Phase II fludarabine and cyclophosphamide for the treatment of indolent B cell non-follicular lymphomas: final results of the LL02 trialof ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-03

AUTHORS

Andrea Ferrario, Francesco Merli, Stefano Luminari, Caterina Stelitano, Donato Mannina, Mario Russo, Patrizio Mazza, Luigi Marcheselli, Maria Cecilia Goldaniga, Massimo Federico, Luca Baldini, for the Gruppo Italiano per lo Studio dei Linfomi

ABSTRACT

Indolent non-follicular non-Hodgkin lymphomas (INFL) are a heterogeneous subset whose treatment has been poorly investigated. In this context we have evaluated the efficacy and safety of combined fludarabine and cyclophosphamide (FC) upfront therapy. Sixty-three patients with advanced INFL were enrolled in the study. Therapy consisted in FC combination (25 and 250 mg/m(2), i.v., respectively, for three consecutive days) every 28 days for six courses. After histological review, 61 patients (36 men, median age 64 years, range 40-70 years) were evaluated (22 small lymphocytic, 11 lymphoplasmacytic, 25 marginal zone and 3 CD5-negative non-Hodgkin lymphomas not otherwise specified). Further two patients were excluded for lack of essential data; six patients were withdrawn before the third cycle because of WHO grade III and IV toxicity. At the final evaluation, the overall response rate was 83% with 40.7% of complete remission. Intention-to-treat analysis showed that at the median follow-up of 36 months, overall survival, progression-free survival and failure-free survival were respectively 78%, 60% and 46%; remission duration among the 49 patients achieving complete remission/partial remission at the end of treatment was 65% (44-78) without significant differences between the main histotypes. The most frequent grade III and IV toxic events were haematological (neutropaenia 34%, anaemia 18% and thrombocytopaenia 11%) and infectious (10%). FC is effective for advanced untreated INFL. Early deaths and haematological toxicity suggest careful patient selection and monitoring. More... »

PAGES

323-330

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-010-1067-1

DOI

http://dx.doi.org/10.1007/s00277-010-1067-1

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20848104


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curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-010-1067-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-010-1067-1'


 

This table displays all metadata directly associated to this object as RDF triples.

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316 https://www.grid.ac/institutes/grid.7548.e schema:alternateName University of Modena and Reggio Emilia
317 schema:name Dipartimento di Oncologia ed Ematologia, Università di Modena e Reggio Emilia, Modena, Italy
318 rdf:type schema:Organization
 




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