KIT D816 mutation associates with adverse outcomes in core binding factor acute myeloid leukemia, especially in the subgroup with RUNX1/RUNX1T1 ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-02

AUTHORS

Hee-Jin Kim, Hee Kyung Ahn, Chul Won Jung, Joon Ho Moon, Chang-Hun Park, Ki-O Lee, Sun-Hee Kim, Yeo-Kyeoung Kim, Hyeoung-Joon Kim, Sang Kyun Sohn, Sung Hyun Kim, Won Sik Lee, Kyoung Ha Kim, Yeung-Chul Mun, Hawk Kim, Jinny Park, Woo-Sung Min, Hee-Je Kim, Dong Hwan Dennis Kim, on behalf of AML/MDS working party, Korean Society of Hematology

ABSTRACT

Core binding factor (CBF)-positive acute myeloid leukemia (AML) presents a favorable prognosis, except for patients with KIT mutation, especially D816 mutation. The current retrospective study attempted to validate a prognostic role of KIT mutation in 121 Korean patients with CBF AML. The study patients consisted of 121 patients with CBF AML (82 patients with RUNX1/RUNX1T1 [67.8 %] and 39 patients with CBFB/MYH11 [32.2 %]) recruited from eight institutions in Korea. All patients received idarubicin plus cytarabine or behenoyl cytosine arabinoside 3 + 7 induction chemotherapy. The KIT gene mutation status was determined by direct sequencing analyses. A KIT mutation was detected in 32 cases (26.4 %) in our series of patients. The KIT mutation was most frequent in exon 17 (n = 18, 14.9 %; n = 16 with D816 mutation), followed by exon 8 (n = 10, 8.3 %). The presence of KIT D816 mutation was associated with adverse outcomes for the event-free survival (p = 0.03) and for the overall survival (p = 0.02). The unfavorable impact of D816 mutation was more prominent when the analysis was confined to the RUNX1/RUNX1T1 subtype. The KIT mutation was detected in 26.4 % of Korean patients with CBF AML. The KIT D816 mutation demonstrated an unfavorable prognostic implication, particularly in the RUNX1/RUNX1T1 subtype. More... »

PAGES

163-171

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-012-1580-5

DOI

http://dx.doi.org/10.1007/s00277-012-1580-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041770820

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23053179


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