ESHAP as salvage therapy for relapsed or refractory Hodgkin’s lymphoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-10

AUTHORS

Jorge Labrador, Mónica Cabrero-Calvo, Estefanía Pérez-López, María Victoria Mateos, Lourdes Vázquez, María Dolores Caballero, Ramón García-Sanz

ABSTRACT

The management of relapsed or refractory Hodgkin's lymphoma (RR-HL) remains a challenge for hematologists and oncologists. Salvage chemotherapy followed by autologous stem cell transplantation (ASCT) is the standard of care for RR-HL. However, one of the most controversial aspects is which the best salvage protocol could be. We retrospectively analyzed 82 consecutive RR-HL who received etoposide, steroids, ara-C, and cisplatin (ESHAP) as salvage therapy followed by ASCT. Fifty percent of patients were refractory and 23 % early relapses. Overall response rate (ORR) was 67 % (50 % complete remission (CR)). Ninety one percent of patients (75/82) were transplanted. With a mean follow-up of 87 ± 53 months, the median progression-free survival (PFS) and time to tumor progression (TTP) for the whole population were 52 and 56 months, respectively, and the 5-year overall survival was 72.6 %. Achieving CR after ESHAP was associated with a longer PFS (78 vs 16 % 5-year PFS, respectively, P < 0.01) and TTP (80 vs 19 % 5-year TTP, respectively, P < 0.01). However, there were no differences for overall survival (OS) when comparing CR and partial response (PR) after ESHAP. Toxicity was low and <10 % of patients developed neutropenic fever, with no toxic deaths. Mobilization was possible in 94 % of patients. ESHAP is a safe and efficient therapeutic option for patients with RR-HL who are candidates for ASCT, since it combines a high response rate and mobilizing potential with a low toxicity profile. More... »

PAGES

1745-1753

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-014-2114-0

DOI

http://dx.doi.org/10.1007/s00277-014-2114-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038271507

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24863692


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