Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-08

AUTHORS

Felicitas Thol, Haiyang Yun, Ann-Kathrin Sonntag, Frederik Damm, Eva M. Weissinger, Jürgen Krauter, Katharina Wagner, Michael Morgan, Martin Wichmann, Gudrun Göhring, Gesine Bug, Oliver Ottmann, Wolf-Karsten Hofmann, Axel Schambach, Brigitte Schlegelberger, Torsten Haferlach, David Bowen, Ken Mills, Arnold Ganser, Michael Heuser

ABSTRACT

Overexpression of MN1, ERG, BAALC, and EVI1 (MEBE) genes in cytogenetically normal acute myeloid leukemia (AML) patients is associated with poor prognosis, but their prognostic effect in patients with myelodysplastic syndromes (MDS) has not been studied systematically. Expression data of the four genes from 140 MDS patients were combined in an additive score, which was validated in an independent patient cohort of 110 MDS patients. A high MEBE score, defined as high expression of at least two of the four genes, predicted a significantly shorter overall survival (OS) (HR 2.29, 95 % CI 1.3-4.09, P= .005) and time to AML progression (HR 4.83, 95 % CI 2.01-11.57, P< .001) compared to a low MEBE score in multivariate analysis independent of karyotype, percentage of bone marrow blasts, transfusion dependence, ASXL1, and IDH1 mutation status. In a validation cohort of 110 MDS patients, a high MEBE score predicted shorter OS (HR 1.77; 95 % CI 1.04-3.0, P= .034) and time to AML progression (HR 3.0, 95 % CI 1.17-7.65, P= .022). A high MEBE expression score is an unfavorable prognostic marker in MDS and is associated with an increased risk for progression to AML. Expression of the MEBE genes is regulated by FLI1 and c-MYC, which are potential upstream targets of the MEBE signature. More... »

PAGES

1221-1233

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-012-1457-7

DOI

http://dx.doi.org/10.1007/s00277-012-1457-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043794595

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22488406


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Leukemic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myeloid, Acute", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MDS1 and EVI1 Complex Locus Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myelodysplastic Syndromes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Preleukemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trans-Activators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcriptional Regulator ERG", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Validation Studies as Topic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thol", 
        "givenName": "Felicitas", 
        "id": "sg:person.01237266651.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237266651.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yun", 
        "givenName": "Haiyang", 
        "id": "sg:person.0704264637.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704264637.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sonntag", 
        "givenName": "Ann-Kathrin", 
        "id": "sg:person.01223347757.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223347757.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Damm", 
        "givenName": "Frederik", 
        "id": "sg:person.01330043755.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330043755.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weissinger", 
        "givenName": "Eva M.", 
        "id": "sg:person.01204267030.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204267030.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krauter", 
        "givenName": "J\u00fcrgen", 
        "id": "sg:person.0650270713.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650270713.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wagner", 
        "givenName": "Katharina", 
        "id": "sg:person.01154204022.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154204022.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morgan", 
        "givenName": "Michael", 
        "id": "sg:person.01361555537.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361555537.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wichmann", 
        "givenName": "Martin", 
        "id": "sg:person.0776534057.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776534057.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "G\u00f6hring", 
        "givenName": "Gudrun", 
        "id": "sg:person.01257266136.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257266136.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bug", 
        "givenName": "Gesine", 
        "id": "sg:person.0660354231.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660354231.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Goethe University Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.7839.5", 
          "name": [
            "Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ottmann", 
        "givenName": "Oliver", 
        "id": "sg:person.01051501512.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051501512.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Centre Mannheim", 
          "id": "https://www.grid.ac/institutes/grid.411778.c", 
          "name": [
            "Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hofmann", 
        "givenName": "Wolf-Karsten", 
        "id": "sg:person.0710371040.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710371040.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Department of Experimental Hematology, Hannover Medical School, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schambach", 
        "givenName": "Axel", 
        "id": "sg:person.01125237061.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125237061.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schlegelberger", 
        "givenName": "Brigitte", 
        "id": "sg:person.0627247726.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627247726.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Munich Leukemia Laboratory (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.420057.4", 
          "name": [
            "MLL, Munich Leukemia Laboratory, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haferlach", 
        "givenName": "Torsten", 
        "id": "sg:person.01237731352.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237731352.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St James's University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.443984.6", 
          "name": [
            "St James\u2019s Institute of Oncology, Leeds Teaching Hospitals, Leeds, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bowen", 
        "givenName": "David", 
        "id": "sg:person.012161426302.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012161426302.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Queen's University Belfast", 
          "id": "https://www.grid.ac/institutes/grid.4777.3", 
          "name": [
            "Centre for Cancer Research and Cell Biology, Queen\u2019s University Belfast, Belfast, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mills", 
        "givenName": "Ken", 
        "id": "sg:person.016674401562.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016674401562.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ganser", 
        "givenName": "Arnold", 
        "id": "sg:person.01225227464.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225227464.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hannover Medical School", 
          "id": "https://www.grid.ac/institutes/grid.10423.34", 
          "name": [
            "Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heuser", 
        "givenName": "Michael", 
        "id": "sg:person.0716104605.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716104605.17"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1600-0609.1989.tb00300.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001272497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0609.1989.tb00300.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001272497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.31.1118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002015562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.26.0646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006874505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.4780050306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008204596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008245757", 
          "https://doi.org/10.1038/nature10496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010733563", 
          "https://doi.org/10.1038/nm.2088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010733563", 
          "https://doi.org/10.1038/nm.2088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-11-187724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012619441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-03-272146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012726115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2010.025494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013566562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2011-12-399774", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014583056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-10-053850", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014617792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20110447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014933913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2010.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015392938", 
          "https://doi.org/10.1038/leu.2010.31"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015449707", 
          "https://doi.org/10.1038/sj.leu.2403239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2403239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015449707", 
          "https://doi.org/10.1038/sj.leu.2403239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2010.07.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015642068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-04-014845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015960371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-11-320515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016901837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-02-0359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017075829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci21716", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017511179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.35.4894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017658510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2008.06.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020922155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exphem.2003.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025116539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exphem.2003.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025116539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1013343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027110305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2011.321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027148028", 
          "https://doi.org/10.1038/leu.2011.321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa040465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027799720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2011.228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032065354", 
          "https://doi.org/10.1038/leu.2011.228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gki022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033237811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.hoc.2010.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035798556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.31.2686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035803992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.33.4938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036660359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002770050488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036902767", 
          "https://doi.org/10.1007/s002770050488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.20.6110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037153764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-12-317990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038238874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2011.06.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039002288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-03-080523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039649442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.10.8720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040550572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2011-12-399337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041184075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2011.045559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041263255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2011-12-400994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042194292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2008.118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044068214", 
          "https://doi.org/10.1038/leu.2008.118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.20.5328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044849071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-10-187203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045855246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.01.6253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047287690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-02-205443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047541277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-05-1459", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048949058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2405070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050071498", 
          "https://doi.org/10.1038/sj.leu.2405070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-11-253070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050076672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-0075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051127662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cyto.a.21072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051256434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2010.08174.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052749521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2010.08174.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052749521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1103283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052892849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083056512", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-08", 
    "datePublishedReg": "2012-08-01", 
    "description": "Overexpression of MN1, ERG, BAALC, and EVI1 (MEBE) genes in cytogenetically normal acute myeloid leukemia (AML) patients is associated with poor prognosis, but their prognostic effect in patients with myelodysplastic syndromes (MDS) has not been studied systematically. Expression data of the four genes from 140 MDS patients were combined in an additive score, which was validated in an independent patient cohort of 110 MDS patients. A high MEBE score, defined as high expression of at least two of the four genes, predicted a significantly shorter overall survival (OS) (HR 2.29, 95 % CI 1.3-4.09, P=\u2009.005) and time to AML progression (HR 4.83, 95 % CI 2.01-11.57, P<\u2009.001) compared to a low MEBE score in multivariate analysis independent of karyotype, percentage of bone marrow blasts, transfusion dependence, ASXL1, and IDH1 mutation status. In a validation cohort of 110 MDS patients, a high MEBE score predicted shorter OS (HR 1.77; 95 % CI 1.04-3.0, P=\u2009.034) and time to AML progression (HR 3.0, 95 % CI 1.17-7.65, P=\u2009.022). A high MEBE expression score is an unfavorable prognostic marker in MDS and is associated with an increased risk for progression to AML. Expression of the MEBE genes is regulated by FLI1 and c-MYC, which are potential upstream targets of the MEBE signature.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00277-012-1457-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018247", 
        "issn": [
          "1269-3286", 
          "1279-8509"
        ], 
        "name": "Annals of Hematology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "91"
      }
    ], 
    "name": "Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes", 
    "pagination": "1221-1233", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d09c6cf312ea4fece9299164f873a8a3c6688bf82a32bca687908871bc665013"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22488406"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9107334"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00277-012-1457-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043794595"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00277-012-1457-7", 
      "https://app.dimensions.ai/details/publication/pub.1043794595"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000352_0000000352/records_60375_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00277-012-1457-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00277-012-1457-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00277-012-1457-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-012-1457-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-012-1457-7'


 

This table displays all metadata directly associated to this object as RDF triples.

494 TRIPLES      21 PREDICATES      109 URIs      48 LITERALS      36 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00277-012-1457-7 schema:about N132091efd1cb43899302ba723a9e8cf5
2 N1956f1691cda4e049a5d81828023150c
3 N1961cc7d70324df7bea597c5fcd1ef92
4 N1a859919c5364d54af415a5b1a325d18
5 N1ba819ae8fd54c7484ace87913b136f6
6 N1da7d748d3ec409995530e70a2a04b02
7 N1f1adb1f280d44c0b9bb291a9f889a16
8 N217504ab588440fda0e5f5c48b1192a8
9 N3e7338ffe89941139c8dc648ed028d9e
10 N68c157c92c34409fb0634150bcd5355a
11 N6dac53707a6a40f98c05adfcda2df106
12 N711ba31305a847febadae81644fe8216
13 N74bf02cc965e447e9f1595f7b5c60780
14 N89963a8f90af447ab9ff8f6c3a8f6209
15 N98437e3634da4610bb4a69e4f6610509
16 N9b1261afe63944d684c49b2ea9509f07
17 Na8a63d01161c48e99d09c153bcb0446d
18 Nb44bb889308949e6886912a6eab9d194
19 Nbbbe55a2a2034b5e959f4f0f2306fa10
20 Nc4dffa3e8dcb4255a53f6e0782c87cac
21 Nc543aa74441b48da837474e5f8b4e5c8
22 Nce94bd3cbb4f4f1ca81b94207f983bf1
23 Nd4828b346deb4555ae0613c725f76be5
24 Nd4b36419182244b78b4484263e6681dd
25 Nd54708a6e8ad45f4b03fbbe3c22008fc
26 Nf6d7a7c743604d83b34165ff6643ec35
27 Nfd324254dcf141d2835e91f1589f1577
28 anzsrc-for:11
29 anzsrc-for:1112
30 schema:author N20cddabb58244d7891ec358dfdbaed44
31 schema:citation sg:pub.10.1007/s002770050488
32 sg:pub.10.1038/leu.2008.118
33 sg:pub.10.1038/leu.2010.31
34 sg:pub.10.1038/leu.2011.228
35 sg:pub.10.1038/leu.2011.321
36 sg:pub.10.1038/nature10496
37 sg:pub.10.1038/nm.2088
38 sg:pub.10.1038/sj.leu.2403239
39 sg:pub.10.1038/sj.leu.2405070
40 https://app.dimensions.ai/details/publication/pub.1083056512
41 https://doi.org/10.1002/cyto.a.21072
42 https://doi.org/10.1002/sim.4780050306
43 https://doi.org/10.1016/j.ccr.2011.06.020
44 https://doi.org/10.1016/j.exphem.2003.08.004
45 https://doi.org/10.1016/j.hoc.2010.02.005
46 https://doi.org/10.1016/j.stem.2008.06.002
47 https://doi.org/10.1016/j.stem.2010.07.016
48 https://doi.org/10.1056/nejmoa040465
49 https://doi.org/10.1056/nejmoa1013343
50 https://doi.org/10.1056/nejmoa1103283
51 https://doi.org/10.1073/pnas.0506580102
52 https://doi.org/10.1084/jem.20110447
53 https://doi.org/10.1093/nar/gki022
54 https://doi.org/10.1111/j.1365-2141.2010.08174.x
55 https://doi.org/10.1111/j.1600-0609.1989.tb00300.x
56 https://doi.org/10.1158/0008-5472.can-09-0075
57 https://doi.org/10.1172/jci21716
58 https://doi.org/10.1182/blood-2002-05-1459
59 https://doi.org/10.1182/blood-2003-02-0359
60 https://doi.org/10.1182/blood-2006-04-014845
61 https://doi.org/10.1182/blood-2006-10-053850
62 https://doi.org/10.1182/blood-2007-03-080523
63 https://doi.org/10.1182/blood-2008-10-187203
64 https://doi.org/10.1182/blood-2008-11-187724
65 https://doi.org/10.1182/blood-2009-02-205443
66 https://doi.org/10.1182/blood-2009-11-253070
67 https://doi.org/10.1182/blood-2010-03-272146
68 https://doi.org/10.1182/blood-2010-11-320515
69 https://doi.org/10.1182/blood-2010-12-317990
70 https://doi.org/10.1182/blood-2011-12-399337
71 https://doi.org/10.1182/blood-2011-12-399774
72 https://doi.org/10.1182/blood-2011-12-400994
73 https://doi.org/10.1200/jco.2005.01.6253
74 https://doi.org/10.1200/jco.2007.10.8720
75 https://doi.org/10.1200/jco.2008.20.5328
76 https://doi.org/10.1200/jco.2008.20.6110
77 https://doi.org/10.1200/jco.2009.26.0646
78 https://doi.org/10.1200/jco.2010.31.1118
79 https://doi.org/10.1200/jco.2010.31.2686
80 https://doi.org/10.1200/jco.2010.33.4938
81 https://doi.org/10.1200/jco.2011.35.4894
82 https://doi.org/10.3324/haematol.2010.025494
83 https://doi.org/10.3324/haematol.2011.045559
84 schema:datePublished 2012-08
85 schema:datePublishedReg 2012-08-01
86 schema:description Overexpression of MN1, ERG, BAALC, and EVI1 (MEBE) genes in cytogenetically normal acute myeloid leukemia (AML) patients is associated with poor prognosis, but their prognostic effect in patients with myelodysplastic syndromes (MDS) has not been studied systematically. Expression data of the four genes from 140 MDS patients were combined in an additive score, which was validated in an independent patient cohort of 110 MDS patients. A high MEBE score, defined as high expression of at least two of the four genes, predicted a significantly shorter overall survival (OS) (HR 2.29, 95 % CI 1.3-4.09, P= .005) and time to AML progression (HR 4.83, 95 % CI 2.01-11.57, P< .001) compared to a low MEBE score in multivariate analysis independent of karyotype, percentage of bone marrow blasts, transfusion dependence, ASXL1, and IDH1 mutation status. In a validation cohort of 110 MDS patients, a high MEBE score predicted shorter OS (HR 1.77; 95 % CI 1.04-3.0, P= .034) and time to AML progression (HR 3.0, 95 % CI 1.17-7.65, P= .022). A high MEBE expression score is an unfavorable prognostic marker in MDS and is associated with an increased risk for progression to AML. Expression of the MEBE genes is regulated by FLI1 and c-MYC, which are potential upstream targets of the MEBE signature.
87 schema:genre research_article
88 schema:inLanguage en
89 schema:isAccessibleForFree false
90 schema:isPartOf N5f2455e0c2574236a7ba3809fa327ee6
91 N9351731e91c14e8db895e50a2e92dc25
92 sg:journal.1018247
93 schema:name Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes
94 schema:pagination 1221-1233
95 schema:productId N47e82451f35446fb9cb74830e6d7253d
96 N5e7508cfc4ae4962a79dba69bc9a37b1
97 N934144fad9e6492b87cae374ac5fa91a
98 Na839a27434f84d6298879a7bc2d60de1
99 Nc4ad10458f3342e1a331047be7608d0d
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043794595
101 https://doi.org/10.1007/s00277-012-1457-7
102 schema:sdDatePublished 2019-04-11T11:06
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher N3b8979b9fa29443b83a775485ec2a2fd
105 schema:url http://link.springer.com/10.1007/s00277-012-1457-7
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N132091efd1cb43899302ba723a9e8cf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Aged
111 rdf:type schema:DefinedTerm
112 N1956f1691cda4e049a5d81828023150c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Predictive Value of Tests
114 rdf:type schema:DefinedTerm
115 N1961cc7d70324df7bea597c5fcd1ef92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Transcriptional Regulator ERG
117 rdf:type schema:DefinedTerm
118 N1a859919c5364d54af415a5b1a325d18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name MDS1 and EVI1 Complex Locus Protein
120 rdf:type schema:DefinedTerm
121 N1ba819ae8fd54c7484ace87913b136f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Neoplasm Proteins
123 rdf:type schema:DefinedTerm
124 N1da7d748d3ec409995530e70a2a04b02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Prognosis
126 rdf:type schema:DefinedTerm
127 N1f1adb1f280d44c0b9bb291a9f889a16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Preleukemia
129 rdf:type schema:DefinedTerm
130 N20cddabb58244d7891ec358dfdbaed44 rdf:first sg:person.01237266651.57
131 rdf:rest Na705663a4b86461abcc3ab9feacfc40f
132 N217504ab588440fda0e5f5c48b1192a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Trans-Activators
134 rdf:type schema:DefinedTerm
135 N2381379ee7f74c72ac985bdf183a0337 rdf:first sg:person.01330043755.24
136 rdf:rest N274d6d06685f4a5baeee95e42f5e2db2
137 N274d6d06685f4a5baeee95e42f5e2db2 rdf:first sg:person.01204267030.84
138 rdf:rest Nf46fee0a99d94386b9fd40ba20b680bf
139 N3213015eedf54028924e176ac59b573b rdf:first sg:person.016674401562.40
140 rdf:rest Nb5a53d0d0c4947238a54a4378867e79c
141 N3b8979b9fa29443b83a775485ec2a2fd schema:name Springer Nature - SN SciGraph project
142 rdf:type schema:Organization
143 N3be3114461214402b98d3f5453fa3218 rdf:first sg:person.01154204022.12
144 rdf:rest N4101cdc4c6b6469fa5e22ee5f447d0e5
145 N3e7338ffe89941139c8dc648ed028d9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Male
147 rdf:type schema:DefinedTerm
148 N4101cdc4c6b6469fa5e22ee5f447d0e5 rdf:first sg:person.01361555537.79
149 rdf:rest Ncb2bf05359534aa588e32344a0de0bc2
150 N4622897d29964508acf44f81ade7ae07 rdf:first sg:person.01257266136.63
151 rdf:rest N7519ad6adfe3426682923a800faef7a2
152 N47e82451f35446fb9cb74830e6d7253d schema:name pubmed_id
153 schema:value 22488406
154 rdf:type schema:PropertyValue
155 N49c9902b2e2546cf91eeccd9657dfcb0 rdf:first sg:person.0716104605.17
156 rdf:rest rdf:nil
157 N5e7508cfc4ae4962a79dba69bc9a37b1 schema:name dimensions_id
158 schema:value pub.1043794595
159 rdf:type schema:PropertyValue
160 N5f2455e0c2574236a7ba3809fa327ee6 schema:issueNumber 8
161 rdf:type schema:PublicationIssue
162 N68c157c92c34409fb0634150bcd5355a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Aged, 80 and over
164 rdf:type schema:DefinedTerm
165 N6dac53707a6a40f98c05adfcda2df106 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Leukemia, Myeloid, Acute
167 rdf:type schema:DefinedTerm
168 N711ba31305a847febadae81644fe8216 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Adult
170 rdf:type schema:DefinedTerm
171 N74bf02cc965e447e9f1595f7b5c60780 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Cohort Studies
173 rdf:type schema:DefinedTerm
174 N7519ad6adfe3426682923a800faef7a2 rdf:first sg:person.0660354231.27
175 rdf:rest Nca6d4dd92c71497f9a86f679c19147c3
176 N7a32a83859c44ecd93cab930acf4c6fc rdf:first sg:person.0627247726.09
177 rdf:rest N90216a136c814c11bd38c087f3b6fad0
178 N88df14eb3aeb4a3da1e0c14bef143fb2 rdf:first sg:person.01125237061.67
179 rdf:rest N7a32a83859c44ecd93cab930acf4c6fc
180 N89963a8f90af447ab9ff8f6c3a8f6209 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Disease Progression
182 rdf:type schema:DefinedTerm
183 N90216a136c814c11bd38c087f3b6fad0 rdf:first sg:person.01237731352.62
184 rdf:rest Nb294d79bdf7b4a30b70583f1bfc4e901
185 N934144fad9e6492b87cae374ac5fa91a schema:name doi
186 schema:value 10.1007/s00277-012-1457-7
187 rdf:type schema:PropertyValue
188 N9351731e91c14e8db895e50a2e92dc25 schema:volumeNumber 91
189 rdf:type schema:PublicationVolume
190 N98437e3634da4610bb4a69e4f6610509 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Female
192 rdf:type schema:DefinedTerm
193 N9b1261afe63944d684c49b2ea9509f07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Validation Studies as Topic
195 rdf:type schema:DefinedTerm
196 Na705663a4b86461abcc3ab9feacfc40f rdf:first sg:person.0704264637.11
197 rdf:rest Nfa6c97e6976f4a18a843a0a451b245d1
198 Na839a27434f84d6298879a7bc2d60de1 schema:name readcube_id
199 schema:value d09c6cf312ea4fece9299164f873a8a3c6688bf82a32bca687908871bc665013
200 rdf:type schema:PropertyValue
201 Na8a63d01161c48e99d09c153bcb0446d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Gene Expression Regulation, Leukemic
203 rdf:type schema:DefinedTerm
204 Nb294d79bdf7b4a30b70583f1bfc4e901 rdf:first sg:person.012161426302.63
205 rdf:rest N3213015eedf54028924e176ac59b573b
206 Nb44bb889308949e6886912a6eab9d194 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Proto-Oncogenes
208 rdf:type schema:DefinedTerm
209 Nb5a53d0d0c4947238a54a4378867e79c rdf:first sg:person.01225227464.09
210 rdf:rest N49c9902b2e2546cf91eeccd9657dfcb0
211 Nbbbe55a2a2034b5e959f4f0f2306fa10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Transcription Factors
213 rdf:type schema:DefinedTerm
214 Nbe037c1352f048a391dc7631ea755dc1 rdf:first sg:person.0710371040.30
215 rdf:rest N88df14eb3aeb4a3da1e0c14bef143fb2
216 Nc4ad10458f3342e1a331047be7608d0d schema:name nlm_unique_id
217 schema:value 9107334
218 rdf:type schema:PropertyValue
219 Nc4dffa3e8dcb4255a53f6e0782c87cac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Gene Expression
221 rdf:type schema:DefinedTerm
222 Nc543aa74441b48da837474e5f8b4e5c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Tumor Suppressor Proteins
224 rdf:type schema:DefinedTerm
225 Nca6d4dd92c71497f9a86f679c19147c3 rdf:first sg:person.01051501512.14
226 rdf:rest Nbe037c1352f048a391dc7631ea755dc1
227 Ncb2bf05359534aa588e32344a0de0bc2 rdf:first sg:person.0776534057.21
228 rdf:rest N4622897d29964508acf44f81ade7ae07
229 Nce94bd3cbb4f4f1ca81b94207f983bf1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
230 schema:name Gene Expression Profiling
231 rdf:type schema:DefinedTerm
232 Nd4828b346deb4555ae0613c725f76be5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name DNA-Binding Proteins
234 rdf:type schema:DefinedTerm
235 Nd4b36419182244b78b4484263e6681dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
236 schema:name Cell Transformation, Neoplastic
237 rdf:type schema:DefinedTerm
238 Nd54708a6e8ad45f4b03fbbe3c22008fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
239 schema:name Humans
240 rdf:type schema:DefinedTerm
241 Nf46fee0a99d94386b9fd40ba20b680bf rdf:first sg:person.0650270713.67
242 rdf:rest N3be3114461214402b98d3f5453fa3218
243 Nf6d7a7c743604d83b34165ff6643ec35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
244 schema:name Middle Aged
245 rdf:type schema:DefinedTerm
246 Nfa6c97e6976f4a18a843a0a451b245d1 rdf:first sg:person.01223347757.23
247 rdf:rest N2381379ee7f74c72ac985bdf183a0337
248 Nfd324254dcf141d2835e91f1589f1577 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
249 schema:name Myelodysplastic Syndromes
250 rdf:type schema:DefinedTerm
251 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
252 schema:name Medical and Health Sciences
253 rdf:type schema:DefinedTerm
254 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
255 schema:name Oncology and Carcinogenesis
256 rdf:type schema:DefinedTerm
257 sg:journal.1018247 schema:issn 1269-3286
258 1279-8509
259 schema:name Annals of Hematology
260 rdf:type schema:Periodical
261 sg:person.01051501512.14 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
262 schema:familyName Ottmann
263 schema:givenName Oliver
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051501512.14
265 rdf:type schema:Person
266 sg:person.01125237061.67 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
267 schema:familyName Schambach
268 schema:givenName Axel
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125237061.67
270 rdf:type schema:Person
271 sg:person.01154204022.12 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
272 schema:familyName Wagner
273 schema:givenName Katharina
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154204022.12
275 rdf:type schema:Person
276 sg:person.01204267030.84 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
277 schema:familyName Weissinger
278 schema:givenName Eva M.
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204267030.84
280 rdf:type schema:Person
281 sg:person.012161426302.63 schema:affiliation https://www.grid.ac/institutes/grid.443984.6
282 schema:familyName Bowen
283 schema:givenName David
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012161426302.63
285 rdf:type schema:Person
286 sg:person.01223347757.23 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
287 schema:familyName Sonntag
288 schema:givenName Ann-Kathrin
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223347757.23
290 rdf:type schema:Person
291 sg:person.01225227464.09 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
292 schema:familyName Ganser
293 schema:givenName Arnold
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225227464.09
295 rdf:type schema:Person
296 sg:person.01237266651.57 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
297 schema:familyName Thol
298 schema:givenName Felicitas
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237266651.57
300 rdf:type schema:Person
301 sg:person.01237731352.62 schema:affiliation https://www.grid.ac/institutes/grid.420057.4
302 schema:familyName Haferlach
303 schema:givenName Torsten
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237731352.62
305 rdf:type schema:Person
306 sg:person.01257266136.63 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
307 schema:familyName Göhring
308 schema:givenName Gudrun
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257266136.63
310 rdf:type schema:Person
311 sg:person.01330043755.24 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
312 schema:familyName Damm
313 schema:givenName Frederik
314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330043755.24
315 rdf:type schema:Person
316 sg:person.01361555537.79 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
317 schema:familyName Morgan
318 schema:givenName Michael
319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361555537.79
320 rdf:type schema:Person
321 sg:person.016674401562.40 schema:affiliation https://www.grid.ac/institutes/grid.4777.3
322 schema:familyName Mills
323 schema:givenName Ken
324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016674401562.40
325 rdf:type schema:Person
326 sg:person.0627247726.09 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
327 schema:familyName Schlegelberger
328 schema:givenName Brigitte
329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627247726.09
330 rdf:type schema:Person
331 sg:person.0650270713.67 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
332 schema:familyName Krauter
333 schema:givenName Jürgen
334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650270713.67
335 rdf:type schema:Person
336 sg:person.0660354231.27 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
337 schema:familyName Bug
338 schema:givenName Gesine
339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660354231.27
340 rdf:type schema:Person
341 sg:person.0704264637.11 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
342 schema:familyName Yun
343 schema:givenName Haiyang
344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704264637.11
345 rdf:type schema:Person
346 sg:person.0710371040.30 schema:affiliation https://www.grid.ac/institutes/grid.411778.c
347 schema:familyName Hofmann
348 schema:givenName Wolf-Karsten
349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710371040.30
350 rdf:type schema:Person
351 sg:person.0716104605.17 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
352 schema:familyName Heuser
353 schema:givenName Michael
354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716104605.17
355 rdf:type schema:Person
356 sg:person.0776534057.21 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
357 schema:familyName Wichmann
358 schema:givenName Martin
359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776534057.21
360 rdf:type schema:Person
361 sg:pub.10.1007/s002770050488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036902767
362 https://doi.org/10.1007/s002770050488
363 rdf:type schema:CreativeWork
364 sg:pub.10.1038/leu.2008.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044068214
365 https://doi.org/10.1038/leu.2008.118
366 rdf:type schema:CreativeWork
367 sg:pub.10.1038/leu.2010.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015392938
368 https://doi.org/10.1038/leu.2010.31
369 rdf:type schema:CreativeWork
370 sg:pub.10.1038/leu.2011.228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032065354
371 https://doi.org/10.1038/leu.2011.228
372 rdf:type schema:CreativeWork
373 sg:pub.10.1038/leu.2011.321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027148028
374 https://doi.org/10.1038/leu.2011.321
375 rdf:type schema:CreativeWork
376 sg:pub.10.1038/nature10496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008245757
377 https://doi.org/10.1038/nature10496
378 rdf:type schema:CreativeWork
379 sg:pub.10.1038/nm.2088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010733563
380 https://doi.org/10.1038/nm.2088
381 rdf:type schema:CreativeWork
382 sg:pub.10.1038/sj.leu.2403239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015449707
383 https://doi.org/10.1038/sj.leu.2403239
384 rdf:type schema:CreativeWork
385 sg:pub.10.1038/sj.leu.2405070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050071498
386 https://doi.org/10.1038/sj.leu.2405070
387 rdf:type schema:CreativeWork
388 https://app.dimensions.ai/details/publication/pub.1083056512 schema:CreativeWork
389 https://doi.org/10.1002/cyto.a.21072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051256434
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1002/sim.4780050306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008204596
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1016/j.ccr.2011.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039002288
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1016/j.exphem.2003.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025116539
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1016/j.hoc.2010.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035798556
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1016/j.stem.2008.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020922155
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1016/j.stem.2010.07.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015642068
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1056/nejmoa040465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027799720
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1056/nejmoa1013343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027110305
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1056/nejmoa1103283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052892849
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1084/jem.20110447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014933913
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1093/nar/gki022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033237811
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1111/j.1365-2141.2010.08174.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052749521
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1111/j.1600-0609.1989.tb00300.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001272497
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1158/0008-5472.can-09-0075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051127662
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1172/jci21716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017511179
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1182/blood-2002-05-1459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048949058
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1182/blood-2003-02-0359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017075829
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1182/blood-2006-04-014845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015960371
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1182/blood-2006-10-053850 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014617792
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1182/blood-2007-03-080523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039649442
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1182/blood-2008-10-187203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045855246
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1182/blood-2008-11-187724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012619441
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1182/blood-2009-02-205443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047541277
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1182/blood-2009-11-253070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050076672
440 rdf:type schema:CreativeWork
441 https://doi.org/10.1182/blood-2010-03-272146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012726115
442 rdf:type schema:CreativeWork
443 https://doi.org/10.1182/blood-2010-11-320515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016901837
444 rdf:type schema:CreativeWork
445 https://doi.org/10.1182/blood-2010-12-317990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038238874
446 rdf:type schema:CreativeWork
447 https://doi.org/10.1182/blood-2011-12-399337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041184075
448 rdf:type schema:CreativeWork
449 https://doi.org/10.1182/blood-2011-12-399774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014583056
450 rdf:type schema:CreativeWork
451 https://doi.org/10.1182/blood-2011-12-400994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042194292
452 rdf:type schema:CreativeWork
453 https://doi.org/10.1200/jco.2005.01.6253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047287690
454 rdf:type schema:CreativeWork
455 https://doi.org/10.1200/jco.2007.10.8720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040550572
456 rdf:type schema:CreativeWork
457 https://doi.org/10.1200/jco.2008.20.5328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044849071
458 rdf:type schema:CreativeWork
459 https://doi.org/10.1200/jco.2008.20.6110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037153764
460 rdf:type schema:CreativeWork
461 https://doi.org/10.1200/jco.2009.26.0646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006874505
462 rdf:type schema:CreativeWork
463 https://doi.org/10.1200/jco.2010.31.1118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002015562
464 rdf:type schema:CreativeWork
465 https://doi.org/10.1200/jco.2010.31.2686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035803992
466 rdf:type schema:CreativeWork
467 https://doi.org/10.1200/jco.2010.33.4938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036660359
468 rdf:type schema:CreativeWork
469 https://doi.org/10.1200/jco.2011.35.4894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017658510
470 rdf:type schema:CreativeWork
471 https://doi.org/10.3324/haematol.2010.025494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013566562
472 rdf:type schema:CreativeWork
473 https://doi.org/10.3324/haematol.2011.045559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041263255
474 rdf:type schema:CreativeWork
475 https://www.grid.ac/institutes/grid.10423.34 schema:alternateName Hannover Medical School
476 schema:name Department of Experimental Hematology, Hannover Medical School, Hannover, Germany
477 Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany
478 Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
479 rdf:type schema:Organization
480 https://www.grid.ac/institutes/grid.411778.c schema:alternateName University Medical Centre Mannheim
481 schema:name Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany
482 rdf:type schema:Organization
483 https://www.grid.ac/institutes/grid.420057.4 schema:alternateName Munich Leukemia Laboratory (Germany)
484 schema:name MLL, Munich Leukemia Laboratory, Munich, Germany
485 rdf:type schema:Organization
486 https://www.grid.ac/institutes/grid.443984.6 schema:alternateName St James's University Hospital
487 schema:name St James’s Institute of Oncology, Leeds Teaching Hospitals, Leeds, UK
488 rdf:type schema:Organization
489 https://www.grid.ac/institutes/grid.4777.3 schema:alternateName Queen's University Belfast
490 schema:name Centre for Cancer Research and Cell Biology, Queen’s University Belfast, Belfast, UK
491 rdf:type schema:Organization
492 https://www.grid.ac/institutes/grid.7839.5 schema:alternateName Goethe University Frankfurt
493 schema:name Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany
494 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...