Interim PET/CT-based prognostic model for the treatment of diffuse large B cell lymphoma in the post-rituximab era View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-04

AUTHORS

Deok-Hwan Yang, Jae-Sook Ahn, Byung Hyun Byun, Jung Joon Min, Sun-Seog Kweon, Yee Soo Chae, Sang Kyun Sohn, Sang Woo Lee, Hae Won Kim, Sung-Hoon Jung, Yeo-Kyeoung Kim, Hyeoung-Joon Kim, Hee-Seung Bom, Je-Jung Lee

ABSTRACT

The prognostic accuracy of interim (18)F-fluoro-2-dexoy-D-glucose positron emission tomography/computerized tomography (PET/CT) using three different methods of response assessments during rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy was investigated in 186 patients with newly diagnosed diffuse large B cell lymphoma (DLBCL). The response of interim PET/CT was assessed based on a combined evaluation of the Deauville five-point scale (5-PS), the rates of reduction in the maximal standardized uptake value (ΔSUVmax), and the rates of reduction in the metabolic tumor volume (ΔMTV2.5). Positivity on the 5-PS, the optimal cutoff of ΔSUVmax, or the optimal cutoff of ΔMTV2.5 could each predict disease progression. Over a median follow-up of 22.8 months, the assessment of responses based on the 5-PS, ΔSUVmax, and ΔMTV2.5 had prognostic value for progression-free survival. When patients were allocated a score of 0 to 3 depending on the presence of an inadequate response by visual, ΔSUVmax, or ΔMTV2.5, the outcomes of patients with a score of 0 were significantly superior to those with a score of 1, 2, or 3. The interim PET/CT response based on visual, SUV-based, and MTV-based assessment had significant negative predictive value for disease progression and a high potential for predicting outcomes of patients with DLBCL. More... »

PAGES

471-479

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-012-1640-x

DOI

http://dx.doi.org/10.1007/s00277-012-1640-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043703793

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23238895


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