Breakthrough invasive fungal diseases during echinocandin treatment in high-risk hospitalized hematologic patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-08-15

AUTHORS

Thomas S. Y. Chan, Harinder Gill, Yu-Yan Hwang, Joycelyn Sim, Alan C. T. Tse, Florence Loong, Pek-Lan Khong, Eric Tse, Anskar Y. H. Leung, Chor-Sang Chim, Albert K. W. Lie, Yok-Lam Kwong

ABSTRACT

The frequency of breakthrough invasive fungal diseases (IFDs) during echinocandin therapy is unclear. We retrospectively analyzed 534 hematologic patients treated with echinocandin (caspofungin, N = 55; micafungin, N = 306; anidulafungin, N = 173). Four proven IFDs were found, caused by Candida parapsilosis (N = 2), C. parapsilosis and Candida glabrata (N = 1), and Fusarium species (N = 1). Four cases of possible IFDs were observed, all showing pulmonary infection. One case showed features suggestive of hepatosplenic candidiasis. Six of these eight cases had previously received the purine analog clofarabine. Breakthrough IFD during echinocandin treatment occurred infrequently (1.5 %), caused predominantly by Candida species. Clofarabine usage was an important risk factor. More... »

PAGES

493-498

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-013-1882-2

DOI

http://dx.doi.org/10.1007/s00277-013-1882-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042675123

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23949318


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