Allogeneic hematopoietic stem cell transplantation in patients with diffuse large B cell lymphoma relapsed after autologous stem cell transplantation: A ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01-14

AUTHORS

Luigi Rigacci, Bendetta Puccini, Anna Dodero, Pasquale Iacopino, Luca Castagna, Stefania Bramanti, Fabio Ciceri, Renato Fanin, Alessandro Rambaldi, Michele Falda, Giuseppe Milone, Stefano Guidi, Massimo Fabrizio Martelli, Patrizio Mazza, Rosi Oneto, Alberto Bosi, Gruppo Italiano Trapianto di Midollo Osseo (GITMO)

ABSTRACT

Patients who relapse after an autologous hematopoietic stem cell transplantation (SCT) have a very poor prognosis. We have retrospectively analyzed diffuse large B cell lymphoma patients who underwent an allo-SCT after an auto-SCT relapse reported in the Gruppo Italiano Trapianto di Midollo Osseo (GITMO) database. From 1995 to 2008, 3449 autologous transplants were reported in the GITMO database. Eight hundred eighty-four patients relapsed or progressed after transplant; 165 patients, 19% of the relapsed patients, were treated with allo-transplant. The stem cell donor was related to the patient in 108 cases. A reduced intensity conditioning regimen was used in 116. After allo-SCT, 72 patients (43%) obtained a complete response and 9 obtained a partial response with an overall response rate of 49%; 84 patients (51%) experienced rapid progression of disease. Ninety-one patients died, 45 due to disease and 46 due to treatment-related mortality. Acute graft-versus-host disease was recorded in 57 patients and a chronic GvHD in 38 patients. With a median follow-up of 24 months (2–144) after allo, overall survival (OS) was 39%, and after a median of 21 months (2–138) after allo, progression-free survival (PFS) was 32%. Multivariate analysis indicated that the only factors affecting OS were status at allo-SCT, and those affecting PFS were status at allo-SCT and stem cell donor. This retrospective analysis shows that about one-fifth of patients with diffuse large B cell lymphoma who experience relapse after autologous transplantation may be treated with allogeneic transplantation. Moreover, the only parameter affecting either OS or PFS was the response status at the time of allo-SCT. More... »

PAGES

931-939

References to SciGraph publications

  • 2000-03-01. Allogeneic bone marrow transplantation for low-grade lymphoma and chronic lymphocytic leukemia in BONE MARROW TRANSPLANTATION
  • 1997-01-01. Bone marrow transplantation after failure of autologous transplant for non-Hodgkin’s lymphoma in BONE MARROW TRANSPLANTATION
  • 2000-10-01. Allogeneic or autologous bone marrow transplantation (BMT) for non-Hodgkin’s lymphoma (NHL): results of a provincial strategy in BONE MARROW TRANSPLANTATION
  • 2007-06-28. Allogeneic stem cell transplantation following reduced-intensity conditioning can induce durable clinical and molecular remissions in relapsed lymphomas: pre-transplant disease status and histotype heavily influence outcome in LEUKEMIA
  • 2000-05-01. Allogeneic peripheral blood stem cell transplantation using a fludarabine-based low intensity conditioning regimen for malignant lymphoma in BONE MARROW TRANSPLANTATION
  • 2003-04-01. Factors associated with survival in patients with progressive disease following autologous transplant for lymphoma in BONE MARROW TRANSPLANTATION
  • 2005-06-06. Reduced-intensity hematopoietic stem-cell transplantation for malignant lymphoma: a retrospective survey of 112 adult patients in Japan in BONE MARROW TRANSPLANTATION
  • 1997-11-01. Allogeneic bone marrow transplantation in patients who relapse after autologous transplantation in BONE MARROW TRANSPLANTATION
  • 2000-01-01. Second allogeneic hematopoietic stem cell transplantation as treatment for leukemia relapsing following a first transplant in BONE MARROW TRANSPLANTATION
  • Journal

    TITLE

    Annals of Hematology

    ISSUE

    6

    VOLUME

    91

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00277-011-1395-9

    DOI

    http://dx.doi.org/10.1007/s00277-011-1395-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004917219

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22245922


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