A high sIL-2R/ferritin ratio is a useful marker for the diagnosis of lymphoma-associated hemophagocytic syndrome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-05

AUTHORS

Takahiro Tsuji, Taichi Hirano, Hiroshi Yamasaki, Mayumi Tsuji, Hiroyuki Tsuda

ABSTRACT

Lymphoma-associated hemophagocytic syndrome (LAHS), which is the major subtype of adult-onset secondary hemophagocytic lymphohistiocytosis (HLH), has a poor outcome. Although the early diagnosis and treatment of LAHS contributes to a better outcome, the lack of mass formation and the absence of distinct lymph node enlargement often delay the diagnosis of underlying lymphoma. A recent study, which statistically analyzed HLH cases in the literature, showed that the serum soluble interleukin-2 receptor (sIL-2R)/ferritin ratio could be used as a marker to diagnosis of LAHS. To verify this finding, we retrospectively analyzed the laboratory findings of 21 patients with HLH (10 benign disease-associated HLH and 11 LAHS). No significant differences were observed in the levels of LDH or CRP levels. The mean sIL-2R levels (units per milliliter) were significantly higher in the LAHS group (4,176 vs. 13,451, p = 0.0031), and ferritin levels (nanogram per milliliter) were higher in the benign disease-associated HLH group (20,462 vs. 2,561, p = 0.0031). Consequently, the mean serum sIL-2R/ferritin ratio of patients with LAHS was markedly higher than that of patients with benign disease-associated HLH (0.66 vs. 8.56, p = 0.0004). Thus, the results of this study demonstrated that the serum sIL-2R/ferritin ratio is a very useful marker for diagnosing of LAHS, which was further supported by clinical case analysis. Further studies to clarify the pathophysiology of secondary HLH caused by various triggers are needed. More... »

PAGES

821-826

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-013-1925-8

DOI

http://dx.doi.org/10.1007/s00277-013-1925-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050680736

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24705932


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "C-Reactive Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ferritins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "L-Lactate Dehydrogenase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphohistiocytosis, Hemophagocytic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Interleukin-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Solubility", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kumamoto City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415532.4", 
          "name": [
            "Division of Hematology and Oncology, Kumamoto City Hospital, Kotoh 1-1-60, 862-8505, Kumamoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsuji", 
        "givenName": "Takahiro", 
        "id": "sg:person.01247637033.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247637033.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kumamoto City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415532.4", 
          "name": [
            "Division of Hematology and Oncology, Kumamoto City Hospital, Kotoh 1-1-60, 862-8505, Kumamoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirano", 
        "givenName": "Taichi", 
        "id": "sg:person.01071074502.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071074502.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kumamoto City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415532.4", 
          "name": [
            "Division of Hematology and Oncology, Kumamoto City Hospital, Kotoh 1-1-60, 862-8505, Kumamoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamasaki", 
        "givenName": "Hiroshi", 
        "id": "sg:person.07660263202.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07660263202.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Occupational and Environmental Health Japan", 
          "id": "https://www.grid.ac/institutes/grid.271052.3", 
          "name": [
            "Department of Environmental Health, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyusyu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsuji", 
        "givenName": "Mayumi", 
        "id": "sg:person.01005253747.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005253747.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kumamoto City Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415532.4", 
          "name": [
            "Division of Hematology and Oncology, Kumamoto City Hospital, Kotoh 1-1-60, 862-8505, Kumamoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsuda", 
        "givenName": "Hiroyuki", 
        "id": "sg:person.011035353042.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011035353042.18"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jpeds.2004.12.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008106783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1532/ijh97.07012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008162141", 
          "https://doi.org/10.1532/ijh97.07012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00043426-199302000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009114499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00043426-199302000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009114499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/gene.2012.3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024645884", 
          "https://doi.org/10.1038/gene.2012.3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.blre.2007.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030460431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0b013e3181caf100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032261112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0b013e3181caf100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032261112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00277-011-1239-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034781191", 
          "https://doi.org/10.1007/s00277-011-1239-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0889-8588(05)70521-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048484106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.21039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050573606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0925-5710(96)00560-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054664004", 
          "https://doi.org/10.1016/s0925-5710(96)00560-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0925-5710(97)00584-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054664111", 
          "https://doi.org/10.1016/s0925-5710(97)00584-7"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-05", 
    "datePublishedReg": "2014-05-01", 
    "description": "Lymphoma-associated hemophagocytic syndrome (LAHS), which is the major subtype of adult-onset secondary hemophagocytic lymphohistiocytosis (HLH), has a poor outcome. Although the early diagnosis and treatment of LAHS contributes to a better outcome, the lack of mass formation and the absence of distinct lymph node enlargement often delay the diagnosis of underlying lymphoma. A recent study, which statistically analyzed HLH cases in the literature, showed that the serum soluble interleukin-2 receptor (sIL-2R)/ferritin ratio could be used as a marker to diagnosis of LAHS. To verify this finding, we retrospectively analyzed the laboratory findings of 21 patients with HLH (10 benign disease-associated HLH and 11 LAHS). No significant differences were observed in the levels of LDH or CRP levels. The mean sIL-2R levels (units per milliliter) were significantly higher in the LAHS group (4,176 vs. 13,451, p\u2009=\u20090.0031), and ferritin levels (nanogram per milliliter) were higher in the benign disease-associated HLH group (20,462 vs. 2,561, p\u2009=\u20090.0031). Consequently, the mean serum sIL-2R/ferritin ratio of patients with LAHS was markedly higher than that of patients with benign disease-associated HLH (0.66 vs. 8.56, p\u2009=\u20090.0004). Thus, the results of this study demonstrated that the serum sIL-2R/ferritin ratio is a very useful marker for diagnosing of LAHS, which was further supported by clinical case analysis. Further studies to clarify the pathophysiology of secondary HLH caused by various triggers are needed. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00277-013-1925-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1018247", 
        "issn": [
          "1269-3286", 
          "1279-8509"
        ], 
        "name": "Annals of Hematology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "93"
      }
    ], 
    "name": "A high sIL-2R/ferritin ratio is a useful marker for the diagnosis of lymphoma-associated hemophagocytic syndrome", 
    "pagination": "821-826", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f16cc930432829b97af27e434f3e9ac3f419b6904ffe38a5d85aadba557a23a1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24705932"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9107334"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00277-013-1925-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1050680736"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00277-013-1925-8", 
      "https://app.dimensions.ai/details/publication/pub.1050680736"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89793_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00277-013-1925-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00277-013-1925-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00277-013-1925-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-013-1925-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-013-1925-8'


 

This table displays all metadata directly associated to this object as RDF triples.

206 TRIPLES      21 PREDICATES      57 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00277-013-1925-8 schema:about N1be3874e981b4521bd7a47ab3075b1b4
2 N2a56b032cbc84bcaa3026bae59001268
3 N371a612bfeb5456897266627c47dbb89
4 N4644d74face34239a54a9f6b765fa93d
5 N4cd2d6a7b27b4afcbaa6677ffab64f6c
6 N5561a824d29147ec85526e207975bd7c
7 N602bbb2f0b074b068f8f61e3f4d2aaa6
8 N65a012c21bac46e48713f4b093eda56e
9 N832b357d293148459afb7040a88ed3bf
10 Na937ad1b52e046a8aef221207737b587
11 Nbbbc46c3d6444cda9a33bf0c6c73f836
12 Ne0d24cd7772642ec9a964c7e1da80693
13 Ne143a4f5aa604f8ab59e7e591b7d863a
14 Ne29a8cd5244249fea857b761809d2138
15 Ne7917864c43744bd860ae8b1306ebd6e
16 Nec63db0cd3144340bb43afcc9a7719cd
17 Nf4aa8ce4f0c74b1eb2f6b1a6ef777c19
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author Nd0bbb8ec01d54c33899d5fa53ca154e1
21 schema:citation sg:pub.10.1007/s00277-011-1239-7
22 sg:pub.10.1016/s0925-5710(96)00560-9
23 sg:pub.10.1016/s0925-5710(97)00584-7
24 sg:pub.10.1038/gene.2012.3
25 sg:pub.10.1532/ijh97.07012
26 https://doi.org/10.1002/pbc.21039
27 https://doi.org/10.1016/j.blre.2007.05.001
28 https://doi.org/10.1016/j.jpeds.2004.12.016
29 https://doi.org/10.1016/s0889-8588(05)70521-9
30 https://doi.org/10.1097/00043426-199302000-00012
31 https://doi.org/10.1097/md.0b013e3181caf100
32 schema:datePublished 2014-05
33 schema:datePublishedReg 2014-05-01
34 schema:description Lymphoma-associated hemophagocytic syndrome (LAHS), which is the major subtype of adult-onset secondary hemophagocytic lymphohistiocytosis (HLH), has a poor outcome. Although the early diagnosis and treatment of LAHS contributes to a better outcome, the lack of mass formation and the absence of distinct lymph node enlargement often delay the diagnosis of underlying lymphoma. A recent study, which statistically analyzed HLH cases in the literature, showed that the serum soluble interleukin-2 receptor (sIL-2R)/ferritin ratio could be used as a marker to diagnosis of LAHS. To verify this finding, we retrospectively analyzed the laboratory findings of 21 patients with HLH (10 benign disease-associated HLH and 11 LAHS). No significant differences were observed in the levels of LDH or CRP levels. The mean sIL-2R levels (units per milliliter) were significantly higher in the LAHS group (4,176 vs. 13,451, p = 0.0031), and ferritin levels (nanogram per milliliter) were higher in the benign disease-associated HLH group (20,462 vs. 2,561, p = 0.0031). Consequently, the mean serum sIL-2R/ferritin ratio of patients with LAHS was markedly higher than that of patients with benign disease-associated HLH (0.66 vs. 8.56, p = 0.0004). Thus, the results of this study demonstrated that the serum sIL-2R/ferritin ratio is a very useful marker for diagnosing of LAHS, which was further supported by clinical case analysis. Further studies to clarify the pathophysiology of secondary HLH caused by various triggers are needed.
35 schema:genre research_article
36 schema:inLanguage en
37 schema:isAccessibleForFree true
38 schema:isPartOf N273dc28d7cd146fd8a52c7163a3300a8
39 Ne5108f88953f4a0b8eb612792b9d5fc7
40 sg:journal.1018247
41 schema:name A high sIL-2R/ferritin ratio is a useful marker for the diagnosis of lymphoma-associated hemophagocytic syndrome
42 schema:pagination 821-826
43 schema:productId N1a23a1308ffc4bea8c395cab18075bb0
44 N3e4af38563954b5289bb69bfbeec1642
45 Na84b947c253d4bdab98a1973ca0b43cd
46 Ncfbd3dc8db7b4a0e96e0600fa4d2875c
47 Nf8d171853a674553965449cd558cf014
48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050680736
49 https://doi.org/10.1007/s00277-013-1925-8
50 schema:sdDatePublished 2019-04-11T09:53
51 schema:sdLicense https://scigraph.springernature.com/explorer/license/
52 schema:sdPublisher N794773de32f240c4a2945ada34bdfc09
53 schema:url http://link.springer.com/10.1007/s00277-013-1925-8
54 sgo:license sg:explorer/license/
55 sgo:sdDataset articles
56 rdf:type schema:ScholarlyArticle
57 N1a23a1308ffc4bea8c395cab18075bb0 schema:name dimensions_id
58 schema:value pub.1050680736
59 rdf:type schema:PropertyValue
60 N1be3874e981b4521bd7a47ab3075b1b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
61 schema:name Biomarkers, Tumor
62 rdf:type schema:DefinedTerm
63 N273dc28d7cd146fd8a52c7163a3300a8 schema:volumeNumber 93
64 rdf:type schema:PublicationVolume
65 N2a56b032cbc84bcaa3026bae59001268 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Ferritins
67 rdf:type schema:DefinedTerm
68 N371a612bfeb5456897266627c47dbb89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Aged
70 rdf:type schema:DefinedTerm
71 N392b31836991417d92647ccc25a50666 rdf:first sg:person.07660263202.22
72 rdf:rest N5995baa1499a4ab7b1062682c0dab4a9
73 N3e4af38563954b5289bb69bfbeec1642 schema:name pubmed_id
74 schema:value 24705932
75 rdf:type schema:PropertyValue
76 N4644d74face34239a54a9f6b765fa93d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Middle Aged
78 rdf:type schema:DefinedTerm
79 N4cd2d6a7b27b4afcbaa6677ffab64f6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Female
81 rdf:type schema:DefinedTerm
82 N5561a824d29147ec85526e207975bd7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name C-Reactive Protein
84 rdf:type schema:DefinedTerm
85 N5995baa1499a4ab7b1062682c0dab4a9 rdf:first sg:person.01005253747.92
86 rdf:rest N88528063c88e4c26860e5fb1b8fe4e4b
87 N602bbb2f0b074b068f8f61e3f4d2aaa6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Gene Expression
89 rdf:type schema:DefinedTerm
90 N65a012c21bac46e48713f4b093eda56e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Solubility
92 rdf:type schema:DefinedTerm
93 N77a002c374b54e1bbe9e5c8d34ce132c rdf:first sg:person.01071074502.51
94 rdf:rest N392b31836991417d92647ccc25a50666
95 N794773de32f240c4a2945ada34bdfc09 schema:name Springer Nature - SN SciGraph project
96 rdf:type schema:Organization
97 N832b357d293148459afb7040a88ed3bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Lymphoma
99 rdf:type schema:DefinedTerm
100 N88528063c88e4c26860e5fb1b8fe4e4b rdf:first sg:person.011035353042.18
101 rdf:rest rdf:nil
102 Na84b947c253d4bdab98a1973ca0b43cd schema:name readcube_id
103 schema:value f16cc930432829b97af27e434f3e9ac3f419b6904ffe38a5d85aadba557a23a1
104 rdf:type schema:PropertyValue
105 Na937ad1b52e046a8aef221207737b587 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Male
107 rdf:type schema:DefinedTerm
108 Nbbbc46c3d6444cda9a33bf0c6c73f836 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Adolescent
110 rdf:type schema:DefinedTerm
111 Ncfbd3dc8db7b4a0e96e0600fa4d2875c schema:name nlm_unique_id
112 schema:value 9107334
113 rdf:type schema:PropertyValue
114 Nd0bbb8ec01d54c33899d5fa53ca154e1 rdf:first sg:person.01247637033.15
115 rdf:rest N77a002c374b54e1bbe9e5c8d34ce132c
116 Ne0d24cd7772642ec9a964c7e1da80693 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Lymphohistiocytosis, Hemophagocytic
118 rdf:type schema:DefinedTerm
119 Ne143a4f5aa604f8ab59e7e591b7d863a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Retrospective Studies
121 rdf:type schema:DefinedTerm
122 Ne29a8cd5244249fea857b761809d2138 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Receptors, Interleukin-2
124 rdf:type schema:DefinedTerm
125 Ne5108f88953f4a0b8eb612792b9d5fc7 schema:issueNumber 5
126 rdf:type schema:PublicationIssue
127 Ne7917864c43744bd860ae8b1306ebd6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name L-Lactate Dehydrogenase
129 rdf:type schema:DefinedTerm
130 Nec63db0cd3144340bb43afcc9a7719cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Humans
132 rdf:type schema:DefinedTerm
133 Nf4aa8ce4f0c74b1eb2f6b1a6ef777c19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Adult
135 rdf:type schema:DefinedTerm
136 Nf8d171853a674553965449cd558cf014 schema:name doi
137 schema:value 10.1007/s00277-013-1925-8
138 rdf:type schema:PropertyValue
139 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
140 schema:name Medical and Health Sciences
141 rdf:type schema:DefinedTerm
142 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
143 schema:name Clinical Sciences
144 rdf:type schema:DefinedTerm
145 sg:journal.1018247 schema:issn 1269-3286
146 1279-8509
147 schema:name Annals of Hematology
148 rdf:type schema:Periodical
149 sg:person.01005253747.92 schema:affiliation https://www.grid.ac/institutes/grid.271052.3
150 schema:familyName Tsuji
151 schema:givenName Mayumi
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005253747.92
153 rdf:type schema:Person
154 sg:person.01071074502.51 schema:affiliation https://www.grid.ac/institutes/grid.415532.4
155 schema:familyName Hirano
156 schema:givenName Taichi
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071074502.51
158 rdf:type schema:Person
159 sg:person.011035353042.18 schema:affiliation https://www.grid.ac/institutes/grid.415532.4
160 schema:familyName Tsuda
161 schema:givenName Hiroyuki
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011035353042.18
163 rdf:type schema:Person
164 sg:person.01247637033.15 schema:affiliation https://www.grid.ac/institutes/grid.415532.4
165 schema:familyName Tsuji
166 schema:givenName Takahiro
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247637033.15
168 rdf:type schema:Person
169 sg:person.07660263202.22 schema:affiliation https://www.grid.ac/institutes/grid.415532.4
170 schema:familyName Yamasaki
171 schema:givenName Hiroshi
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07660263202.22
173 rdf:type schema:Person
174 sg:pub.10.1007/s00277-011-1239-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034781191
175 https://doi.org/10.1007/s00277-011-1239-7
176 rdf:type schema:CreativeWork
177 sg:pub.10.1016/s0925-5710(96)00560-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054664004
178 https://doi.org/10.1016/s0925-5710(96)00560-9
179 rdf:type schema:CreativeWork
180 sg:pub.10.1016/s0925-5710(97)00584-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054664111
181 https://doi.org/10.1016/s0925-5710(97)00584-7
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/gene.2012.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024645884
184 https://doi.org/10.1038/gene.2012.3
185 rdf:type schema:CreativeWork
186 sg:pub.10.1532/ijh97.07012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008162141
187 https://doi.org/10.1532/ijh97.07012
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1002/pbc.21039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050573606
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.blre.2007.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030460431
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.jpeds.2004.12.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008106783
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/s0889-8588(05)70521-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048484106
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1097/00043426-199302000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009114499
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1097/md.0b013e3181caf100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032261112
200 rdf:type schema:CreativeWork
201 https://www.grid.ac/institutes/grid.271052.3 schema:alternateName University of Occupational and Environmental Health Japan
202 schema:name Department of Environmental Health, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyusyu, Japan
203 rdf:type schema:Organization
204 https://www.grid.ac/institutes/grid.415532.4 schema:alternateName Kumamoto City Hospital
205 schema:name Division of Hematology and Oncology, Kumamoto City Hospital, Kotoh 1-1-60, 862-8505, Kumamoto, Japan
206 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...