Health care setting and severity, symptom burden, and complications in patients with Philadelphia-negative myeloproliferative neoplasms (MPN): a comparison between university ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-06-22

AUTHORS

A. Kaifie, S. Isfort, N. Gattermann, W. Hollburg, M. Klausmann, D. Wolf, C. Maintz, M. Hänel, E. Goekkurt, J. R. Göthert, U. Platzbecker, T. Geer, S. Parmentier, E. Jost, H. Serve, G. Ehninger, W. E. Berdel, T. H. Brümmendorf, Steffen Koschmieder, for the Study Alliance Leukemia (SAL)

ABSTRACT

Philadelphia-negative myeloproliferative neoplasms (MPN) comprise a heterogeneous group of chronic hematological malignancies with significant variations in clinical characteristics. Due to the long survival and the feasibility of oral or subcutaneous therapy, these patients are frequently treated outside of larger academic centers. This analysis was performed to elucidate differences in MPN patients in three different health care settings: university hospitals (UH), community hospitals (CH), and office-based physicians (OBP). The MPN registry of the Study Alliance Leukemia is a non-interventional prospective study including adult patients with an MPN according to WHO criteria (2008). For statistical analysis, descriptive methods and tests for significant differences were used. Besides a different distribution of MPN subtypes between the settings, patients contributed by UH showed an impaired medical condition, a higher comorbidity burden, and more vascular complications. In the risk group analyses, the majority of polycythemia vera (PV) and essential thrombocythemia (ET) patients from UH were classified into the high-risk category due to previous vascular events, while for PV and ET patients in the CH and OBP settings, age was the major parameter for a high-risk categorization. Regarding MPN-directed therapy, PV patients from the UH setting were more likely to receive ruxolitinib within the framework of a clinical trial. In summary, the characteristics and management of patients differed significantly between the three health care settings with a higher burden of vascular events and comorbidities in patients contributed by UH. These differences need to be taken into account for further analyses and design of clinical trials. More... »

PAGES

1399-1410

Journal

TITLE

Annals of Hematology

ISSUE

9

VOLUME

95

Author Affiliations

  • Institute for Occupational and Social Medicine, Faculty of Medicine, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany
  • Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany
  • Department for Hematology, Oncology and Clinical Immunology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, 40225, Düsseldorf, Germany
  • Practice for Hematology and Oncology Altona, Mörkenstrasse 47, 22767, Hamburg, Germany
  • Practice for Hematology and Oncology, Elisenstrasse 28, 63739, Aschaffenburg, Germany
  • Internal Medicine 3, Oncology, Hematology, Immunooncology, and Rheumatology, University Clinic Bonn, Sigmund-Freud-Strasse 25, 53127, Bonn, Germany
  • Practice for Hematology and Oncology, Mauerfeldchen 72, 52146, Würselen, Germany
  • Department for Hematology, Oncology, Stem Cell Transplantation, Hospital Chemnitz, Bürgerstrasse 2, 09113, Chemnitz, Germany
  • Practice for Hematology-Oncology Eppendorf, Eppendorfer Landstrasse 42, 20249, Hamburg, Germany
  • Department for Hematology, University Hospital Essen, Hufelandstrasse 55, 45147, Essen, Germany
  • Department for Hematology, University Hospital Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
  • Department for Internal Medicine III, Diakonie Hospital Schwäbisch Hall, Diakoniestrasse 20, 74523, Schwäbisch-Hall, Germany
  • Department for Hematology, Oncology and Palliative Care, Rems-Murr-Hospitals, Am Jakobsweg 1, 71364, Winnenden, Germany
  • Department for Hematology and Oncology, University Hospital Frankfurt/Main, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany
  • Department of Medicine A, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00277-016-2730-y

    DOI

    http://dx.doi.org/10.1007/s00277-016-2730-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004161456

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27334946


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