Ontology type: schema:ScholarlyArticle
2013-07
AUTHORSJe-Hwan Lee, Yunsuk Choi, Sung-Doo Kim, Dae-Young Kim, Jung-Hee Lee, Kyoo-Hyung Lee, Sang-Min Lee, Su-Hee Cho, Won-Sik Lee, Young-Don Joo
ABSTRACTTwo DNA methyltransferase inhibitors, azacitidine and decitabine, are currently approved for the treatment of myelodysplastic syndrome (MDS). Choosing between these drugs is an important practical issue. In this retrospective study, patients receiving AZA-7d (azacitidine 75 mg/m2 subcutaneously × 7 days, n = 75) or DEC-5d (decitabine 20 mg/m2 intravenously × 5 days, n = 74) were compared. The rates of hematologic response (complete response [CR]/partial response [PR]/marrow CR) were 12.0 % (AZA-7d) vs. 29.7 % (DEC-5d) (P = 0.008), and the overall response rates (CR/PR/marrow CR/hematologic improvement) were 52.0 % (AZA-7d) vs. 63.5 % (DEC-5d) (P = 0.155). Grade 3 or higher neutropenia occurred more frequently with DEC-5d (79.6 %) than with AZA-7d (72.2 %) (P = 0.040). Overall survival probabilities at 2 years were 42.1 % (AZA-7d) vs. 42.2 % (DEC-5d) (P = 0.944). Subgroup analysis revealed that AZA-7d associated with higher survival rates than DEC-5d in patients whose MDS duration exceeded 1 year or who had poor performance status. In conclusion, both AZA-7d and DEC-5d regimens were effective in treating patients with MDS. However, the two regimens differed in terms of clinical responses and toxicities. One hypomethylating regimen may be superior to the other regimen in particular subgroups. More... »
PAGES889-897
http://scigraph.springernature.com/pub.10.1007/s00277-013-1702-8
DOIhttp://dx.doi.org/10.1007/s00277-013-1702-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1009533874
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/23420388
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Azacitidine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Blood Transfusion",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Combined Modality Therapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA (Cytosine-5-)-Methyltransferase 1",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA (Cytosine-5-)-Methyltransferases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA Methylation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Evaluation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Enzyme Inhibitors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kaplan-Meier Estimate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Myelodysplastic Syndromes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Rate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Young Adult",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Asan Medical Center",
"id": "https://www.grid.ac/institutes/grid.413967.e",
"name": [
"Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-gu, 138-736, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Je-Hwan",
"id": "sg:person.0662756754.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662756754.16"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Asan Medical Center",
"id": "https://www.grid.ac/institutes/grid.413967.e",
"name": [
"Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-gu, 138-736, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Choi",
"givenName": "Yunsuk",
"id": "sg:person.010407476714.96",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010407476714.96"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Asan Medical Center",
"id": "https://www.grid.ac/institutes/grid.413967.e",
"name": [
"Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-gu, 138-736, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Sung-Doo",
"id": "sg:person.01335125432.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335125432.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Asan Medical Center",
"id": "https://www.grid.ac/institutes/grid.413967.e",
"name": [
"Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-gu, 138-736, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Dae-Young",
"id": "sg:person.01123465164.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123465164.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Asan Medical Center",
"id": "https://www.grid.ac/institutes/grid.413967.e",
"name": [
"Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-gu, 138-736, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Jung-Hee",
"id": "sg:person.014506145120.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014506145120.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Asan Medical Center",
"id": "https://www.grid.ac/institutes/grid.413967.e",
"name": [
"Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Asanbyeongwon-gil 86, Songpa-gu, 138-736, Seoul, South Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Kyoo-Hyung",
"id": "sg:person.01045457301.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045457301.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Inje University Busan Paik Hospital",
"id": "https://www.grid.ac/institutes/grid.411625.5",
"name": [
"Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Sang-Min",
"id": "sg:person.01315300754.59",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315300754.59"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Inje University Haeundae Paik Hospital",
"id": "https://www.grid.ac/institutes/grid.411631.0",
"name": [
"Department of Hematology, Haeundae Paik Hospital, Inje University College of Medicine, 875, Haeun-daero, Haeundae-gu, 612-862, Busan, South Korea"
],
"type": "Organization"
},
"familyName": "Cho",
"givenName": "Su-Hee",
"id": "sg:person.0641422557.96",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641422557.96"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Inje University Busan Paik Hospital",
"id": "https://www.grid.ac/institutes/grid.411625.5",
"name": [
"Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Won-Sik",
"id": "sg:person.01031456242.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031456242.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Inje University Haeundae Paik Hospital",
"id": "https://www.grid.ac/institutes/grid.411631.0",
"name": [
"Department of Hematology, Haeundae Paik Hospital, Inje University College of Medicine, 875, Haeun-daero, Haeundae-gu, 612-862, Busan, South Korea"
],
"type": "Organization"
},
"familyName": "Joo",
"givenName": "Young-Don",
"id": "sg:person.0730330375.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730330375.72"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1371/journal.pone.0009001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001069540"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.hoc.2010.02.012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003787212"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3324/haematol.2009.010611",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004579823"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2400526",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004603814",
"https://doi.org/10.1038/sj.leu.2400526"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2400526",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004603814",
"https://doi.org/10.1038/sj.leu.2400526"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.21792",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012150990"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.21792",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012150990"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00277-010-1015-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015878395",
"https://doi.org/10.1007/s00277-010-1015-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00277-010-1015-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015878395",
"https://doi.org/10.1007/s00277-010-1015-0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(09)70003-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021469613"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrd1930",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021896263",
"https://doi.org/10.1038/nrd1930"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrd1930",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021896263",
"https://doi.org/10.1038/nrd1930"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.23607",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022009278"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2005.05.4346",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028981358"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3324/haematol.2011.046078",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029030091"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2008-02-140038",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030097698"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/10428194.2011.651618",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031474493"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2006-05-021162",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033395535"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2008.19.6550",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034007980"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0501034102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034476465"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2008.17.1058",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036396235"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.leukres.2007.08.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039700801"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/0091270004271947",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040963711"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2008.397",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041986402",
"https://doi.org/10.1038/leu.2008.397"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.01799-07",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042159419"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0017388",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045094070"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/dji311",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045229588"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/dji311",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045229588"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3324/haematol.2009.017764",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046229199"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2005-10-4149",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048007831"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0012994",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049238772"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/jmbi.1998.2491",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050564128"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2010.30.9245",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050883436"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2007-07-103960",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051918054"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2002.04.117",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064202976"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2000.18.5.956",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074597154"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081113889",
"type": "CreativeWork"
}
],
"datePublished": "2013-07",
"datePublishedReg": "2013-07-01",
"description": "Two DNA methyltransferase inhibitors, azacitidine and decitabine, are currently approved for the treatment of myelodysplastic syndrome (MDS). Choosing between these drugs is an important practical issue. In this retrospective study, patients receiving AZA-7d (azacitidine 75 mg/m2 subcutaneously\u2009\u00d7\u20097 days, n\u2009=\u200975) or DEC-5d (decitabine 20 mg/m2 intravenously\u2009\u00d7\u20095 days, n\u2009=\u200974) were compared. The rates of hematologic response (complete response [CR]/partial response [PR]/marrow CR) were 12.0 % (AZA-7d) vs. 29.7 % (DEC-5d) (P\u2009=\u20090.008), and the overall response rates (CR/PR/marrow CR/hematologic improvement) were 52.0 % (AZA-7d) vs. 63.5 % (DEC-5d) (P\u2009=\u20090.155). Grade 3 or higher neutropenia occurred more frequently with DEC-5d (79.6 %) than with AZA-7d (72.2 %) (P\u2009=\u20090.040). Overall survival probabilities at 2 years were 42.1 % (AZA-7d) vs. 42.2 % (DEC-5d) (P\u2009=\u20090.944). Subgroup analysis revealed that AZA-7d associated with higher survival rates than DEC-5d in patients whose MDS duration exceeded 1 year or who had poor performance status. In conclusion, both AZA-7d and DEC-5d regimens were effective in treating patients with MDS. However, the two regimens differed in terms of clinical responses and toxicities. One hypomethylating regimen may be superior to the other regimen in particular subgroups.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00277-013-1702-8",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1018247",
"issn": [
"1269-3286",
"1279-8509"
],
"name": "Annals of Hematology",
"type": "Periodical"
},
{
"issueNumber": "7",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "92"
}
],
"name": "Comparison of 7-day azacitidine and 5-day decitabine for treating myelodysplastic syndrome",
"pagination": "889-897",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"2d6a776d59953ee38bfde49d6cf256c5e87dfd42d854557d3ee249d7e3ac3107"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"23420388"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9107334"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00277-013-1702-8"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1009533874"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00277-013-1702-8",
"https://app.dimensions.ai/details/publication/pub.1009533874"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T20:39",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000480.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/s00277-013-1702-8"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00277-013-1702-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00277-013-1702-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-013-1702-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-013-1702-8'
This table displays all metadata directly associated to this object as RDF triples.
321 TRIPLES
21 PREDICATES
82 URIs
42 LITERALS
30 BLANK NODES