Ontology type: schema:ScholarlyArticle
2013-02
AUTHORSHee-Jin Kim, Hee Kyung Ahn, Chul Won Jung, Joon Ho Moon, Chang-Hun Park, Ki-O Lee, Sun-Hee Kim, Yeo-Kyeoung Kim, Hyeoung-Joon Kim, Sang Kyun Sohn, Sung Hyun Kim, Won Sik Lee, Kyoung Ha Kim, Yeung-Chul Mun, Hawk Kim, Jinny Park, Woo-Sung Min, Hee-Je Kim, Dong Hwan Dennis Kim, on behalf of AML/MDS working party, Korean Society of Hematology
ABSTRACTCore binding factor (CBF)-positive acute myeloid leukemia (AML) presents a favorable prognosis, except for patients with KIT mutation, especially D816 mutation. The current retrospective study attempted to validate a prognostic role of KIT mutation in 121 Korean patients with CBF AML. The study patients consisted of 121 patients with CBF AML (82 patients with RUNX1/RUNX1T1 [67.8 %] and 39 patients with CBFB/MYH11 [32.2 %]) recruited from eight institutions in Korea. All patients received idarubicin plus cytarabine or behenoyl cytosine arabinoside 3 + 7 induction chemotherapy. The KIT gene mutation status was determined by direct sequencing analyses. A KIT mutation was detected in 32 cases (26.4 %) in our series of patients. The KIT mutation was most frequent in exon 17 (n = 18, 14.9 %; n = 16 with D816 mutation), followed by exon 8 (n = 10, 8.3 %). The presence of KIT D816 mutation was associated with adverse outcomes for the event-free survival (p = 0.03) and for the overall survival (p = 0.02). The unfavorable impact of D816 mutation was more prominent when the analysis was confined to the RUNX1/RUNX1T1 subtype. The KIT mutation was detected in 26.4 % of Korean patients with CBF AML. The KIT D816 mutation demonstrated an unfavorable prognostic implication, particularly in the RUNX1/RUNX1T1 subtype. More... »
PAGES163-171
http://scigraph.springernature.com/pub.10.1007/s00277-012-1580-5
DOIhttp://dx.doi.org/10.1007/s00277-012-1580-5
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/23053179
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"description": "Core binding factor (CBF)-positive acute myeloid leukemia (AML) presents a favorable prognosis, except for patients with KIT mutation, especially D816 mutation. The current retrospective study attempted to validate a prognostic role of KIT mutation in 121 Korean patients with CBF AML. The study patients consisted of 121 patients with CBF AML (82 patients with RUNX1/RUNX1T1 [67.8\u00a0%] and 39 patients with CBFB/MYH11 [32.2\u00a0%]) recruited from eight institutions in Korea. All patients received idarubicin plus cytarabine or behenoyl cytosine arabinoside 3\u2009+\u20097 induction chemotherapy. The KIT gene mutation status was determined by direct sequencing analyses. A KIT mutation was detected in 32 cases (26.4\u00a0%) in our series of patients. The KIT mutation was most frequent in exon 17 (n\u2009=\u200918, 14.9\u00a0%; n\u2009=\u200916 with D816 mutation), followed by exon 8 (n\u2009=\u200910, 8.3\u00a0%). The presence of KIT D816 mutation was associated with adverse outcomes for the event-free survival (p\u2009=\u20090.03) and for the overall survival (p\u2009=\u20090.02). The unfavorable impact of D816 mutation was more prominent when the analysis was confined to the RUNX1/RUNX1T1 subtype. The KIT mutation was detected in 26.4\u00a0% of Korean patients with CBF AML. The KIT D816 mutation demonstrated an unfavorable prognostic implication, particularly in the RUNX1/RUNX1T1 subtype.",
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]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1041770820"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00277-012-1580-5",
"https://app.dimensions.ai/details/publication/pub.1041770820"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T00:11",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000490.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/s00277-012-1580-5"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00277-012-1580-5'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00277-012-1580-5'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-012-1580-5'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-012-1580-5'
This table displays all metadata directly associated to this object as RDF triples.
411 TRIPLES
21 PREDICATES
75 URIs
54 LITERALS
42 BLANK NODES