A prospective survey of febrile events in hematological malignancies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-11-29

AUTHORS

L. Pagano, M. Caira, G. Rossi, M. Tumbarello, R. Fanci, M. G. Garzia, N. Vianelli, N. Filardi, P. De Fabritiis, A. Beltrame, M. Musso, A. Piccin, A. Cuneo, C. Cattaneo, T. Aloisi, M. Riva, G. Rossi, U. Salvadori, M. Brugiatelli, S. Sannicolò, M. Morselli, A. Bonini, P. Viale, A. Nosari, F. Aversa, for the Hema e-Chart Group, Italy

ABSTRACT

The Hema e-Chart prospectively collected data on febrile events (FEs) in hematological malignancy patients (HMs). The aim of the study was to assess the number, causes and outcome of HM-related FEs. Data were collected in a computerized registry that systematically approached the study and the evolution of FEs developing in a cohort of adult HMs who were admitted to 19 hematology departments in Italy from March 2007 to December 2008. A total of 869 FEs in 3,197 patients with newly diagnosed HMs were recorded. Fever of unidentified origin (FUO) was observed in 386 cases (44.4%). The other causes of FE were identified as noninfectious in 48 cases (5.5%) and infectious in 435 cases (50.1%). Bacteria were the most common cause of infectious FEs (301 cases), followed by fungi (95 cases), and viruses (7 cases). Mixed agents were isolated in 32 episodes. The attributable mortality rate was 6.7% (58 FEs). No deaths were observed in viral infection or in the noninfectious groups, while 25 deaths were due to FUO, 16 to bacterial infections, 14 to fungal infections, and three to mixed infections. The Hema e-Chart provided a complete system for the epidemiological study of infectious complications in HMs. More... »

PAGES

767-774

Journal

TITLE

Annals of Hematology

ISSUE

5

VOLUME

91

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-011-1373-2

DOI

http://dx.doi.org/10.1007/s00277-011-1373-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019542955

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22124621


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369 schema:name Clinica di Malattie Infettive, Università di Bologna, Bologna, Italy
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372 grid-institutes:grid.6530.0 schema:alternateName U.O. Ematologia Pol. Univ. Tor Vergata, Roma, Italy
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380 grid-institutes:grid.9027.c schema:alternateName Istituto di Ematologia, Università di Perugia, Perugia, Italy
381 schema:name Istituto di Ematologia, Università di Perugia, Perugia, Italy
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