Cytomegalovirus retinitis complicating combination therapy with rituximab and fludarabine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01-10

AUTHORS

Thomas S. Y. Chan, Carol Y. M. Cheung, Ian Y. L. Yeung, Yu-Yan Hwang, Harinder Gill, Ian Y. Wong, Yok-Lam Kwong

ABSTRACT

Cytomegalovirus (CMV) retinitis is exceptionally rare outside the clinical context of acquired immunodeficiency syndrome and organ allografting. In a population where seropositivity for past CMV infection exceeded 90 %, CMV retinitis was observed in five of 138 patients (3.6 %) receiving fludarabine-containing regimens together with rituximab, which was significantly more frequent than in 141 patients receiving fludarabine-containing regimens alone, where no case was observed (P = 0.029). Treatment of CMV retinitis comprised both intravitreal and systemic ganciclovir/foscarnet. Upon recovery, secondary retinal atrophy occurred in all patients, leading to blindness in 86 % of affected eyes. CMV retinitis is an important complication in patients receiving concomitant rituximab and fludarabine-containing regimens. More... »

PAGES

1043-1047

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-014-2296-5

DOI

http://dx.doi.org/10.1007/s00277-014-2296-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007263683

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25572171


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