Role of reduced-intensity conditioning allogeneic hematopoietic cell transplantation in older patients with de novo acute myeloid leukemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11-12

AUTHORS

Satoshi Yamasaki, Akihiro Hirakawa, Jun Aoki, Naoyuki Uchida, Takahiro Fukuda, Hiroyasu Ogawa, Kazuteru Ohashi, Tadakazu Kondo, Tetsuya Eto, Heiwa Kanamori, Hirokazu Okumura, Koji Iwato, Tatsuo Ichinohe, Junya Kanda, Makoto Onizuka, Yachiyo Kuwatsuka, Masamitsu Yanada, Yoshiko Atsuta, Akiyoshi Takami, Shingo Yano

ABSTRACT

Reduced-intensity conditioning (RIC) regimens extend the therapeutic use of allogeneic hematopoietic cell transplantation (HCT) to older patients. The survival trend in 2325 patients aged >50 years presenting with de novo acute myeloid leukemia (AML) who underwent first reduced-intensity HCT (RIC-HCT) was assessed by retrospectively analyzing outcomes between 2000 and 2013. The annual number of RIC-HCTs in Japan was higher in the 2008–2013 period (n = 205/year [1229/6 years]) than in the 2000–2007 period (n = 137/year [1096/8 years]). Overall and disease-free survival were higher in the 2008–2013 period (P < 0.001) because of the improvement in transplant-related mortality (TRM). Survival regarding RIC-HCT for AML has improved over time, with an increased number of RIC-HCTs in patients with a Karnofsky performance status (KPS) ≥80. However, TRM remains high and the relapse rate has not improved over time. Multivariate analyses showed that a KPS ≥80 and complete remission at HCT were associated with less TRM and relapse, and better survival regardless of age ≥65 years. Accurate timing and prospective identification of patients at risk of TRM may aid the development of risk-adapted strategies for RIC-HCT in AML patients regardless of age. More... »

PAGES

289-297

References to SciGraph publications

  • 2015-02-24. Factors prognostic of eligibility for allogeneic HCT among older patients with AML-CR1 and adverse- or intermediate-risk cytogenetics in ANNALS OF HEMATOLOGY
  • 2015-07-13. Patient age, remission status and HCT-CI in a combined score are prognostic for patients with AML undergoing allogeneic hematopoietic cell transplantation in CR1 and CR2 in BONE MARROW TRANSPLANTATION
  • 2005-09-29. Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia: a retrospective survey from the Acute Leukemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT) in LEUKEMIA
  • 2015-11-07. Introduction of Transplant Registry Unified Management Program 2 (TRUMP2): scripts for TRUMP data analyses, part I (variables other than HLA-related data) in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2007-10-01. Unification of Hematopoietic Stem Cell Transplantation Registries in Japan and Establishment of the TRUMP System in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2004-11-04. Hematopoietic stem-cell transplantation from unrelated donors in elderly patients (age>55 years) with hematologic malignancies: older age is no longer a contraindication when using reduced intensity conditioning in LEUKEMIA
  • 2012-12-03. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics in BONE MARROW TRANSPLANTATION
  • Journal

    TITLE

    Annals of Hematology

    ISSUE

    2

    VOLUME

    96

    Author Affiliations

  • Department of Hematology and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, 810-8563, Chuo-ku, Fukuoka, Japan
  • Biostatistics and Bioinformatics Section, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan
  • Department of Hematology, Kanagawa Cancer Center, Kanagawa, Japan
  • Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan
  • Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
  • Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Kobe, Japan
  • Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
  • Department of Hematology/Oncology, Kyoto University Hospital, Kyoto, Japan
  • Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
  • Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan
  • Department of Hematology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima, Japan
  • Department of Hematology and Oncology, Hiroshima University Hospital, Hiroshima, Japan
  • Division of Hematology, Saitama Medical Center, Jichi Medical University, Shimotsuke, Japan
  • Department of Hematology/Oncology, Tokai University School of Medicine, Isehara, Japan
  • Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan
  • Department of Hematology, Fujita Health University School of Medicine, Toyoake, Japan
  • Department of Healthcare Administration, Nagoya University Graduate School of Medicine and Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
  • Department of Hematology, Aichi Medical University, Nagoya, Japan
  • Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00277-016-2872-y

    DOI

    http://dx.doi.org/10.1007/s00277-016-2872-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1050065713

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27838773


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Age Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Follow-Up Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hematopoietic Stem Cell Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Karnofsky Performance Status", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukemia, Myeloid, Acute", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Longitudinal Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Registries", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Survival Rate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transplantation Conditioning", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transplantation, Homologous", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, 810-8563, Chuo-ku, Fukuoka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415613.4", 
              "name": [
                "Department of Hematology and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, 810-8563, Chuo-ku, Fukuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamasaki", 
            "givenName": "Satoshi", 
            "id": "sg:person.01242043214.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242043214.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Biostatistics and Bioinformatics Section, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.437848.4", 
              "name": [
                "Biostatistics and Bioinformatics Section, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hirakawa", 
            "givenName": "Akihiro", 
            "id": "sg:person.0617766767.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617766767.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Kanagawa Cancer Center, Kanagawa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414944.8", 
              "name": [
                "Department of Hematology, Kanagawa Cancer Center, Kanagawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aoki", 
            "givenName": "Jun", 
            "id": "sg:person.01264262573.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264262573.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410813.f", 
              "name": [
                "Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Uchida", 
            "givenName": "Naoyuki", 
            "id": "sg:person.01243564276.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243564276.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272242.3", 
              "name": [
                "Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukuda", 
            "givenName": "Takahiro", 
            "id": "sg:person.016452523632.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Kobe, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272264.7", 
              "name": [
                "Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Kobe, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ogawa", 
            "givenName": "Hiroyasu", 
            "id": "sg:person.0625547166.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625547166.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415479.a", 
              "name": [
                "Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ohashi", 
            "givenName": "Kazuteru", 
            "id": "sg:person.012430503152.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012430503152.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology/Oncology, Kyoto University Hospital, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411217.0", 
              "name": [
                "Department of Hematology/Oncology, Kyoto University Hospital, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kondo", 
            "givenName": "Tadakazu", 
            "id": "sg:person.0666225507.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666225507.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413617.6", 
              "name": [
                "Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eto", 
            "givenName": "Tetsuya", 
            "id": "sg:person.0720274373.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720274373.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Kanagawa Cancer Center, Kanagawa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414944.8", 
              "name": [
                "Department of Hematology, Kanagawa Cancer Center, Kanagawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanamori", 
            "givenName": "Heiwa", 
            "id": "sg:person.01060176576.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060176576.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.417235.6", 
              "name": [
                "Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Okumura", 
            "givenName": "Hirokazu", 
            "id": "sg:person.01007060226.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007060226.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414175.2", 
              "name": [
                "Department of Hematology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iwato", 
            "givenName": "Koji", 
            "id": "sg:person.01045601306.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045601306.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology and Oncology, Hiroshima University Hospital, Hiroshima, Japan", 
              "id": "http://www.grid.ac/institutes/grid.470097.d", 
              "name": [
                "Department of Hematology and Oncology, Hiroshima University Hospital, Hiroshima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ichinohe", 
            "givenName": "Tatsuo", 
            "id": "sg:person.0623252373.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623252373.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, Saitama Medical Center, Jichi Medical University, Shimotsuke, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410804.9", 
              "name": [
                "Division of Hematology, Saitama Medical Center, Jichi Medical University, Shimotsuke, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanda", 
            "givenName": "Junya", 
            "id": "sg:person.01100640630.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100640630.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology/Oncology, Tokai University School of Medicine, Isehara, Japan", 
              "id": "http://www.grid.ac/institutes/grid.265061.6", 
              "name": [
                "Department of Hematology/Oncology, Tokai University School of Medicine, Isehara, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Onizuka", 
            "givenName": "Makoto", 
            "id": "sg:person.01046262603.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046262603.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.437848.4", 
              "name": [
                "Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kuwatsuka", 
            "givenName": "Yachiyo", 
            "id": "sg:person.01310604123.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310604123.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Fujita Health University School of Medicine, Toyoake, Japan", 
              "id": "http://www.grid.ac/institutes/grid.256115.4", 
              "name": [
                "Department of Hematology, Fujita Health University School of Medicine, Toyoake, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yanada", 
            "givenName": "Masamitsu", 
            "id": "sg:person.01024604275.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024604275.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Healthcare Administration, Nagoya University Graduate School of Medicine and Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.511247.4", 
              "name": [
                "Department of Healthcare Administration, Nagoya University Graduate School of Medicine and Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Atsuta", 
            "givenName": "Yoshiko", 
            "id": "sg:person.01146754030.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Hematology, Aichi Medical University, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411234.1", 
              "name": [
                "Department of Hematology, Aichi Medical University, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takami", 
            "givenName": "Akiyoshi", 
            "id": "sg:person.0577702220.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577702220.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411898.d", 
              "name": [
                "Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yano", 
            "givenName": "Shingo", 
            "id": "sg:person.01265010246.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s12185-015-1894-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036307316", 
              "https://doi.org/10.1007/s12185-015-1894-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403591", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028314263", 
              "https://doi.org/10.1038/sj.leu.2403591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2015.165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007290520", 
              "https://doi.org/10.1038/bmt.2015.165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403967", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023301181", 
              "https://doi.org/10.1038/sj.leu.2403967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00277-015-2338-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029074433", 
              "https://doi.org/10.1007/s00277-015-2338-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1532/ijh97.06239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054504897", 
              "https://doi.org/10.1532/ijh97.06239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bmt.2012.244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028358194", 
              "https://doi.org/10.1038/bmt.2012.244"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-11-12", 
        "datePublishedReg": "2016-11-12", 
        "description": "Reduced-intensity conditioning (RIC) regimens extend the therapeutic use of allogeneic hematopoietic cell transplantation (HCT) to older patients. The survival trend in 2325 patients aged >50\u00a0years presenting with de novo acute myeloid leukemia (AML) who underwent first reduced-intensity HCT (RIC-HCT) was assessed by retrospectively analyzing outcomes between 2000 and 2013. The annual number of RIC-HCTs in Japan was higher in the 2008\u20132013 period (n\u2009=\u2009205/year [1229/6\u00a0years]) than in the 2000\u20132007 period (n\u2009=\u2009137/year [1096/8\u00a0years]). Overall and disease-free survival were higher in the 2008\u20132013 period (P\u2009<\u20090.001) because of the improvement in transplant-related mortality (TRM). Survival regarding RIC-HCT for AML has improved over time, with an increased number of RIC-HCTs in patients with a Karnofsky performance status (KPS) \u226580. However, TRM remains high and the relapse rate has not improved over time. Multivariate analyses showed that a KPS \u226580 and complete remission at HCT were associated with less TRM and relapse, and better survival regardless of age \u226565\u00a0years. Accurate timing and prospective identification of patients at risk of TRM may aid the development of risk-adapted strategies for RIC-HCT in AML patients regardless of age.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00277-016-2872-y", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6161302", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5872875", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1358129", 
            "issn": [
              "0939-5555", 
              "1432-0584"
            ], 
            "name": "Annals of Hematology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "96"
          }
        ], 
        "keywords": [
          "transplant-related mortality", 
          "hematopoietic cell transplantation", 
          "acute myeloid leukemia", 
          "Karnofsky performance status", 
          "de novo acute myeloid leukemia", 
          "allogeneic hematopoietic cell transplantation", 
          "novo acute myeloid leukemia", 
          "RIC-HCT", 
          "older patients", 
          "cell transplantation", 
          "myeloid leukemia", 
          "reduced-intensity conditioning allogeneic hematopoietic cell transplantation", 
          "risk of TRM", 
          "less transplant-related mortality", 
          "reduced-intensity conditioning regimens", 
          "reduced-intensity hematopoietic cell transplantation", 
          "disease-free survival", 
          "risk-adapted strategy", 
          "complete remission", 
          "conditioning regimens", 
          "performance status", 
          "relapse rate", 
          "AML patients", 
          "survival trends", 
          "better survival", 
          "patients", 
          "prospective identification", 
          "multivariate analysis", 
          "therapeutic use", 
          "transplantation", 
          "survival", 
          "annual number", 
          "leukemia", 
          "age", 
          "remission", 
          "regimens", 
          "relapse", 
          "years", 
          "period", 
          "mortality", 
          "outcomes", 
          "risk", 
          "status", 
          "number", 
          "role", 
          "time", 
          "rate", 
          "timing", 
          "improvement", 
          "use", 
          "accurate timing", 
          "identification", 
          "development", 
          "strategies", 
          "Japan", 
          "analysis", 
          "trends"
        ], 
        "name": "Role of reduced-intensity conditioning allogeneic hematopoietic cell transplantation in older patients with de novo acute myeloid leukemia", 
        "pagination": "289-297", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1050065713"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00277-016-2872-y"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27838773"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00277-016-2872-y", 
          "https://app.dimensions.ai/details/publication/pub.1050065713"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:04", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_700.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00277-016-2872-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00277-016-2872-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00277-016-2872-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-016-2872-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-016-2872-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    400 TRIPLES      21 PREDICATES      105 URIs      90 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00277-016-2872-y schema:about N101ec89ede584ac5a863fcd9310f04e4
    2 N17512679a69a4d3098ffa6b6b025742c
    3 N42cac04f5cf84a84bab084487a5655bc
    4 N51a94d15b47141099740ef12b45a2892
    5 N6f45ae5824614fe88240183ab4401013
    6 N77211997dccc4ff98326ad5e0d45582b
    7 N8b886020f07e47d48c22949a7fae63d8
    8 N9710955ed38a411ca48c84b0b90eb16e
    9 Nb8a081130319407c80d786a760538f5f
    10 Nc6a24c56887f4b278dd91daae98172d1
    11 Ncc722d90721845e2b27cbe700b8de2b2
    12 Nd162bd6a0eb64052b1b1c638f29fb186
    13 Nd18ab0bf28b644c998c4ca9d200743f3
    14 Nd789275d39514ce6a2f82faf18059ec4
    15 Ndbb493ef75854a98a4a41cd9e0a83742
    16 Nfa574d149f354270ae76c815b2769c30
    17 anzsrc-for:11
    18 anzsrc-for:1112
    19 schema:author N070c275c44a74cabb3bb37e268bdf61a
    20 schema:citation sg:pub.10.1007/s00277-015-2338-7
    21 sg:pub.10.1007/s12185-015-1894-x
    22 sg:pub.10.1038/bmt.2012.244
    23 sg:pub.10.1038/bmt.2015.165
    24 sg:pub.10.1038/sj.leu.2403591
    25 sg:pub.10.1038/sj.leu.2403967
    26 sg:pub.10.1532/ijh97.06239
    27 schema:datePublished 2016-11-12
    28 schema:datePublishedReg 2016-11-12
    29 schema:description Reduced-intensity conditioning (RIC) regimens extend the therapeutic use of allogeneic hematopoietic cell transplantation (HCT) to older patients. The survival trend in 2325 patients aged >50 years presenting with de novo acute myeloid leukemia (AML) who underwent first reduced-intensity HCT (RIC-HCT) was assessed by retrospectively analyzing outcomes between 2000 and 2013. The annual number of RIC-HCTs in Japan was higher in the 2008–2013 period (n = 205/year [1229/6 years]) than in the 2000–2007 period (n = 137/year [1096/8 years]). Overall and disease-free survival were higher in the 2008–2013 period (P < 0.001) because of the improvement in transplant-related mortality (TRM). Survival regarding RIC-HCT for AML has improved over time, with an increased number of RIC-HCTs in patients with a Karnofsky performance status (KPS) ≥80. However, TRM remains high and the relapse rate has not improved over time. Multivariate analyses showed that a KPS ≥80 and complete remission at HCT were associated with less TRM and relapse, and better survival regardless of age ≥65 years. Accurate timing and prospective identification of patients at risk of TRM may aid the development of risk-adapted strategies for RIC-HCT in AML patients regardless of age.
    30 schema:genre article
    31 schema:isAccessibleForFree false
    32 schema:isPartOf N4aec51e15ae94706a6b65510eeea8526
    33 N4c699c2dd14b4e7baf4868fbdef065fa
    34 sg:journal.1358129
    35 schema:keywords AML patients
    36 Japan
    37 Karnofsky performance status
    38 RIC-HCT
    39 accurate timing
    40 acute myeloid leukemia
    41 age
    42 allogeneic hematopoietic cell transplantation
    43 analysis
    44 annual number
    45 better survival
    46 cell transplantation
    47 complete remission
    48 conditioning regimens
    49 de novo acute myeloid leukemia
    50 development
    51 disease-free survival
    52 hematopoietic cell transplantation
    53 identification
    54 improvement
    55 less transplant-related mortality
    56 leukemia
    57 mortality
    58 multivariate analysis
    59 myeloid leukemia
    60 novo acute myeloid leukemia
    61 number
    62 older patients
    63 outcomes
    64 patients
    65 performance status
    66 period
    67 prospective identification
    68 rate
    69 reduced-intensity conditioning allogeneic hematopoietic cell transplantation
    70 reduced-intensity conditioning regimens
    71 reduced-intensity hematopoietic cell transplantation
    72 regimens
    73 relapse
    74 relapse rate
    75 remission
    76 risk
    77 risk of TRM
    78 risk-adapted strategy
    79 role
    80 status
    81 strategies
    82 survival
    83 survival trends
    84 therapeutic use
    85 time
    86 timing
    87 transplant-related mortality
    88 transplantation
    89 trends
    90 use
    91 years
    92 schema:name Role of reduced-intensity conditioning allogeneic hematopoietic cell transplantation in older patients with de novo acute myeloid leukemia
    93 schema:pagination 289-297
    94 schema:productId N03050e042bda4e01a6f0130483dc4eb9
    95 N609a723dd14d477a8b3fd2603a619595
    96 Ne4e2ad92627c479cab475a82ba4b5207
    97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050065713
    98 https://doi.org/10.1007/s00277-016-2872-y
    99 schema:sdDatePublished 2022-08-04T17:04
    100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    101 schema:sdPublisher N56126323efa54f19a304ada708bb9d5a
    102 schema:url https://doi.org/10.1007/s00277-016-2872-y
    103 sgo:license sg:explorer/license/
    104 sgo:sdDataset articles
    105 rdf:type schema:ScholarlyArticle
    106 N00557eebe7ac4e53865104f0fd544fd0 rdf:first sg:person.0666225507.36
    107 rdf:rest N098c35c509b14d1b9d7c94fc8348eada
    108 N03050e042bda4e01a6f0130483dc4eb9 schema:name pubmed_id
    109 schema:value 27838773
    110 rdf:type schema:PropertyValue
    111 N06b995ea540f409cabd028e033dbf1bb rdf:first sg:person.012430503152.76
    112 rdf:rest N00557eebe7ac4e53865104f0fd544fd0
    113 N070c275c44a74cabb3bb37e268bdf61a rdf:first sg:person.01242043214.01
    114 rdf:rest N8312992a2e96404e9e1890eab120d285
    115 N098c35c509b14d1b9d7c94fc8348eada rdf:first sg:person.0720274373.65
    116 rdf:rest N36151a02b294427aaf5410c40d636829
    117 N101ec89ede584ac5a863fcd9310f04e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Karnofsky Performance Status
    119 rdf:type schema:DefinedTerm
    120 N1277d1c429be49b18298478ae2c2690b rdf:first sg:person.01046262603.08
    121 rdf:rest Ndd140f90a2bd4e2cabc2a0c5cdc06172
    122 N12a57d94e4334aa78ee1bcc9af513385 rdf:first sg:person.0623252373.33
    123 rdf:rest Nad3ed1ebf9044fdb812d3d2399eab017
    124 N17512679a69a4d3098ffa6b6b025742c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Age Factors
    126 rdf:type schema:DefinedTerm
    127 N36151a02b294427aaf5410c40d636829 rdf:first sg:person.01060176576.11
    128 rdf:rest N468cbf64a6e547a48f47e594ae11e0a6
    129 N42cac04f5cf84a84bab084487a5655bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Aged, 80 and over
    131 rdf:type schema:DefinedTerm
    132 N468cbf64a6e547a48f47e594ae11e0a6 rdf:first sg:person.01007060226.82
    133 rdf:rest N85ed1ebc873a464382f96f64e7ded17a
    134 N4aec51e15ae94706a6b65510eeea8526 schema:issueNumber 2
    135 rdf:type schema:PublicationIssue
    136 N4c699c2dd14b4e7baf4868fbdef065fa schema:volumeNumber 96
    137 rdf:type schema:PublicationVolume
    138 N4f3aa67aa0b44d579686c7754db0544a rdf:first sg:person.01146754030.08
    139 rdf:rest Nbf313b4feb18485aa85ad0186fc1cc24
    140 N51a94d15b47141099740ef12b45a2892 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Registries
    142 rdf:type schema:DefinedTerm
    143 N56126323efa54f19a304ada708bb9d5a schema:name Springer Nature - SN SciGraph project
    144 rdf:type schema:Organization
    145 N609a723dd14d477a8b3fd2603a619595 schema:name dimensions_id
    146 schema:value pub.1050065713
    147 rdf:type schema:PropertyValue
    148 N6f45ae5824614fe88240183ab4401013 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Middle Aged
    150 rdf:type schema:DefinedTerm
    151 N77211997dccc4ff98326ad5e0d45582b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Aged
    153 rdf:type schema:DefinedTerm
    154 N8312992a2e96404e9e1890eab120d285 rdf:first sg:person.0617766767.00
    155 rdf:rest N9ef900ac0d3b457d8317a1ea6117b705
    156 N85ed1ebc873a464382f96f64e7ded17a rdf:first sg:person.01045601306.75
    157 rdf:rest N12a57d94e4334aa78ee1bcc9af513385
    158 N8654fa5aed9448a6aea58c3028080c42 rdf:first sg:person.01243564276.76
    159 rdf:rest N8e7f6c5025c84f03b5d8b35197aef31f
    160 N8b886020f07e47d48c22949a7fae63d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Follow-Up Studies
    162 rdf:type schema:DefinedTerm
    163 N8e7f6c5025c84f03b5d8b35197aef31f rdf:first sg:person.016452523632.46
    164 rdf:rest N96961dd747d346bfa0b65ee75242dd5c
    165 N96961dd747d346bfa0b65ee75242dd5c rdf:first sg:person.0625547166.22
    166 rdf:rest N06b995ea540f409cabd028e033dbf1bb
    167 N9710955ed38a411ca48c84b0b90eb16e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Leukemia, Myeloid, Acute
    169 rdf:type schema:DefinedTerm
    170 N9ef900ac0d3b457d8317a1ea6117b705 rdf:first sg:person.01264262573.40
    171 rdf:rest N8654fa5aed9448a6aea58c3028080c42
    172 Nad3ed1ebf9044fdb812d3d2399eab017 rdf:first sg:person.01100640630.10
    173 rdf:rest N1277d1c429be49b18298478ae2c2690b
    174 Nb8a081130319407c80d786a760538f5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Transplantation, Homologous
    176 rdf:type schema:DefinedTerm
    177 Nbf313b4feb18485aa85ad0186fc1cc24 rdf:first sg:person.0577702220.98
    178 rdf:rest Nd11d206282e442989d6ee556a0ad91f4
    179 Nc6a24c56887f4b278dd91daae98172d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Humans
    181 rdf:type schema:DefinedTerm
    182 Ncc722d90721845e2b27cbe700b8de2b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Male
    184 rdf:type schema:DefinedTerm
    185 Nd11d206282e442989d6ee556a0ad91f4 rdf:first sg:person.01265010246.42
    186 rdf:rest rdf:nil
    187 Nd162bd6a0eb64052b1b1c638f29fb186 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Survival Rate
    189 rdf:type schema:DefinedTerm
    190 Nd18ab0bf28b644c998c4ca9d200743f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Longitudinal Studies
    192 rdf:type schema:DefinedTerm
    193 Nd789275d39514ce6a2f82faf18059ec4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    194 schema:name Transplantation Conditioning
    195 rdf:type schema:DefinedTerm
    196 Ndbb493ef75854a98a4a41cd9e0a83742 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Hematopoietic Stem Cell Transplantation
    198 rdf:type schema:DefinedTerm
    199 Ndd140f90a2bd4e2cabc2a0c5cdc06172 rdf:first sg:person.01310604123.28
    200 rdf:rest Ne244c2cab5ba420f88d51d6ab4e84ffa
    201 Ne244c2cab5ba420f88d51d6ab4e84ffa rdf:first sg:person.01024604275.66
    202 rdf:rest N4f3aa67aa0b44d579686c7754db0544a
    203 Ne4e2ad92627c479cab475a82ba4b5207 schema:name doi
    204 schema:value 10.1007/s00277-016-2872-y
    205 rdf:type schema:PropertyValue
    206 Nfa574d149f354270ae76c815b2769c30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Female
    208 rdf:type schema:DefinedTerm
    209 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    210 schema:name Medical and Health Sciences
    211 rdf:type schema:DefinedTerm
    212 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    213 schema:name Oncology and Carcinogenesis
    214 rdf:type schema:DefinedTerm
    215 sg:grant.5872875 http://pending.schema.org/fundedItem sg:pub.10.1007/s00277-016-2872-y
    216 rdf:type schema:MonetaryGrant
    217 sg:grant.6161302 http://pending.schema.org/fundedItem sg:pub.10.1007/s00277-016-2872-y
    218 rdf:type schema:MonetaryGrant
    219 sg:journal.1358129 schema:issn 0939-5555
    220 1432-0584
    221 schema:name Annals of Hematology
    222 schema:publisher Springer Nature
    223 rdf:type schema:Periodical
    224 sg:person.01007060226.82 schema:affiliation grid-institutes:grid.417235.6
    225 schema:familyName Okumura
    226 schema:givenName Hirokazu
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007060226.82
    228 rdf:type schema:Person
    229 sg:person.01024604275.66 schema:affiliation grid-institutes:grid.256115.4
    230 schema:familyName Yanada
    231 schema:givenName Masamitsu
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024604275.66
    233 rdf:type schema:Person
    234 sg:person.01045601306.75 schema:affiliation grid-institutes:grid.414175.2
    235 schema:familyName Iwato
    236 schema:givenName Koji
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045601306.75
    238 rdf:type schema:Person
    239 sg:person.01046262603.08 schema:affiliation grid-institutes:grid.265061.6
    240 schema:familyName Onizuka
    241 schema:givenName Makoto
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046262603.08
    243 rdf:type schema:Person
    244 sg:person.01060176576.11 schema:affiliation grid-institutes:grid.414944.8
    245 schema:familyName Kanamori
    246 schema:givenName Heiwa
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060176576.11
    248 rdf:type schema:Person
    249 sg:person.01100640630.10 schema:affiliation grid-institutes:grid.410804.9
    250 schema:familyName Kanda
    251 schema:givenName Junya
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100640630.10
    253 rdf:type schema:Person
    254 sg:person.01146754030.08 schema:affiliation grid-institutes:grid.511247.4
    255 schema:familyName Atsuta
    256 schema:givenName Yoshiko
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146754030.08
    258 rdf:type schema:Person
    259 sg:person.01242043214.01 schema:affiliation grid-institutes:grid.415613.4
    260 schema:familyName Yamasaki
    261 schema:givenName Satoshi
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242043214.01
    263 rdf:type schema:Person
    264 sg:person.012430503152.76 schema:affiliation grid-institutes:grid.415479.a
    265 schema:familyName Ohashi
    266 schema:givenName Kazuteru
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012430503152.76
    268 rdf:type schema:Person
    269 sg:person.01243564276.76 schema:affiliation grid-institutes:grid.410813.f
    270 schema:familyName Uchida
    271 schema:givenName Naoyuki
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243564276.76
    273 rdf:type schema:Person
    274 sg:person.01264262573.40 schema:affiliation grid-institutes:grid.414944.8
    275 schema:familyName Aoki
    276 schema:givenName Jun
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264262573.40
    278 rdf:type schema:Person
    279 sg:person.01265010246.42 schema:affiliation grid-institutes:grid.411898.d
    280 schema:familyName Yano
    281 schema:givenName Shingo
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42
    283 rdf:type schema:Person
    284 sg:person.01310604123.28 schema:affiliation grid-institutes:grid.437848.4
    285 schema:familyName Kuwatsuka
    286 schema:givenName Yachiyo
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310604123.28
    288 rdf:type schema:Person
    289 sg:person.016452523632.46 schema:affiliation grid-institutes:grid.272242.3
    290 schema:familyName Fukuda
    291 schema:givenName Takahiro
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016452523632.46
    293 rdf:type schema:Person
    294 sg:person.0577702220.98 schema:affiliation grid-institutes:grid.411234.1
    295 schema:familyName Takami
    296 schema:givenName Akiyoshi
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577702220.98
    298 rdf:type schema:Person
    299 sg:person.0617766767.00 schema:affiliation grid-institutes:grid.437848.4
    300 schema:familyName Hirakawa
    301 schema:givenName Akihiro
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617766767.00
    303 rdf:type schema:Person
    304 sg:person.0623252373.33 schema:affiliation grid-institutes:grid.470097.d
    305 schema:familyName Ichinohe
    306 schema:givenName Tatsuo
    307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623252373.33
    308 rdf:type schema:Person
    309 sg:person.0625547166.22 schema:affiliation grid-institutes:grid.272264.7
    310 schema:familyName Ogawa
    311 schema:givenName Hiroyasu
    312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625547166.22
    313 rdf:type schema:Person
    314 sg:person.0666225507.36 schema:affiliation grid-institutes:grid.411217.0
    315 schema:familyName Kondo
    316 schema:givenName Tadakazu
    317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666225507.36
    318 rdf:type schema:Person
    319 sg:person.0720274373.65 schema:affiliation grid-institutes:grid.413617.6
    320 schema:familyName Eto
    321 schema:givenName Tetsuya
    322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720274373.65
    323 rdf:type schema:Person
    324 sg:pub.10.1007/s00277-015-2338-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029074433
    325 https://doi.org/10.1007/s00277-015-2338-7
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1007/s12185-015-1894-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036307316
    328 https://doi.org/10.1007/s12185-015-1894-x
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
    331 https://doi.org/10.1038/bmt.2012.244
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/bmt.2015.165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007290520
    334 https://doi.org/10.1038/bmt.2015.165
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/sj.leu.2403591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028314263
    337 https://doi.org/10.1038/sj.leu.2403591
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/sj.leu.2403967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023301181
    340 https://doi.org/10.1038/sj.leu.2403967
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1532/ijh97.06239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054504897
    343 https://doi.org/10.1532/ijh97.06239
    344 rdf:type schema:CreativeWork
    345 grid-institutes:grid.256115.4 schema:alternateName Department of Hematology, Fujita Health University School of Medicine, Toyoake, Japan
    346 schema:name Department of Hematology, Fujita Health University School of Medicine, Toyoake, Japan
    347 rdf:type schema:Organization
    348 grid-institutes:grid.265061.6 schema:alternateName Department of Hematology/Oncology, Tokai University School of Medicine, Isehara, Japan
    349 schema:name Department of Hematology/Oncology, Tokai University School of Medicine, Isehara, Japan
    350 rdf:type schema:Organization
    351 grid-institutes:grid.272242.3 schema:alternateName Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
    352 schema:name Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
    353 rdf:type schema:Organization
    354 grid-institutes:grid.272264.7 schema:alternateName Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Kobe, Japan
    355 schema:name Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Kobe, Japan
    356 rdf:type schema:Organization
    357 grid-institutes:grid.410804.9 schema:alternateName Division of Hematology, Saitama Medical Center, Jichi Medical University, Shimotsuke, Japan
    358 schema:name Division of Hematology, Saitama Medical Center, Jichi Medical University, Shimotsuke, Japan
    359 rdf:type schema:Organization
    360 grid-institutes:grid.410813.f schema:alternateName Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan
    361 schema:name Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan
    362 rdf:type schema:Organization
    363 grid-institutes:grid.411217.0 schema:alternateName Department of Hematology/Oncology, Kyoto University Hospital, Kyoto, Japan
    364 schema:name Department of Hematology/Oncology, Kyoto University Hospital, Kyoto, Japan
    365 rdf:type schema:Organization
    366 grid-institutes:grid.411234.1 schema:alternateName Department of Hematology, Aichi Medical University, Nagoya, Japan
    367 schema:name Department of Hematology, Aichi Medical University, Nagoya, Japan
    368 rdf:type schema:Organization
    369 grid-institutes:grid.411898.d schema:alternateName Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    370 schema:name Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    371 rdf:type schema:Organization
    372 grid-institutes:grid.413617.6 schema:alternateName Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
    373 schema:name Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
    374 rdf:type schema:Organization
    375 grid-institutes:grid.414175.2 schema:alternateName Department of Hematology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima, Japan
    376 schema:name Department of Hematology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima, Japan
    377 rdf:type schema:Organization
    378 grid-institutes:grid.414944.8 schema:alternateName Department of Hematology, Kanagawa Cancer Center, Kanagawa, Japan
    379 schema:name Department of Hematology, Kanagawa Cancer Center, Kanagawa, Japan
    380 rdf:type schema:Organization
    381 grid-institutes:grid.415479.a schema:alternateName Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
    382 schema:name Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
    383 rdf:type schema:Organization
    384 grid-institutes:grid.415613.4 schema:alternateName Department of Hematology and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, 810-8563, Chuo-ku, Fukuoka, Japan
    385 schema:name Department of Hematology and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, 810-8563, Chuo-ku, Fukuoka, Japan
    386 rdf:type schema:Organization
    387 grid-institutes:grid.417235.6 schema:alternateName Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan
    388 schema:name Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan
    389 rdf:type schema:Organization
    390 grid-institutes:grid.437848.4 schema:alternateName Biostatistics and Bioinformatics Section, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan
    391 Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan
    392 schema:name Biostatistics and Bioinformatics Section, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan
    393 Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan
    394 rdf:type schema:Organization
    395 grid-institutes:grid.470097.d schema:alternateName Department of Hematology and Oncology, Hiroshima University Hospital, Hiroshima, Japan
    396 schema:name Department of Hematology and Oncology, Hiroshima University Hospital, Hiroshima, Japan
    397 rdf:type schema:Organization
    398 grid-institutes:grid.511247.4 schema:alternateName Department of Healthcare Administration, Nagoya University Graduate School of Medicine and Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
    399 schema:name Department of Healthcare Administration, Nagoya University Graduate School of Medicine and Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
    400 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...