Witte, Ulrich Germing

ABSTRACT

The European LeukemiaNet MDS (EUMDS) registry is collecting data of myelodysplastic syndrome (MDS) patients belonging to the IPSS low or intermediate-1 category, newly diagnosed by local cytologists. The diagnosis of MDS can be challenging, and some data report inter-observer variability with regard to the assessment of the MDS subtype. In order to ensure that correct diagnoses were made by the participating centres, blood and bone marrow slides of 10% of the first 1000 patients were reviewed by an 11-person panel of cytomorphologists. All slides were rated by at least 3 panel members (median 8 panel members; range 3–9). Marrow slides from 98 out of 105 patients were of good quality and therefore could be rated properly according to the WHO 2001 classification, including assessment of dysplastic lineages. The agreement between the reviewers whether the diagnosis was MDS or non-MDS was strong with an intra-class correlation coefficient (ICC) of 0.85. Six cases were detected not to fit the entry criteria of the registry, because they were diagnosed uniformly as CMML or AML by the panel members. The agreement by WHO 2001 classification was strong as well (ICC = 0.83). The concordance of the assessment of dysplastic lineages was substantial for megakaryopoiesis and myelopoiesis and moderate for erythropoiesis. Our data show that in general, the inter-observer agreement was high and a very low percentage of misdiagnosed cases had been entered into the EUMDS registry. Further studies including histomorphology are warranted. More... »

PAGES

1105-1112

Journal

TITLE

Annals of Hematology

ISSUE

7

VOLUME

96

Author Affiliations

  • Department of Haematology, Radboud University Medical Centre, Nijmegen, The Netherlands
  • Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK
  • Department of Medicine, Division of Haematology, University of Patras Medical School, Patras, Greece
  • Department of Haematology, Oncology and Clinical Immunology, Universitätsklinik Düsseldorf, Düsseldorf, Germany
  • Department of Clinical Haematology, Institution of Haematology and Blood Transfusion, Praha, Czech Republic
  • Department of Haematology, Haematological Cytogenetics Unit, University Hospital of Vall d’Hebron, Barcelona, Spain
  • Haematology Institute, Catholic University of Sacred Heart, Rome, Italy
  • Department of Haematology, Oncology and Internal Medicine, Warszawa Medical University, Warszawa, Poland
  • Department of Haematology, Royal Cornwall Hospital, Truro, UK
  • Department of Pathology and Cytology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
  • Service d’Hématologie, Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris (AP-HP) and Université Paris 7, Paris, France
  • St. James’s Institute of Oncology, Leeds Teaching Hospitals, Leeds, UK
  • Department of Medicine, Division of Haematology, Karolinska Institutet, Stockholm, Sweden
  • Department of Internal Medicine V (Haematology and Oncology), Innsbruck Medical University, Innsbruck, Austria
  • Centre of Haematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania
  • Department of Haematology, Aarhus University Hospital, Aarhus, Denmark
  • Department of Haematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
  • Department of Tumor Immunology - Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre (TIL, 278), P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00277-017-3009-7

    DOI

    http://dx.doi.org/10.1007/s00277-017-3009-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085450095

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28526957


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Marrow Examination", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytodiagnosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myelodysplastic Syndromes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Observer Variation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Registries", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reproducibility of Results", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sensitivity and Specificity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Haematology, Radboud University Medical Centre, Nijmegen, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10417.33", 
              "name": [
                "Department of Haematology, Radboud University Medical Centre, Nijmegen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Swart", 
            "givenName": "Louise", 
            "id": "sg:person.0755526470.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755526470.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK", 
              "id": "http://www.grid.ac/institutes/grid.5685.e", 
              "name": [
                "Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Smith", 
            "givenName": "Alex", 
            "id": "sg:person.01070606157.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070606157.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Haematology, Radboud University Medical Centre, Nijmegen, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10417.33", 
              "name": [
                "Department of Haematology, Radboud University Medical Centre, Nijmegen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "MacKenzie", 
            "givenName": "Marius", 
            "id": "sg:person.0575501465.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575501465.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Division of Haematology, University of Patras Medical School, Patras, Greece", 
              "id": "http://www.grid.ac/institutes/grid.11047.33", 
              "name": [
                "Department of Medicine, Division of Haematology, University of Patras Medical School, Patras, Greece"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Symeonidis", 
            "givenName": "Argiris", 
            "id": "sg:person.01306361566.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306361566.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Haematology, Oncology and Clinical Immunology, Universit\u00e4tsklinik D\u00fcsseldorf, D\u00fcsseldorf, Germany", 
              "id": "http://www.grid.ac/institutes/grid.14778.3d", 
              "name": [
                "Department of Haematology, Oncology and Clinical Immunology, Universit\u00e4tsklinik D\u00fcsseldorf, D\u00fcsseldorf, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Neukirchen", 
            "givenName": "Judith", 
            "id": "sg:person.0643404664.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643404664.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Haematology, Institution of Haematology and Blood Transfusion, Praha, Czech Republic", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Clinical Haematology, Institution of Haematology and Blood Transfusion, Praha, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mikulenkov\u00e1", 
            "givenName": "Dana", 
            "id": "sg:person.0707665633.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707665633.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Haematology, Haematological Cytogenetics Unit, University Hospital of Vall d\u2019Hebron, Barcelona, Spain", 
              "id": "http://www.grid.ac/institutes/grid.411083.f", 
              "name": [
                "Department of Haematology, Haematological Cytogenetics Unit, University Hospital of Vall d\u2019Hebron, Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vallesp\u00ed", 
            "givenName": "Teresa", 
            "id": "sg:person.01354005266.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354005266.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Haematology Institute, Catholic University of Sacred Heart, Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.8142.f", 
              "name": [
                "Haematology Institute, Catholic University of Sacred Heart, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zini", 
            "givenName": "Gina", 
            "id": "sg:person.01233565776.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233565776.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Haematology, Oncology and Internal Medicine, Warszawa Medical University, Warszawa, Poland", 
              "id": "http://www.grid.ac/institutes/grid.13339.3b", 
              "name": [
                "Department of Haematology, Oncology and Internal Medicine, Warszawa Medical University, Warszawa, Poland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Paszkowska-Kowalewska", 
            "givenName": "Malgorzata", 
            "id": "sg:person.01166714637.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166714637.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Haematology, Royal Cornwall Hospital, Truro, UK", 
              "id": "http://www.grid.ac/institutes/grid.416116.5", 
              "name": [
                "Department of Haematology, Royal Cornwall Hospital, Truro, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kruger", 
            "givenName": "Anton", 
            "id": "sg:person.01303002216.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303002216.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Cytology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden", 
              "id": "http://www.grid.ac/institutes/grid.4714.6", 
              "name": [
                "Department of Pathology and Cytology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saft", 
            "givenName": "Leonie", 
            "id": "sg:person.01012624116.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012624116.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service d\u2019H\u00e9matologie, H\u00f4pital Saint-Louis, Assistance Publique des H\u00f4pitaux de Paris (AP-HP) and Universit\u00e9 Paris 7, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.413328.f", 
              "name": [
                "Service d\u2019H\u00e9matologie, H\u00f4pital Saint-Louis, Assistance Publique des H\u00f4pitaux de Paris (AP-HP) and Universit\u00e9 Paris 7, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fenaux", 
            "givenName": "Pierre", 
            "id": "sg:person.0766554473.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766554473.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. James\u2019s Institute of Oncology, Leeds Teaching Hospitals, Leeds, UK", 
              "id": "http://www.grid.ac/institutes/grid.443984.6", 
              "name": [
                "St. James\u2019s Institute of Oncology, Leeds Teaching Hospitals, Leeds, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bowen", 
            "givenName": "David", 
            "id": "sg:person.010142003347.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010142003347.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Division of Haematology, Karolinska Institutet, Stockholm, Sweden", 
              "id": "http://www.grid.ac/institutes/grid.4714.6", 
              "name": [
                "Department of Medicine, Division of Haematology, Karolinska Institutet, Stockholm, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hellstr\u00f6m-Lindberg", 
            "givenName": "Eva", 
            "id": "sg:person.0730110062.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730110062.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Haematology, Institution of Haematology and Blood Transfusion, Praha, Czech Republic", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Clinical Haematology, Institution of Haematology and Blood Transfusion, Praha, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "\u010cerm\u00e1k", 
            "givenName": "Jaroslav", 
            "id": "sg:person.0726561165.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726561165.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Internal Medicine V (Haematology and Oncology), Innsbruck Medical University, Innsbruck, Austria", 
              "id": "http://www.grid.ac/institutes/grid.5361.1", 
              "name": [
                "Department of Internal Medicine V (Haematology and Oncology), Innsbruck Medical University, Innsbruck, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stauder", 
            "givenName": "Reinhard", 
            "id": "sg:person.0617564545.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617564545.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre of Haematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania", 
              "id": "http://www.grid.ac/institutes/grid.415180.9", 
              "name": [
                "Centre of Haematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tatic", 
            "givenName": "Aurelia", 
            "id": "sg:person.01211700172.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211700172.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Haematology, Aarhus University Hospital, Aarhus, Denmark", 
              "id": "http://www.grid.ac/institutes/grid.154185.c", 
              "name": [
                "Department of Haematology, Aarhus University Hospital, Aarhus, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Holm", 
            "givenName": "Mette Skov", 
            "id": "sg:person.01242177302.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242177302.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Haematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Haematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Malcovati", 
            "givenName": "Luca", 
            "id": "sg:person.01015506717.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015506717.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Haematology, Oncology and Internal Medicine, Warszawa Medical University, Warszawa, Poland", 
              "id": "http://www.grid.ac/institutes/grid.13339.3b", 
              "name": [
                "Department of Haematology, Oncology and Internal Medicine, Warszawa Medical University, Warszawa, Poland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "M\u0105dry", 
            "givenName": "Krzysztof", 
            "id": "sg:person.01067020547.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067020547.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Haematology, Radboud University Medical Centre, Nijmegen, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10417.33", 
              "name": [
                "Department of Haematology, Radboud University Medical Centre, Nijmegen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Droste", 
            "givenName": "Jackie", 
            "id": "sg:person.012752673175.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012752673175.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Haematology, Radboud University Medical Centre, Nijmegen, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10417.33", 
              "name": [
                "Department of Haematology, Radboud University Medical Centre, Nijmegen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blijlevens", 
            "givenName": "Nicole", 
            "id": "sg:person.01067363064.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067363064.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Tumor Immunology - Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre (TIL, 278), P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10417.33", 
              "name": [
                "Department of Tumor Immunology - Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre (TIL, 278), P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Witte", 
            "givenName": "Theo", 
            "id": "sg:person.015730551677.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015730551677.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Haematology, Oncology and Clinical Immunology, Universit\u00e4tsklinik D\u00fcsseldorf, D\u00fcsseldorf, Germany", 
              "id": "http://www.grid.ac/institutes/grid.14778.3d", 
              "name": [
                "Department of Haematology, Oncology and Clinical Immunology, Universit\u00e4tsklinik D\u00fcsseldorf, D\u00fcsseldorf, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Germing", 
            "givenName": "Ulrich", 
            "id": "sg:person.01362464041.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362464041.20"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00277-012-1565-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038749957", 
              "https://doi.org/10.1007/s00277-012-1565-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-014-2252-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023560375", 
              "https://doi.org/10.1007/s00277-014-2252-4"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-05-20", 
        "datePublishedReg": "2017-05-20", 
        "description": "The European LeukemiaNet MDS (EUMDS) registry is collecting data of myelodysplastic syndrome (MDS) patients belonging to the IPSS low or intermediate-1 category, newly diagnosed by local cytologists. The diagnosis of MDS can be challenging, and some data report inter-observer variability with regard to the assessment of the MDS subtype. In order to ensure that correct diagnoses were made by the participating centres, blood and bone marrow slides of 10% of the first 1000 patients were reviewed by an 11-person panel of cytomorphologists. All slides were rated by at least 3 panel members (median 8 panel members; range 3\u20139). Marrow slides from 98 out of 105 patients were of good quality and therefore could be rated properly according to the WHO 2001 classification, including assessment of dysplastic lineages. The agreement between the reviewers whether the diagnosis was MDS or non-MDS was strong with an intra-class correlation coefficient (ICC) of 0.85. Six cases were detected not to fit the entry criteria of the registry, because they were diagnosed uniformly as CMML or AML by the panel members. The agreement by WHO 2001 classification was strong as well (ICC\u00a0=\u00a00.83). The concordance of the assessment of dysplastic lineages was substantial for megakaryopoiesis and myelopoiesis and moderate for erythropoiesis. Our data show that in general, the inter-observer agreement was high and a very low percentage of misdiagnosed cases had been entered into the EUMDS registry. Further studies including histomorphology are warranted.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00277-017-3009-7", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1358129", 
            "issn": [
              "0939-5555", 
              "1432-0584"
            ], 
            "name": "Annals of Hematology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "96"
          }
        ], 
        "keywords": [
          "intra-class correlation coefficient", 
          "MDS Registry", 
          "dysplastic lineages", 
          "high inter-observer concordance", 
          "low-risk MDS patients", 
          "diagnosis of MDS", 
          "myelodysplastic syndrome patients", 
          "bone marrow slides", 
          "inter-observer concordance", 
          "inter-observer agreement", 
          "MDS patients", 
          "MDS subtypes", 
          "entry criteria", 
          "syndrome patients", 
          "marrow slides", 
          "misdiagnosed cases", 
          "correct diagnosis", 
          "panel members", 
          "patients", 
          "registry", 
          "inter-observer variability", 
          "diagnosis", 
          "Further studies", 
          "lower percentage", 
          "MDS", 
          "concordance", 
          "cytomorphologists", 
          "IPSS", 
          "assessment", 
          "CMML", 
          "AML", 
          "subtypes", 
          "marrow", 
          "blood", 
          "histomorphology", 
          "erythropoiesis", 
          "myelopoiesis", 
          "correlation coefficient", 
          "reviewers", 
          "cases", 
          "cytologists", 
          "megakaryopoiesis", 
          "slides", 
          "good quality", 
          "review", 
          "percentage", 
          "data", 
          "members", 
          "criteria", 
          "lineages", 
          "center", 
          "study", 
          "classification", 
          "panel", 
          "regard", 
          "categories", 
          "quality", 
          "variability", 
          "agreement", 
          "order", 
          "coefficient"
        ], 
        "name": "Cytomorphology review of 100 newly diagnosed lower-risk MDS patients in the European LeukemiaNet MDS (EUMDS) registry reveals a high inter-observer concordance", 
        "pagination": "1105-1112", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1085450095"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00277-017-3009-7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28526957"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00277-017-3009-7", 
          "https://app.dimensions.ai/details/publication/pub.1085450095"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:44", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_753.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00277-017-3009-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00277-017-3009-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00277-017-3009-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-017-3009-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-017-3009-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    399 TRIPLES      21 PREDICATES      103 URIs      93 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00277-017-3009-7 schema:about N19751ce9209f46f493dee6f540cc848c
    2 N23cd52f8e576473aa2a77a54e7890938
    3 N2f8abfd0af714b038dd08875d6a65a03
    4 N4885aafebcfe47af8d66c1675f45e88b
    5 N5473923ccdb04019afd00b5d6db75649
    6 N674b8f5e9ee3442f8ebd3c29dca83352
    7 N75f83d38bb244d87bff14866485e6b4e
    8 N90c3540dc17b481f856e8fa04150e987
    9 N9b0dc20f60694d8cb29cb16c1c403de9
    10 N9dd89f318820452788c2774fc3de943a
    11 Nab9beabb6bde4502807cc3c37ad3a60f
    12 Nb092f87028de43a2846c2a7f5572d0bc
    13 Nc5bac11f5e8e4a24b08866ad9fcba77e
    14 Nccf07d54b779403b8960503c60fd11c0
    15 Ne62cc145634d4588b42fb8da5ff96d71
    16 anzsrc-for:11
    17 anzsrc-for:1102
    18 schema:author Nd35b6232548342d29a92692790f9cf9a
    19 schema:citation sg:pub.10.1007/s00277-012-1565-4
    20 sg:pub.10.1007/s00277-014-2252-4
    21 schema:datePublished 2017-05-20
    22 schema:datePublishedReg 2017-05-20
    23 schema:description The European LeukemiaNet MDS (EUMDS) registry is collecting data of myelodysplastic syndrome (MDS) patients belonging to the IPSS low or intermediate-1 category, newly diagnosed by local cytologists. The diagnosis of MDS can be challenging, and some data report inter-observer variability with regard to the assessment of the MDS subtype. In order to ensure that correct diagnoses were made by the participating centres, blood and bone marrow slides of 10% of the first 1000 patients were reviewed by an 11-person panel of cytomorphologists. All slides were rated by at least 3 panel members (median 8 panel members; range 3–9). Marrow slides from 98 out of 105 patients were of good quality and therefore could be rated properly according to the WHO 2001 classification, including assessment of dysplastic lineages. The agreement between the reviewers whether the diagnosis was MDS or non-MDS was strong with an intra-class correlation coefficient (ICC) of 0.85. Six cases were detected not to fit the entry criteria of the registry, because they were diagnosed uniformly as CMML or AML by the panel members. The agreement by WHO 2001 classification was strong as well (ICC = 0.83). The concordance of the assessment of dysplastic lineages was substantial for megakaryopoiesis and myelopoiesis and moderate for erythropoiesis. Our data show that in general, the inter-observer agreement was high and a very low percentage of misdiagnosed cases had been entered into the EUMDS registry. Further studies including histomorphology are warranted.
    24 schema:genre article
    25 schema:isAccessibleForFree true
    26 schema:isPartOf N326a6aeda350434cba65f587d55d21fe
    27 N85032272c2ad43dd959d4981201b46d7
    28 sg:journal.1358129
    29 schema:keywords AML
    30 CMML
    31 Further studies
    32 IPSS
    33 MDS
    34 MDS Registry
    35 MDS patients
    36 MDS subtypes
    37 agreement
    38 assessment
    39 blood
    40 bone marrow slides
    41 cases
    42 categories
    43 center
    44 classification
    45 coefficient
    46 concordance
    47 correct diagnosis
    48 correlation coefficient
    49 criteria
    50 cytologists
    51 cytomorphologists
    52 data
    53 diagnosis
    54 diagnosis of MDS
    55 dysplastic lineages
    56 entry criteria
    57 erythropoiesis
    58 good quality
    59 high inter-observer concordance
    60 histomorphology
    61 inter-observer agreement
    62 inter-observer concordance
    63 inter-observer variability
    64 intra-class correlation coefficient
    65 lineages
    66 low-risk MDS patients
    67 lower percentage
    68 marrow
    69 marrow slides
    70 megakaryopoiesis
    71 members
    72 misdiagnosed cases
    73 myelodysplastic syndrome patients
    74 myelopoiesis
    75 order
    76 panel
    77 panel members
    78 patients
    79 percentage
    80 quality
    81 regard
    82 registry
    83 review
    84 reviewers
    85 slides
    86 study
    87 subtypes
    88 syndrome patients
    89 variability
    90 schema:name Cytomorphology review of 100 newly diagnosed lower-risk MDS patients in the European LeukemiaNet MDS (EUMDS) registry reveals a high inter-observer concordance
    91 schema:pagination 1105-1112
    92 schema:productId N2155ea0336504fcbb15cb0d8474bd439
    93 N56d0b3d1eb6040a0b11db102490810a7
    94 N72fe372a5bc04ad481989ceb3fec217c
    95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085450095
    96 https://doi.org/10.1007/s00277-017-3009-7
    97 schema:sdDatePublished 2022-10-01T06:44
    98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    99 schema:sdPublisher N8229d25fb35f4b76b0f3ef579278ed32
    100 schema:url https://doi.org/10.1007/s00277-017-3009-7
    101 sgo:license sg:explorer/license/
    102 sgo:sdDataset articles
    103 rdf:type schema:ScholarlyArticle
    104 N0cdd23aa2cd04f9fae04618b5780f4e5 rdf:first sg:person.01354005266.47
    105 rdf:rest N69f393a49ea44255bd815322ce8ab439
    106 N0f037ce035e1427aafee3ed81c7b54b6 rdf:first sg:person.0575501465.68
    107 rdf:rest N6993020eea7e4265aff652e8306fd26f
    108 N19751ce9209f46f493dee6f540cc848c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Male
    110 rdf:type schema:DefinedTerm
    111 N2155ea0336504fcbb15cb0d8474bd439 schema:name dimensions_id
    112 schema:value pub.1085450095
    113 rdf:type schema:PropertyValue
    114 N2225b5354ddc4353992c3ef2b93c18c9 rdf:first sg:person.01166714637.11
    115 rdf:rest N8688f43df43743bdb0d7b6d4a14c52ca
    116 N23a015749390457fb6fd1fcb1a7ae9bc rdf:first sg:person.01242177302.57
    117 rdf:rest N452371e89fb946b7bce4941de62dd05a
    118 N23cd52f8e576473aa2a77a54e7890938 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Myelodysplastic Syndromes
    120 rdf:type schema:DefinedTerm
    121 N29019a8cac604c09934a78fdade311ca rdf:first sg:person.01362464041.20
    122 rdf:rest rdf:nil
    123 N2f8abfd0af714b038dd08875d6a65a03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Observer Variation
    125 rdf:type schema:DefinedTerm
    126 N326a6aeda350434cba65f587d55d21fe schema:issueNumber 7
    127 rdf:type schema:PublicationIssue
    128 N33e539e79f714621a0477737b8ba9ede rdf:first sg:person.01070606157.27
    129 rdf:rest N0f037ce035e1427aafee3ed81c7b54b6
    130 N3dbf5ddf201a4202b96eae63842ab7a0 rdf:first sg:person.012752673175.83
    131 rdf:rest N9764085b3d80473496dc4a28ce4ebe2b
    132 N3e60d8c351994da98f05c56cacc4a82b rdf:first sg:person.0643404664.08
    133 rdf:rest N6f8a6b7b2ca848bd9de805e82ff734cf
    134 N452371e89fb946b7bce4941de62dd05a rdf:first sg:person.01015506717.02
    135 rdf:rest Nc65607703dc74a30ac8f7f37c4f44c94
    136 N4885aafebcfe47af8d66c1675f45e88b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Registries
    138 rdf:type schema:DefinedTerm
    139 N5473923ccdb04019afd00b5d6db75649 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Aged, 80 and over
    141 rdf:type schema:DefinedTerm
    142 N56d0b3d1eb6040a0b11db102490810a7 schema:name doi
    143 schema:value 10.1007/s00277-017-3009-7
    144 rdf:type schema:PropertyValue
    145 N5a6ec1287c4d43b5842a2c11f764bb8f rdf:first sg:person.01211700172.81
    146 rdf:rest N23a015749390457fb6fd1fcb1a7ae9bc
    147 N5ae840e97cd245b88514ee26d597e3d7 rdf:first sg:person.0617564545.58
    148 rdf:rest N5a6ec1287c4d43b5842a2c11f764bb8f
    149 N674b8f5e9ee3442f8ebd3c29dca83352 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Reproducibility of Results
    151 rdf:type schema:DefinedTerm
    152 N6993020eea7e4265aff652e8306fd26f rdf:first sg:person.01306361566.09
    153 rdf:rest N3e60d8c351994da98f05c56cacc4a82b
    154 N69f393a49ea44255bd815322ce8ab439 rdf:first sg:person.01233565776.55
    155 rdf:rest N2225b5354ddc4353992c3ef2b93c18c9
    156 N6cb703c4e11f4c4491bd3c631955180e rdf:first sg:person.0726561165.17
    157 rdf:rest N5ae840e97cd245b88514ee26d597e3d7
    158 N6f8a6b7b2ca848bd9de805e82ff734cf rdf:first sg:person.0707665633.97
    159 rdf:rest N0cdd23aa2cd04f9fae04618b5780f4e5
    160 N72fe372a5bc04ad481989ceb3fec217c schema:name pubmed_id
    161 schema:value 28526957
    162 rdf:type schema:PropertyValue
    163 N75f83d38bb244d87bff14866485e6b4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Humans
    165 rdf:type schema:DefinedTerm
    166 N7b8a7af0e2b74867bef8fd22bd97f9ba rdf:first sg:person.0766554473.71
    167 rdf:rest Nc6864a8c5dc34e9c89fb67b86f3e3cae
    168 N8229d25fb35f4b76b0f3ef579278ed32 schema:name Springer Nature - SN SciGraph project
    169 rdf:type schema:Organization
    170 N85032272c2ad43dd959d4981201b46d7 schema:volumeNumber 96
    171 rdf:type schema:PublicationVolume
    172 N8688f43df43743bdb0d7b6d4a14c52ca rdf:first sg:person.01303002216.30
    173 rdf:rest Ndc7e1d2df8cb4708b27357399c6f1361
    174 N90c3540dc17b481f856e8fa04150e987 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Bone Marrow Examination
    176 rdf:type schema:DefinedTerm
    177 N9764085b3d80473496dc4a28ce4ebe2b rdf:first sg:person.01067363064.24
    178 rdf:rest Ndbecb7687c964ee5bfa052a3a5897baa
    179 N9b0dc20f60694d8cb29cb16c1c403de9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Young Adult
    181 rdf:type schema:DefinedTerm
    182 N9dd89f318820452788c2774fc3de943a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Female
    184 rdf:type schema:DefinedTerm
    185 Nab9beabb6bde4502807cc3c37ad3a60f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Middle Aged
    187 rdf:type schema:DefinedTerm
    188 Nb092f87028de43a2846c2a7f5572d0bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Cytodiagnosis
    190 rdf:type schema:DefinedTerm
    191 Nc5bac11f5e8e4a24b08866ad9fcba77e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Adult
    193 rdf:type schema:DefinedTerm
    194 Nc65607703dc74a30ac8f7f37c4f44c94 rdf:first sg:person.01067020547.55
    195 rdf:rest N3dbf5ddf201a4202b96eae63842ab7a0
    196 Nc6864a8c5dc34e9c89fb67b86f3e3cae rdf:first sg:person.010142003347.01
    197 rdf:rest Neb3a5a0171f24ce891b9447abefab953
    198 Nccf07d54b779403b8960503c60fd11c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Aged
    200 rdf:type schema:DefinedTerm
    201 Nd35b6232548342d29a92692790f9cf9a rdf:first sg:person.0755526470.64
    202 rdf:rest N33e539e79f714621a0477737b8ba9ede
    203 Ndbecb7687c964ee5bfa052a3a5897baa rdf:first sg:person.015730551677.08
    204 rdf:rest N29019a8cac604c09934a78fdade311ca
    205 Ndc7e1d2df8cb4708b27357399c6f1361 rdf:first sg:person.01012624116.44
    206 rdf:rest N7b8a7af0e2b74867bef8fd22bd97f9ba
    207 Ne62cc145634d4588b42fb8da5ff96d71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Sensitivity and Specificity
    209 rdf:type schema:DefinedTerm
    210 Neb3a5a0171f24ce891b9447abefab953 rdf:first sg:person.0730110062.04
    211 rdf:rest N6cb703c4e11f4c4491bd3c631955180e
    212 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    213 schema:name Medical and Health Sciences
    214 rdf:type schema:DefinedTerm
    215 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    216 schema:name Cardiorespiratory Medicine and Haematology
    217 rdf:type schema:DefinedTerm
    218 sg:journal.1358129 schema:issn 0939-5555
    219 1432-0584
    220 schema:name Annals of Hematology
    221 schema:publisher Springer Nature
    222 rdf:type schema:Periodical
    223 sg:person.01012624116.44 schema:affiliation grid-institutes:grid.4714.6
    224 schema:familyName Saft
    225 schema:givenName Leonie
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012624116.44
    227 rdf:type schema:Person
    228 sg:person.010142003347.01 schema:affiliation grid-institutes:grid.443984.6
    229 schema:familyName Bowen
    230 schema:givenName David
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010142003347.01
    232 rdf:type schema:Person
    233 sg:person.01015506717.02 schema:affiliation grid-institutes:None
    234 schema:familyName Malcovati
    235 schema:givenName Luca
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015506717.02
    237 rdf:type schema:Person
    238 sg:person.01067020547.55 schema:affiliation grid-institutes:grid.13339.3b
    239 schema:familyName Mądry
    240 schema:givenName Krzysztof
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067020547.55
    242 rdf:type schema:Person
    243 sg:person.01067363064.24 schema:affiliation grid-institutes:grid.10417.33
    244 schema:familyName Blijlevens
    245 schema:givenName Nicole
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067363064.24
    247 rdf:type schema:Person
    248 sg:person.01070606157.27 schema:affiliation grid-institutes:grid.5685.e
    249 schema:familyName Smith
    250 schema:givenName Alex
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070606157.27
    252 rdf:type schema:Person
    253 sg:person.01166714637.11 schema:affiliation grid-institutes:grid.13339.3b
    254 schema:familyName Paszkowska-Kowalewska
    255 schema:givenName Malgorzata
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166714637.11
    257 rdf:type schema:Person
    258 sg:person.01211700172.81 schema:affiliation grid-institutes:grid.415180.9
    259 schema:familyName Tatic
    260 schema:givenName Aurelia
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211700172.81
    262 rdf:type schema:Person
    263 sg:person.01233565776.55 schema:affiliation grid-institutes:grid.8142.f
    264 schema:familyName Zini
    265 schema:givenName Gina
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233565776.55
    267 rdf:type schema:Person
    268 sg:person.01242177302.57 schema:affiliation grid-institutes:grid.154185.c
    269 schema:familyName Holm
    270 schema:givenName Mette Skov
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242177302.57
    272 rdf:type schema:Person
    273 sg:person.012752673175.83 schema:affiliation grid-institutes:grid.10417.33
    274 schema:familyName Droste
    275 schema:givenName Jackie
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012752673175.83
    277 rdf:type schema:Person
    278 sg:person.01303002216.30 schema:affiliation grid-institutes:grid.416116.5
    279 schema:familyName Kruger
    280 schema:givenName Anton
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303002216.30
    282 rdf:type schema:Person
    283 sg:person.01306361566.09 schema:affiliation grid-institutes:grid.11047.33
    284 schema:familyName Symeonidis
    285 schema:givenName Argiris
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306361566.09
    287 rdf:type schema:Person
    288 sg:person.01354005266.47 schema:affiliation grid-institutes:grid.411083.f
    289 schema:familyName Vallespí
    290 schema:givenName Teresa
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354005266.47
    292 rdf:type schema:Person
    293 sg:person.01362464041.20 schema:affiliation grid-institutes:grid.14778.3d
    294 schema:familyName Germing
    295 schema:givenName Ulrich
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362464041.20
    297 rdf:type schema:Person
    298 sg:person.015730551677.08 schema:affiliation grid-institutes:grid.10417.33
    299 schema:familyName de Witte
    300 schema:givenName Theo
    301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015730551677.08
    302 rdf:type schema:Person
    303 sg:person.0575501465.68 schema:affiliation grid-institutes:grid.10417.33
    304 schema:familyName MacKenzie
    305 schema:givenName Marius
    306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575501465.68
    307 rdf:type schema:Person
    308 sg:person.0617564545.58 schema:affiliation grid-institutes:grid.5361.1
    309 schema:familyName Stauder
    310 schema:givenName Reinhard
    311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617564545.58
    312 rdf:type schema:Person
    313 sg:person.0643404664.08 schema:affiliation grid-institutes:grid.14778.3d
    314 schema:familyName Neukirchen
    315 schema:givenName Judith
    316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643404664.08
    317 rdf:type schema:Person
    318 sg:person.0707665633.97 schema:affiliation grid-institutes:None
    319 schema:familyName Mikulenková
    320 schema:givenName Dana
    321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707665633.97
    322 rdf:type schema:Person
    323 sg:person.0726561165.17 schema:affiliation grid-institutes:None
    324 schema:familyName Čermák
    325 schema:givenName Jaroslav
    326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726561165.17
    327 rdf:type schema:Person
    328 sg:person.0730110062.04 schema:affiliation grid-institutes:grid.4714.6
    329 schema:familyName Hellström-Lindberg
    330 schema:givenName Eva
    331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730110062.04
    332 rdf:type schema:Person
    333 sg:person.0755526470.64 schema:affiliation grid-institutes:grid.10417.33
    334 schema:familyName de Swart
    335 schema:givenName Louise
    336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755526470.64
    337 rdf:type schema:Person
    338 sg:person.0766554473.71 schema:affiliation grid-institutes:grid.413328.f
    339 schema:familyName Fenaux
    340 schema:givenName Pierre
    341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766554473.71
    342 rdf:type schema:Person
    343 sg:pub.10.1007/s00277-012-1565-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038749957
    344 https://doi.org/10.1007/s00277-012-1565-4
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1007/s00277-014-2252-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023560375
    347 https://doi.org/10.1007/s00277-014-2252-4
    348 rdf:type schema:CreativeWork
    349 grid-institutes:None schema:alternateName Department of Clinical Haematology, Institution of Haematology and Blood Transfusion, Praha, Czech Republic
    350 Department of Haematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    351 schema:name Department of Clinical Haematology, Institution of Haematology and Blood Transfusion, Praha, Czech Republic
    352 Department of Haematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    353 rdf:type schema:Organization
    354 grid-institutes:grid.10417.33 schema:alternateName Department of Haematology, Radboud University Medical Centre, Nijmegen, The Netherlands
    355 Department of Tumor Immunology - Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre (TIL, 278), P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands
    356 schema:name Department of Haematology, Radboud University Medical Centre, Nijmegen, The Netherlands
    357 Department of Tumor Immunology - Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre (TIL, 278), P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands
    358 rdf:type schema:Organization
    359 grid-institutes:grid.11047.33 schema:alternateName Department of Medicine, Division of Haematology, University of Patras Medical School, Patras, Greece
    360 schema:name Department of Medicine, Division of Haematology, University of Patras Medical School, Patras, Greece
    361 rdf:type schema:Organization
    362 grid-institutes:grid.13339.3b schema:alternateName Department of Haematology, Oncology and Internal Medicine, Warszawa Medical University, Warszawa, Poland
    363 schema:name Department of Haematology, Oncology and Internal Medicine, Warszawa Medical University, Warszawa, Poland
    364 rdf:type schema:Organization
    365 grid-institutes:grid.14778.3d schema:alternateName Department of Haematology, Oncology and Clinical Immunology, Universitätsklinik Düsseldorf, Düsseldorf, Germany
    366 schema:name Department of Haematology, Oncology and Clinical Immunology, Universitätsklinik Düsseldorf, Düsseldorf, Germany
    367 rdf:type schema:Organization
    368 grid-institutes:grid.154185.c schema:alternateName Department of Haematology, Aarhus University Hospital, Aarhus, Denmark
    369 schema:name Department of Haematology, Aarhus University Hospital, Aarhus, Denmark
    370 rdf:type schema:Organization
    371 grid-institutes:grid.411083.f schema:alternateName Department of Haematology, Haematological Cytogenetics Unit, University Hospital of Vall d’Hebron, Barcelona, Spain
    372 schema:name Department of Haematology, Haematological Cytogenetics Unit, University Hospital of Vall d’Hebron, Barcelona, Spain
    373 rdf:type schema:Organization
    374 grid-institutes:grid.413328.f schema:alternateName Service d’Hématologie, Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris (AP-HP) and Université Paris 7, Paris, France
    375 schema:name Service d’Hématologie, Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris (AP-HP) and Université Paris 7, Paris, France
    376 rdf:type schema:Organization
    377 grid-institutes:grid.415180.9 schema:alternateName Centre of Haematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania
    378 schema:name Centre of Haematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania
    379 rdf:type schema:Organization
    380 grid-institutes:grid.416116.5 schema:alternateName Department of Haematology, Royal Cornwall Hospital, Truro, UK
    381 schema:name Department of Haematology, Royal Cornwall Hospital, Truro, UK
    382 rdf:type schema:Organization
    383 grid-institutes:grid.443984.6 schema:alternateName St. James’s Institute of Oncology, Leeds Teaching Hospitals, Leeds, UK
    384 schema:name St. James’s Institute of Oncology, Leeds Teaching Hospitals, Leeds, UK
    385 rdf:type schema:Organization
    386 grid-institutes:grid.4714.6 schema:alternateName Department of Medicine, Division of Haematology, Karolinska Institutet, Stockholm, Sweden
    387 Department of Pathology and Cytology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
    388 schema:name Department of Medicine, Division of Haematology, Karolinska Institutet, Stockholm, Sweden
    389 Department of Pathology and Cytology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
    390 rdf:type schema:Organization
    391 grid-institutes:grid.5361.1 schema:alternateName Department of Internal Medicine V (Haematology and Oncology), Innsbruck Medical University, Innsbruck, Austria
    392 schema:name Department of Internal Medicine V (Haematology and Oncology), Innsbruck Medical University, Innsbruck, Austria
    393 rdf:type schema:Organization
    394 grid-institutes:grid.5685.e schema:alternateName Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK
    395 schema:name Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK
    396 rdf:type schema:Organization
    397 grid-institutes:grid.8142.f schema:alternateName Haematology Institute, Catholic University of Sacred Heart, Rome, Italy
    398 schema:name Haematology Institute, Catholic University of Sacred Heart, Rome, Italy
    399 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...