Pharmacokinetics for once-daily modified release formulation of tacrolimus hydrate in unrelated hematopoietic stem cell transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-10-19

AUTHORS

Shingo Yano, Shinichiro Mori, Takeshi Saito, Hiroki Yokoyama, Tomohito Machishima, Takaki Shimada, Yuichi Yahagi, Katsuki Sugiyama, Yoji Ogasawara, Shinobu Takahara, Kinuyo Kasama, Atsushi Katsube, Yutaro Kamiyama, Kazuhito Suzuki, Yumiko Inui, Noriko Usui, Keisuke Aiba, Takuya Yamashita

ABSTRACT

A once-daily modified release formulation of oral tacrolimus (Tac QD) has been developed in response to the problem of nonadherence. However, there have been no data available about the efficacy of Tac QD conversion from intravenous Tac (Tac i.v.) in allogeneic hematopoietic stem cell transplantation (allo-SCT). We analyzed the pharmacokinetics (PK) of Tac QD in allo-SCT recipients. A total of 10 patients with hematological malignancies who received allo-SCT from unrelated donors were enrolled. Patients received Tac i.v. at 0.03 mg/kg a day before transplantation. Administration of Tac i.v. was converted to Tac QD at a 1:4 ratio when the patients had recovered from regimen-related gastrointestinal toxicity and could tolerate oral medication. After conversion, six out of 10 patients (60 %) showed a sustained decrease in Tac exposure and required dose adjustment. The conversion from Tac i.v. to Tac QD should be performed under close medical supervision. Area under the curve (AUC) and the trough of Tac QD showed a correlation, and the trough should be maintained above 7.5 ng/ml to provide an adequate AUC. Although four patients received bone marrow from an HLA DRB1 1 antigen-mismatched unrelated donor, no patients developed grade III–IV acute graft-versus-host disease (GVHD). The modification of Tac QD to maintain a whole-blood trough concentration above 7.5 ng/ml may be as effective as Tac BID. More... »

PAGES

491-496

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-014-2233-7

DOI

http://dx.doi.org/10.1007/s00277-014-2233-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046165065

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25325985


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Delayed-Action Preparations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Administration Schedule", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunosuppressive Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, Non-Hodgkin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myelodysplastic Syndromes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tacrolimus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation Conditioning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Homologous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Unrelated Donors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yano", 
        "givenName": "Shingo", 
        "id": "sg:person.01265010246.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, St. Luke\u2019s International Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.430395.8", 
          "name": [
            "Department of Hematology and Oncology, St. Luke\u2019s International Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mori", 
        "givenName": "Shinichiro", 
        "id": "sg:person.016544605712.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016544605712.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saito", 
        "givenName": "Takeshi", 
        "id": "sg:person.015754574322.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015754574322.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yokoyama", 
        "givenName": "Hiroki", 
        "id": "sg:person.01015104665.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015104665.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Machishima", 
        "givenName": "Tomohito", 
        "id": "sg:person.01323461671.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323461671.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimada", 
        "givenName": "Takaki", 
        "id": "sg:person.01145477026.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145477026.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yahagi", 
        "givenName": "Yuichi", 
        "id": "sg:person.0607517346.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607517346.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sugiyama", 
        "givenName": "Katsuki", 
        "id": "sg:person.01165130270.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165130270.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ogasawara", 
        "givenName": "Yoji", 
        "id": "sg:person.0766546265.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766546265.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takahara", 
        "givenName": "Shinobu", 
        "id": "sg:person.0670105772.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670105772.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kasama", 
        "givenName": "Kinuyo", 
        "id": "sg:person.01145707123.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145707123.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katsube", 
        "givenName": "Atsushi", 
        "id": "sg:person.01044035446.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044035446.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kamiyama", 
        "givenName": "Yutaro", 
        "id": "sg:person.01120562772.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120562772.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Kazuhito", 
        "id": "sg:person.01237063604.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237063604.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inui", 
        "givenName": "Yumiko", 
        "id": "sg:person.01174666661.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174666661.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Usui", 
        "givenName": "Noriko", 
        "id": "sg:person.01114721672.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114721672.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411898.d", 
          "name": [
            "Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aiba", 
        "givenName": "Keisuke", 
        "id": "sg:person.0656467117.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656467117.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Department of Hematology and Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamashita", 
        "givenName": "Takuya", 
        "id": "sg:person.01276656114.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276656114.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.bmt.1702053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025737910", 
          "https://doi.org/10.1038/sj.bmt.1702053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bmt.2012.244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028358194", 
          "https://doi.org/10.1038/bmt.2012.244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1704596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023557577", 
          "https://doi.org/10.1038/sj.bmt.1704596"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-10-19", 
    "datePublishedReg": "2014-10-19", 
    "description": "A once-daily modified release formulation of oral tacrolimus (Tac QD) has been developed in response to the problem of nonadherence. However, there have been no data available about the efficacy of Tac QD conversion from intravenous Tac (Tac i.v.) in allogeneic hematopoietic stem cell transplantation (allo-SCT). We analyzed the pharmacokinetics (PK) of Tac QD in allo-SCT recipients. A total of 10 patients with hematological malignancies who received allo-SCT from unrelated donors were enrolled. Patients received Tac i.v. at 0.03\u00a0mg/kg a day before transplantation. Administration of Tac i.v. was converted to Tac QD at a 1:4 ratio when the patients had recovered from regimen-related gastrointestinal toxicity and could tolerate oral medication. After conversion, six out of 10 patients (60\u00a0%) showed a sustained decrease in Tac exposure and required dose adjustment. The conversion from Tac i.v. to Tac QD should be performed under close medical supervision. Area under the curve (AUC) and the trough of Tac QD showed a correlation, and the trough should be maintained above 7.5\u00a0ng/ml to provide an adequate AUC. Although four patients received bone marrow from an HLA DRB1 1 antigen-mismatched unrelated donor, no patients developed grade III\u2013IV acute graft-versus-host disease (GVHD). The modification of Tac QD to maintain a whole-blood trough concentration above 7.5\u00a0ng/ml may be as effective as Tac BID.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00277-014-2233-7", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1358129", 
        "issn": [
          "0939-5555", 
          "1432-0584"
        ], 
        "name": "Annals of Hematology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "94"
      }
    ], 
    "keywords": [
      "hematopoietic stem cell transplantation", 
      "Tac-QD", 
      "stem cell transplantation", 
      "unrelated donors", 
      "cell transplantation", 
      "modified release formulations", 
      "allogeneic hematopoietic stem cell transplantation", 
      "whole blood trough concentrations", 
      "unrelated hematopoietic stem cell transplantation", 
      "allo-SCT recipients", 
      "close medical supervision", 
      "problem of nonadherence", 
      "oral tacrolimus", 
      "TAC exposure", 
      "adequate AUC", 
      "acute graft", 
      "Tac-BID", 
      "allo-SCT", 
      "gastrointestinal toxicity", 
      "host disease", 
      "oral medications", 
      "trough concentrations", 
      "dose adjustment", 
      "release formulation", 
      "tacrolimus hydrate", 
      "grade III", 
      "hematological malignancies", 
      "patients", 
      "bone marrow", 
      "medical supervision", 
      "transplantation", 
      "pharmacokinetics", 
      "tacrolimus", 
      "nonadherence", 
      "medications", 
      "malignancy", 
      "graft", 
      "marrow", 
      "donors", 
      "disease", 
      "administration", 
      "recipients", 
      "AUC", 
      "efficacy", 
      "total", 
      "toxicity", 
      "exposure", 
      "days", 
      "TAC", 
      "i.", 
      "response", 
      "adjustment", 
      "decrease", 
      "correlation", 
      "concentration", 
      "supervision", 
      "data", 
      "ratio", 
      "curves", 
      "area", 
      "bid", 
      "QDs", 
      "modification", 
      "conversion", 
      "formulation", 
      "trough", 
      "problem", 
      "hydrate"
    ], 
    "name": "Pharmacokinetics for once-daily modified release formulation of tacrolimus hydrate in unrelated hematopoietic stem cell transplantation", 
    "pagination": "491-496", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046165065"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00277-014-2233-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25325985"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00277-014-2233-7", 
      "https://app.dimensions.ai/details/publication/pub.1046165065"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T17:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_624.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00277-014-2233-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00277-014-2233-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00277-014-2233-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-014-2233-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-014-2233-7'


 

This table displays all metadata directly associated to this object as RDF triples.

338 TRIPLES      21 PREDICATES      114 URIs      103 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00277-014-2233-7 schema:about N03aac92bf83d423b8a0a0cac8f5a18e7
2 N06b380ae7a10489c9dbaffbfb988f7e6
3 N11e7708d1cae4a0596202a2b2f02a57f
4 N22972f6633b046dea2890e9720d92d83
5 N3490a9fa8e1d43b1b00d5e07eaa118ba
6 N5a9bfcbe76874afba39d99cb8cdf1cb7
7 N67e631b41ca54547b4d9d5df55584aa6
8 N82eb750beee54a31aab2b75d8be3fc95
9 N8ad81388b44a4adf9d8e63dd190bcb43
10 N917d520935474374990ac4865af281c2
11 Na7942761cdad49c9b0a23dc78a36b637
12 Nac36b870b9a34417be578fa442269edd
13 Nc805bf1d62e740f893d06c4133fbba6d
14 Nd6289a4737e6419baee434efc2ed99d0
15 Nd6b906efdf29442fabd61c5c654da70f
16 Ndea107e7395244feb1211a6997ee0f35
17 Ne2231bc9e29d4f879099b11aedc8446e
18 Ned6e8ac8744445e2882ffd9b436281d5
19 anzsrc-for:11
20 anzsrc-for:1102
21 schema:author N42c7480f47494eb18de512d31b3165d2
22 schema:citation sg:pub.10.1038/bmt.2012.244
23 sg:pub.10.1038/sj.bmt.1702053
24 sg:pub.10.1038/sj.bmt.1704596
25 schema:datePublished 2014-10-19
26 schema:datePublishedReg 2014-10-19
27 schema:description A once-daily modified release formulation of oral tacrolimus (Tac QD) has been developed in response to the problem of nonadherence. However, there have been no data available about the efficacy of Tac QD conversion from intravenous Tac (Tac i.v.) in allogeneic hematopoietic stem cell transplantation (allo-SCT). We analyzed the pharmacokinetics (PK) of Tac QD in allo-SCT recipients. A total of 10 patients with hematological malignancies who received allo-SCT from unrelated donors were enrolled. Patients received Tac i.v. at 0.03 mg/kg a day before transplantation. Administration of Tac i.v. was converted to Tac QD at a 1:4 ratio when the patients had recovered from regimen-related gastrointestinal toxicity and could tolerate oral medication. After conversion, six out of 10 patients (60 %) showed a sustained decrease in Tac exposure and required dose adjustment. The conversion from Tac i.v. to Tac QD should be performed under close medical supervision. Area under the curve (AUC) and the trough of Tac QD showed a correlation, and the trough should be maintained above 7.5 ng/ml to provide an adequate AUC. Although four patients received bone marrow from an HLA DRB1 1 antigen-mismatched unrelated donor, no patients developed grade III–IV acute graft-versus-host disease (GVHD). The modification of Tac QD to maintain a whole-blood trough concentration above 7.5 ng/ml may be as effective as Tac BID.
28 schema:genre article
29 schema:isAccessibleForFree false
30 schema:isPartOf Nebbacbb3503d4ee3b7799bad5fd601d7
31 Nfd719395c3834e3ea9a7ab0bf7940ccb
32 sg:journal.1358129
33 schema:keywords AUC
34 QDs
35 TAC
36 TAC exposure
37 Tac-BID
38 Tac-QD
39 acute graft
40 adequate AUC
41 adjustment
42 administration
43 allo-SCT
44 allo-SCT recipients
45 allogeneic hematopoietic stem cell transplantation
46 area
47 bid
48 bone marrow
49 cell transplantation
50 close medical supervision
51 concentration
52 conversion
53 correlation
54 curves
55 data
56 days
57 decrease
58 disease
59 donors
60 dose adjustment
61 efficacy
62 exposure
63 formulation
64 gastrointestinal toxicity
65 grade III
66 graft
67 hematological malignancies
68 hematopoietic stem cell transplantation
69 host disease
70 hydrate
71 i.
72 malignancy
73 marrow
74 medical supervision
75 medications
76 modification
77 modified release formulations
78 nonadherence
79 oral medications
80 oral tacrolimus
81 patients
82 pharmacokinetics
83 problem
84 problem of nonadherence
85 ratio
86 recipients
87 release formulation
88 response
89 stem cell transplantation
90 supervision
91 tacrolimus
92 tacrolimus hydrate
93 total
94 toxicity
95 transplantation
96 trough
97 trough concentrations
98 unrelated donors
99 unrelated hematopoietic stem cell transplantation
100 whole blood trough concentrations
101 schema:name Pharmacokinetics for once-daily modified release formulation of tacrolimus hydrate in unrelated hematopoietic stem cell transplantation
102 schema:pagination 491-496
103 schema:productId N026e726c6918448089239241c23e4275
104 N6dc4ac9ffda6411b915b0c0554fc7592
105 Ncf30f746f4e44d65b2ea0eb6f9f92320
106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046165065
107 https://doi.org/10.1007/s00277-014-2233-7
108 schema:sdDatePublished 2022-08-04T17:01
109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
110 schema:sdPublisher Ncf66b3e855ea43cda0ad5b281f3a233d
111 schema:url https://doi.org/10.1007/s00277-014-2233-7
112 sgo:license sg:explorer/license/
113 sgo:sdDataset articles
114 rdf:type schema:ScholarlyArticle
115 N026e726c6918448089239241c23e4275 schema:name pubmed_id
116 schema:value 25325985
117 rdf:type schema:PropertyValue
118 N03aac92bf83d423b8a0a0cac8f5a18e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Immunosuppressive Agents
120 rdf:type schema:DefinedTerm
121 N06b380ae7a10489c9dbaffbfb988f7e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Adult
123 rdf:type schema:DefinedTerm
124 N11e7708d1cae4a0596202a2b2f02a57f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Leukemia
126 rdf:type schema:DefinedTerm
127 N1c349501a9624cd981265a55f17af211 rdf:first sg:person.016544605712.57
128 rdf:rest N9cd93e3b12bd4390930ca6b79fd98337
129 N22972f6633b046dea2890e9720d92d83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Humans
131 rdf:type schema:DefinedTerm
132 N3490a9fa8e1d43b1b00d5e07eaa118ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Unrelated Donors
134 rdf:type schema:DefinedTerm
135 N42c7480f47494eb18de512d31b3165d2 rdf:first sg:person.01265010246.42
136 rdf:rest N1c349501a9624cd981265a55f17af211
137 N55f5222c4d224eadb3b093588d2fbe72 rdf:first sg:person.01145707123.23
138 rdf:rest Na7754b70162b44f69a03407db8dba7fb
139 N59a0af92207c4eee9613b568af17ee16 rdf:first sg:person.0656467117.84
140 rdf:rest Nbcec5c19867742f7b73b993a4acf1ea4
141 N5a9bfcbe76874afba39d99cb8cdf1cb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Male
143 rdf:type schema:DefinedTerm
144 N5b23488a27224115bea4ded64127ae69 rdf:first sg:person.01165130270.06
145 rdf:rest N9fa6fc9a0d1d48f693281c8777db6063
146 N602a715944584a10bcd3c3732050f6f0 rdf:first sg:person.0670105772.95
147 rdf:rest N55f5222c4d224eadb3b093588d2fbe72
148 N62e042eb2ffd460dba19ace6fb308f6b rdf:first sg:person.01237063604.97
149 rdf:rest Nde951592639f448e8626c40cda5c427c
150 N67e631b41ca54547b4d9d5df55584aa6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Delayed-Action Preparations
152 rdf:type schema:DefinedTerm
153 N6dc4ac9ffda6411b915b0c0554fc7592 schema:name dimensions_id
154 schema:value pub.1046165065
155 rdf:type schema:PropertyValue
156 N705e7fd709154696bf7749f85004a445 rdf:first sg:person.01145477026.42
157 rdf:rest Nfb175445cea6419487bad1456581a74c
158 N82eb750beee54a31aab2b75d8be3fc95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Aged
160 rdf:type schema:DefinedTerm
161 N86dcc5190b224ef1a97d56588c5c886e rdf:first sg:person.01015104665.33
162 rdf:rest Nfac81e375e6f4362bf840866bf693ca2
163 N8ad81388b44a4adf9d8e63dd190bcb43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Transplantation, Homologous
165 rdf:type schema:DefinedTerm
166 N917d520935474374990ac4865af281c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Drug Administration Schedule
168 rdf:type schema:DefinedTerm
169 N9cd93e3b12bd4390930ca6b79fd98337 rdf:first sg:person.015754574322.05
170 rdf:rest N86dcc5190b224ef1a97d56588c5c886e
171 N9fa6fc9a0d1d48f693281c8777db6063 rdf:first sg:person.0766546265.87
172 rdf:rest N602a715944584a10bcd3c3732050f6f0
173 Na7754b70162b44f69a03407db8dba7fb rdf:first sg:person.01044035446.65
174 rdf:rest Nd22215939bff41a4bca0901c9b150fc1
175 Na7942761cdad49c9b0a23dc78a36b637 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Transplantation Conditioning
177 rdf:type schema:DefinedTerm
178 Nac36b870b9a34417be578fa442269edd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Middle Aged
180 rdf:type schema:DefinedTerm
181 Nbcec5c19867742f7b73b993a4acf1ea4 rdf:first sg:person.01276656114.09
182 rdf:rest rdf:nil
183 Nc805bf1d62e740f893d06c4133fbba6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Hematopoietic Stem Cell Transplantation
185 rdf:type schema:DefinedTerm
186 Ncf30f746f4e44d65b2ea0eb6f9f92320 schema:name doi
187 schema:value 10.1007/s00277-014-2233-7
188 rdf:type schema:PropertyValue
189 Ncf66b3e855ea43cda0ad5b281f3a233d schema:name Springer Nature - SN SciGraph project
190 rdf:type schema:Organization
191 Nd22215939bff41a4bca0901c9b150fc1 rdf:first sg:person.01120562772.99
192 rdf:rest N62e042eb2ffd460dba19ace6fb308f6b
193 Nd5891d5e978c4edf830d2513b3de0b4f rdf:first sg:person.01114721672.90
194 rdf:rest N59a0af92207c4eee9613b568af17ee16
195 Nd6289a4737e6419baee434efc2ed99d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Lymphoma, Non-Hodgkin
197 rdf:type schema:DefinedTerm
198 Nd6b906efdf29442fabd61c5c654da70f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Female
200 rdf:type schema:DefinedTerm
201 Nde951592639f448e8626c40cda5c427c rdf:first sg:person.01174666661.48
202 rdf:rest Nd5891d5e978c4edf830d2513b3de0b4f
203 Ndea107e7395244feb1211a6997ee0f35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Tacrolimus
205 rdf:type schema:DefinedTerm
206 Ne2231bc9e29d4f879099b11aedc8446e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Young Adult
208 rdf:type schema:DefinedTerm
209 Nebbacbb3503d4ee3b7799bad5fd601d7 schema:volumeNumber 94
210 rdf:type schema:PublicationVolume
211 Ned6e8ac8744445e2882ffd9b436281d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Myelodysplastic Syndromes
213 rdf:type schema:DefinedTerm
214 Nfac81e375e6f4362bf840866bf693ca2 rdf:first sg:person.01323461671.08
215 rdf:rest N705e7fd709154696bf7749f85004a445
216 Nfb175445cea6419487bad1456581a74c rdf:first sg:person.0607517346.52
217 rdf:rest N5b23488a27224115bea4ded64127ae69
218 Nfd719395c3834e3ea9a7ab0bf7940ccb schema:issueNumber 3
219 rdf:type schema:PublicationIssue
220 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
221 schema:name Medical and Health Sciences
222 rdf:type schema:DefinedTerm
223 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
224 schema:name Cardiorespiratory Medicine and Haematology
225 rdf:type schema:DefinedTerm
226 sg:journal.1358129 schema:issn 0939-5555
227 1432-0584
228 schema:name Annals of Hematology
229 schema:publisher Springer Nature
230 rdf:type schema:Periodical
231 sg:person.01015104665.33 schema:affiliation grid-institutes:grid.411898.d
232 schema:familyName Yokoyama
233 schema:givenName Hiroki
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015104665.33
235 rdf:type schema:Person
236 sg:person.01044035446.65 schema:affiliation grid-institutes:grid.411898.d
237 schema:familyName Katsube
238 schema:givenName Atsushi
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044035446.65
240 rdf:type schema:Person
241 sg:person.01114721672.90 schema:affiliation grid-institutes:grid.411898.d
242 schema:familyName Usui
243 schema:givenName Noriko
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114721672.90
245 rdf:type schema:Person
246 sg:person.01120562772.99 schema:affiliation grid-institutes:grid.411898.d
247 schema:familyName Kamiyama
248 schema:givenName Yutaro
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120562772.99
250 rdf:type schema:Person
251 sg:person.01145477026.42 schema:affiliation grid-institutes:grid.411898.d
252 schema:familyName Shimada
253 schema:givenName Takaki
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145477026.42
255 rdf:type schema:Person
256 sg:person.01145707123.23 schema:affiliation grid-institutes:grid.411898.d
257 schema:familyName Kasama
258 schema:givenName Kinuyo
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145707123.23
260 rdf:type schema:Person
261 sg:person.01165130270.06 schema:affiliation grid-institutes:grid.411898.d
262 schema:familyName Sugiyama
263 schema:givenName Katsuki
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165130270.06
265 rdf:type schema:Person
266 sg:person.01174666661.48 schema:affiliation grid-institutes:grid.411898.d
267 schema:familyName Inui
268 schema:givenName Yumiko
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174666661.48
270 rdf:type schema:Person
271 sg:person.01237063604.97 schema:affiliation grid-institutes:grid.411898.d
272 schema:familyName Suzuki
273 schema:givenName Kazuhito
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237063604.97
275 rdf:type schema:Person
276 sg:person.01265010246.42 schema:affiliation grid-institutes:grid.411898.d
277 schema:familyName Yano
278 schema:givenName Shingo
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265010246.42
280 rdf:type schema:Person
281 sg:person.01276656114.09 schema:affiliation grid-institutes:grid.272242.3
282 schema:familyName Yamashita
283 schema:givenName Takuya
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276656114.09
285 rdf:type schema:Person
286 sg:person.01323461671.08 schema:affiliation grid-institutes:grid.411898.d
287 schema:familyName Machishima
288 schema:givenName Tomohito
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323461671.08
290 rdf:type schema:Person
291 sg:person.015754574322.05 schema:affiliation grid-institutes:grid.411898.d
292 schema:familyName Saito
293 schema:givenName Takeshi
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015754574322.05
295 rdf:type schema:Person
296 sg:person.016544605712.57 schema:affiliation grid-institutes:grid.430395.8
297 schema:familyName Mori
298 schema:givenName Shinichiro
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016544605712.57
300 rdf:type schema:Person
301 sg:person.0607517346.52 schema:affiliation grid-institutes:grid.411898.d
302 schema:familyName Yahagi
303 schema:givenName Yuichi
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607517346.52
305 rdf:type schema:Person
306 sg:person.0656467117.84 schema:affiliation grid-institutes:grid.411898.d
307 schema:familyName Aiba
308 schema:givenName Keisuke
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656467117.84
310 rdf:type schema:Person
311 sg:person.0670105772.95 schema:affiliation grid-institutes:grid.411898.d
312 schema:familyName Takahara
313 schema:givenName Shinobu
314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670105772.95
315 rdf:type schema:Person
316 sg:person.0766546265.87 schema:affiliation grid-institutes:grid.411898.d
317 schema:familyName Ogasawara
318 schema:givenName Yoji
319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766546265.87
320 rdf:type schema:Person
321 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
322 https://doi.org/10.1038/bmt.2012.244
323 rdf:type schema:CreativeWork
324 sg:pub.10.1038/sj.bmt.1702053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025737910
325 https://doi.org/10.1038/sj.bmt.1702053
326 rdf:type schema:CreativeWork
327 sg:pub.10.1038/sj.bmt.1704596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023557577
328 https://doi.org/10.1038/sj.bmt.1704596
329 rdf:type schema:CreativeWork
330 grid-institutes:grid.272242.3 schema:alternateName Department of Hematology and Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
331 schema:name Department of Hematology and Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan
332 rdf:type schema:Organization
333 grid-institutes:grid.411898.d schema:alternateName Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan
334 schema:name Division of Clinical Oncology and Hematology, Jikei University School of Medicine, 3-25-8 Nishi Shinbashi, 105-8461, Minatoku, Tokyo, Japan
335 rdf:type schema:Organization
336 grid-institutes:grid.430395.8 schema:alternateName Department of Hematology and Oncology, St. Luke’s International Hospital, Tokyo, Japan
337 schema:name Department of Hematology and Oncology, St. Luke’s International Hospital, Tokyo, Japan
338 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...