Differential expression of JAK2 and Src kinase genes in response to hydroxyurea treatment in polycythemia vera and essential thrombocythemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-02-18

AUTHORS

Enriqueta Albizua, Miguel Gallardo, Santiago Barrio, Inmaculada Rapado, Ana Jimenez, Rosa Ayala, Daniel Rueda, Beatriz Sanchez-Espiridion, Eulalia Puigdecanet, Blanca Espinet, Lourdes Florensa, Carles Besses, Joaquin Martinez-Lopez

ABSTRACT

This study investigates the differential gene expression profile of JAK2V617F-positive myeloproliferative neoplasm (MPN) patients, with and without response to hydroxyurea (HU) treatment. Twenty-one polycythemia vera, 28 essential thrombocythemia, eight secondary erythrocytosis, and 30 controls were studied. Thirty-four genes were overexpressed in patients who did not respond to HU. Of these, some participate in proliferative pathways: MAPK, AKT, Src kinase (SFK), and JAK2 pathway. JAK2 allele burden was similar between groups of responders and nonresponder. A molecular fingerprint distinguishes JAK2V617F-positive MPN patients without response to HU treatment, with overexpression of JAK2, MAPK14, PIK3CA, and SFK genes. More... »

PAGES

939-946

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-011-1179-2

DOI

http://dx.doi.org/10.1007/s00277-011-1179-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034631079

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21331593


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31 schema:description This study investigates the differential gene expression profile of JAK2V617F-positive myeloproliferative neoplasm (MPN) patients, with and without response to hydroxyurea (HU) treatment. Twenty-one polycythemia vera, 28 essential thrombocythemia, eight secondary erythrocytosis, and 30 controls were studied. Thirty-four genes were overexpressed in patients who did not respond to HU. Of these, some participate in proliferative pathways: MAPK, AKT, Src kinase (SFK), and JAK2 pathway. JAK2 allele burden was similar between groups of responders and nonresponder. A molecular fingerprint distinguishes JAK2V617F-positive MPN patients without response to HU treatment, with overexpression of JAK2, MAPK14, PIK3CA, and SFK genes.
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39 HU
40 HU treatment
41 JAK2
42 JAK2 allele burden
43 JAK2 pathway
44 JAK2V617F-positive MPN patients
45 JAK2V617F-positive myeloproliferative neoplasm (MPN) patients
46 MAPK
47 MAPK14
48 MPN patients
49 PIK3CA
50 SFK genes
51 Src kinase
52 Src kinase genes
53 allele burden
54 burden
55 control
56 differential expression
57 differential gene expression profiles
58 erythrocytosis
59 essential thrombocythemia
60 expression
61 expression profiles
62 fingerprints
63 gene expression profiles
64 genes
65 group
66 group of responders
67 hydroxyurea treatment
68 kinase
69 kinase gene
70 molecular fingerprints
71 myeloproliferative neoplasm patients
72 neoplasm patients
73 nonresponders
74 overexpression
75 overexpression of JAK2
76 pathway
77 patients
78 polycythemia vera
79 profile
80 proliferative pathways
81 responders
82 response
83 secondary erythrocytosis
84 study
85 thrombocythemia
86 treatment
87 vera
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