Ontology type: schema:ScholarlyArticle
2016-05
AUTHORSHo Sup Lee, Chang-Ki Min, Je-Jung Lee, Kihyun Kim, Seok Jin Kim, Dok Hyun Yoon, Hyeon-Seok Eom, Hyewon Lee, Won Sik Lee, Ho-Jin Shin, Ji Hyun Lee, Yong Park, Jae-Cheol Jo, Young Rok Do, Yeung-Chul Mun, Mark Hong Lee, The Korean Multiple Myeloma Working Party (KMMWP)
ABSTRACTIn real clinical settings (not clinical trials), thalidomide has been accepted as maintenance therapy to patients with multiple myeloma (MM) because of the cost of drugs, the limitations of medical insurance, etc., in our country (South Korea). The purpose of this study was to evaluate the utility of thalidomide maintenance for improving survival in transplantation-eligible patients with MM in the real clinical field. Differences in survival rates were estimated in patients treated with or without thalidomide maintenance. The 3-year progression-free survival rates (PFS) of patients with and without maintenance, respectively, were 55.4 and 37.2 % (p = 0.005). The 3-year overall survival rates (OS) were 88.0 and 84.0 % (p = 0.105). No difference in 3-year OS after relapse or progression (OS2) was observed between the two groups (50.4 and 55.3 %, p = 0.661). The 3-year PFS of patients with and without maintenance therapy who had shown less than CR after ASCT were 68.4 and 23.3 % (p < 0.001). In conclusion, Thalidomide maintenance therapy showed longer PFS in real clinical practice, and long-term use of thalidomide did not interfere with the efficacy of salvage chemotherapy in patients who experienced progression or relapse after ASCT. In addition, thalidomide maintenance might be also useful for patients who have shown less than CR after ASCT. More... »
PAGES911-919
http://scigraph.springernature.com/pub.10.1007/s00277-016-2660-8
DOIhttp://dx.doi.org/10.1007/s00277-016-2660-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1020172588
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/27052989
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Follow-Up Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hematopoietic Stem Cell Transplantation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunosuppressive Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Multiple Myeloma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Republic of Korea",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Rate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Thalidomide",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transplantation, Autologous",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Kosin University",
"id": "https://www.grid.ac/institutes/grid.411144.5",
"name": [
"Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Ho Sup",
"id": "sg:person.0670171614.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670171614.80"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Catholic University of Korea",
"id": "https://www.grid.ac/institutes/grid.411947.e",
"name": [
"Hematology, Department of Internal Medicine, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, 505, Banpo-dong, Seocho-gu, 137-701, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Min",
"givenName": "Chang-Ki",
"id": "sg:person.01301124447.27",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301124447.27"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Chonnam National University Hwasun Hospital",
"id": "https://www.grid.ac/institutes/grid.411602.0",
"name": [
"Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeollanamdo, South Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Je-Jung",
"id": "sg:person.01204441075.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204441075.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Samsung Medical Center",
"id": "https://www.grid.ac/institutes/grid.414964.a",
"name": [
"Department of Medicine, Samsung Medical Center, Sunkyunkwan University School of Medicine, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Kihyun",
"id": "sg:person.01135306324.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135306324.87"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Samsung Medical Center",
"id": "https://www.grid.ac/institutes/grid.414964.a",
"name": [
"Department of Medicine, Samsung Medical Center, Sunkyunkwan University School of Medicine, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Seok Jin",
"id": "sg:person.01276437501.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276437501.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Asan Medical Center",
"id": "https://www.grid.ac/institutes/grid.413967.e",
"name": [
"Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Yoon",
"givenName": "Dok Hyun",
"id": "sg:person.0761614433.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761614433.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Cancer Center",
"id": "https://www.grid.ac/institutes/grid.410914.9",
"name": [
"Department of Internal Medicine, National Cancer Center of Korea, Goyang, South Korea"
],
"type": "Organization"
},
"familyName": "Eom",
"givenName": "Hyeon-Seok",
"id": "sg:person.01246615653.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246615653.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Cancer Center",
"id": "https://www.grid.ac/institutes/grid.410914.9",
"name": [
"Department of Internal Medicine, National Cancer Center of Korea, Goyang, South Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Hyewon",
"id": "sg:person.01135245046.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135245046.31"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Inje University Busan Paik Hospital",
"id": "https://www.grid.ac/institutes/grid.411625.5",
"name": [
"Department of Internal Medicine, Busan Paik Hospital, Busan, South Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Won Sik",
"id": "sg:person.01031456242.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031456242.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Pusan National University Hospital",
"id": "https://www.grid.ac/institutes/grid.412588.2",
"name": [
"Department of Internal Medicine, Pusan National University Hospital, Busan, South Korea"
],
"type": "Organization"
},
"familyName": "Shin",
"givenName": "Ho-Jin",
"id": "sg:person.01046763234.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046763234.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Dong-A University",
"id": "https://www.grid.ac/institutes/grid.255166.3",
"name": [
"Department of Internal Medicine, Dong-A University College of Medicine, Busan, South Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Ji Hyun",
"id": "sg:person.011114726520.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011114726520.76"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Park",
"givenName": "Yong",
"id": "sg:person.01321276455.27",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321276455.27"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Ulsan",
"id": "https://www.grid.ac/institutes/grid.267370.7",
"name": [
"Department of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea"
],
"type": "Organization"
},
"familyName": "Jo",
"givenName": "Jae-Cheol",
"id": "sg:person.01162367557.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162367557.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Keimyung University Dongsan Medical Center",
"id": "https://www.grid.ac/institutes/grid.414067.0",
"name": [
"Department of Hemato-Oncology, Keimyung University Dongsan Medical Center, Daegu, South Korea"
],
"type": "Organization"
},
"familyName": "Do",
"givenName": "Young Rok",
"id": "sg:person.07411674401.59",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07411674401.59"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ewha Womans University",
"id": "https://www.grid.ac/institutes/grid.255649.9",
"name": [
"Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Mun",
"givenName": "Yeung-Chul",
"id": "sg:person.01260404633.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260404633.80"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Konkuk University Medical Center",
"id": "https://www.grid.ac/institutes/grid.411120.7",
"name": [
"Division of Hematology-Oncology, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Mark Hong",
"id": "sg:person.0605272546.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605272546.19"
],
"type": "Person"
},
{
"familyName": "The Korean Multiple Myeloma Working Party (KMMWP)",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1200/jco.2013.52.0023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002732784"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1600-0609.2008.01121.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003454755"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1600-0609.2004.00272.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013304727"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2013.293",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013434190",
"https://doi.org/10.1038/leu.2013.293"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2013.293",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013434190",
"https://doi.org/10.1038/leu.2013.293"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/10428194.2012.760736",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014548445"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1114083",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018136303"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbmt.2010.02.020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020832043"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2009-05-222539",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020922291"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hon.1025",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021022462"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.mayocp.2013.01.019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023181533"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ajh.23390",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024877734"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2011.39.6820",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029641259"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa053583",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030067631"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/ejh.12257",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031299567"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2011-06-357038",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032504869"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2404284",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033553106",
"https://doi.org/10.1038/sj.leu.2404284"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2404284",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033553106",
"https://doi.org/10.1038/sj.leu.2404284"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1114138",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037322752"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2011-11-374249",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040451549"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2006-05-022962",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046874148"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00277-009-0813-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047327835",
"https://doi.org/10.1007/s00277-009-0813-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00277-009-0813-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047327835",
"https://doi.org/10.1007/s00277-009-0813-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00277-009-0813-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047327835",
"https://doi.org/10.1007/s00277-009-0813-8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2012-09-451872",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048932153"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2008.18.8573",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050138920"
],
"type": "CreativeWork"
}
],
"datePublished": "2016-05",
"datePublishedReg": "2016-05-01",
"description": "In real clinical settings (not clinical trials), thalidomide has been accepted as maintenance therapy to patients with multiple myeloma (MM) because of the cost of drugs, the limitations of medical insurance, etc., in our country (South Korea). The purpose of this study was to evaluate the utility of thalidomide maintenance for improving survival in transplantation-eligible patients with MM in the real clinical field. Differences in survival rates were estimated in patients treated with or without thalidomide maintenance. The 3-year progression-free survival rates (PFS) of patients with and without maintenance, respectively, were 55.4 and 37.2\u00a0% (p\u2009=\u20090.005). The 3-year overall survival rates (OS) were 88.0 and 84.0\u00a0% (p\u2009=\u20090.105). No difference in 3-year OS after relapse or progression (OS2) was observed between the two groups (50.4 and 55.3\u00a0%, p\u2009=\u20090.661). The 3-year PFS of patients with and without maintenance therapy who had shown less than CR after ASCT were 68.4 and 23.3\u00a0% (p\u2009<\u20090.001). In conclusion, Thalidomide maintenance therapy showed longer PFS in real clinical practice, and long-term use of thalidomide did not interfere with the efficacy of salvage chemotherapy in patients who experienced progression or relapse after ASCT. In addition, thalidomide maintenance might be also useful for patients who have shown less than CR after ASCT. ",
"genre": "research_article",
"id": "sg:pub.10.1007/s00277-016-2660-8",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1018247",
"issn": [
"1269-3286",
"1279-8509"
],
"name": "Annals of Hematology",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "95"
}
],
"name": "The clinical impact of thalidomide maintenance after autologous stem cell transplantation in patients with newly diagnosed multiple myeloma in real clinical practice of Korea",
"pagination": "911-919",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"601d8038d3fd2c06c36a32b8b9a36b9c64bf2408a095e06a88461fa90edb921e"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"27052989"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9107334"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00277-016-2660-8"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1020172588"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00277-016-2660-8",
"https://app.dimensions.ai/details/publication/pub.1020172588"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T15:45",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000487.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/s00277-016-2660-8"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00277-016-2660-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00277-016-2660-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-016-2660-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-016-2660-8'
This table displays all metadata directly associated to this object as RDF triples.
349 TRIPLES
21 PREDICATES
67 URIs
37 LITERALS
25 BLANK NODES