Tcf-1 gene silence suppresses downstream gene expression in CD4+ T cells from bone marrow of aplastic anemia patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-09-01

AUTHORS

Miao Zheng, Kai Zheng, Jianfeng Zhou, Hanying Sun, Lifang Huang, Wenli Liu

ABSTRACT

CD4+ T cells play a crucial role in the pathogenesis of acquired aplastic anemia (AA). Tcf-1 gene regulates T cell development and function, and it is significantly upregulated in the bone marrow CD4+ T cells from patients with acquired AA. To explore the role of Tcf-1 in the pathogenesis of AA, we knocked down Tcf-1 gene in CD4+ T cells of AA patients and studied the effects of Tcf-1 silencing on its downstream gene expression. Upon transfection of psiRNA into marrow CD4+ T cells from bone marrow of aplastic anemia patients, the expression of Tcf-1 was significantly knocked down; consequently, expressions of c-Myc and CD44 were also significantly reduced. Our results suggest that Tcf-1 may contribute to pathogenesis of AA by regulating downstream gene expression such as c-myc and CD44. More... »

PAGES

353-358

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-011-1314-0

DOI

http://dx.doi.org/10.1007/s00277-011-1314-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016427675

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21881822


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