Differential expression of JAK2 and Src kinase genes in response to hydroxyurea treatment in polycythemia vera and essential thrombocythemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-08

AUTHORS

Enriqueta Albizua, Miguel Gallardo, Santiago Barrio, Inmaculada Rapado, Ana Jimenez, Rosa Ayala, Daniel Rueda, Beatriz Sanchez-Espiridion, Eulalia Puigdecanet, Blanca Espinet, Lourdes Florensa, Carles Besses, Joaquin Martinez-Lopez

ABSTRACT

This study investigates the differential gene expression profile of JAK2(V617F)-positive myeloproliferative neoplasm (MPN) patients, with and without response to hydroxyurea (HU) treatment. Twenty-one polycythemia vera, 28 essential thrombocythemia, eight secondary erythrocytosis, and 30 controls were studied. Thirty-four genes were overexpressed in patients who did not respond to HU. Of these, some participate in proliferative pathways: MAPK, AKT, Src kinase (SFK), and JAK2 pathway. JAK2 allele burden was similar between groups of responders and nonresponder. A molecular fingerprint distinguishes JAK2(V617F)-positive MPN patients without response to HU treatment, with overexpression of JAK2, MAPK14, PIK3CA, and SFK genes. More... »

PAGES

939-946

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-011-1179-2

DOI

http://dx.doi.org/10.1007/s00277-011-1179-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034631079

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21331593


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00277-011-1179-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00277-011-1179-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-011-1179-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-011-1179-2'


 

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