Clofarabine and high-dose cytosine arabinoside in the treatment of refractory or relapsed acute myeloid leukaemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-04-01

AUTHORS

Eric Tse, Anskar Y. H. Leung, Joycelyn Sim, Harold K. K. Lee, Herman S. Y. Liu, Sze-Fai Yip, Yok-Lam Kwong

ABSTRACT

Clofarabine (40 mg/m2/day × 5) and high-dose cytosine arabinoside (Ara-C, 1–2 g/m2/day × 5) were used in 10 men and 11 women, at a median age of 45 (22–62) years, with refractory (N = 4) and relapsed (N = 17) acute myeloid leukaemia, after a median of 3 (2–5) prior regimens. Grade 4 myelosuppression was observed in all cases, with two patients dying of bacterial sepsis. Nine patients achieved a complete remission. Disease status, number of prior therapies, and cytogenetic aberrations were not associated with the outcome. However, remission was only achieved with Ara-C at 2 g/m2/day and not 1 g/m2/day (9/15 versus 0/4, P = 0.03). More... »

PAGES

1277-1281

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-011-1223-2

DOI

http://dx.doi.org/10.1007/s00277-011-1223-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025106768

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21455604


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