Selective expansion of regulatory T cells during lenalidomide treatment of myelodysplastic syndrome with isolated deletion 5q View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-08-10

AUTHORS

Ekaterina Balaian, Claudia Schuster, Claudia Schönefeldt, Ulrich Germing, Detlef Haase, Sebastian Tuve, Rainer Ordemann, Gerhard Ehninger, Martin Bornhäuser, Uta Oelschlaegel, Brigitte Mohr, Malte von Bonin, Uwe Platzbecker, Martin Wermke

ABSTRACT

Lenalidomide (LEN) leads to erythroid improvement in the majority of patients with myelodysplastic syndrome and isolated deletion of the long arm of chromosome 5 (MDS-del(5q)). This effect is believed to be exerted via its immunomodulatory properties, although the precise nature is still incompletely understood. We prospectively performed immune profiling in the bone marrow and blood of MDS-del(5q) patients undergoing LEN therapy for a median of 6 cycles. Therapy with LEN led to a significant increase in the median absolute lymphocyte count (1.3-fold, p = 0.013) without changes in the distribution of the T helper cells within the entire compartment. In parallel, the frequency of Treg increased significantly during treatment both in the peripheral blood (5.0 vs. 9.6 %, p = 0.001) and bone marrow (3.4 vs. 8.1 %, p = 0.001). Surprisingly, LEN treatment led to a decrease in TGFbeta levels, both in the peripheral blood (4.9 vs. 2.3 ng/ml, p = 0.039) and bone marrow (4.5 vs. 0.8 ng/ml, p = 0.023). These changes were not associated with an increase in pro-inflammatory Th17 cells. Taken together, our results demonstrate that LEN induces a shift in lymphocytic populations towards immunosuppression in MDS-del(5q) patients. More... »

PAGES

1805-1810

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-016-2775-y

DOI

http://dx.doi.org/10.1007/s00277-016-2775-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008131707

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27510179


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